Ua loiloi ʻia, kālailai ʻia a hōʻuluʻulu ʻia nā palapala pili ma ka home a ma waho i ka hoʻomākaukau ʻana i nā mea hoʻohui lāʻau lapaʻau hydroxypropyl methylcellulose (HPMC) i nā makahiki i hala iho nei, a me kāna noi ʻana i nā hoʻomākaukau paʻa, nā hoʻomākaukau wai, nā hoʻomākaukau hoʻokuʻu mau a kāohi ʻia, nā hoʻomākaukau capsule, gelatin. ʻO nā noi hou loa ma ke kahua o nā ʻano hana hou e like me nā ʻano hana hoʻopili a me nā bioadhesives. Ma muli o ka ʻokoʻa o ke kaumaha molekala pili a me ka viscosity o HPMC, loaʻa iā ia nā ʻano a me nā hoʻohana o ka emulsification, adhesion, thickening, viscosity increasing, suspending, gelling a me ka hana ʻana i ka kiʻiʻoniʻoni. Hoʻohana nui ʻia ia i nā hoʻomākaukau lāʻau lapaʻau a e pāʻani i kahi hana nui aʻe ma ke kahua o nā hoʻomākaukau. Me ke aʻo hohonu ʻana i kona mau waiwai a me ka hoʻomaikaʻi ʻana i ka ʻenehana hoʻolālā, e hoʻohana nui ʻia ʻo HPMC i ka noiʻi ʻana i nā ʻano dosage hou a me nā ʻōnaehana lawe lāʻau hou, no laila e hoʻolaha ana i ka hoʻomohala mau ʻana o nā ʻano hana.
hydroxypropyl methylcellulose; nā hoʻomākaukau lāʻau lapaʻau; nā mea hoʻohui lāʻau lapaʻau.
ʻAʻole wale nā mea hoʻohui lāʻau lapaʻau ke kumu waiwai no ka hoʻokumu ʻana i nā hoʻomākaukau lāʻau maka, akā pili pū kekahi i ka paʻakikī o ke kaʻina hana hoʻomākaukau, ka maikaʻi o ka lāʻau, ke kūpaʻa, ka palekana, ka wikiwiki o ka hoʻokuʻu ʻana i ka lāʻau, ke ʻano o ka hana, ka pono lapaʻau, a me ka hoʻomohala ʻana i nā ʻano dosage hou a me nā ala hou o ka hoʻokele. pili loa. ʻO ka puka ʻana mai o nā mea hoʻohui lāʻau lapaʻau hou e paipai pinepine i ka hoʻomaikaʻi ʻana i ka maikaʻi o ka hoʻomākaukau ʻana a me ka hoʻomohala ʻana i nā ʻano dosage hou. ʻO Hydroxypropyl methylcellulose (HPMC) kekahi o nā mea hoʻohui lāʻau lapaʻau kaulana loa ma ka home a ma waho. Ma muli o kona kaumaha molekala like ʻole a me ka viscosity, loaʻa iā ia nā hana o ka emulsifying, binding, thickening, thickening, suspending, a me ka glueing. Hoʻohana nui ʻia nā hiʻohiʻona a me nā hoʻohana e like me ka coagulation a me ka hoʻokumu ʻana i ka kiʻiʻoniʻoni i ka ʻenehana lāʻau lapaʻau. Nānā nui kēia ʻatikala i ka hoʻohana ʻana o hydroxypropyl methylcellulose (HPMC) i nā formulations i nā makahiki i hala iho nei.
1.Nā waiwai kumu o HPMC
ʻO Hydroxypropyl methyl cellulose (HPMC), ʻo ke ʻano molekala ʻo C8H15O8-(C10 H18O6) n- C8H15O8, a ʻo ka nui molekala pili ma kahi o 86 000. He mea semi-synthetic kēia huahana, ʻo ia kekahi hapa o ka methyl a me kahi hapa o ka polyhydroxypropyl ether o ka cellulose. Hiki ke hana ʻia ma nā ʻano ʻelua: ʻO kekahi, ʻo ka methyl cellulose o kahi papa kūpono e mālama ʻia me NaOH a laila e hana ʻia me ka propylene oxide ma lalo o ke ana wela a me ke kaomi kiʻekiʻe. Pono ka manawa hana e lōʻihi e ʻae i ka methyl a me ka hydroxypropyl e hana i nā pilina ether. Hoʻopili ʻia ia i ke apo anhydroglucose o ka cellulose ma ke ʻano o ka cellulose, a hiki ke hiki i ke kekelē i makemake ʻia; ʻo kekahi, ʻo ia ka mālama ʻana i ka linter pulupulu a i ʻole ka pulp lāʻau me ka soda caustic, a laila e hana me ka methane chlorinated a me ka propylene oxide ma hope, a laila e hoʻomaʻemaʻe hou iā ia. , i kuʻi ʻia i loko o ka pauka maikaʻi a like a i ʻole nā granules.
He keʻokeʻo a he keʻokeʻo waiū ke kala o kēia huahana, ʻaʻohe ʻala a ʻono ʻole, a he pauka granular a fibrous paha ke ʻano e kahe maʻalahi ana. Hiki ke hoʻoheheʻe ʻia kēia huahana i loko o ka wai e hana i kahi hopena colloidal keʻokeʻo a maopopo me kahi mānoanoa. Hiki ke hana ʻia ka hanana interconversion sol-gel ma muli o ka loli ʻana o ka mahana o ka hopena me kahi ʻano kikoʻī.
