Zvinyorwa zvine chekuita nazvo kumba nekune dzimwe nyika mukugadzirira mishonga inobatsira hydroxypropyl methylcellulose (HPMC) mumakore achangopfuura zvakaongororwa, kuongororwa uye kupfupikiswa, uye kushandiswa kwayo mukugadzirira kwakasimba, kugadzira mvura, kugadzirira kusunungurwa kwakasimba uye kwakadzorwa, kugadzirira makapisi, gelatin. Mashandisirwo matsva mumunda wemafomu matsva akadai semagadzirirwo eglue uye bioadhesives. Nekuda kwekusiyana kwehuremu hwemamorekuru uye viscosity yeHPMC, ine hunhu uye mashandisirwo e emulsification, adhesion, thickening, viscosity inowedzera, suspending, gelling uye film-forming. Inoshandiswa zvakanyanya mukugadzirira mishonga uye ichaita basa rakakura mumunda wekugadzirira. Nekudzidza kwakadzama kwehunhu hwayo uye kuvandudzwa kwetekinoroji yekugadzira, HPMC ichashandiswa zvakanyanya mukutsvaga mafomu matsva edosi uye masisitimu matsva ekutumira mishonga, nokudaro ichikurudzira kuvandudzwa kunoramba kuripo kwemafomu.
hydroxypropyl methylcellulose; mishonga; zvinhu zvinobatsira mumishonga.
Zvinhu zvinosanganisa mishonga hazvisi izvo chete zvinoita kuti pave nekugadzirwa kwemishonga isina kugadzirwa, asiwo zvine chekuita nekuoma kwekugadzirwa kwayo, kunaka kwemushonga, kugadzikana, kuchengetedzeka, mwero wekuburitswa kwemushonga, maitiro ekushanda, kushanda zvakanaka kwekiriniki, uye kugadzirwa kwemhando itsva dzemushonga uye nzira itsva dzekuushandisa. Kubuda kwezvinobatsira mishonga kunowanzo kurudzira kuvandudzwa kwemhando yemushonga uye kugadzirwa kwemhando itsva dzemushonga. Hydroxypropyl methylcellulose (HPMC) ndeimwe yemishonga inonyanya kufarirwa kumba nekune dzimwe nyika. Nekuda kwehuremu hwayo hwakasiyana hwemamorekuru uye viscosity, ine mabasa ekubatanidza, kusunga, kukora, kukora, kumisa, uye kunamira. Zvinhu uye mashandisirwo akadai sekukanda uye kugadzira mafirimu zvinoshandiswa zvakanyanya muhunyanzvi hwemishonga. Chinyorwa chino chinonyanya kuongorora kushandiswa kwehydroxypropyl methylcellulose (HPMC) mumafomu mumakore achangopfuura.
1.Hunhu hwekutanga hweHPMC
Hydroxypropyl methyl cellulose (HPMC), fomura yemamorekuru ndeye C8H15O8-(C10 H18O6) n-C8H15O8, uye huwandu hwemamorekuru hunosvika 86 000. Chigadzirwa ichi chinhu che semi-synthetic material, chiri chikamu chemethyl uye chikamu che polyhydroxypropyl ether ye cellulose. Chinogona kugadzirwa nenzira mbiri: Imwe ndeyekuti methyl cellulose yemhando yakakodzera inorapwa neNaOH uye yobva yagadziriswa ne propylene oxide pasi pekupisa kwakanyanya uye kumanikidzwa kwakanyanya. Nguva yekuita inofanira kugara kwenguva yakareba zvakakwana kuti methyl ne hydroxypropyl zvigadzire ether bonds. Yakabatana ne anhydroglucose ring ye cellulose muchimiro che cellulose, uye inogona kusvika padanho rinodiwa; imwe ndeyekurapa cotton linter kana wood pulp fiber ne caustic soda, uye yobva yagadziriswa ne chlorinated methane ne propylene oxide zvakateerana, uye yozoigadzirisa zvakare, yakapwanywa kuita upfu hwakatsetseka kana granules.
Ruvara rwechigadzirwa ichi ruchena kusvika kuchena semukaka, harunhuwi uye haruna kunaka, uye chimiro chacho ihupfu hwakatsetseka kana kuti hune fibrous hunofamba nyore nyore. Chigadzirwa ichi chinogona kunyungudutswa mumvura kuti chigadzire mhinduro yecolloidal yakachena kusvika kuchena ine viscosity yakati. Chiitiko che sol-gel interconversion chinogona kuitika nekuda kwekuchinja kwekushisa kwemushonga nekuwedzera kwakati.
