I arotakehia, i tātarihia, i whakarāpopototia hoki ngā tuhinga e pā ana ki te whakarite i ngā matū rongoā hydroxypropyl methylcellulose (HPMC) i ngā tau tata nei, me tōna whakamahinga i roto i ngā whakaritenga totoka, ngā whakaritenga wai, ngā whakaritenga tukunga pumau me te whakahaere, ngā whakaritenga kāpū, te gelatin. Ko ngā tono hou i roto i te mara o ngā whakatakotoranga hou pēnei i ngā whakatakotoranga piri me ngā bioadhesives. Nā te rerekētanga o te taumaha ngota me te matotoru o te HPMC, kei a ia ngā āhuatanga me ngā whakamahinga o te emulsification, te piri, te matotoru, te whakanui i te matotoru, te whakatārewatanga, te whakapūmau me te hanga kiriata. He whānuitia te whakamahinga i roto i ngā whakaritenga rongoā, ā, ka nui ake te mahi i roto i te mara o ngā whakaritenga. Mā te rangahau hohonu o ōna āhuatanga me te whakapainga o te hangarau whakatakotoranga, ka nui ake te whakamahinga o te HPMC i roto i te rangahau o ngā momo horopeta hou me ngā pūnaha tuku rongoā hou, ā, ka whakatairanga i te whanaketanga tonu o ngā whakatakotoranga.
hydroxypropyl methylcellulose; ngā whakaritenga rongoā; ngā mea tāpiri rongoā.
Ehara i te mea ko ngā tāpiringa rongoā anake te pūtake rauemi mō te hanganga o ngā whakaritenga rongoā mata, engari e pā ana hoki ki te uauatanga o te tukanga whakarite, te kounga o te rongoā, te pumau, te haumaru, te tere tukunga rongoā, te momo mahi, te whai huatanga haumanu, me te whanaketanga o ngā momo horopeta hou me ngā huarahi whakahaere hou. He hononga tata. Ko te putanga mai o ngā tāpiringa rongoā hou ka whakatairanga i te whakapainga o te kounga whakarite me te whanaketanga o ngā momo horopeta hou. Ko te Hydroxypropyl methylcellulose (HPMC) tētahi o ngā tāpiringa rongoā rongonui i te kāinga me tāwāhi. Nā te rerekētanga o te taumaha ngota me te matotoru, he mahi āna ki te whakaemulsifying, te here, te whakamātotoru, te whakamātotoru, te whakatārewatanga, me te whakapiri. Ko ngā āhuatanga me ngā whakamahinga pēnei i te coagulation me te hanganga kiriata e whakamahia whānuitia ana i roto i te hangarau rongoā. Ko te nuinga o tēnei tuhinga e arotake ana i te whakamahinga o te hydroxypropyl methylcellulose (HPMC) i roto i ngā whakatakotoranga i ngā tau tata nei.
1.Ngā āhuatanga taketake o te HPMC
Ko te Hydroxypropyl methyl cellulose (HPMC), ko te tātai ngota ko C8H15O8-(C10 H18O6) n- C8H15O8, ā, ko te papatipu ngota whanaunga he tata ki te 86 000. He rauemi hanga-haurua tēnei hua, he wāhanga o te methyl me te wāhanga o te polyhydroxypropyl ether o te cellulose. E rua ngā huarahi e taea ai te whakaputa: Ko tētahi ko te tukatuka i te methyl cellulose o te taumata e tika ana ki te NaOH, kātahi ka tauhohe ki te propylene oxide i raro i te pāmahana teitei me te pēhanga teitei. Me roa te wā tauhohe kia taea ai e te methyl me te hydroxypropyl te hanga hononga ether. Ka honoa ki te mowhiti anhydroglucose o te cellulose i roto i te āhua o te cellulose, ā, ka taea te eke ki te taumata e hiahiatia ana; ko tētahi ko te tukatuka i te miro miro, i te muka penupenu rakau rānei ki te houra caustic, kātahi ka tauhohe ki te methane chlorinated me te propylene oxide, kātahi ka whakapai ake. , ka kuruhia kia rite te paura, kia rite te matotoru, kia rite rānei.