Ma muli o ka ʻokoʻa o ka ʻike o kēia mau mea pani ʻelua i loko o ke ʻano o ka methoxy a me ka hydroxypropyl, ua ʻike ʻia nā ʻano huahana like ʻole. I nā ʻano kikoʻī, loaʻa i nā ʻano huahana like ʻole nā ʻano kikoʻī. ʻO ka viscosity a me ka mahana gelation thermal, no laila he mau waiwai like ʻole a hiki ke hoʻohana ʻia no nā kumu like ʻole. Loaʻa i ka Pharmacopoeia o nā ʻāina like ʻole nā lula a me nā ʻano hōʻike ma ke kumu hoʻohālike: Hoʻokumu ʻia ka European Pharmacopoeia ma nā papa like ʻole o nā viscosities like ʻole a me nā kekelē like ʻole o ka pani ʻana o nā huahana i kūʻai ʻia ma ka mākeke, i hōʻike ʻia e nā papa me nā helu, a ʻo ke anakahi ʻo "mPa s". Ma ka US Pharmacopoeia, ua hoʻohui ʻia nā huahelu 4 ma hope o ka inoa generic e hōʻike i ka ʻike a me ke ʻano o kēlā me kēia mea pani o ka hydroxypropyl methylcellulose, e like me ka hydroxypropyl methylcellulose 2208. Hōʻike nā huahelu mua ʻelua i ka waiwai kokoke o ka hui methoxy. Pakeneka, hōʻike nā huahelu hope ʻelua i ka pakeneka kokoke o ka hydroxypropyl.
He 3 mau moʻo o ka hydroxypropyl methylcellulose a Calocan, ʻo ia hoʻi nā moʻo E, nā moʻo F a me nā moʻo K, loaʻa i kēlā me kēia moʻo nā ʻano hoʻohālike like ʻole e koho ai. Hoʻohana nui ʻia nā moʻo E ma ke ʻano he uhi kiʻiʻoniʻoni, hoʻohana ʻia no ka uhi ʻana i nā papa, nā ʻōpū papa pani; Hoʻohana ʻia nā moʻo E, F ma ke ʻano he viscosifiers a me nā mea hoʻomaha hoʻokuʻu no nā hoʻomākaukau ophthalmic, nā mea hoʻomaha, nā mea mānoanoa no nā hoʻomākaukau wai, nā papa a me nā mea hoʻopaʻa o nā granules; Hoʻohana nui ʻia nā moʻo K ma ke ʻano he mea hoʻōki hoʻokuʻu a me nā mea matrix gel hydrophilic no nā hoʻomākaukau hoʻokuʻu lohi a kāohi ʻia.
ʻO nā mea hana kūloko nui ka Fuzhou No. 2 Chemical Factory, Huzhou Food and Chemical Co., Ltd., Sichuan Luzhou Pharmaceutical Accessories Factory, Hubei Jinxian Chemical Factory No. 1, Feicheng Ruitai Fine Chemical Co., Ltd., Shandong Liaocheng Ahua Pharmaceutical Co., Ltd., Xi'an Huian chemical plants, etc.
2.Nā Pōmaikaʻi o HPMC
Ua lilo ʻo HPMC i hoʻokahi o nā mea hoʻohui lāʻau lapaʻau i hoʻohana nui ʻia ma ka home a ma waho, no ka mea, he mau pono ko HPMC i loaʻa ʻole i nā mea hoʻohui ʻē aʻe.
2.1 Ka hoʻoheheʻe ʻia ʻana i ka wai anuanu
Hoʻoheheʻe ʻia i ka wai anuanu ma lalo o 40 ℃ a i ʻole 70% ethanol, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka wai wela ma luna o 60 ℃, akā hiki ke hoʻoheheʻe ʻia.
2.2 ʻAʻohe hana kemika
ʻO HPMC kahi ʻano o ka cellulose ether non-ionic, ʻaʻohe uku ionic o kāna hopena a ʻaʻole ia e launa pū me nā paʻakai metala a i ʻole nā hui organik ionic, no laila ʻaʻole pane nā mea hoʻohui ʻē aʻe me ia i ke kaʻina hana o ka hoʻomākaukau ʻana.
2.3 Paʻa
He kūpaʻa iki ia i ka waikawa a me ka alkali, a hiki ke mālama ʻia no ka manawa lōʻihi ma waena o ka pH 3 a me 11 me ka ʻole o ka loli nui o ka viscosity. Loaʻa i ka hopena wai o HPMC ka hopena anti-mildew a mālama i ka paʻa viscosity maikaʻi i ka wā mālama lōʻihi. ʻOi aku ka maikaʻi o ke kūpaʻa o nā mea hoʻohui lāʻau lapaʻau e hoʻohana ana i ka HPMC ma mua o nā mea e hoʻohana ana i nā mea hoʻohui kuʻuna (e like me dextrin, starch, a pēlā aku).
2.4 Hoʻoponopono ʻana i ka Viscosity
Hiki ke hoʻohui ʻia nā ʻano viscosity like ʻole o ka HPMC i nā ʻano like ʻole, a hiki ke hoʻololi ʻia kona viscosity e like me kekahi kānāwai, a he pilina linear maikaʻi, no laila hiki ke koho ʻia ka ʻano e like me nā pono.
2.5 Ka inertness metabolic
ʻAʻole i komo a hoʻoheheʻe ʻia paha ka HPMC i loko o ke kino, a ʻaʻole hoʻi e hāʻawi i ka wela, no laila he mea hoʻohui palekana ia no ka hoʻomākaukau ʻana i nā lāʻau lapaʻau. 2.6 Palekana Ua manaʻo nui ʻia ʻo ka HPMC he mea ʻawahia ʻole a ʻaʻole hoʻonāukiuki, ʻo ka nui make waena no nā ʻiole he 5 g·kg – 1, a ʻo ka nui make waena no nā ʻiole he 5.2 g · kg – 1. ʻAʻohe mea ʻino ka nui o kēlā me kēia lā i ke kino kanaka.
3.Ka hoʻohana ʻana o HPMC i nā ʻano hana
3.1 Ma ke ʻano he mea uhi kiʻiʻoniʻoni a me nā mea hana kiʻiʻoniʻoni
Ke hoʻohana nei i ka HPMC ma ke ʻano he mea papa i uhi ʻia i ka ʻiliʻili, ʻaʻohe pono maopopo o ka papa i uhi ʻia i ka uhi ʻana i ka ʻono a me ke ʻano i hoʻohālikelike ʻia me nā papa i uhi ʻia i ka ʻiliʻili kuʻuna e like me nā papa i uhi ʻia i ke kō, akā ʻoi aku ka maikaʻi o kona paʻakikī, friability, omo wai, kekelē disintegration. , loaʻa ke kaumaha o ka uhi ʻana a me nā hōʻailona maikaʻi ʻē aʻe. Hoʻohana ʻia ka papa viscosity haʻahaʻa o kēia huahana ma ke ʻano he mea uhi ʻiliʻili wai-hoʻoheheʻe ʻia no nā papa a me nā pila, a hoʻohana ʻia ka papa viscosity kiʻekiʻe ma ke ʻano he mea uhi ʻiliʻili no nā ʻōnaehana hoʻoheheʻe organik, maʻamau ma ka nui o 2% a 20%.
