A tụlere, nyochaa ma chịkọta akwụkwọ ndị metụtara ya n'ụlọ na mba ofesi n'ịkwadebe ihe mgbakwunye ọgwụ hydroxypropyl methylcellulose (HPMC) n'afọ ndị na-adịbeghị anya, yana ojiji ya na nkwadebe siri ike, nkwadebe mmiri mmiri, nkwadebe ntọhapụ na-adịgide adịgide na nke a na-achịkwa, nkwadebe capsules, gelatin Ngwa kachasị ọhụrụ n'ọhịa nke usoro ọhụrụ dị ka usoro gluu na bioadhesives. N'ihi ọdịiche dị na ibu molekul na viscosity nke HPMC, o nwere njirimara na ojiji nke emulsification, adhesion, thickening, viscosity abawanye, suspension, gelling na film-forming. A na-eji ya eme ihe nke ukwuu na nkwadebe ọgwụ ma ga-arụ ọrụ ka ukwuu n'ọhịa nkwadebe. Site na ọmụmụ miri emi nke ihe onwunwe ya na mmezi nke teknụzụ nhazi, a ga-eji HPMC eme ihe nke ọma na nyocha nke ụdị dose ọhụrụ na sistemụ nnyefe ọgwụ ọhụrụ, si otú a na-akwalite mmepe na-aga n'ihu nke usoro nhazi.
hydroxypropyl methylcellulose; nkwadebe ọgwụ; ihe mgbakwunye ọgwụ.
Ihe ndị e ji ọgwụ eme abụghị naanị ihe ndabere maka imepụta nkwadebe ọgwụ ndị e ji aka rụọ, kamakwa ọ na-ejikọta ya na ihe isi ike nke usoro nkwadebe, ịdị mma ọgwụ, nkwụsi ike, nchekwa, ọnụego mwepụta ọgwụ, ụdị ọrụ, arụmọrụ ahụike, na mmepe nke ụdị ọgwụ ọhụrụ na ụzọ nchịkwa ọhụrụ. Ọdịiche dị n'etiti. Mpụta nke ihe ndị e ji ọgwụ eme ihe ọhụrụ na-akwalite mmụba nke ịdị mma nkwadebe na mmepe nke ụdị ọgwụ ọhụrụ. Hydroxypropyl methylcellulose (HPMC) bụ otu n'ime ihe ndị e ji ọgwụ eme ihe kacha ewu ewu n'ụlọ na mba ofesi. N'ihi ịdị arọ molekul ya dị iche iche na viscosity ya, ọ nwere ọrụ nke emulsifying, ijikọ, ịka nká, ịka nká, ịka nká, na gluing. A na-ejikarị atụmatụ na ojiji dị ka coagulation na nhazi ihe nkiri eme ihe na teknụzụ ọgwụ. Edemede a na-enyochakarị ojiji nke hydroxypropyl methylcellulose (HPMC) na usoro n'afọ ndị na-adịbeghị anya.
1.Isi Njirimara nke HPMC
Hydroxypropyl methyl cellulose (HPMC), usoro molekul bụ C8H15O8-(C10 H18O6) n-C8H15O8, oke molekul dịkwa ihe dịka 86 000. Ngwaahịa a bụ ihe e ji ihe ndị na-emepụta ihe, nke bụ akụkụ nke methyl na akụkụ nke polyhydroxypropyl ether nke cellulose. Enwere ike imepụta ya n'ụzọ abụọ: Otu bụ na a na-eji NaOH agwọ methyl cellulose nke ọkwa kwesịrị ekwesị wee meghachi omume na propylene oxide n'okpuru okpomọkụ dị elu na nrụgide dị elu. Oge mmeghachi omume ga-adịru ogologo oge iji kwe ka methyl na hydroxypropyl mepụta njikọ ether. A na-ejikọ ya na mgbanaka anhydroglucose nke cellulose n'ụdị cellulose, ma nwee ike iru ogo achọrọ; nke ọzọ bụ iji soda caustic gwọọ owu linte ma ọ bụ eriri pulp osisi, wee meghachi omume na methane na propylene oxide nke a kpụkọrọ akpụkọ n'usoro, wee mee ka ọ dịkwuo mma. , gwerie ya ka ọ bụrụ ntụ ntụ ma ọ bụ granules dị mma ma dị iche.
Agba nke ngwaahịa a bụ ọcha ruo ọcha, ọ naghị esi isi ma ọ bụ enweghị ụtọ, ụdị ya bụ ntụ ntụ granular ma ọ bụ fibrous dị mfe ịgbaze. Enwere ike ịgbaze ngwaahịa a na mmiri iji mepụta mmiri colloidal ọcha doro anya ruo mmiri ara ehi nke nwere viscosity ụfọdụ. Ihe omume ntụgharị sol-gel nwere ike ime n'ihi mgbanwe okpomọkụ nke ngwọta ahụ na oke mkpokọta.