He mā ki te mā miraka te tae o tēnei hua, kāore he kakara, kāore he reka, ā, he paura kirikiri, he paura muka rānei te āhua, he ngāwari te rere. Ka taea te whakarewa i tēnei hua ki te wai hei hanga i tētahi wairewa korori mārama ki te mā miraka me tētahi matotoru. Ka puta pea te āhuatanga whakawhiti sol-gel nā te huringa pāmahana o te wairewa me tētahi kukū.
Nā te rerekētanga o te ihirangi o ēnei whakakapinga e rua i roto i te hanganga o te methoxy me te hydroxypropyl, kua puta mai ngā momo hua rerekē. I roto i ngā kukū motuhake, he momo hua rerekē ngā āhuatanga. Nō reira, he rerekē ngā āhuatanga o te matotoru me te pāmahana whakamahana, ā, ka taea te whakamahi mō ngā kaupapa rerekē. He rerekē ngā ture me ngā whakaaturanga o te Pharmacopoeia o ngā whenua rerekē mō te tauira: Ko te Pharmacopoeia Pākehā e hangai ana ki ngā momo taumata o ngā matotoru rerekē me ngā nekehanga rerekē o te whakakapinga o ngā hua e hokona ana i te mākete, e whakaatuhia ana e ngā tohu me ngā tau, ā, ko te waeine ko "mPa s". I roto i te Pharmacopoeia o Amerika, e 4 ngā mati ka tāpirihia i muri i te ingoa whānui hei tohu i te ihirangi me te momo o ia whakakapinga o te hydroxypropyl methylcellulose, pērā i te hydroxypropyl methylcellulose 2208. Ko ngā mati tuatahi e rua e tohu ana i te uara tata o te rōpū methoxy. Ko te ōrau, ko ngā mati whakamutunga e rua e tohu ana i te ōrau tata o te hydroxypropyl.
E toru ngā raupapa o te hydroxypropyl methylcellulose a Calocan, arā, ko te raupapa E, te raupapa F me te raupapa K, he maha ngā tauira hei whiriwhiri mā ia raupapa. Ko te nuinga o te raupapa E e whakamahia ana hei paninga kiriata, hei paninga papa, hei papa matua kua kati; ko te raupapa E, F e whakamahia ana hei whakakīkī me hei aukati tukunga mō ngā whakaritenga kanohi, ngā kaihoko whakatārewatanga, ngā kaiwhakamātotoru mō ngā whakaritenga wai, ngā papa me ngā mea here o ngā granules; ko te nuinga o te raupapa K e whakamahia ana hei aukati tukunga me ngā rauemi matihiko gel hydrophilic mō ngā whakaritenga tukunga puhoi me te whakahaere.
Ko ngā kaihanga o roto ko te nuinga o Fuzhou Nama 2 Chemical Factory, Huzhou Food and Chemical Co., Ltd., Sichuan Luzhou Pharmaceutical Accessories Factory, Hubei Jinxian Chemical Factory Nama 1, Feicheng Ruitai Fine Chemical Co., Ltd., Shandong Liaocheng Ahua Pharmaceutical Co., Ltd., Xi'an Huian chemical plant, me ētahi atu.
2.Ngā Painga o te HPMC
Kua riro te HPMC hei tētahi o ngā matū rongoā e whakamahia whānuitia ana i te kāinga me tāwāhi, nā te mea he painga tō te HPMC kāore i te rite ki ētahi atu matū.
2.1 Te wairewatanga i roto i te wai matao
Ka wairewa i te wai matao i raro i te 40 ℃, i te 70% rānei o te waiwaro, kāore e wairewa i te wai wera i runga ake i te 60 ℃, engari ka taea te whakapūkara.
2.2 Kāore e mahi matū
Ko te HPMC he momo cellulose ether kore-ionic, kāore he utu ionic i roto i tana otinga, ā, kāore e taunekeneke ki ngā tote whakarewa, ki ngā pūhui waro ionic rānei, nō reira kāore ētahi atu excipients e tauhohe ki a ia i te wā o te tukanga whakaputa o ngā whakaritenga.