Nekuda kwekusiyana kwezviri mukati mezvinhu zviviri izvi zvinotsiva muchimiro chemethoxy nehydroxypropyl, mhando dzakasiyana dzezvigadzirwa dzakaonekwa. Mune huwandu hwakasiyana, mhando dzakasiyana dzezvigadzirwa dzine hunhu hwakasiyana. Saka, viscosity uye thermal gelation tembiricha, zvine hunhu hwakasiyana uye zvinogona kushandiswa kune zvinangwa zvakasiyana. Pharmacopoeia yenyika dzakasiyana ine mitemo yakasiyana uye mimiririro pamuenzaniso: European Pharmacopoeia yakavakirwa pamagiredhi akasiyana e viscosities akasiyana uye madhigirii akasiyana ekutsiva zvigadzirwa zvinotengeswa mumusika, zvinoratidzwa nemagiredhi pamwe nenhamba, uye unit yacho i "mPa s". MuUS Pharmacopoeia, manhamba mana anowedzerwa mushure mezita re generic kuratidza zvirimo uye rudzi rwechimwe nechimwe chinotsiva hydroxypropyl methylcellulose, senge hydroxypropyl methylcellulose 2208. Manhamba maviri ekutanga anomiririra kukosha kweboka re methoxy. Percentage, manhamba maviri ekupedzisira anomiririra percentage ye hydroxypropyl.
Calocan's hydroxypropyl methylcellulose ine mhando nhatu, dzinoti E series, F series uye K series, imwe neimwe ine mhando dzakasiyana dzekusarudza kubva. E series dzinonyanya kushandiswa semafirimu ekuvhara, dzinoshandiswa pakuputira mapiritsi, ma closed tablet cores; E, F series dzinoshandiswa se viscosifiers uye release retarding agents dzekugadzirira maziso, suspending agents, thickeners dzekugadzirira mvura, mapiritsi uye Binders of granules; K series dzinonyanya kushandiswa se release inhibitors uye hydrophilic gel matrix materials ekugadzirira kuburitswa kunononoka uye kunodzorwa.
Vagadziri vemumba vanosanganisira Fuzhou Nhamba 2 Chemical Factory, Huzhou Food and Chemical Co., Ltd., Sichuan Luzhou Pharmaceutical Accessories Factory, Hubei Jinxian Chemical Factory Nhamba 1, Feicheng Ruitai Fine Chemical Co., Ltd., Shandong Liaocheng Ahua Pharmaceutical Co., Ltd., Xi'an Huian chemical plants, nezvimwewo.
2.Mabhenefiti eHPMC
HPMC yave imwe yemishonga inoshandiswa zvakanyanya munyika nekunze kwenyika, nekuti HPMC ine zvakanakira zvisina mimwe mishonga.
2.1 Kunyungudika kwemvura inotonhora
Inonyungudika mumvura inotonhora iri pasi pe40 ℃ kana 70% ethanol, isinganyungudike mumvura inopisa iri pamusoro pe60 ℃, asi inogona kunyungudika.
2.2 Kusashanda kwemakemikari
HPMC imhando ye non-ionic cellulose ether, mhinduro yayo haina ionic charge uye haishande nesimbi munyu kana ionic organic compounds, saka zvimwe zvinhu zvinobatsira hazvishande nayo panguva yekugadzira gadziriro.
2.3 Kugadzikana
Haina kugadzikana zvakanyanya kune ese ari maviri asidhi nealkali, uye inogona kuchengetwa kwenguva yakareba pakati pe pH 3 ne 11 pasina shanduko huru mukupenya. Mvura inobuda muHPMC ine simba rekudzivirira kusviba uye inochengetedza kupenya kwakanaka panguva yekuchengetwa kwenguva refu. Mishonga inoshandisa HPMC ine kugadzikana kwemhando yepamusoro kupfuura iyo inoshandisa mishonga yechinyakare (yakadai se dextrin, starch, nezvimwewo).
2.4 Kugadziriswa kweViscosity
Zvigadzirwa zvakasiyana zveHPMC zvinogona kusanganiswa muzvikamu zvakasiyana, uye viscosity yayo inogona kuchinjwa zvichienderana nemutemo wakati, uye ine hukama hwakanaka hwemutsara, saka chiyero chinogona kusarudzwa zvichienderana nezvinodiwa.
2.5 Kusashanda zvakanaka kwemetabolism
HPMC hainyudzwe kana kugayiwa mumuviri, uye haipe kupisa, saka chinhu chakachengeteka chekugadzira mishonga. 2.6 Kuchengetedzwa Kazhinji zvinofungidzirwa kuti HPMC chinhu chisina chepfu uye chisingatsamwisi, chiyero chepakati chemushonga unouraya mbeva i5 g·kg – 1, uye chiyero chepakati chemushonga unouraya mbeva i5. 2 g · kg – 1. Chipimo chezuva nezuva hachina njodzi kumuviri wemunhu.