Ua hoʻohana ʻo Zhang Jixing et al. i ke ʻano hopena o ka ʻili e hoʻomaikaʻi i ka hoʻohuihui premix me HPMC ma ke ʻano he uhi kiʻiʻoniʻoni. Ma ka lawe ʻana i ka mea hana kiʻiʻoniʻoni HPMC, ʻo ka nui o ka polyvinyl alcohol a me ka plasticizer polyethylene glycol ma ke ʻano he mau mea noiʻi, ka ikaika tensile a me ka permeability o ke kiʻiʻoniʻoni a me ka viscosity o ka hopena uhi kiʻiʻoniʻoni ʻo ia ka helu nānā, a ua wehewehe ʻia ka pilina ma waena o ka helu nānā a me nā mea nānā e kahi kumu hoʻohālike makemakika, a ua loaʻa hope ke kaʻina hana hoʻohui maikaʻi loa. ʻO kāna hoʻohana ʻana he 11.88 g ka mea hana kiʻiʻoniʻoni hydroxypropyl methylcellulose (HPMCE5), 24.12 g polyvinyl alcohol, 13.00 g plasticizer polyethylene glycol, a ʻo ka viscosity suspension coating he 20 mPa·s, ua hiki i ka permeability a me ka ikaika tensile o ke kiʻiʻoniʻoni ka hopena maikaʻi loa. Ua hoʻomaikaʻi ʻo Zhang Yuan i ke kaʻina hana hoʻomākaukau, hoʻohana iā HPMC ma ke ʻano he mea hoʻopaʻa e pani i ka slurry starch, a hoʻololi i nā papa Jiahua i nā papa i uhi ʻia i ka kiʻiʻoniʻoni e hoʻomaikaʻi i ka maikaʻi o kāna hoʻomākaukau ʻana, hoʻomaikaʻi i kona hygroscopicity, maʻalahi ke mae, nā papa wehe, nā splintered a me nā pilikia ʻē aʻe, e hoʻonui i ke kūpaʻa o ka papa. Ua hoʻoholo ʻia ke kaʻina hana hoʻohui kūpono e nā hoʻokolohua orthogonal, ʻo ia hoʻi, ʻo ka nui o ka slurry he 2% HPMC i loko o ka 70% ethanol solution i ka wā o ka uhi ʻana, a ʻo ka manawa hoʻouluulu i ka wā o ka granulation he 15 min. Nā Hualoaʻa Ua hoʻomaikaʻi nui ʻia ke ʻano o nā papa i uhi ʻia me ka ʻili Jiahua i hoʻomākaukau ʻia e ke kaʻina hana hou a me ke kauoha ʻana i ke ʻano, ka manawa disintegration a me ka paʻakikī o ke kumu ma mua o nā mea i hana ʻia e ke kaʻina hana kauoha mua, a ua hoʻomaikaʻi nui ʻia ka helu kūpono o nā papa i uhi ʻia me ka ʻili. ua hiki aku ma mua o 95%. Ua hoʻohana pū ʻo Liang Meiyi, Lu Xiaohui, a pēlā aku i ka hydroxypropyl methylcellulose ma ke ʻano he mea hana ʻili e hoʻomākaukau ai i ka papa hoʻonohonoho colon patinae a me ka papa hoʻonohonoho colon matrine, kēlā me kēia. hoʻopilikia i ka hoʻokuʻu ʻana i ka lāʻau. Ua hoʻomākaukau ʻo Huang Yunran i nā Papa Hoʻonohonoho Colon Blood a Dragon, a ua hoʻopili i ka HPMC i ka hopena uhi o ka papa pehu, a ʻo kona hapa nui he 5%. Hiki ke ʻike ʻia hiki ke hoʻohana nui ʻia ka HPMC i ka ʻōnaehana lawe lāʻau i kuhikuhi ʻia i ka colon.
ʻAʻole wale ka Hydroxypropyl methylcellulose he mea uhi kiʻiʻoniʻoni maikaʻi loa, akā hiki ke hoʻohana ʻia ma ke ʻano he mea hana kiʻiʻoniʻoni i nā ʻano kiʻiʻoniʻoni. Ua hoʻonohonoho pono ʻia ʻo Wang Tongshun etc. no ke kuhikuhi ʻana o ka hui zinc licorice a me ka aminolexanol oral composite film, me ka maʻalahi, ka like, ka laumania, ka transparency o ka mea hana kiʻiʻoniʻoni e like me ka helu noiʻi, loaʻa ka palapala kuhikuhi kūpono ʻo PVA 6.5 g, HPMC 0.1 g a me 6.0 g o ka propylene glycol e hoʻokō i nā koi o ka hoʻokuʻu lohi a me ka palekana, a hiki ke hoʻohana ʻia ma ke ʻano he kuhikuhi hoʻomākaukau o ka kiʻiʻoniʻoni composite.
3.2 ma ke ʻano he mea hoʻopaʻa a me ka mea hoʻoheheʻe
Hiki ke hoʻohana ʻia ke ʻano viscosity haʻahaʻa o kēia huahana ma ke ʻano he mea hoʻopaʻa a me ka mea hoʻoheheʻe no nā papa, nā pila a me nā granules, a ʻo ke ʻano viscosity kiʻekiʻe hiki ke hoʻohana wale ʻia ma ke ʻano he mea hoʻopaʻa. ʻOkoʻa ka nui o ka lāʻau ma muli o nā hiʻohiʻona a me nā koi like ʻole. Ma ke ʻano laulā, ʻo ka nui o ka mea hoʻopaʻa no nā papa granulation maloʻo he 5%, a ʻo ka nui o ka mea hoʻopaʻa no nā papa granulation pulu he 2%.