2.3 Te Pūmautanga
He tino pumau ki te waikawa me te kawakore, ā, ka taea te rongoa mō te wā roa i waenga i te pH 3 me te 11 me te kore e nui te panoni o te matotoru. He pānga ārai-haruru te otinga wai o te HPMC, ā, ka mau tonu te pumau o te matotoru i te wā e rongoatia ana mō te wā roa. He pai ake te pumau o ngā matū rongoā e whakamahi ana i te HPMC i ērā e whakamahi ana i ngā matū tuku iho (pērā i te dextrin, te māngaro, me ētahi atu).
2.4 Te Whakarerekētanga o te Matatini
Ka taea te whakaranu i ngā momo matotoru rerekē o te HPMC i ngā ōwehenga rerekē, ā, ka taea te whakarerekē i tōna matotoru kia rite ki tētahi ture, ā, he pai te whanaungatanga rārangi, kia taea ai te whiriwhiri i te ōwehenga kia rite ki ngā hiahia.
2.5 Te ngoikore o te pūnaha io
Kāore te HPMC e mimitia, e whakapūkaratia rānei i roto i te tinana, ā, kāore hoki e tukuna he wera, nō reira he mea haumaru hei tāpiri i te rongoā. 2.6 Haumaru E whakaarohia whānuitia ana ko te HPMC he rauemi kore-paitini, kāore hoki e whakapataritari, ko te horopeta whakamate toharite mō ngā kiore ko 5 g·kg – 1, ā, ko te horopeta whakamate toharite mō ngā kiore ko 5.2 g · kg – 1. Kāore he kino o te horopeta o ia rā ki te tinana tangata.
3.Te whakamahinga o te HPMC i roto i ngā whakatakotoranga
3.1 Hei rauemi paninga kiriata me te rauemi hanga kiriata
Mā te whakamahi i te HPMC hei rauemi papa paninga-kiriata, kāore he painga kitea o te papa paninga ki te huna i te reka me te āhua ki te whakataurite ki ngā papa paninga tuku iho pērā i ngā papa paninga-huka, engari he pai ake tōna pakeke, tōna ngawari ki te pakarukaru, tōna mimiti makuku, tōna nekehanga pakarukaru, tōna pikinga taumaha o te paninga me ētahi atu tohu kounga. Ko te taumata matotoru iti o tēnei hua e whakamahia ana hei rauemi paninga kiriata wairewa-wai mō ngā papa me ngā pire, ā, ko te taumata matotoru teitei e whakamahia ana hei rauemi paninga kiriata mō ngā pūnaha whakarewa waro, ko te nuinga o te wā he 2% ki te 20% te kukū.
I whakamahia e Zhang Jixing me ētahi atu te tikanga mata pānga hei arotau i te whakatakotoranga premix me te HPMC hei paninga kiriata. Mā te tango i te rauemi hanga kiriata HPMC, ko te nui o te waipiro polyvinyl me te polyethylene glycol plasticizer hei take rangahau, ko te kaha kume me te urunga o te kiriata me te matotoru o te otinga paninga kiriata ko te taupū tirotiro, ā, ko te whanaungatanga i waenga i te taupū tirotiro me ngā take tirotiro ka whakaahuahia e te tauira pāngarau, ā, ka whiwhi i te tukanga whakatakotoranga tino pai. Ko tana whakamahinga he 11.88 karamu te kaihoko hanga kiriata hydroxypropyl methylcellulose (HPMCE5), 24.12 karamu te waipiro polyvinyl, 13.00 karamu te plasticizer polyethylene glycol plasticizer, ā, ko te matotoru whakatārewatanga paninga he 20 mPa·s, ko te urunga me te kaha kume o te kiriata i eke ki te hua pai rawa atu. I whakapai ake a Zhang Yuan i te tukanga whakarite, i whakamahi i te HPMC hei here hei whakakapi i te paru māngaro, ā, i whakawhiti i ngā papa Jiahua ki ngā papa paninga kiriata hei whakapai ake i te kounga o āna whakaritenga, hei whakapai ake i tōna hygroscopicity, ngāwari ki te memeha, papa wetekina, papa pakaru me ētahi atu raruraru, hei whakarei ake i te pumau o te papa. I whakatauhia te tukanga whakatakotoranga tino pai mā roto i ngā whakamātautau orthogonal, arā, ko te kukū o te paru he 2% HPMC i roto i te otinga etanoru 70% i te wā