3.Kushandiswa kweHPMC mumafomura
3.1 Sezvinhu zvekufukidza firimu uye zvinhu zvinogadzira firimu
Uchishandisa HPMC sepiritsi rakaputirwa nefirimu, piritsi rakaputirwa harina zvakanakira zviri pachena pakuvhara kunaka uye chitarisiko kana richienzaniswa nemapiritsi akaputirwa echinyakare akadai semapiritsi akaputirwa neshuga, asi kuomarara kwaro, kupfava, kunyungudika kwaro, kupatsanuka, kuwedzera huremu hwepurasitiki nezvimwe zviratidzo zvemhando zviri nani. Chikamu chepasi che viscosity chechigadzirwa ichi chinoshandiswa sepurasitiki inonyungudika mumvura yemapiritsi nemapiritsi, uye chikamu chepamusoro che viscosity chinoshandiswa sepurasitiki inoputira masisitimu e organic solvent, kazhinji pahuwandu hwe2% kusvika 20%.
Zhang Jixing nevamwe vake vakashandisa nzira yekubuda nayo pamusoro pechinhu kuti vagadzirise premix formulation neHPMC sefirimu. Vachitora HPMC yezvinhu zvinogadzira firimu, huwandu hwepolyvinyl alcohol neplasticizer polyethylene glycol sezvinhu zvekuferefeta, simba rekudhonza uye kupenya kwefirimu uye viscosity yemhinduro yekudhonza firimu ndiyo index yekuongorora, uye hukama huripo pakati pe index yekuongorora nezvinhu zvekuongorora hunotsanangurwa nemuenzaniso wemasvomhu, uye maitiro ekugadzira akanakisa anowanikwa pakupedzisira. Kushandiswa kwayo kunoenderana nemushonga wekugadzira firimu hydroxypropyl methylcellulose (HPMCE5) 11.88 g, polyvinyl alcohol 24.12 g, plasticizer polyethylene glycol 13.00 g, uye viscosity yekumisikidzwa kwepurasitiki i20 mPa·s, kupenya uye simba rekudhonza kwefirimu zvakasvika pamhedzisiro yakanaka. Zhang Yuan akavandudza maitiro ekugadzirira, akashandisa HPMC sechinobatanidza kutsiva starch slurry, uye akachinja mapiritsi eJiahua kuita mapiritsi akaputirwa nefirimu kuti avandudze mhando yezvigadzirwa zvayo, avandudze hygroscopicity yayo, ave nyore kupera, mapiritsi akareruka, akatsemuka nezvimwe zvinetso, awedzere kugadzikana kwepiritsi. Maitiro ekugadzira akanakisa akaonekwa nekuyedza kwe orthogonal, kureva kuti, huwandu hweslurry hwaive 2% HPMC mu 70% ethanol solution panguva yekupenda, uye nguva yekusanganisa panguva yegranulation yaive maminetsi gumi nemashanu. Mhedzisiro Mapiritsi akaputirwa nefirimu eJiahua akagadzirwa nemaitiro matsva uye mushonga wekurapa akavandudzwa zvikuru muchitarisiko, nguva yekuora uye kuoma kwemukati kupfuura izvo zvakagadzirwa nemaitiro ekutanga ekurapa, uye mwero wakakodzera wemapiritsi akaputirwa nefirimu wakavandudzwa zvikuru. Akasvika anopfuura 95%. Liang Meiyi, Lu Xiaohui, nezvimwewo. vakashandisawo hydroxypropyl methylcellulose sechinhu chekugadzira firimu kugadzirira patinae colon positioning tablet uye matrine colon positioning tablet, zvichiteerana. Zvinokanganisa kuburitswa kwemushonga. Huang Yunran akagadzira Mapiritsi eDragon's Blood Colon Positioning, ndokuisa HPMC mumushonga wekufukidza weganda rakazvimba, uye huwandu hwayo hwaive 5%. Zvinogona kuonekwa kuti HPMC inogona kushandiswa zvakanyanya muhurongwa hwekuendesa mishonga inotarirwa nekoloni.
Hydroxypropyl methylcellulose haisi chinhu chakanaka chete chekufukidza firimu, asiwo inogona kushandiswa sechinhu chinogadzira firimu mumafirimu. Wang Tongshun nezvimwewo zvinogadziriswa zvinoenderana nekurapwa kwe compound zinc licorice ne aminolexanol oral composite film, ine kuchinjika, kufanana, kupfava, uye kujeka kwemushonga wefirimu se investigation index, zvinowana mushonga wakakodzera wePVA 6.5 g, HPMC 0.1 g uye 6.0 g ye propylene glycol inosangana nezvinodiwa zvekunonoka kuburitswa uye kuchengetedzeka, uye inogona kushandiswa semushonga wekugadzirira firimu re composite.
3.2 sechinobatanidza uye chinoparadzana
Chiyero che viscosity yakaderera chechigadzirwa ichi chinogona kushandiswa sechinobatanidza uye chinoparadza mapiritsi, mapiritsi nemagranules, uye chiyero che viscosity chakakwirira chinogona kushandiswa chete sechinobatanidza. Chiyero chinosiyana zvichienderana nemamodheru akasiyana uye zvinodiwa. Kazhinji, chiyero chebinder yemapiritsi akaoma granulation i5%, uye chiyero chebinder yemapiritsi e granulation akanyorova i2%.