Ua nānā ʻo Li Houtao et al i ka mea hoʻopaʻa o nā papa tinidazole. Ua noiʻi ʻia ka 8% polyvinylpyrrolidone (PVP-K30), 40% syrup, 10% slurry starch, 2.0% hydroxypropyl methylcellulose K4 (HPMCK4M), 50% ethanol ma ke ʻano he hoʻopili ʻana o nā papa tinidazole. hoʻomākaukau ʻana o nā papa tinidazole. Ua hoʻohālikelike ʻia nā loli o ke ʻano o nā papa maʻemaʻe a ma hope o ka uhi ʻana, a ua ana ʻia ka friability, ka paʻakikī, ka palena manawa disintegration a me ka helu hoʻoheheʻe o nā papa kuhikuhi like ʻole. Nā Hualoaʻa Ua ʻālohilohi nā papa i hoʻomākaukau ʻia e 2.0% hydroxypropyl methylcellulose, a ʻaʻole i loaʻa i ke ana friability ka ʻaoʻao chipping a me ke kihi, a ma hope o ka uhi ʻana, ua piha ke ʻano o ka papa a ua maikaʻi ke ʻano. No laila, ua hoʻohana ʻia nā papa tinidazole i hoʻomākaukau ʻia me 2.0% HPMC-K4 a me 50% ethanol ma ke ʻano he mea hoʻopaʻa. Ua aʻo ʻo Guan Shihai i ke kaʻina hana hoʻokumu o nā Papa Fuganning, nānā i nā mea hoʻopili, a nānā i ka 50% ethanol, 15% starch paste, 10% PVP a me 50% ethanol solutions me ka compressibility, smoothness, a me ka friability e like me nā hōʻailona loiloi. , 5% CMC-Na a me 15% HPMC solution (5 mPa s). Nā Hualoaʻa ʻO nā pepa i hoʻomākaukau ʻia e 50% ethanol, 15% starch paste, 10% PVP 50% ethanol solution a me 5% CMC-Na he ʻili laumania, akā ʻaʻole maikaʻi ka compressibility a me ka paʻakikī haʻahaʻa, ʻaʻole hiki ke hoʻokō i nā pono o ka uhi ʻana; 15% HPMC solution (5 mPa·s), laumania ka ʻili o ka papa, kūpono ka friability, a maikaʻi ka compressibility, hiki ke hoʻokō i nā pono o ka uhi ʻana. No laila, ua koho ʻia ʻo HPMC (5 mPa s) ma ke ʻano he mea hoʻopili.
3.3 ma ke ʻano he mea hoʻokuʻu
Hoʻohana ʻia ke kiʻekiʻe o ka viscosity o kēia huahana ma ke ʻano he mea hoʻokuʻu e hoʻomākaukau i kahi hoʻomākaukau wai ʻano hoʻokuʻu. Loaʻa iā ia ka hopena hoʻokuʻu maikaʻi, maʻalahi ke hoʻokuʻu hou ʻia, ʻaʻole e pipili i ka paia, a he mau ʻāpana flocculation maikaʻi. ʻO ka dosage maʻamau he 0.5% a i 1.5%. Ua hoʻohana ʻo Song Tian et al. i nā mea polymer i hoʻohana pinepine ʻia (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, povidone, xanthan gum, methylcellulose, etc.) ma ke ʻano he mau mea hoʻokuʻu e hoʻomākaukau i ka racecadotril. hoʻokuʻu maloʻo. Ma o ka ratio sedimentation volume o nā hoʻokuʻu like ʻole, ua ʻike ʻia ka redispersibility index, a me ka rheology, ka viscosity hoʻokuʻu a me ke ʻano microscopic, a ua noiʻi pū ʻia ke kūpaʻa o nā ʻāpana lāʻau lapaʻau ma lalo o ka hoʻokolohua wikiwiki. Nā Hualoaʻa ʻO ka hoʻokuʻu maloʻo i hoʻomākaukau ʻia me 2% HPMC ma ke ʻano he mea hoʻokuʻu he hana maʻalahi a me ke kūpaʻa maikaʻi.
Ke hoʻohālikelike ʻia me ka methyl cellulose, loaʻa i ka hydroxypropyl methyl cellulose nā ʻano o ka hoʻokumu ʻana i kahi hopena ʻoi aku ka maopopo, a he liʻiliʻi wale nō ka nui o nā mea fibrous i hoʻopuehu ʻole ʻia, no laila hoʻohana pinepine ʻia ʻo HPMC ma ke ʻano he mea hoʻomaha i nā hoʻomākaukau ophthalmic. Ua hoʻohana ʻo Liu Jie et al. iā HPMC, hydroxypropyl cellulose (HPC), carbomer 940, polyethylene glycol (PEG), sodium hyaluronate (HA) a me ka hui pū ʻana o HA/HPMC ma ke ʻano he mau mea hoʻomaha e hoʻomākaukau i nā kikoʻī like ʻole No ka hoʻomaha ʻana o ka Ciclovir ophthalmic, ua koho ʻia ka lakio o ka sedimentation, ka nui o ka ʻāpana a me ka redispersibility ma ke ʻano he mau hōʻailona nānā e nānā i ka mea hoʻomaha maikaʻi loa. Hōʻike nā hopena ua hoʻomākaukau ʻia ka hoʻomaha ʻana o ka acyclovir ophthalmic e 0.05% HA a me 0.05% HPMC ma ke ʻano he mea hoʻomaha, ʻo ka lakio o ka sedimentation volume he 0.998, like ka nui o ka ʻāpana, maikaʻi ka redispersibility, a paʻa ka hoʻomākaukau ʻana. Hoʻonui ka wahine.