paninga, ā, ko te wā whakaoho i te wā whakapūkara he 15 meneti. Ngā Hua Ko ngā papa paninga kiriata Jiahua i whakaritea e te tukanga hou me te whakahaunga i tino pai ake te āhua, te wā pakaru me te pakeke o te matua i ērā i hangaia e te tukanga whakahaunga taketake, ā, i tino pai ake te tere whaimana o ngā papa paninga kiriata. neke atu i te 95%. I whakamahia hoki e Liang Meiyi, e Lu Xiaohui, me ētahi atu te hydroxypropyl methylcellulose hei rauemi hanga kiriata hei whakarite i te papa tūnga koroni patinae me te papa tūnga koroni matrine. I whakaritea e Huang Yunran ngā Papa Tūnga Koroni Toto a Dragon, ā, i whakamahia te HPMC ki te otinga paninga o te paparanga pupuhi, ā, ko tōna wāhanga papatipu he 5%. Ka kitea ka taea te whakamahi whānui i te HPMC i roto i te pūnaha tuku rongoā e arotahi ana ki te koroni.
Ehara i te mea he rauemi paninga kiriata pai anake te Hydroxypropyl methylcellulose, engari ka taea hoki te whakamahi hei rauemi hanga kiriata i roto i ngā hanganga kiriata. Kua arotauhia a Wang Tongshun me ētahi atu ki te whakaritenga o te matū konutea licorice me te aminolexanol kiriata hiato waha, me te ngāwari, te ōritetanga, te maeneene, te māramatanga o te kaihoko kiriata hei tohu rangahau, ko te whakaritenga pai ko te PVA 6.5 karamu, HPMC 0.1 karamu me te 6.0 karamu o te propylene glycol e tutuki ana i ngā whakaritenga o te tukunga puhoi me te haumaru, ā, ka taea te whakamahi hei whakaritenga whakarite mō te kiriata hiato.
3.2 hei here me te whakarewa
Ka taea te whakamahi i te taumata matotoru iti o tēnei hua hei here me te whakarewa mō ngā papa, pire me ngā kirikiri, ā, ko te taumata matotoru teitei ka taea anake te whakamahi hei here. Ka rerekē te horopeta i runga i ngā tauira me ngā whakaritenga rerekē. Ko te tikanga, ko te horopeta here mō ngā papa kirikiri maroke he 5%, ā, ko te horopeta here mō ngā papa kirikiri mākū he 2%.
I tirotirohia e Li Houtao me ētahi atu te here o ngā papa tinidazole. I tirotirohia te 8% polyvinylpyrrolidone (PVP-K30), 40% tirikara, 10% paraoa māngaro, 2.0% hydroxypropyl methylcellulose K4 (HPMCK4M), 50% etanoru hei tohu i te piri o ngā papa tinidazole. I whakaritea ngā panonitanga āhua o ngā papa maamaa me muri i te paninga, ā, i inehia te ngawari, te pakeke, te wā pakaru me te tere whakarewa o ngā papa rerekē. Ngā Hua He kanapa ngā papa i whakaritea mā te 2.0% hydroxypropyl methylcellulose, ā, i kitea i te ine ngawari kāore he āhuatanga pakaru me te kokonga o te taha, ā, i muri i te paninga, kua oti te āhua o te papa, ā, he pai te āhua. Nō reira, i whakamahia ngā papa tinidazole i whakaritea mā te 2.0% HPMC-K4 me te 50% etanoru hei here. I ako a Guan Shihai i te tukanga hanga o ngā Papa Fuganning, i tirotirohia ngā piripiri, ā, i tirotirohia hoki te 50% etanoru, te 15% whakapiri mārika, te 10% PVP me te 50% otinga etanoru me te kaha pēhi, te maeneene, me te ngawari hei tohu aromatawai. , 5% CMC-Na me te 15% otinga HPMC (5 mPa s). Ngā Hua He maeneene te mata o ngā pepa i whakaritea mā te 50% etanoru, te 15% whakapiri mārika, te 10% PVP 50% otinga etanoru me te 5% CMC-Na, engari he ngoikore te kaha pēhi me te iti o te pakeke, kāore i taea te whakatutuki i ngā hiahia o te paninga; 15% otinga HPMC (5 mPa·s), he maeneene te mata o te papa, he pai te ngawari pēhi, ā, he pai te kaha pēhi, ka taea te whakatutuki i ngā hiahia o te paninga. Nō reira, i whiriwhiria te HPMC (5 mPa s) hei piripiri.