Li Houtao nevamwe vake vakaongorora chivharo chemapiritsi etinidazole. 8% polyvinylpyrrolidone (PVP-K30), 40% syrup, 10% starch slurry, 2.0% hydroxypropyl methylcellulose K4 (HPMCK4M), 50% ethanol zvakaongororwa sekunamatira kwemapiritsi etinidazole. Kuchinja kwechitarisiko chemapiritsi asina kurongeka uye mushure mekuputirwa kwakaenzaniswa, uye kuputsika, kuomarara, nguva yekuputsika uye mwero wekunyungudika kwemapiritsi akasiyana akanyorerwa zvakayerwa. Mhedzisiro Mapiritsi akagadzirwa ne2.0% hydroxypropyl methylcellulose aive akapenya, uye chiyero chekuputsika hachina kuwana chiitiko chekupwanya uye chekukona, uye mushure mekuputirwa, chimiro chepiritsi chakanga chakwana uye chitarisiko chakanga chakanaka. Nokudaro, mapiritsi etinidazole akagadzirwa ne2.0% HPMC-K4 uye 50% ethanol sezvivharo akashandiswa. Guan Shihai akadzidza maitiro ekugadzira mapiritsi eFuganning, akaongorora zvinonamatira, uye akaongorora 50% ethanol, 15% starch paste, 10% PVP uye 50% ethanol solutions nekudzvanywa, kutsetseka, uye kukwesha sezviratidzo zvekuongorora. , 5% CMC-Na uye 15% HPMC solution (5 mPa s). Mhedzisiro Mapepa akagadzirwa ne50% ethanol, 15% starch paste, 10% PVP 50% ethanol solution uye 5% CMC-Na aive nepamusoro pakatsetseka, asi kukwesha kwakashata uye kuomarara kwakaderera, izvo zvaisagona kusangana nezvinodiwa zvekukwesha; 15% HPMC solution (5 mPa·s), pamusoro pepiritsi pakatsetseka, kukwesha kwakakodzera, uye kukwesha kwakanaka, izvo zvinogona kusangana nezvinodiwa zvekukwesha. Nokudaro, HPMC (5 mPa s) yakasarudzwa sechinamira.
3.3 semumiririri anomisa basa
Chiyero chepamusoro che viscosity chechigadzirwa ichi chinoshandiswa se suspending agent kugadzira suspension-type liquid preparation. Chine simba rakanaka rekumisa, chiri nyore kudispersa, hachinamati pamadziro, uye chine flocculation particles. Chipimo chakajairika i0.5% kusvika 1.5%. Song Tian nevamwe vake vakashandisa zvinhu zve polymer zvinoshandiswa kazhinji (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, povidone, xanthan gum, methylcellulose, nezvimwewo) se suspending agents kugadzira racecadotril. dry suspension. Kuburikidza ne sedimentation volume ratio ye suspensions dzakasiyana, redispersibility index, uye rheology, suspension viscosity uye microscopic morphology zvakaonekwa, uye kugadzikana kwe drug particles pasi pe experiment yakakurumidza kwakaongororwawo. Mhedzisiro Dry suspension yakagadzirwa ne 2% HPMC se suspension agent yaive nemaitiro ari nyore uye kugadzikana kwakanaka.
Zvichienzaniswa nemethyl cellulose, hydroxypropyl methyl cellulose ine hunhu hwekuumba mhinduro yakajeka, uye huwandu hushoma hwezvinhu zvisina kupararira zve fibrous zviripo, saka HPMC inowanzoshandiswawo se suspending agent mukugadzirira maziso. Liu Jie nevamwe vakashandisa HPMC, hydroxypropyl cellulose (HPC), carbomer 940, polyethylene glycol (PEG), sodium hyaluronate (HA) uye musanganiswa weHA/HPMC se suspending agents kugadzirira zvakasiyana. Kune Ciclovir ophthalmic suspension, sedimentation volume ratio, particle size uye redispersibility zvinosarudzwa sezviratidzo zvekuongorora kuti zvionekwe se suspending agent yakanakisa. Mhedzisiro yacho inoratidza kuti acyclovir ophthalmic suspension yakagadzirwa ne 0.05% HA uye 0.05% HPMC se suspending agent, sedimentation volume ratio i 0.998, particle size yakafanana, redispersibility yakanaka, uye kugadzirira kwacho kwakasimba. Kuwanda kwepabonde.