3.4 Ma ke ʻano he mea pale, mea hoʻokuʻu lohi a kāohi ʻia a me ka mea hana pore
Hoʻohana ʻia ke kiʻekiʻe o ka viscosity o kēia huahana no ka hoʻomākaukau ʻana i nā papa hoʻokuʻu mau ʻia o ka matrix gel hydrophilic, nā mea pale a me nā mea hoʻokuʻu i kāohi ʻia o nā papa hoʻokuʻu mau ʻia o ka matrix mixed-material, a he hopena hoʻopaneʻe i ka hoʻokuʻu ʻana i ka lāʻau. ʻO kona ʻano he 10% a 80%. Hoʻohana ʻia nā pae viscosity haʻahaʻa e like me nā porogens no nā hoʻomākaukau hoʻokuʻu mau ʻia a i ʻole ka hoʻokuʻu ʻia. Hiki ke hoʻokō koke ʻia ka nui mua e pono ai no ka hopena therapeutic o ia mau papa, a laila hoʻokō ʻia ka hopena hoʻokuʻu mau ʻia a i ʻole ka hoʻokuʻu ʻia ʻana, a mālama ʻia ka nui o ka lāʻau koko maikaʻi i loko o ke kino. . Hoʻomaʻū ʻia ka Hydroxypropyl methylcellulose e hana i kahi papa gel ke hui pū me ka wai. ʻO ke ʻano o ka hoʻokuʻu ʻana i ka lāʻau mai ka papa matrix e pili ana i ka hoʻolaha ʻana o ka papa gel a me ka ʻino ʻana o ka papa gel. Ua hoʻomākaukau ʻo Jung Bo Shim et al i nā papa hoʻokuʻu mau ʻia me ka carvedilol me ka HPMC ma ke ʻano he mea hoʻokuʻu mau ʻia.
Hoʻohana nui ʻia ʻo Hydroxypropyl methylcellulose i nā papa matrix hoʻokuʻu mau ʻia o ka lāʻau lapaʻau kuʻuna Kina, a ʻo ka hapa nui o nā mea hana, nā ʻāpana kūpono a me nā hoʻomākaukau hoʻokahi o ka lāʻau lapaʻau kuʻuna Kina e hoʻohana ʻia. Ua hoʻohana ʻo Liu Wen et al. i 15% hydroxypropyl methylcellulose ma ke ʻano he mea matrix, 1% lactose a me 5% microcrystalline cellulose ma ke ʻano he mea hoʻopiha, a ua hoʻomākaukau ʻo Jingfang Taohe Chengqi Decoction i loko o nā papa hoʻokuʻu mau ʻia o ka matrix waha. ʻO ke kumu hoʻohālike ʻo ia ka hoʻohālikelike Higuchi. He maʻalahi ka ʻōnaehana hoʻonohonoho formula, maʻalahi ka hoʻomākaukau ʻana, a paʻa loa ka ʻikepili hoʻokuʻu, kahi e hoʻokō ai i nā koi o ka Pharmacopoeia Kina. Ua hoʻohana ʻo Tang Guangguang et al. i nā saponins āpau o Astragalus ma ke ʻano he lāʻau hoʻohālike, ua hoʻomākaukau i nā papa matrix HPMC, a ua ʻimi i nā mea e pili ana i ka hoʻokuʻu ʻana o ka lāʻau mai nā ʻāpana kūpono o ka lāʻau lapaʻau kuʻuna Kina i nā papa matrix HPMC. Nā hopena I ka piʻi ʻana o ka dosage o HPMC, ua emi ka hoʻokuʻu ʻana o ka astragaloside, a ua pili kokoke ka pakeneka hoʻokuʻu o ka lāʻau me ka helu hoʻoheheʻe o ka matrix. I loko o ka papa matrix hypromellose HPMC, aia kekahi pilina ma waena o ka hoʻokuʻu ʻana o ka ʻāpana kūpono o ka lāʻau lapaʻau kuʻuna Kina a me ka nui a me ke ʻano o HPMC, a ua like ke kaʻina hana hoʻokuʻu o ka monomer kemika hydrophilic me ia. ʻAʻole kūpono wale ka Hydroxypropyl methylcellulose no nā hui hydrophilic, akā no nā mea non-hydrophilic. Ua hoʻohana ʻo Liu Guihua i ka 17% hydroxypropyl methylcellulose (HPMCK15M) ma ke ʻano he mea matrix hoʻokuʻu mau, a ua hoʻomākaukau ʻo Tianshan Xuelian sustained-release matrix tableting ma o ka granulation pulu a me ke ʻano tableting. Ua maopopo ka hopena hoʻokuʻu mau, a ua paʻa a hiki ke hana i ke kaʻina hana hoʻomākaukau.
ʻAʻole hoʻopili wale ʻia ka Hydroxypropyl methylcellulose i nā papa matrix hoʻokuʻu mau ʻia o nā mea hana a me nā ʻāpana kūpono o ka lāʻau lapaʻau kuʻuna Kina, akā hoʻohana nui ʻia i nā hoʻomākaukau hui lāʻau lapaʻau kuʻuna Kina. Ua hoʻohana ʻo Wu Huichao et al. i ka 20% hydroxypropyl methyl cellulose (HPMCK4M) ma ke ʻano he mea matrix, a hoʻohana i ke ʻano hoʻopili pololei o ka pauka e hoʻomākaukau i ka papa matrix gel hydrophilic Yizhi i hiki ke hoʻokuʻu mau i ka lāʻau lapaʻau a paʻa no 12 mau hola. Ua hoʻohana ʻia ʻo Saponin Rg1, ginsenoside Rb1 a me Panax notoginseng saponin R1 ma ke ʻano he mau hōʻailona loiloi e noiʻi i ka hoʻokuʻu ʻana i loko o vitro, a ua hoʻokomo ʻia ke ʻano hoʻokuʻu lāʻau lapaʻau e aʻo i ke ʻano hoʻokuʻu lāʻau lapaʻau. Nā Hualoaʻa Ua kūlike ke ʻano hoʻokuʻu lāʻau lapaʻau me ka hoʻohālikelike kinetic zero-order a me ka hoʻohālikelike Ritger-Peppas, kahi i hoʻokuʻu ʻia ai ka geniposide e ka diffusion non-Fick, a ua hoʻokuʻu ʻia nā ʻāpana ʻekolu i loko o Panax notoginseng e ka erosion skeletal.
3.5 Ke kāpili pale e like me ka mea hoʻomānoanoa a me ke colloid
Ke hoʻohana ʻia kēia huahana ma ke ʻano he mea hoʻomānoanoa, ʻo ka pakeneka maʻamau he 0.45% a i 1.0%. Hiki iā ia ke hoʻonui i ke kūpaʻa o ka glue hydrophobic, hana i kahi colloid pale, pale i nā ʻāpana mai ka hui pū ʻana a me ka hoʻopili ʻana, a laila e kāohi ana i ka hoʻokumu ʻia ʻana o nā sediments. ʻO kona pakeneka maʻamau he 0.5% a i 1.5%.