N'ihi ọdịiche dị n'ime ihe abụọ a na-anọchi anya ha n'usoro nke methoxy na hydroxypropyl, ụdị ngwaahịa dị iche iche apụtala. N'ime mkpokọta pụrụ iche, ụdị ngwaahịa dị iche iche nwere njirimara pụrụ iche. Viscosity na okpomọkụ gelation okpomọkụ, ya mere, ha nwere njirimara dị iche iche ma enwere ike iji ya maka ebumnuche dị iche iche. Pharmacopoeia nke mba dị iche iche nwere iwu na nnọchi anya dị iche iche na ihe nlereanya ahụ: European Pharmacopoeia dabere na ọkwa dị iche iche nke viscosities dị iche iche na ọkwa dị iche iche nke nnọchi nke ngwaahịa a na-ere n'ahịa, nke a na-egosipụta site na ọkwa gbakwunyere ọnụọgụ, nkeji ahụ bụkwa "mPa s". Na US Pharmacopoeia, a na-agbakwunye ọnụọgụ anọ mgbe aha nkịtị gasịrị iji gosi ọdịnaya na ụdị nke nnọchi ọ bụla nke hydroxypropyl methylcellulose, dị ka hydroxypropyl methylcellulose 2208. Ọnụọgụ abụọ mbụ na-anọchite anya uru dị nso nke otu methoxy. Pasentị, ọnụọgụ abụọ ikpeazụ na-anọchite anya pasentị ihe dị ka nke hydroxypropyl.
Calocan's hydroxypropyl methylcellulose nwere usoro atọ, ya bụ usoro E, usoro F na usoro K, usoro ọ bụla nwere ọtụtụ ụdị ịhọrọ. A na-ejikarị usoro E eme ihe dị ka ihe mkpuchi ihe nkiri, eji maka mkpuchi mbadamba, isi mbadamba mechiri emechi; A na-eji usoro E, F dị ka ihe na-egbochi mwepụta na ihe na-egbochi mwepụta maka nkwadebe anya, ihe na-egbochi nkwụsịtụ, ihe na-eme ka ihe sie ike maka nkwadebe mmiri mmiri, mbadamba na ihe ndị na-ejikọta granules; A na-ejikarị usoro K eme ihe dị ka ihe mgbochi ntọhapụ na ihe matrix gel hydrophilic maka nkwadebe ntọhapụ nwayọ na nke a na-achịkwa.
Ndị na-emepụta ihe n'ime ụlọ gụnyere Fuzhou Nke 2 Chemical Factory, Huzhou Food and Chemical Co., Ltd., Sichuan Luzhou Pharmaceutical Accessories Factory, Hubei Jinxian Chemical Factory Nke 1, Feicheng Ruitai Fine Chemical Co., Ltd., Shandong Liaocheng Ahua Pharmaceutical Co., Ltd., Xi'an Huian chemical plants, wdg.
2.Uru nke HPMC
HPMC abụrụla otu n'ime ihe ndị a na-ejikarị agwọ ọrịa n'obodo na mba ofesi, n'ihi na HPMC nwere uru ndị ọzọ na-enweghị.
2.1 Mmiri oyi na-agbaze
A na-agbaze ya na mmiri oyi n'okpuru 40 ℃ ma ọ bụ 70% ethanol, ọ naghị agbaze na mmiri ọkụ karịa 60 ℃, mana ọ nwere ike ịgbaze.
2.2 Kemịkalụ anaghị arụ ọrụ nke ọma
HPMC bụ ụdị cellulose ether na-abụghị ionic, ihe ngwọta ya enweghị chajị ionic ma ọ naghị ejikọta ya na nnu ígwè ma ọ bụ ihe ndị dị ndụ ionic, yabụ ihe ndị ọzọ na-enye aka anaghị emeghachi omume na ya n'oge mmepụta nkwadebe.
2.3 Ịkwụsi ike
Ọ kwụsiri ike ma na acid na alkali, a pụkwara ịchekwa ya ruo ogologo oge n'etiti pH 3 na 11 na-enweghị mgbanwe dị ukwuu na viscosity. Mmiri mmiri nke HPMC nwere mmetụta mgbochi mildew ma na-eme ka viscosity dị mma n'oge nchekwa ogologo oge. Ihe ndị na-enye ọgwụ na-eji HPMC nwere nkwụsi ike ka mma karịa ndị na-eji ihe ndị na-enye ọgwụ ọdịnala (dịka dextrin, starch, wdg).
2.4 Mgbanwe Viscosity
Enwere ike ịgwakọta ụdị viscosity dị iche iche nke HPMC n'ogo dị iche iche, enwere ike ịgbanwe viscosity ya dịka iwu ụfọdụ si dị, ma nwee ezigbo mmekọrịta kwụ ọtọ, yabụ enwere ike ịhọrọ oke dịka mkpa si dị.
2.5 Ike ọgwụgwụ nke metabolic
A naghị etinye HPMC n'ime ahụ ma ọ bụ na-eme ka ọ dị nro, ọ naghịkwa enye okpomọkụ, yabụ ọ bụ ihe na-enye ọgwụ dị mma. 2.6 Nchekwa A na-ewerekarị na HPMC bụ ihe na-adịghị egbu egbu ma na-anaghị akpasu iwe, oke oke bụ 5 g·kg – 1, oke oke bụ 5.2 g · kg – 1. Oke kwa ụbọchị anaghị emerụ ahụ mmadụ ahụ.