3.3 hei kaihoko whakatārewatanga
Ko te taumata matotoru teitei o tēnei hua e whakamahia ana hei kaiwhakatārewa hei whakarite i tētahi wai whakatārewatanga. He pai te pānga whakatārewatanga, he ngāwari ki te horapa anō, kāore e piri ki te pakitara, ā, he pai ngā matūriki pupuhi. Ko te horopeta noa ko te 0.5% ki te 1.5%. I whakamahia e Song Tian me ētahi atu ngā rauemi polymer e whakamahia whānuitia ana (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, povidone, xanthan gum, methylcellulose, me ētahi atu) hei kaiwhakatārewatanga hei whakarite i te racecadotril. Whakatārewatanga maroke. Mā te ōwehenga rōrahi whakatōpuku o ngā whakatārewatanga rerekē, i kitea te taupū whakatārewatanga anō, me te rheology, te matotoru whakatārewatanga me te āhua moroiti, ā, i tirotirohia hoki te pumau o ngā matūriki rongoā i raro i te whakamātautau tere. Ngā Hua He tukanga māmā te whakatārewatanga maroke i whakaritea ki te 2% HPMC hei kaiwhakatārewatanga, ā, he pai te pumau.
Ki te whakatauritea ki te methyl cellulose, ko ngā āhuatanga o te hydroxypropyl methyl cellulose he hanga i tētahi otinga mārama ake, ā, he iti noa iho ngā matū muka kāore i te marara, nō reira he mea noa te whakamahi i te HPMC hei kaiwhakatārewa i roto i ngā whakaritenga kanohi. I whakamahia e Liu Jie me ētahi atu te HPMC, te hydroxypropyl cellulose (HPC), te carbomer 940, te polyethylene glycol (PEG), te sodium hyaluronate (HA) me te whakakotahitanga o te HA/HPMC hei kaiwhakatārewa hei whakarite i ngā whakaritenga rerekē. Mō te Ciclovir ophthalmic suspension, ko te ōwehenga rōrahi whakatō, te rahi matūriki me te redispersibility kua tohua hei tohu tirotiro hei tirotiro i te kaihoko whakatārewa pai rawa atu. E whakaatu ana ngā hua ko te acyclovir ophthalmic suspension i whakaritea mā te 0.05% HA me te 0.05% HPMC hei kaiwhakatārewa, ko te ōwehenga rōrahi whakatō he 0.998, he ōrite te rahi matūriki, he pai te redispersibility, ā, he pumau te whakaritenga. Ka piki ake te ira.
3.4 Hei ārai, hei kaihoko tuku puhoi, whakahaeretia hoki, me te kaihoko hanga pore
Ko te taumata matotoru teitei o tēnei hua e whakamahia ana mō te whakarite i ngā papa tuku-tonu o te matrix gel hydrophilic, ngā aukati me ngā kaihoko tuku-mana whakahaere o ngā papa tuku-tonu rauemi whakauru, ā, he pānga ki te whakaroa i te tukunga rongoā. Ko tōna kukū he 10% ki te 80%. Ka whakamahia ngā taumata matotoru iti hei porogens mō ngā whakaritenga tuku-tonu, tuku-mana whakahaere rānei. Ka taea te tere te whakatutuki i te horopeta tuatahi e hiahiatia ana mō te pānga rongoā o aua papa, kātahi ka puta te pānga tuku-tonu, tuku-mana whakahaere rānei, ā, ka mau tonu te kukū rongoā toto whai hua i roto i te tinana. . Ka whakamakukuhia te Hydroxypropyl methylcellulose kia hanga he paparanga gel ina tūtaki ki te wai. Ko te tikanga tukunga rongoā mai i te papa matrix ko te horapa o te paparanga gel me te mimiti o te paparanga gel. I whakaritea e Jung Bo Shim me ētahi atu papa tuku-tonu carvedilol me te HPMC hei rauemi tuku-tonu.