Ua hoʻohana ʻo Wang Zhen et al. i ke ʻano hoʻolālā hoʻokolohua orthogonal L9 e noiʻi i ke kaʻina hana hoʻomākaukau o ka enema kalapona hoʻāla lāʻau lapaʻau. ʻO nā kūlana hana kūpono no ka hoʻoholo hope loa o ka enema kalapona hoʻāla lāʻau lapaʻau, ʻo ia ka hoʻohana ʻana i ka 0.5% sodium carboxymethyl cellulose a me 2.0% hydroxypropyl methylcellulose (loaʻa i ka HPMC he 23.0% methoxyl group, hydroxypropoxyl Base 11.6%) ma ke ʻano he thickener, kōkua nā kūlana hana e hoʻonui i ke kūpaʻa o ka lāʻau lapaʻau i hoʻāla ʻia. Ua hoʻomohala ʻo Zhang Zhiqiang et al. i kahi gel levofloxacin hydrochloride ophthalmic pH-sensitive me ka hopena hoʻokuʻu mau, me ka hoʻohana ʻana i ka carbopol ma ke ʻano he matrix gel a me ka hydroxypropyl methylcellulose ma ke ʻano he thickening agent. ʻO ke kauoha kūpono loa ma o ka hoʻokolohua, i ka hopena, loaʻa ka kauoha kūpono loa ʻo levofloxacin hydrochloride 0.1 g, carbopol (9400) 3 g, hydroxypropyl methylcellulose (E50 LV) 20 g, disodium hydrogen phosphate 0.35 g, phosphoric acid 0.45 g o ka sodium dihydrogen, 0.50 g o ka sodium chloride, 0.03 g o ka ethyl paraben, a ua hoʻohui ʻia ka wai e hana i 100 mL. I ka hoʻāʻo ʻana, ua nānā ka mea kākau i ka moʻo hydroxypropyl methylcellulose METHOCEL o Colorcon Company me nā kikoʻī like ʻole (K4M, E4M, E15 LV, E50LV) e hoʻomākaukau i nā mea hoʻomānoanoa me nā ʻano like ʻole, a ua koho ka hopena iā HPMC E50 LV ma ke ʻano he mea hoʻomānoanoa. Mea hoʻomānoanoa no nā gels koke levofloxacin hydrochloride pH-sensitive.
3.6 ma ke ʻano he mea capsule
ʻO ka maʻamau, ʻo ka mea nui o ka pūpū capsule o nā capsules he gelatin. He maʻalahi ke kaʻina hana o ka pūpū capsule, akā aia kekahi mau pilikia a me nā hanana e like me ka pale maikaʻi ʻole i nā lāʻau lapaʻau e pili ana i ka makū a me ka oxygen, ka emi ʻana o ka hoʻoheheʻe ʻana o ka lāʻau, a me ka lohi o ka hoʻoheheʻe ʻana o ka pūpū capsule i ka wā e mālama ai. No laila, hoʻohana ʻia ka hydroxypropyl methylcellulose ma ke ʻano he pani no nā capsules gelatin no ka hoʻomākaukau ʻana i nā capsules, kahi e hoʻomaikaʻi ai i ke ʻano hana capsule a me ka hopena hoʻohana, a ua hoʻolaha nui ʻia ma ka home a ma waho.
Ma ka hoʻohana ʻana i ka theophylline ma ke ʻano he lāʻau hoʻomalu, ua ʻike ʻo Podczeck et al. ʻoi aku ka nui o ka hoʻoheheʻe ʻana o ka lāʻau lapaʻau o nā capsules me nā pūpū hydroxypropyl methylcellulose ma mua o nā capsules gelatin. ʻO ke kumu o ka nānā ʻana, ʻo ka hoʻoheheʻe ʻana o HPMC ka hoʻoheheʻe ʻana o ka capsule holoʻokoʻa i ka manawa like, ʻoiai ʻo ka hoʻoheheʻe ʻana o ka capsule gelatin ka hoʻoheheʻe ʻana o ke ʻano pūnaewele mua, a laila ka hoʻoheheʻe ʻana o ka capsule holoʻokoʻa, no laila ʻoi aku ka kūpono o ka capsule HPMC no nā pūpū Capsule no nā ʻano hoʻokuʻu koke. Ua loaʻa pū ʻo Chiwele et al. i nā hopena like a hoʻohālikelike i ka hoʻoheheʻe ʻana o ka gelatin, gelatin/polyethylene glycol a me nā pūpū HPMC. Ua hōʻike nā hopena ua hoʻoheheʻe koke ʻia nā pūpū HPMC ma lalo o nā kūlana pH like ʻole, ʻoiai ua hoʻopilikia nui ʻia nā capsules gelatin e nā kūlana pH like ʻole. Ua nānā ʻo Tang Yue et al. i kahi ʻano hou o ka pūpū capsule no ka ʻōnaehana lawe inhaler pauka maloʻo lāʻau haʻahaʻa. I ka hoʻohālikelike ʻia me ka pūpū capsule o ka hydroxypropyl methylcellulose a me ka pūpū capsule o ka gelatin, ua noiʻi ʻia ke kūpaʻa o ka pūpū capsule a me nā waiwai o ka pauka i loko o ka pūpū ma lalo o nā kūlana like ʻole, a ua hoʻokō ʻia ka hoʻāʻo friability. Hōʻike nā hopena i ka hoʻohālikelike ʻia me nā capsules gelatin, ʻoi aku ka maikaʻi o nā pūpū capsule HPMC i ke kūpaʻa a me ka pale ʻana i ka pauka, ʻoi aku ka ikaika o ke kūpaʻa ʻana i ka makū, a ʻoi aku ka haʻahaʻa o ka friability ma mua o nā pūpū capsule gelatin, no laila ʻoi aku ka kūpono o nā pūpū capsule HPMC no nā Capsules no ka hanu ʻana i ka pauka maloʻo.