3.Ojiji nke HPMC na usoro
3.1 Dị ka ihe mkpuchi ihe nkiri na ihe na-akpụ ihe nkiri
Site na iji HPMC mee ihe dị ka ihe e ji ihe mkpuchi ihe nkiri kpuchie, mbadamba ihe mkpuchi ahụ enweghị uru doro anya n'ikpuchi uto na ọdịdị ya ma e jiri ya tụnyere mbadamba ihe mkpuchi ọdịnala dịka mbadamba ihe mkpuchi shuga, mana ike ya, ike ya, mmiri ya, oke ya na-agbaze, ibu arọ mkpuchi na ihe ngosi ndị ọzọ dị mma ka mma. A na-eji ọkwa dị ala nke ngwaahịa a dị ka ihe mkpuchi ihe nkiri mmiri na-agbaze maka mbadamba na mkpụrụ ọgwụ, a na-ejikwa ọkwa dị elu nke viscosity dị ka ihe mkpuchi ihe nkiri maka sistemụ ihe mgbaze organic, na-abụkarị na mkpokọta nke 2% ruo 20%.
Zhang Jixing na ndị otu ya jiri usoro elu mmetụta mee ka usoro premix dị mma na HPMC dị ka mkpuchi ihe nkiri ahụ. Site n'iji ihe na-akpụ ihe nkiri HPMC, ọnụọgụ nke polyvinyl alcohol na plasticizer polyethylene glycol dị ka ihe nyocha, ike nrụgide na ikike nke ihe nkiri ahụ na viscosity nke ngwọta mkpuchi ihe nkiri ahụ bụ ndeksi nyocha, a na-akọwakwa mmekọrịta dị n'etiti ndeksi nyocha na ihe nlele site na ụdị mgbakọ na mwepụ, a na-enwetakwa usoro nhazi kacha mma n'ikpeazụ. Oriri ya bụ ihe na-akpụ ihe nkiri hydroxypropyl methylcellulose (HPMCE5) 11.88 g, polyvinyl alcohol 24.12 g, plasticizer polyethylene glycol 13.00 g, na viscosity mkpuchi mkpuchi bụ 20 mPa·s, ikike permeability na tensile nke ihe nkiri ahụ ruru mmetụta kacha mma. Zhang Yuan mere ka usoro nkwadebe ahụ ka mma, jiri HPMC mee ihe iji dochie slurry starch, ma gbanwee mbadamba Jiahua ka ọ bụrụ mbadamba ihe mkpuchi fim iji melite ịdị mma nke nkwadebe ya, melite hygroscopicity ya, mfe ịcha, mbadamba ndị na-adịghị ike, splitted na nsogbu ndị ọzọ, mee ka nkwụsi ike mbadamba ahụ dịkwuo mma. E jiri nnwale orthogonal chọpụta usoro nhazi kacha mma, ya bụ, ntinye slurry bụ 2% HPMC na 70% ngwọta ethanol n'oge mkpuchi, oge mkpali n'oge granulation bụ nkeji 15. Nsonaazụ Mbadamba ihe mkpuchi fim Jiahua nke usoro ọhụrụ na ndenye ọgwụ kwadebere ka mma nke ukwuu n'ọdịdị, oge mgbawa na ike isi karịa nke usoro ndenye ọgwụ mbụ mepụtara, ọnụego ruru eru nke mbadamba ihe mkpuchi fim ahụ ka mma nke ukwuu. ruru ihe karịrị 95%. Liang Meiyi, Lu Xiaohui, wdg. jikwa hydroxypropyl methylcellulose dị ka ihe na-emepụta fim iji kwadebe mbadamba ihe mkpuchi patinae colon na mbadamba ihe mkpuchi matrine colon, n'otu n'otu. Na-emetụta mwepụta ọgwụ. Huang Yunran kwadebere mbadamba Dragọn nke na-etinye eriri afọ n'ọkwa, wee tinye HPMC n'ime mmiri mkpuchi nke oyi akwa ahụ na-aza aza, oke ibu ya dịkwa 5%. A pụrụ ịhụ na enwere ike iji HPMC mee ihe n'ọtụtụ ebe na sistemụ nnyefe ọgwụ nke eriri afọ.
Hydroxypropyl methylcellulose abụghị naanị ihe mkpuchi fim dị mma, kamakwa enwere ike iji ya dị ka ihe na-akpụ ihe nkiri na usoro ihe nkiri. A na-eme ka Wang Tongshun wdg dị mma site na ndenye ọgwụ nke zinc licorice na aminolexanol nke ihe mejupụtara ọnụ, yana mgbanwe, ịdị n'otu, ịdị ire ụtọ, na nghọta nke ihe nkiri dị ka ndeksi nyocha, nweta ndenye ọgwụ kacha mma bụ PVA 6.5 g, HPMC 0.1 g na 6.0 g nke propylene glycol na-emezu ihe achọrọ maka mwepụta nwayọ na nchekwa, enwere ike iji ya dị ka ntuziaka nkwadebe nke ihe nkiri mejupụtara.
3.2 dị ka ihe njikọta na ihe na-agbawa agbawa
Enwere ike iji obere viscosity nke ngwaahịa a dị ka ihe na-ejikọ ma na-agbaze maka mbadamba, mkpụrụ ọgwụ na granules, a pụkwara iji ọkwa viscosity dị elu naanị dị ka ihe na-ejikọ. Usoro ọgwụgwọ ahụ dịgasị iche iche dabere na ụdị na ihe achọrọ dị iche iche. N'ozuzu, usoro ọgwụgwọ ọgwụgwọ maka mbadamba granulation akọrọ bụ 5%, usoro ọgwụgwọ ọgwụgwọ maka mbadamba granulation mmiri mmiri bụ 2%.