E whakamahia whānuitia ana hoki te Hydroxypropyl methylcellulose i roto i ngā papa matrix tuku-roa o te rongoā tuku iho Hainamana, ā, ko te nuinga o ngā kai hohe, ngā wāhanga whai hua me ngā whakaritenga takitahi o te rongoā tuku iho Hainamana e whakamahia ana. I whakamahia e Liu Wen me ētahi atu te 15% hydroxypropyl methylcellulose hei rauemi matrix, 1% lactose me te 5% microcrystalline cellulose hei whakakī, ā, i whakaritea a Jingfang Taohe Chengqi Decoction ki roto i ngā papa matrix tuku-roa ā-waha. Ko te tauira ko te whārite Higuchi. He māmā te pūnaha hanganga tauira, he ngāwari te whakarite, ā, he pumau ngā raraunga tuku, e tutuki ana i ngā whakaritenga o te Chinese Pharmacopoeia. I whakamahia e Tang Guangguang me ētahi atu ngā saponins katoa o Astragalus hei tauira rongoā, i whakaritea ngā papa matrix HPMC, ā, i tūhuratia ngā āhuatanga e pā ana ki te tukunga rongoā mai i ngā wāhanga whai hua o te rongoā tuku iho Hainamana i roto i ngā papa matrix HPMC. Ngā Hua I te pikinga ake o te horopeta o te HPMC, ka heke te tukunga o te astragaloside, ā, he tata te hononga raina o te ōrau tukunga o te rongoā ki te tere whakarewa o te matrix. I roto i te papa matihiko HPMC hypromellose, he whanaungatanga kei waenganui i te tukunga o te wāhanga whai hua o te rongoā tuku iho Hainamana me te horopeta me te momo HPMC, ā, he rite te tukanga tukunga o te monomer matū hydrophilic ki a ia. Ehara i te mea he pai anake te Hydroxypropyl methylcellulose mō ngā matū hydrophilic, engari mō ngā matū kore-hydrophilic anō hoki. I whakamahia e Liu Guihua te 17% hydroxypropyl methylcellulose (HPMCK15M) hei rauemi matihiko tuku-roa, ā, i whakaritea e ia ngā papa matihiko tuku-roa Tianshan Xuelian mā te tikanga granulation mākū me te papa. He mārama te pānga tuku-roa, ā, he pumau, he taea hoki te tukanga whakarite.
Kāore te Hydroxypropyl methylcellulose e whakamahia ana ki ngā papa matihiko tuku-roa o ngā kai hohe me ngā wāhanga whai hua o te rongoā tuku iho Hainamana anake, engari e whakamahia ana hoki i roto i ngā whakaritenga matū rongoā tuku iho Hainamana. I whakamahia e Wu Huichao me ētahi atu te 20% hydroxypropyl methyl cellulose (HPMCK4M) hei rauemi matihiko, ā, i whakamahia te tikanga pēhi tika paura hei whakarite i te papa matihiko gel hydrophilic Yizhi ka taea te tuku tonu me te pumau i te rongoā mō ngā haora 12. I whakamahia te Saponin Rg1, te ginsenoside Rb1 me te Panax notoginseng saponin R1 hei tohu aromatawai hei tirotiro i te tukunga i roto i te vitro, ā, i whakauruhia te whārite tukunga rongoā hei ako i te tikanga tukunga rongoā. Ngā Hua I rite te tikanga tukunga rongoā ki te whārite nekeneke kore-raupapa me te whārite Ritger-Peppas, i tukuna ai te geniposide mā te tohatoha kore-Fick, ā, i tukuna ngā wāhanga e toru i roto i te Panax notoginseng mā te horo o te angaanga.