3.7 ma ke ʻano he bioadhesive
Hoʻohana ka ʻenehana Bioadhesion i nā mea hoʻohui me nā polymers bioadhesive. Ma ka hoʻopili ʻana i ka mucosa biological, hoʻonui ia i ka hoʻomau a me ka paʻa o ka pilina ma waena o ka hoʻomākaukau a me ka mucosa, i hoʻokuʻu mālie ʻia ka lāʻau a omo ʻia e ka mucosa e hoʻokō ai i ke kumu o ka mālama ʻana. Hoʻohana nui ʻia i kēia manawa. Mālama i nā maʻi o ka ʻōpū gastrointestinal, vagina, mucosa waha a me nā ʻāpana ʻē aʻe.
ʻO ka ʻenehana bioadhesion Gastrointestinal kahi ʻōnaehana lawe lāʻau hou i hoʻomohala ʻia i nā makahiki i hala iho nei. ʻAʻole ia e hoʻolōʻihi wale i ka manawa noho o nā hoʻomākaukau lāʻau i loko o ke ala gastrointestinal, akā hoʻomaikaʻi pū i ka hana pili ma waena o ka lāʻau a me ka membrane cell ma kahi omo, hoʻololi i ke kahe o ka membrane cell, a hoʻolilo i ka Hoʻonui ʻia ke komo ʻana o ka lāʻau i loko o nā cell epithelial ʻōpū liʻiliʻi, no laila e hoʻomaikaʻi ana i ka bioavailability o ka lāʻau. Ua nānā ʻo Wei Keda et al. i ke kuhikuhi papa me ka dosage o HPMCK4M a me Carbomer 940 ma ke ʻano he mau kumu noiʻi, a hoʻohana i kahi mea bioadhesion i hana ponoʻī ʻia e ana i ka ikaika peeling ma waena o ka papa a me ka biofilm simulated e ka maikaʻi o ka wai i loko o ka ʻeke plastik. , a ua koho hope ʻia ka ʻike o HPMCK40 a me ka carbomer 940 i 15 a me 27.5 mg ma ka wahi kuhikuhi kūpono o nā ʻōpū papa NCaEBT, kēlā me kēia, e hoʻomākaukau i nā ʻōpū papa NCaEBT, e hōʻike ana e hiki i nā mea bioadhesive (e like me hydroxypropyl methylcellulose) ke hōʻemi nui i ka Hoʻomaikaʻi i ka hoʻopili ʻana o ka hoʻomākaukau ʻana i ka ʻiʻo.
ʻO nā hoʻomākaukau bioadhesive waha kekahi ʻano hou o ka ʻōnaehana lawe lāʻau i aʻo nui ʻia i nā makahiki i hala iho nei. Hiki i nā hoʻomākaukau bioadhesive waha ke hoʻopili i ka lāʻau i ka ʻāpana i hoʻopilikia ʻia o ka lua waha, ʻaʻole wale ia e hoʻolōʻihi i ka manawa noho o ka lāʻau i loko o ka mucosa waha, akā pale pū i ka mucosa waha. ʻOi aku ka maikaʻi o ka hopena therapeutic a hoʻomaikaʻi i ka bioavailability lāʻau. Ua hoʻomaikaʻi ʻo Xue Xiaoyan et al. i ka hoʻokumu ʻana o nā papa hoʻopili waha insulin, me ka hoʻohana ʻana i ka apple pectin, chitosan, carbomer 934P, hydroxypropyl methylcellulose (HPMC K392) a me ka sodium alginate ma ke ʻano he mau mea bioadhesive, a me ka hoʻomaloʻo hau e hoʻomākaukau i ka insulin waha. Pepa papa pālua hoʻopili. ʻO ka papa hoʻopili waha insulin i hoʻomākaukau ʻia he ʻano porous sponge-like, kahi mea kūpono no ka hoʻokuʻu ʻana o ka insulin, a he papa pale hydrophobic, hiki ke hōʻoia i ka hoʻokuʻu ʻana o ka lāʻau a pale i ka nalowale ʻana o ka lāʻau. Ua hoʻomākaukau pū ʻo Hao Jifu et al. i nā beads polū-melemele i nā ʻāpana bioadhesive waha me ka hoʻohana ʻana i ka Baiji glue, HPMC a me carbomer ma ke ʻano he mau mea bioadhesive.
I loko o nā ʻōnaehana lawe lāʻau vaginal, ua hoʻohana nui ʻia ka ʻenehana bioadhesion. Ua hoʻohana ʻo Zhu Yuting et al. i ka carbomer (CP) a me HPMC ma ke ʻano he mea hoʻopili a me ka matrix hoʻokuʻu mau ʻia e hoʻomākaukau i nā papa vaginal clotrimazole bioadhesive me nā ʻano like ʻole a me nā lakio, a ana i ko lākou hoʻopili ʻana, ka manawa hoʻopili a me ka pakeneka pehu i loko o ke kaiapuni o ka wai vaginal artificial. , ua nānā ʻia ke kauoha kūpono e like me CP-HPMC1: 1, ua maikaʻi ka hana hoʻopili o ka pepa hoʻopili i hoʻomākaukau ʻia, a ua maʻalahi a hiki ke hana.
3.8 ma ke ʻano he gel topical
Ma ke ʻano he mea hoʻomākaukau hoʻopili, loaʻa i ka gel kekahi mau pono e like me ka palekana, ka nani, ka maʻalahi o ka hoʻomaʻemaʻe ʻana, ke kumukūʻai haʻahaʻa, ke kaʻina hana hoʻomākaukau maʻalahi, a me ka launa pū ʻana me nā lāʻau lapaʻau. Ke kuhikuhi o ka hoʻomohala ʻana. No ka laʻana, ʻo ka gel transdermal kahi ʻano dosage hou i aʻo hou ʻia i nā makahiki i hala iho nei. ʻAʻole hiki iā ia ke pale wale i ka luku ʻia ʻana o nā lāʻau lapaʻau i loko o ke ala gastrointestinal a hōʻemi i ka loli o ka piko-a-trough o ka nui o ka lāʻau lapaʻau koko, akā ua lilo pū kekahi i hoʻokahi o nā ʻōnaehana hoʻokuʻu lāʻau lapaʻau kūpono e lanakila ai i nā hopena ʻaoʻao o ka lāʻau. .