Li Houtao na ndị otu ya nyochachara ihe njikọta nke mbadamba tinidazole. 8% polyvinylpyrrolidone (PVP-K30), sirop 40%, 10% starch slurry, 2.0% hydroxypropyl methylcellulose K4 (HPMCK4M), 50% ethanol ka a nyochachara dịka njikọta nke mbadamba tinidazole n'otu n'otu. Nkwadebe nke mbadamba tinidazole. A tụnyere mgbanwe ọdịdị nke mbadamba nkịtị na mgbe mkpuchi gasịrị, a tụkwara ike, ike, oke oge nkewa na ọnụego nke mbadamba ọgwụ dị iche iche. Nsonaazụ Mbadamba ndị e ji 2.0% hydroxypropyl methylcellulose kwadebe dị mma, nha nke friability ahụghịkwa ihe mgbawa na ihe na-eme ka ọ dị n'akụkụ, mgbe mkpuchi gasịrị, ọdịdị mbadamba ahụ zuru oke ma ọdịdị ya dị mma. Ya mere, ejiri mbadamba tinidazole nke e ji 2.0% HPMC-K4 na 50% ethanol kwadebe dị ka ihe na-ejikọ. Guan Shihai mụrụ usoro nhazi nke Mbadamba Fuganning, kpuchiri ihe ndị ahụ, ma kpughee ethanol 50%, ntụ ọka starch 15%, 10% PVP na 50% ngwọta ethanol nwere nrụgide, ịdị ire ụtọ, na nrụgide dị ka ihe ngosi nyocha. , 5% CMC-Na na 15% ngwọta HPMC (5 mPa s). Nsonaazụ Mpempe akwụkwọ ndị e ji ethanol 50% kwadebe, ntụ ọka starch 15%, 10% PVP 50% ngwọta ethanol na 5% CMC-Na nwere elu dị larịị, mana enweghị nrụgide na obere ike, nke na-enweghị ike imezu mkpa mkpuchi; 15% ngwọta HPMC (5 mPa·s), elu nke mbadamba ahụ dị nro, nrụgide ruru eru, nrụgide ahụ dịkwa mma, nke nwere ike imezu mkpa mkpuchi. Ya mere, ahọpụtara HPMC (5 mPa s) dị ka nrụgide.
3.3 dị ka onye na-ahụ maka nkwụsịtụ
A na-eji ọkwa dị elu nke ngwaahịa a dị ka ihe na-egbochi ihe iji kwadebe nkwadebe mmiri mmiri nke ụdị nkwụsịtụ. Ọ nwere mmetụta dị mma nke nkwụsịtụ, ọ dị mfe ịgbasa ọzọ, ọ naghị arapara na mgbidi ahụ, ma nwee obere irighiri ihe. Usoro ọgwụgwọ a na-ejikarị bụ 0.5% ruo 1.5%. Song Tian et al. ejiri ihe polymer a na-ejikarị eme ihe (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, povidone, xanthan gum, methylcellulose, wdg) dị ka ihe na-egbochi ihe iji kwadebe nkwụsịtụ akọrọ racecadotril. Site na oke olu sedimentation nke nkwụsịtụ dị iche iche, a hụrụ ihe ngosi redispersibility, na rheology, viscosity nkwụsịtụ na ọdịdị microscopic, a chọpụtakwara nkwụsi ike nke mkpụrụ ọgwụ n'okpuru nnwale ngwa ngwa. Nsonaazụ Nkwụsị akọrọ nke e ji 2% HPMC dị ka ihe na-egbochi ihe nwere usoro dị mfe na ezigbo nkwụsi ike.
Ma e jiri ya tụnyere methyl cellulose, hydroxypropyl methyl cellulose nwere njirimara nke ịmepụta ngwọta doro anya, naanị obere ihe ndị na-anaghị agbasasị na-adị, yabụ a na-ejikarị HPMC eme ihe dị ka ihe na-egbochi anya. Liu Jie na ndị otu ya jiri HPMC, hydroxypropyl cellulose (HPC), carbomer 940, polyethylene glycol (PEG), sodium hyaluronate (HA) na njikọta nke HA/HPMC dị ka ihe na-egbochi anya iji kwadebe nkọwapụta dị iche iche. A na-ahọrọ Ciclovir ophthalmic suspension ratio, nha ihe na mgbanwe dị ka ihe ngosi nyocha iji chọpụta ihe na-egbochi anya kacha mma. Nsonaazụ ya na-egosi na acyclovir ophthalmic suspension nke 0.05% HA na 0.05% HPMC kwadoro dị ka ihe na-egbochi anya, oke olu sedimentation bụ 0.998, nha ihe ahụ dị otu, mgbanwe dị mma, nkwadebe ahụ kwụsiri ike Mmekọahụ na-abawanye.