3.5 Te kāpia tiaki hei whakamātotoru me te kōroiti
Ina whakamahia tēnei hua hei whakamātotoru, ko te ōrau kukū noa ko te 0.45% ki te 1.0%. Ka taea hoki e ia te whakanui ake i te pumau o te kāpia hydrophobic, te hanga i tētahi colloid tiaki, te ārai i ngā matūriki kei honoa, kei kohikohi, ā, mā reira ka ārai i te hanganga o ngā paru. Ko tōna ōrau kukū noa ko te 0.5% ki te 1.5%.
I whakamahia e Wang Zhen me ētahi atu te tikanga hoahoa whakamātautau L9 orthogonal hei tirotiro i te tukanga whakarite o te enema waro whakahohe rongoā. Ko ngā tikanga tukanga tino pai mō te whakatau whakamutunga o te enema waro whakahohe rongoā ko te whakamahi i te 0.5% konutai carboxymethyl cellulose me te 2.0% hydroxypropyl methylcellulose (kei roto i te HPMC te 23.0% methoxyl group, hydroxypropoxyl Base 11.6%) hei whakamātotoru, ā, ka āwhina ngā tikanga tukanga ki te whakarei ake i te pumau o te waro whakahohe rongoā. I whakawhanakehia e Zhang Zhiqiang me ētahi atu he gel ophthalmic levofloxacin hydrochloride kua rite ki te whakamahi me te pānga tukunga pumau, mā te whakamahi i te carbopol hei matrix gel me te hydroxypropyl methylcellulose hei kaihoko whakamātotoru. Ko te whakahaunga tino pai mā te whakamātautau, ā, ko te whakamutunga ka whiwhi i te whakahaunga tino pai ko te levofloxacin hydrochloride 0.1 g, te carbopol (9400) 3 g, te hydroxypropyl methylcellulose (E50 LV) 20 g, te disodium hydrogen phosphate 0.35 g, te waikawa phosphoric 0.45 g o te konutai dihydrogen, 0.50 g o te konutai chloride, 0.03 g o te ethyl paraben, me te wai i tāpirihia kia hanga 100 mL. I roto i te whakamātautau, i tirotirohia e te kaituhi te raupapa hydroxypropyl methylcellulose METHOCEL o te Kamupene Colorcon me ngā whakatakotoranga rerekē (K4M, E4M, E15 LV, E50LV) hei whakarite i ngā whakamātotoru me ngā kukū rerekē, ā, ko te hua i whiriwhiria ko te HPMC E50 LV hei whakamātotoru. He whakamātotoru mō ngā kirikiri tere levofloxacin hydrochloride e aro ana ki te pH.
3.6 hei rauemi kāpūru
Ko te tikanga, ko te anga o ngā kāpū he tiērana te nuinga. He māmā noa te tukanga hanga o te anga o ngā kāpū, engari he raruraru me ngā āhuatanga anō hoki pērā i te kore e pai te tiaki i ngā rongoā e aro ana ki te makuku me te hāora, te iti o te whakarewanga o te rongoā, me te whakaroa i te pakaru o te anga o ngā kāpū i te wā e rongoatia ana. Nō reira, ka whakamahia te hydroxypropyl methylcellulose hei whakakapi mō ngā kāpū tiērana mō te whakarite kāpū, e whakapai ake ana i te hanganga o te kāpū me te pānga whakamahi, ā, kua whānuitia te whakatairanga i te kāinga me tāwāhi.