Ua aʻo ʻo Zhu Jingjie et al. i ka hopena o nā matrices like ʻole ma ka hoʻokuʻu ʻana o ka scutellarin alcohol plastid gel in vitro, a ua nānā ʻia me ka carbomer (980NF) a me ka hydroxypropyl methylcellulose (HPMCK15M) ma ke ʻano he matrices gel, a loaʻa iā ia ka scutellarin kūpono no ka scutellarin. Gel matrix o nā plastids waiʻona. Hōʻike nā hopena hoʻokolohua he 1. 0% carbomer, 1. 5% carbomer, 1. 0% carbomer + 1. 0% HPMC, 1. 5% carbomer + 1. 0% HPMC ma ke ʻano he matrix gel. He kūpono nā mea ʻelua no nā plastids waiʻona scutellarin. I ka wā o ka hoʻokolohua, ua ʻike ʻia hiki i ka HPMC ke hoʻololi i ke ʻano hoʻokuʻu lāʻau lapaʻau o ka matrix gel carbomer ma ke kau ʻana i ka hoʻohālikelike kinetic o ka hoʻokuʻu ʻana i ka lāʻau lapaʻau, a hiki i ka 1.0% HPMC ke hoʻomaikaʻi i ka 1.0% carbomer matrix a me ka 1.5% carbomer matrix. ʻO ke kumu paha, ʻoi aku ka wikiwiki o ka hoʻonui ʻana o ka HPMC, a ʻo ka hoʻonui wikiwiki ʻana i ka wā mua o ka hoʻokolohua e hoʻonui ai i ka hakahaka molekala o ka mea gel carbomer, a laila e wikiwiki ai i kāna wikiwiki hoʻokuʻu lāʻau. Ua hoʻohana ʻo Zhao Wencui et al. i ka carbomer-934 a me ka hydroxypropyl methylcellulose ma ke ʻano he mea lawe e hoʻomākaukau i ka norfloxacin ophthalmic gel. He maʻalahi a hiki ke hana ʻia ke kaʻina hana hoʻomākaukau, a kūlike ke ʻano me ka gel ophthalmic o "Chinese Pharmacopoeia" (2010 edition) Nā koi maikaʻi.
3.9 Mea hoʻōki i ka ua no ka ʻōnaehana microemulsifying ponoʻī
ʻO ka ʻōnaehana hoʻouna lāʻau lapaʻau ponoʻī-microemulsifying (SMEDDS) kahi ʻano hou o ka ʻōnaehana hoʻouna lāʻau lapaʻau waha, he hui like, paʻa a moakaka i haku ʻia me ka lāʻau lapaʻau, ka ʻāpana aila, ka emulsifier a me ka co-emulsifier. He maʻalahi ka haku mele ʻana o ke kauoha, a maikaʻi ka palekana a me ke kūpaʻa. No nā lāʻau lapaʻau hiki ʻole ke hoʻoheheʻe ʻia, hoʻohui pinepine ʻia nā mea polymer fiber wai-hoʻoheheʻe ʻia, e like me HPMC, polyvinylpyrrolidone (PVP), a me nā mea ʻē aʻe, e hana i nā lāʻau lapaʻau manuahi a me nā lāʻau lapaʻau i hoʻopaʻa ʻia i loko o ka microemulsion e hoʻokō i ka hoʻoheheʻe supersaturated i loko o ka ʻōpū gastrointestinal, i mea e hoʻonui ai i ka solubility lāʻau lapaʻau a hoʻomaikaʻi i ka bioavailability.
Ua hoʻomākaukau ʻo Peng Xuan et al. i kahi ʻōnaehana hoʻouna lāʻau lapaʻau supersaturated silibinin (S-SEDDS). ʻO ka ʻaila castor hydrogenated Oxyethylene (Cremophor RH40), 12% caprylic capric acid polyethylene glycol glyceride (Labrasol) ma ke ʻano he co-emulsifier, a me 50 mg·g-1 HPMC. ʻO ka hoʻohui ʻana i ka HPMC i SSEDDS hiki ke hoʻoheheʻe i ka silibinin manuahi i loko o S-SEDDS a pale i ka silibinin mai ka hoʻokahe ʻana i waho. Ke hoʻohālikelike ʻia me nā ʻano hana microemulsion kuʻuna, hoʻohui pinepine ʻia ka nui o ka surfactant e pale i ka hoʻopili ʻole ʻana o ka lāʻau lapaʻau. Hiki i ka hoʻohui ʻana o HPMC ke mālama i ka solubility o silibinin i loko o ka dissolution medium e mau ana, e hōʻemi ana i ka emulsification i loko o nā ʻano hana microemulsion ponoʻī. ka nui o ka mea hana.
4. Hopena
Hiki ke ʻike ʻia ua hoʻohana nui ʻia ʻo HPMC i nā hoʻomākaukau ʻana ma muli o kona mau waiwai kino, kemika a me ke olaola, akā he nui nā hemahema o HPMC i nā hoʻomākaukau ʻana, e like me ke ʻano o ka hoʻokuʻu mua a me ka hoʻokuʻu ʻana ma hope o ka pahū ʻana. methyl methacrylate) e hoʻomaikaʻi. I ka manawa like, ua noiʻi kekahi poʻe noiʻi i ka hoʻopili ʻana o ke kumumanaʻo osmotic ma HPMC ma ka hoʻomākaukau ʻana i nā papa hoʻokuʻu carbamazepine hoʻomau a me nā papa hoʻokuʻu verapamil hydrochloride hoʻomau e aʻo hou aku i kāna ʻano hoʻokuʻu. I kahi huaʻōlelo, ʻoi aku ka nui o nā mea noiʻi e hana nei i ka nui o ka hana no ka hoʻopili maikaʻi ʻana o HPMC i nā hoʻomākaukau ʻana, a me ke aʻo hohonu ʻana i kona mau waiwai a me ka hoʻomaikaʻi ʻana i ka ʻenehana hoʻomākaukau, e hoʻohana nui ʻia ʻo HPMC i nā ʻano dosage hou a me nā ʻano dosage hou. I ka noiʻi ʻana i ka ʻōnaehana lāʻau lapaʻau, a laila hoʻolaha i ka hoʻomohala mau ʻana o ka lāʻau lapaʻau.
Ka manawa hoʻouna: ʻOkakopa-08-2022