3.4 Dịka ihe mgbochi, ihe na-ewepụta ihe na-adịghị ngwa ngwa ma na-achịkwa ya na ihe na-emepụta oghere
A na-eji ọkwa viscosity dị elu nke ngwaahịa a eme ihe maka nkwadebe nke mbadamba gel matrix hydrophilic, ihe mgbochi na ihe nnọchite anya mwepụta nke mbadamba ihe ngwakọta matrix na-adịgide adịgide, ma nwee mmetụta nke igbu oge mwepụta ọgwụ. Ntinye ya bụ 10% ruo 80%. A na-eji ọkwa viscosity dị ala dị ka porogens maka nkwadebe ntọhapụ na-adịgide adịgide ma ọ bụ nke a na-achịkwa. Enwere ike iru dose mbụ achọrọ maka mmetụta ọgwụgwọ nke mbadamba ndị dị otú ahụ ngwa ngwa, wee mee mmetụta ntọhapụ na-adịgide adịgide ma ọ bụ nke a na-achịkwa, a na-ejikwa ntinye ọgwụ dị irè n'ọbara n'ahụ. A na-eme ka mmiri dị na Hydroxypropyl methylcellulose ka ọ bụrụ oyi akwa gel mgbe ọ zutere mmiri. Usoro nke mwepụta ọgwụ site na mbadamba matrix gụnyere mgbasa nke oyi akwa gel na mbibi nke oyi akwa gel. Jung Bo Shim na ndị otu ya kwadebere mbadamba carvedilol na-adịgide adịgide yana HPMC dị ka ihe ntọhapụ na-adịgide adịgide.
A na-ejikwa Hydroxypropyl methylcellulose eme ihe nke ukwuu na mbadamba matrix na-adịgide adịgide nke ọgwụ ọdịnala ndị China, a na-ejikwa ọtụtụ ihe ndị dị mkpa, akụkụ dị irè na nkwadebe otu nke ọgwụ ọdịnala ndị China. Liu Wen na ndị otu ya jiri 15% hydroxypropyl methylcellulose dị ka ihe matrix, 1% lactose na 5% microcrystalline cellulose dị ka ihe na-ejupụta ihe, ma kwadebe Jingfang Taohe Chengqi Decoction n'ime mbadamba ọnụ matrix na-adịgide adịgide. Ihe nlereanya ahụ bụ nha nha Higuchi. Sistemụ nhazi usoro dị mfe, nkwadebe ahụ dị mfe, data mwepụta ahụ kwụsiri ike, nke na-emezu ihe achọrọ nke Chinese Pharmacopoeia. Tang Guanguang na ndị otu ya jiri saponins zuru oke nke Astragalus dị ka ọgwụ nlereanya, kwadebe mbadamba matrix HPMC, ma nyochaa ihe ndị metụtara mwepụta ọgwụ site na akụkụ dị irè nke ọgwụ ọdịnala ndị China na mbadamba matrix HPMC. Nsonaazụ Ka usoro HPMC na-abawanye, mwepụta nke astragaloside belatara, pasent mwepụta nke ọgwụ ahụ nwekwara mmekọrịta dị larịị na ọnụego mgbasa nke matrix ahụ. N'ime mbadamba hypromellose HPMC matrix, enwere njikọ dị n'etiti mwepụta nke akụkụ dị irè nke ọgwụ ọdịnala China na usoro na ụdị HPMC, usoro mwepụta nke monomer kemịkalụ hydrophilic yiri ya. Hydroxypropyl methylcellulose adịghị mma naanị maka ihe ndị na-abụghị hydrophilic, kamakwa maka ihe ndị na-abụghị hydrophilic. Liu Guihua jiri 17% hydroxypropyl methylcellulose (HPMCK15M) dị ka ihe matrix na-adịgide adịgide, ma kwadebe mbadamba matrix Tianshan Xuelian na-adịgide adịgide site na usoro granulation mmiri na mbadamba. Mmetụta ntọhapụ na-adịgide adịgide doro anya, usoro nkwadebe ahụ kwụsiri ike ma kwe omume.
A naghị etinye Hydroxypropyl methylcellulose naanị na mbadamba matrix ndị na-adịgide adịgide nke ihe ndị na-arụ ọrụ na akụkụ dị irè nke ọgwụ ọdịnala China, kamakwa a na-eji ya eme ihe na nkwadebe ọgwụ ọdịnala China. Wu Huichao na ndị otu ya jiri 20% hydroxypropyl methyl cellulose (HPMCK4M) dị ka ihe matrix, ma jiri usoro mkpakọ ntụ ntụ kpọmkwem kwadebe mbadamba matrix gel Yizhi hydrophilic nke nwere ike ịhapụ ọgwụ ahụ mgbe niile ma kwụsie ike ruo awa 12. Ejiri Saponin Rg1, ginsenoside Rb1 na Panax notoginseng saponin R1 dị ka ihe ngosi nyocha iji nyochaa ntọhapụ in vitro, etinyere usoro mwepụta ọgwụ iji mụọ usoro mwepụta ọgwụ. Nsonaazụ Usoro mwepụta ọgwụ kwekọrọ na nha nha nke sinetik efu na nha nha Ritger-Peppas, nke a na-ewepụta geniposide site na mgbasa na-abụghị Fick, a na-ewepụtakwa ihe atọ dị na Panax notoginseng site na mbuze ọkpụkpụ.
3.5 Gluu nchebe dị ka ihe na-eme ka ihe sie ike na colloid
Mgbe ejiri ngwaahịa a mee ihe dị ka ihe na-eme ka ihe sie ike, pasentị a na-ahụkarị bụ 0.45% ruo 1.0%. Ọ nwekwara ike ime ka gluu hydrophobic dịkwuo mma, mepụta colloid nchebe, gbochie ihe ndị dị na ya ịgbakọta ma na-agbakọta, si otú a na-egbochi mmepụta nke sediments. Pasentị a na-ahụkarị bụ 0.5% ruo 1.5%.