3.4 Semushonga unovhara, unononoka uye unodzorwa uye unoumba maburi
Chiyero chepamusoro chemushonga uyu chinoshandiswa pakugadzira mapiritsi e-hydrophilic gel matrix sustainable-release, mablockers uye ma controlled-release agents emapiritsi e-mixed-matrix sustainable-release, uye ane simba rekunonotsa kuburitswa kwemushonga. Kuwanda kwawo kuri 10% kusvika 80%. Ma low-viscosity grades anoshandiswa se porogens yekugadzirira kuburitswa kwenguva refu kana kudzorwa. Dose yekutanga inodiwa pakurapa kwemushonga wemapiritsi akadaro inogona kukurumidza kusvika, uye ipapo kuburitswa kwenguva refu kana kudzorwa kwenguva refu kunoitwa, uye kuwanda kwemushonga weropa kunoshanda kunochengetwa mumuviri. . Hydroxypropyl methylcellulose inonyungudutswa kuti igadzire gel layer kana yasangana nemvura. Maitiro ekuburitswa kwemushonga kubva papiritsi rematrix anosanganisira kupararira kwegel layer uye kuputsika kwegel layer. Jung Bo Shim nevamwe vakagadzira mapiritsi e-carvedilol sustainable-release ane HPMC sechinhu chinosunungurwa kwenguva refu.
Hydroxypropyl methylcellulose inoshandiswawo zvakanyanya mumapiritsi emishonga yechivanhu yechiChinese anoburitswa kwenguva refu, uye zvinhu zvakawanda zvinoshanda, zvikamu zvinoshanda uye gadziriro imwe chete yemishonga yechivanhu yechiChinese zvinoshandiswa. Liu Wen nevamwe vake vakashandisa 15% hydroxypropyl methylcellulose sezvinhu zvematrix, 1% lactose uye 5% microcrystalline cellulose sefillers, uye vakagadzira Jingfang Taohe Chengqi Decoction mumapiritsi emuromo anoburitswa kwenguva refu. Muenzaniso uyu ndiwo musanganiswa weHiguchi. Sisitimu yekuumbwa kwefomula iri nyore, kugadzirira kuri nyore, uye data rekuburitswa rakagadzikana, izvo zvinosangana nezvinodiwa neChinese Pharmacopoeia. Tang Guanguang nevamwe vake vakashandisa total saponins dzeAstragalus semushonga wemuenzaniso, vakagadzira mapiritsi eHPMC matrix, uye vakaongorora zvinhu zvinokanganisa kuburitswa kwemushonga kubva muzvikamu zvinoshanda zvemishonga yechivanhu yechiChinese mumapiritsi eHPMC matrix. Mhedzisiro Sezvo dosage yeHPMC yakawedzera, kuburitswa kweastragaloside kwakadzikira, uye chikamu chekuburitswa kwemushonga chaive nehukama hwakafanana nehuwandu hwekunyungudika kwematrix. Mupiritsi reHypromellose HPMC matrix, pane hukama huripo pakati pekuburitswa kwechikamu chinoshanda chemishonga yechiChinese uye chiyero uye rudzi rweHPMC, uye maitiro ekuburitswa kwehydrophilic chemical monomer akafanana nawo. Hydroxypropyl methylcellulose haingokodzeri chete kune hydrophilic compounds, asiwo kune zvisiri hydrophilic substances. Liu Guihua akashandisa 17% hydroxypropyl methylcellulose (HPMCK15M) sechinhu chinosunungura matrix, uye akagadzira mapiritsi eTianshan Xuelian sustained-release matrix nenzira ye wet granulation uye tableting. Mhedzisiro yekusunungura yakaramba iripo yaive pachena, uye maitiro ekugadzirira aive akagadzikana uye aikwanisika.
Hydroxypropyl methylcellulose haingoshandiswi chete pamapiritsi e-matrix anoburitswa kwenguva refu ezvishandiso zvinoshanda uye zvikamu zvinoshanda zvemishonga yechivanhu yeChinese, asiwo inoshandiswa zvakanyanya mukugadzira mishonga yechivanhu yeChinese. Wu Huichao nevamwe vake vakashandisa 20% hydroxypropyl methyl cellulose (HPMCK4M) sematrix, uye vakashandisa nzira yepoda direct compression kugadzirira piritsi reYizhi hydrophilic gel matrix rinogona kuburitsa mushonga nguva dzose uye zvakagadzikana kwemaawa gumi nemaviri. Saponin Rg1, ginsenoside Rb1 uye Panax notoginseng saponin R1 zvakashandiswa sezviratidzo zvekuongorora kuburitswa kwemushonga mu vitro, uye equation yekuburitswa kwemishonga yakaiswa kuti idzidze nzira yekuburitswa kwemishonga. Mhedzisiro Nzira yekuburitswa kwemishonga yaienderana ne zero-order kinetic equation uye Ritger-Peppas equation, umo geniposide yakaburitswa ne non-Fick diffusion, uye zvikamu zvitatu muPanax notoginseng zvakaburitswa neskeletal erosion.
3.5 Guruu rinodzivirira sechinokora uye sechinokora
Kana chigadzirwa ichi chikashandiswa sechinokora, huwandu hwakajairika hwehuwandu hunobva pa0.45% kusvika 1.0%. Hunogonawo kuwedzera kugadzikana kweglue rinonyungudutsa mvura, kugadzira colloid inodzivirira, kudzivirira zvidimbu kuti zvisaungane uye zviungane, nokudaro zvichidzivisa kuumbwa kwemarara. Huwandu hwayo hwakajairika hunobva pa0.5% kusvika 1.5%.