Wang Zhen na ndị otu ya jiri usoro nhazi nnwale L9 orthogonal mee nnyocha banyere usoro nkwadebe nke enema carbon activated ọgwụ. Ọnọdụ usoro kachasị mma maka mkpebi ikpeazụ nke enema carbon activated ọgwụ bụ iji 0.5% sodium carboxymethyl cellulose na 2.0% hydroxypropyl methylcellulose (HPMC nwere 23.0% methoxyl group, hydroxypropoxyl Base 11.6%) dị ka ihe na-eme ka ihe dị arọ, ọnọdụ usoro ahụ na-enyere aka ime ka carbon activated ọgwụ dịkwuo mma. Zhang Zhiqiang na ndị otu ya mepụtara gel levofloxacin hydrochloride ophthalmic dị njikere iji na pH nke nwere mmetụta ntọhapụ na-adịgide adịgide, na-eji carbopol dị ka gel matrix na hydroxypropyl methylcellulose dị ka ihe na-eme ka ihe dị arọ. Nnwale kachasị mma, nke e mere iji chọpụta ọgwụ kacha mma, bụ levofloxacin hydrochloride 0.1 g, carbopol (9400) 3 g, hydroxypropyl methylcellulose (E50 LV) 20 g, disodium hydrogen phosphate 0.35 g, phosphoric acid 0.45 g nke sodium dihydrogen, 0.50 g nke sodium chloride, 0.03 g nke ethyl paraben, e tinyekwara mmiri iji mee 100 mL. N'ule ahụ, onye dere akwụkwọ ahụ nyochachara usoro hydroxypropyl methylcellulose METHOCEL nke Colorcon Company nwere nkọwapụta dị iche iche (K4M, E4M, E15 LV, E50LV) iji kwadebe ihe ndị na-eme ka ọ dị arọ nwere ọtụtụ ihe dị iche iche, nsonaazụ ya wee họrọ HPMC E50 LV dị ka ihe na-eme ka ọ dị arọ. Ihe na-eme ka ọ dị arọ maka levofloxacin hydrochloride instant gels.
3.6 dị ka ihe dị na kapsụl
Ọtụtụ mgbe, ihe mejupụtara mkpụrụ ọgwụ capsule bụ gelatin. Usoro mmepụta nke mkpụrụ ọgwụ capsule dị mfe, mana enwere ụfọdụ nsogbu na ihe ndị dị ka nchebe na-adịghị mma megide mmiri mmiri na ọgwụ ndị na-emetụta oxygen, mbelata mgbasa ọgwụ, na igbu oge nke mkpụrụ ọgwụ capsule n'oge nchekwa. Ya mere, a na-eji hydroxypropyl methylcellulose dochie mkpụrụ ọgwụ gelatin maka nkwadebe mkpụrụ ọgwụ capsule, nke na-eme ka mmepụta mkpụrụ ọgwụ capsule dịkwuo mma na mmetụta ojiji, a na-akwalitekwa ya nke ukwuu n'ụlọ na mba ofesi.
Site n'iji theophylline mee ihe dị ka ọgwụ njikwa, Podczeck na ndị otu ya chọpụtara na ọnụego mgbasa ọgwụ nke capsules nwere shells hydroxypropyl methylcellulose karịrị nke gelatin capsules. Ihe kpatara nyocha ahụ bụ na mmebi nke HPMC bụ mmebi nke capsule dum n'otu oge, ebe mmebi nke gelatin capsule bụ mmebi nke nhazi netwọk mbụ, wee gbasaa nke capsule dum, yabụ HPMC capsule dabara adaba maka shells Capsule maka nhazi mwepụta ozugbo. Chiwele na ndị otu ya nwetakwara nkwubi okwu yiri nke ahụ ma tụnyere mgbasa nke gelatin, gelatin/polyethylene glycol na shells HPMC. Nsonaazụ gosiri na a gbazere shells HPMC ngwa ngwa n'okpuru ọnọdụ pH dị iche iche, ebe gelatin capsules Ọ na-emetụta nke ukwuu site na ọnọdụ pH dị iche iche. Tang Yue na ndị otu ya nyochachara ụdị shelf capsule ọhụrụ maka sistemụ nnyefe inhaler ntụ ntụ akọrọ dị obere dose. Ma e jiri ya tụnyere shelf capsule nke hydroxypropyl methylcellulose na shelf capsule nke gelatin, a nyochachara nkwụsi ike nke shelf capsule na njirimara nke ntụ ntụ dị na shell n'okpuru ọnọdụ dị iche iche, e mekwara ule friability. Nsonaazụ ya gosiri na ma e jiri ya tụnyere kapsụl gelatin, kapsụl HPMC dị mma n'ịkwụsi ike na nchekwa ntụ, nwee ike iguzogide mmiri siri ike, ma nwee obere ike karịa kapsụl gelatin, yabụ kapsụl HPMC dị mma maka kapsụl maka iku ume ntụ kpọrọ nkụ.
3.7 dị ka ihe na-eme ka ihe dị ndụ
Teknụzụ bioadhesion na-eji ihe mgbakwunye nwere polima bioadhesive eme ihe. Site n'ịrapara na mucosa bayọlọji, ọ na-eme ka mmekọrịta dị n'etiti nkwadebe na mucosa dịkwuo mma ma sie ike, ka ọgwụ ahụ wee jiri nwayọ nwayọ na-apụta ma na-amịkọrọ ya site na mucosa iji mezuo ebumnuche ọgwụgwọ. A na-ejikarị ya eme ihe ugbu a. Ọgwụgwọ nke ọrịa nke eriri afọ, ikpu, mucosa ọnụ na akụkụ ndị ọzọ.
Teknụzụ bioadhesion afọ bụ usoro nnyefe ọgwụ ọhụrụ nke emepụtara n'afọ ndị na-adịbeghị anya. Ọ bụghị naanị na ọ na-agbatị oge nkwadebe ọgwụ na eriri afọ, kamakwa ọ na-eme ka arụmọrụ kọntaktị dị n'etiti ọgwụ ahụ na akpụkpọ ahụ sel dịkwuo mma na ebe a na-amịkọrọ ya, na-agbanwe mmiri nke akpụkpọ ahụ sel, ma na-eme ka ntinye nke ọgwụ ahụ n'ime obere mkpụrụ ndụ epithelial eriri afọ dịkwuo mma, si otú a na-eme ka bioavailability nke ọgwụ ahụ ka mma. Wei Keda et al. jiri usoro HPMCK4M na Carbomer 940 nyochaa ọgwụ isi mbadamba ahụ dị ka ihe ndị na-eme nnyocha, ma jiri ngwaọrụ bioadhesion nke aka ya mee iji tụọ ike peeling n'etiti mbadamba na biofilm e mere site na ịdị mma nke mmiri dị na akpa plastik ahụ. , ma mechaa họrọ ọdịnaya nke HPMCK40 na carbomer 940 ka ọ bụrụ 15 na 27.5 mg n'ebe kacha mma e si ede ọgwụ na mkpụrụ ọgwụ NCaEBT, n'otu n'otu, iji kwadebe mkpụrụ ọgwụ NCaEBT, nke na-egosi na ihe ndị na-eme ka ihe dị ndụ (dị ka hydroxypropyl methylcellulose) nwere ike ibelata nke ukwuu Meziwanye njikọta nke nkwadebe ahụ na anụ ahụ.
Nkwadebe ọgwụ e ji eme ihe n'ọnụ bụkwa ụdị usoro ọhụrụ nke a na-amụkwu banyere ya n'afọ ndị na-adịbeghị anya. Nkwadebe ọgwụ e ji eme ihe n'ọnụ nwere ike ịrapara ọgwụ ahụ n'akụkụ ọnụ metụtara, nke na-eme ka ọ bụghị naanị na ọ na-agbatị oge obibi ọgwụ ahụ n'ime mucosa ọnụ, kamakwa ọ na-echebe mucosa ọnụ. Mmetụta ọgwụgwọ ka mma na mmụba nke bioavailability ọgwụ. Xue Xiaoyan et al. hazigharịrị usoro nke mbadamba ihe nrapado insulin ọnụ, na-eji apụl pectin, chitosan, carbomer 934P, hydroxypropyl methylcellulose (HPMC K392) na sodium alginate dị ka ihe nrapado bio, na ịkpọ nkụ iji kwadebe insulin ọnụ. Mpempe akwụkwọ oyi akwa abụọ na-arapara. Mbadamba ihe nrapado insulin ọnụ nke a kwadebere nwere nhazi dị ka ogbo oghere, nke dị mma maka ntọhapụ insulin, ma nwee oyi akwa nchebe hydrophobic, nke nwere ike hụ na mwepụta ọgwụ ahụ n'otu ụzọ ma zere mfu nke ọgwụ ahụ. Hao Jifu et al. kwadebekwara ihe mkpuchi ihe nrapado acha anụnụ anụnụ-odo odo ọnụ site na iji Baiji gluu, HPMC na carbomer dị ka ihe nrapado bio.
N'ime usoro nnyefe ọgwụ ikpu, a na-ejikwa teknụzụ bioadhesion eme ihe nke ukwuu. Zhu Yuting na ndị otu ya jiri carbomer (CP) na HPMC dị ka ihe na-arapara na matrix na-adịgide adịgide iji kwadebe mbadamba clotrimazole bioadhesive ikpu nwere usoro na oke dị iche iche, ma tụọ nrapado ha, oge nrapado na pasentị ọzịza na gburugburu ebe mmiri ikpu arụrụ arụ. E jiri ọgwụ kwesịrị ekwesị chọpụta CP-HPMC1: 1, mpempe akwụkwọ nrapado akwadoro nwere arụmọrụ nrapado dị mma, usoro ahụ dịkwa mfe ma kwe omume.
3.8 dị ka gel topical
Dịka nkwadebe ihe na-arapara, gel nwere ọtụtụ uru dịka nchekwa, ịma mma, nhicha dị mfe, ọnụ ala dị ala, usoro nkwadebe dị mfe, na ezigbo ndakọrịta na ọgwụ. Ntuziaka mmepe. Dịka ọmụmaatụ, gel transdermal bụ ụdị ọgwụ ọhụrụ a na-amụkwu nke ọma n'afọ ndị na-adịbeghị anya. Ọ bụghị naanị na ọ nwere ike izere mbibi nke ọgwụ na eriri afọ ma belata mgbanwe kachasị elu nke mkpokọta ọgwụ ọbara, kamakwa ọ ghọọla otu n'ime usoro mwepụta ọgwụ dị irè iji merie mmetụta ọjọọ nke ọgwụ.