Wang Zhen nevamwe vake vakashandisa nzira yeL9 orthogonal experimental design kuti vaongorore maitiro ekugadzira medical activated carbon enema. Mamiriro ekuita akanakisa ekutsvaga kwekupedzisira medical activated carbon enema ndeyekushandisa 0.5% sodium carboxymethyl cellulose uye 2.0% hydroxypropyl methylcellulose (HPMC ine 23.0% methoxyl group, hydroxypropoxyl Base 11.6%) se thickener, mamiriro ekuita anobatsira kuwedzera kugadzikana kwe medical activated carbon. Zhang Zhiqiang nevamwe vake vakagadzira gel re levofloxacin hydrochloride ophthalmic ready-to-use rine pH-sensitive release effect, vachishandisa carbopol se gel matrix uye hydroxypropyl methylcellulose se thickening agent. Kunyorerwa kwakakodzera kuburikidza nekuyedza, pakupedzisira kunowana kunyorerwa kwakakodzera i levofloxacin hydrochloride 0.1 g, carbopol (9400) 3 g, hydroxypropyl methylcellulose (E50 LV) 20 g, disodium hydrogen phosphate 0.35 g, phosphoric acid 0.45 g ye sodium dihydrogen, 0.50 g ye sodium chloride, 0.03 g ye ethyl paraben, uye mvura yakawedzerwa kuita 100 mL. Mukuyedzwa, munyori akaongorora hydroxypropyl methylcellulose METHOCEL series yeColorcon Company ine zvirevo zvakasiyana (K4M, E4M, E15 LV, E50LV) kugadzirira thickeners dzine huwandu hwakasiyana, uye mhedzisiro yacho yakasarudza HPMC E50 LV se thickener. Thickener ye pH-sensitive levofloxacin hydrochloride instant gels.
3.6 sechigadzirwa chekapisi
Kazhinji, zvinhu zviri muganda remakapisi zvinoumbwa negelatin. Maitiro ekugadzira ganda remakapisi ari nyore, asi pane zvimwe zvinetso zvakaita sekusadzivirirwa zvakanaka kubva kumishonga inonzwa hunyoro uye oxygen, kuderedzwa kwekunyungudika kwemishonga, uye kunonoka kuputsika kweganda remakapisi panguva yekuchengetwa. Saka, hydroxypropyl methylcellulose inoshandiswa panzvimbo pemakapisi egelatin pakugadzira makapisi, izvo zvinovandudza kugadzirwa kwekapisi uye kushanda kwayo, uye zvave zvichikurudzirwa zvikuru munyika nekune dzimwe nyika.
Vachishandisa theophylline semushonga wekudzora, Podczeck nevamwe vake vakaona kuti mwero wekunyungudika kwemushonga wemacapsules ane magoko ehydroxypropyl methylcellulose waive wakakura kupfuura wemacapsules egelatin. Chikonzero chekuongorora ndechekuti kunyungudika kweHPMC ndiko kunyungudika kwekapsule yese panguva imwe chete, nepo kunyungudika kwekapsule yegelatin kuri kunyungudika kwechimiro chenetwork kutanga, uye ipapo kunyungudika kwekapsule yese, saka kapsule yeHPMC yakakodzera magoko eCapsule kuti abudiswe nekukurumidza. Chiwele nevamwe vake vakawanawo mhedziso dzakafanana uye vakaenzanisa kunyungudika kwegelatin, gelatin/polyethylene glycol nemagoko eHPMC. Mhedzisiro yacho yakaratidza kuti magoko eHPMC akanyungudika nekukurumidza pasi pemamiriro akasiyana epH, nepo macapsules egelatin Akakanganiswa zvakanyanya nemamiriro akasiyana epH. Tang Yue nevamwe vake vakaongorora mhando itsva yegoko rekapsule yemushonga une mushonga wakaderera unobvisa poda yakaoma. Zvichienzaniswa negoko rekapisi rehydroxypropyl methylcellulose negoko rekapisi regelatin, kugadzikana kwegoko rekapisi uye hunhu hwehupfu huri mugoko mumamiriro akasiyana zvakaongororwa, uye bvunzo yekukanganisika yakaitwa. Mhedzisiro yacho inoratidza kuti zvichienzaniswa nekapisi regelatin, magoko ekapisi eHPMC ari nani pakugadzikana uye kudzivirira hupfu, ane hunyoro hwakasimba, uye ane hunyoro hwakaderera pane magoko ekapisi egelatin, saka magoko ekapisi eHPMC akakodzera maKapisi ekufemera hupfu hwakaoma.
3.7 sechinhu chinonamira zvipenyu
Tekinoroji yekunamatira kwemuviri inoshandisa zvinhu zvinobatsira zvine mapolymers anonamatira. Nekunamatira ku mucosa yemuviri, inowedzera kuenderera mberi nekusimba kwekubatana pakati pemushonga ne mucosa, kuitira kuti mushonga unoburitswa zvishoma nezvishoma uye unyudzwe ne mucosa kuti uwane chinangwa chekurapa. Unoshandiswa zvakanyanya pari zvino. Kurapa zvirwere zvemudumbu, nhengo dzemukadzi, mucosa yemuromo nedzimwe nzvimbo.
Tekinoroji yekubikira mudumbu inzira itsva yekuendesa mishonga yakagadzirwa mumakore achangopfuura. Haingowedzere nguva yekugara kwemishonga mudumbu, asiwo inovandudza mashandiro ekubata mushonga nemembrane yesero panzvimbo inonyudzwa, inochinja kuyerera kwemembrane yesero, uye inoita kuti kupinda kwemushonga mumasero madiki eepithelial emudumbu kuwedzere, nokudaro zvichivandudza bioavailability yemushonga. Wei Keda nevamwe vake vakaongorora mushonga wepiritsi nechiyero cheHPMCK4M neCarbomer 940 senzira dzekuongorora, uye vakashandisa mudziyo wekubikira wakazvigadzira wega kuyera simba rekukwesha pakati pepiritsi nebiofilm yakaedzwa nehunhu hwemvura iri mubhegi repurasitiki. , uye pakupedzisira ndakasarudza huwandu hweHPMCK40 necarbomer 940 kuti huve 15 ne27.5 mg munzvimbo yakakodzera yeNCaEBT tablet cores, zvichiteerana, kugadzira NCaEBT tablet cores, zvichiratidza kuti zvinhu zvinonamira (zvakadai sehydroxypropyl methylcellulose) zvinogona kuderedza zvakanyanya kunamira kwemushonga uyu kumatishu.
Mishonga inonamira nemuromo zvakare rudzi rutsva rwenzira yekuendesa mishonga yakadzidzwa zvakanyanya mumakore achangopfuura. Mishonga inonamira nemuromo inogona kunamira mushonga uyu kuchikamu chakakanganiswa chemuromo, izvo zvisingangowedzere nguva yekugara kwemushonga mumuromo, asiwo zvinodzivirira mucosa yemuromo. Mugumisiro uri nani wekurapa uye kuvandudzika kwemishonga. Xue Xiaoyan nevamwe vake vakagadzirisa kugadzirwa kwemapiritsi anonamira nemuromo einsulin, vachishandisa apple pectin, chitosan, carbomer 934P, hydroxypropyl methylcellulose (HPMC K392) uye sodium alginate sezvinhu zvinonamira nemuviri, uye vanoomesa nechando kuti vagadzirire insulin yemuromo. Pepa rinonamira nemuviri rine jira rakaita serechipanje, iro rinobatsira kuburitsa insulin, uye rine jira rinodzivirira re hydrophobic, rinogona kuve nechokwadi chekuburitswa kwemushonga nenzira imwe chete uye kudzivirira kurasikirwa nemushonga. Hao Jifu nevamwe vake vakagadzirawo machira ebhuruu-yellow emuromo anonamira nemuromo vachishandisa Baiji glue, HPMC uye carbomer sezvinhu zvinonamira nemuviri.
Munzira dzekuisa mishonga munhengo dzemukadzi, tekinoroji yekunamatira kwemuviri yakashandiswawo zvakanyanya. Zhu Yuting nevamwe vake vakashandisa carbomer (CP) neHPMC sezvinhu zvinonamira uye matrix inosunungurwa kwenguva refu kugadzira mapiritsi e "clotrimazole bioadhesive vaginal" ane mafomula akasiyana uye zviyero, uye vakayera kunamira kwawo, nguva yekunamatira uye huwandu hwekuzvimba munzvimbo yemvura yemunhengo yemukadzi yakagadzirwa. , mushonga wakakodzera wakaongororwa seCP-HPMC1: 1, pepa rekunamatira rakagadzirwa raive nebasa rakanaka rekunamatira, uye maitiro acho aive nyore uye aikwanisika.
3.8 se gel yemushonga wepamusoro
Semushonga wekunamira, gel ine zvakanakira zvakawanda zvakaita sekuchengetedzeka, runako, kuchenesa kuri nyore, mutengo wakaderera, nzira yekugadzirira iri nyore, uye kushanda zvakanaka nemishonga. Nzira yekukura. Semuenzaniso, gel ye transdermal imhando itsva yemushonga yakadzidzwa zvakanyanya mumakore achangopfuura. Haingogone kudzivirira kuparadzwa kwemishonga mudumbu uye kuderedza kusiyana kwehuwandu hwemishonga muropa, asiwo yave imwe yenzira dzinoshanda dzekuburitsa mishonga kukunda migumisiro yemishonga.