Zhu Jingjie na ndị otu ya mụrụ mmetụta nke matrices dị iche iche nwere na mwepụta nke scutellarin alcohol plastid gel in vitro, ma jiri carbomer (980NF) na hydroxypropyl methylcellulose (HPMCK15M) enyocha ya dị ka gel matrices, wee nweta scutellarin dị mma maka scutellarin. Gel matrix nke alcohol plastids. Nsonaazụ nnwale ahụ na-egosi na 1.0% carbomer, 1.5% carbomer, 1.0% carbomer + 1.0% HPMC, 1.5% carbomer + 1.0% HPMC dị ka gel matrix Ha abụọ dabara adaba maka scutellarin alcohol plastids. N'oge nnwale ahụ, achọpụtara na HPMC nwere ike ịgbanwe ụdị mwepụta ọgwụ nke carbomer gel matrix site na itinye nha anya kinetic nke mwepụta ọgwụ, na 1.0% HPMC nwere ike imeziwanye 1.0% carbomer matrix na 1.5% carbomer matrix. Ihe kpatara ya nwere ike ịbụ na HPMC na-agbasa ngwa ngwa, mmụba ngwa ngwa na mbido nnwale ahụ na-eme ka oghere molekul nke ihe jel carbomer buru ibu, si otú a na-eme ka ọnụego mwepụta ọgwụ ya dịkwuo ngwa ngwa. Zhao Wencui na ndị otu ya jiri carbomer-934 na hydroxypropyl methylcellulose dị ka ndị na-ebu iji kwadebe jel anya norfloxacin. Usoro nkwadebe ahụ dị mfe ma kwe omume, ogo ya kwekọọkwa na jel anya nke "Chinese Pharmacopoeia" (mbipụta 2010) achọrọ maka ịdị mma.
3.9 Ihe mgbochi mmiri mmiri maka sistemụ microemulsifying onwe ya
Sistemụ nnyefe ọgwụ nke na-eme ka ọgwụ dị nro (SMEDDS) bụ ụdị usoro nnyefe ọgwụ ọnụ ọhụrụ, nke bụ ngwakọta yiri nke ahụ, nke kwụsiri ike ma doo anya nke mejupụtara ọgwụ, usoro mmanụ, emulsifier na co-emulsifier. Nhazi nke ọgwụ ahụ dị mfe, nchekwa na nkwụsi ike dịkwa mma. Maka ọgwụ ndị na-anaghị agbaze nke ọma, a na-agbakwụnyekarị ihe polymer eriri mmiri na-agbaze, dị ka HPMC, polyvinylpyrrolidone (PVP), wdg, iji mee ka ọgwụ ndị na-enweghị ihe ọ bụla na ọgwụ ndị e kechiri na microemulsion nweta mgbaze zuru oke na eriri afọ, ka o wee mee ka ọgwụ ahụ dịkwuo mma ma melite nnweta bioavailability.
Peng Xuan na ndị otu ya kwadebere usoro nnyefe ọgwụ silibinin nke na-eme ka ihe na-agbaze onwe ya (S-SEDDS). Mmanụ castor oxyethylene hydrogenated (Cremophor RH40), 12% caprylic capric acid polyethylene glycol glyceride (Labrasol) dị ka co-emulsifier, na 50 mg·g-1 HPMC. Ịtinye HPMC na SSEDDS nwere ike ime ka silibinin nwee oke mmiri ka ọ gbazee na S-SEDDS ma gbochie silibinin ịpụ apụ. Ma e jiri ya tụnyere usoro microemulsion onwe onye, a na-agbakwụnyekarị nnukwu surfactant iji gbochie mkpuchi ọgwụ na-ezughị ezu. Mgbakwunye nke HPMC nwere ike ime ka silibinin nwee ike ịgbaze na usoro mgbasa ahụ na-adịgide adịgide, na-ebelata emulsification na usoro microemulsion onwe onye. dose nke ihe nnọchite anya ahụ.
4. Mmechi
A pụrụ ịhụ na HPMC ejirila ya mee ihe nke ukwuu n'ihe gbasara nkwadebe n'ihi ihe ndị dị na ya, kemịkalụ na ihe ndị dị ndụ, mana HPMC nwekwara ọtụtụ adịghị ike na nkwadebe, dịka ihe na-eme tupu na mgbe mgbawa gbawara agbawa. methyl methacrylate) iji meziwanye. N'otu oge ahụ, ụfọdụ ndị nchọpụta nyochachara itinye ozizi osmotic na HPMC site n'ịkwadebe mbadamba carbamazepine na-adịgide adịgide na mbadamba verapamil hydrochloride na-adịgide adịgide iji mụọ usoro ntọhapụ ya. N'ikwu ya n'ụzọ dị mfe, ọtụtụ ndị nchọpụta na-arụ ọrụ dị ukwuu maka itinye HPMC n'ọrụ nke ọma na nkwadebe, yana site na ọmụmụ miri emi nke ihe onwunwe ya na mmezi nke teknụzụ nkwadebe, a ga-eji HPMC eme ihe nke ọma n'ụdị onunu ogwu ọhụrụ na ụdị onunu ogwu ọhụrụ. Na nyocha nke sistemụ ọgwụ, wee kwalite mmepe na-aga n'ihu nke ọgwụ.
Oge ozi: Ọktoba-08-2022