Zhu Jingjie nevamwe vake vakadzidza mhedzisiro yemamatrices akasiyana pakuburitswa kwescutellarin alcohol plastid gel in vitro, uye vakaongororwa necarbomer (980NF) uye hydroxypropyl methylcellulose (HPMCK15M) semamatrices egel, uye vakawana scutellarin yakakodzera scutellarin. Gel matrix yealcohol plastids. Mhedzisiro yekuyedza inoratidza kuti 1.0% carbomer, 1.5% carbomer, 1.0% carbomer + 1.0% HPMC, 1.5% carbomer + 1.0% HPMC segel matrix. Ose akakodzera scutellarin alcohol plastids. Munguva yekuyedza, zvakaonekwa kuti HPMC inogona kuchinja nzira yekuburitswa kwemishonga yecarbomer gel matrix nekuisa kinetic equation yekuburitswa kwemishonga, uye 1.0% HPMC inogona kuvandudza 1.0% carbomer matrix uye 1.5% carbomer matrix. Chikonzero chingave chekuti HPMC inokura nekukurumidza, uye kuwedzera nekukurumidza muchikamu chekutanga chekuedza kunoita kuti mukaha wemolecular we carbomer gel zvinhu uwedzere, nokudaro zvichikurumidzisa mwero wekuburitswa kwemishonga. Zhao Wencui nevamwe vakashandisa carbomer-934 uye hydroxypropyl methylcellulose sekutakura kugadzira norfloxacin ophthalmic gel. Maitiro ekugadzirira ari nyore uye anogoneka, uye mhando yacho inoenderana ne ophthalmic gel ye "Chinese Pharmacopoeia" (2010 edition) Zvinodiwa zvemhando yepamusoro.
3.9 Inhibitor yemvura inonaya yesystem yekuzvigadzira microemulsifying
Sisitimu yekuendesa mishonga inogadzirwa nemaoko (SMEDDS) imhando itsva yemushonga unonwiwa, inova musanganiswa wakafanana, wakasimba uye wakajeka unoumbwa nemushonga, mafuta, emulsifier uye co-emulsifier. Musanganiswa wemushonga wacho uri nyore, uye kuchengetedzeka nekugadzikana kwakanaka. Pamishonga isinganyungudike zvakanaka, zvinhu zvepolymer zvefiber zvinonyungudika mumvura, zvakaita seHPMC, polyvinylpyrrolidone (PVP), nezvimwewo, zvinowanzowedzerwa kuti mishonga iyi ibude uye mishonga iri mu microemulsion iwane kunyungudika kwakanyanya mudumbu, kuitira kuti mushonga uwedzere kunyungudika uye kuwedzera kugona kwemushonga.
Peng Xuan nevamwe vakagadzira sisitimu yekuendesa mishonga ye silibinin supersaturated self-emulsifying (S-SEDDS). Oxyethylene hydrogenated castor oil (Cremophor RH40), 12% caprylic capric acid polyethylene glycol glyceride (Labrasol) se co-emulsifier, uye 50 mg·g-1 HPMC. Kuwedzera HPMC kuSSEDDS kunogona kuwedzera silibinin isina kunyungudika kuti inyungudike muS-SEDDS uye kudzivirira silibinin kuti isanyungudike. Zvichienzaniswa nemaitiro echinyakare e self-microemulsion, huwandu hwakawanda hwe surfactant hunowanzo kuwedzerwa kudzivirira kusagadzikana kwemishonga. Kuwedzera HPMC kunogona kuchengetedza kunyungudika kwe silibinin munzvimbo yekunyungudika isingachinji, zvichideredza emulsification mu self-microemulsion formulations.
4. Mhedziso
Zvinogona kuonekwa kuti HPMC yave ichishandiswa zvakanyanya mukugadzirira nekuda kwehunhu hwayo hwepanyama, hwemakemikari uye hwezvipenyu, asi HPMC inewo zvikanganiso zvakawanda mukugadzirira, zvakaita sechiitiko chekusunungurwa kwe pre- uye post-burst. methyl methacrylate) kuti ivandudzwe. Panguva imwe chete, vamwe vaongorori vakaongorora kushandiswa kwedzidziso ye osmotic mu HPMC nekugadzira mapiritsi e carbamazepine sustainable-release uye mapiritsi e verapamil hydrochloride sustainable-release kuti vawedzere kudzidza mashandiro ayo ekuburitsa. Muchidimbu, vaongorori vakawanda vari kuita basa rakawanda rekushandisa zviri nani HPMC mukugadzirira, uye nekudzidza kwakadzama kwehunhu hwayo nekuvandudzwa kwetekinoroji yekugadzirira, HPMC ichashandiswa zvakanyanya mumhando itsva dzedosage uye mhando itsva dzedosage. Mukutsvaga kwemishonga, uye zvino kukurudzira kufambira mberi kwekugadzirwa kwemishonga.
Nguva yekutumira: Gumiguru-08-2022