Mā te whakamahi i te theophylline hei rongoā whakahaere, i kitea e Podczeck me ētahi atu he nui ake te tere memeha o te rongoā o ngā kāpūru me ngā anga hydroxypropyl methylcellulose i ērā o ngā kāpūru gelatin. Ko te take o te tātaritanga ko te memeha o te HPMC ko te memeha o te kāpūru katoa i te wā kotahi, ko te memeha o te kāpūru gelatin ko te memeha o te hanganga whatunga i te tuatahi, kātahi ka memeha o te kāpūru katoa, nō reira he pai ake te kāpūru HPMC mō ngā anga Kāpūru mō ngā hanganga tukunga tonu. I whiwhi hoki a Chiwele me ētahi atu i ngā whakatau rite, ā, i whakaritea te memeha o te gelatin, te gelatin/polyethylene glycol me ngā anga HPMC. I whakaatuhia e ngā hua he tere te memeha o ngā anga HPMC i raro i ngā āhuatanga pH rerekē, ko ngā kāpūru gelatin he nui te pānga ki ngā āhuatanga pH rerekē. I tirotirohia e Tang Yue me ētahi atu tētahi momo anga kāpūru hou mō te pūnaha kawe inhaler paura maroke iti-horopeta rongoā. I te whakatauritea ki te anga kāpū o te hydroxypropyl methylcellulose me te anga kāpū o te gelatin, i tirotirohia te pumau o te anga kāpū me ngā āhuatanga o te paura i roto i te anga i raro i ngā āhuatanga rerekē, ā, i whakahaerehia te whakamātautau pakarukaru. E whakaatu ana ngā hua, ki te whakatauritea ki ngā kāpū gelatin, he pai ake te pumau me te tiaki paura o ngā anga kāpū HPMC, he kaha ake te ātete ki te makuku, ā, he iti ake te pakarukaru i ngā anga kāpū gelatin, nō reira he pai ake ngā anga kāpū HPMC mō ngā Kāpū mō te manawa paura maroke.
3.7 hei piripiri koiora
Ka whakamahia e te hangarau piri-koiora ngā mea tāpiri me ngā pūmua piri-koiora. Mā te piri ki te kiriuhi matū koiora, ka whakarei ake i te pumau me te piri o te hononga i waenga i te rongoā me te kiriuhi matū, kia āta tukuna ai te rongoā, kia mimitihia hoki e te kiriuhi matū hei whakatutuki i te kaupapa o te maimoatanga. He whānui te whakamahinga i tēnei wā. Hei rongoā i ngā mate o te ara kai, te tara, te kiriuhi matū waha me ētahi atu wāhanga.
Ko te hangarau piri-koiora o te puku he pūnaha tuku rongoā hou kua whakawhanakehia i ngā tau tata nei. Ehara i te mea ka roa ake te wā noho o ngā whakaritenga rongoā ki te ara puku, engari ka whakapai ake hoki i te mahi whakapā i waenga i te rongoā me te kiriuhi pūtau i te wāhi mimiti, ka whakarerekē i te rere o te kiriuhi pūtau, ā, ka whakapiki ake i te urunga o te rongoā ki roto i ngā pūtau epithelial o te puku iti, ā, ka whakapai ake i te waatea o te rongoā. I tirotirohia e Wei Keda me ētahi atu te whakahaunga matua o te papa me te horopeta o te HPMCK4M me te Carbomer 940 hei take rangahau, ā, i whakamahia he taputapu piri-koiora i hangaia e ia anō hei ine i te kaha tihore i waenga i te papa me te kiriata koiora whakaata mā te kounga o te wai i roto i te putea kirihou. , ā, i te mutunga i tīpakohia te ihirangi o te HPMCK40 me te carbomer 940 kia 15 me te 27.5 mg i roto i te rohe whakahaunga tino pai o ngā matua papa NCaEBT, ia, hei whakarite i ngā matua papa NCaEBT, e tohu ana ka taea e ngā rauemi piripiri koiora (pēnei i te hydroxypropyl methylcellulose) te whakaiti nui i te Whakapai ake i te piri o te whakaritenga ki te kiko.
He momo pūnaha tuku rongoā hou anō hoki ngā whakaritenga piri-koiora ā-waha kua rangahauhia ake i ngā tau tata nei. Ka taea e ngā whakaritenga piri-koiora ā-waha te piri i te rongoā ki te wāhanga e pāngia ana o te kōhao waha, e kore e whakaroa noa i te wā noho o te rongoā ki roto i te kiriuhi waha, engari e tiaki ana hoki i te kiriuhi waha. He pai ake te pānga rongoā me te whakapai ake i te waatea o te rongoā. I arotau a Xue Xiaoyan me ētahi atu i te hanganga o ngā papa piri-koiora ā-waha insulin, mā te whakamahi i te pectin aporo, te chitosan, te carbomer 934P, te hydroxypropyl methylcellulose (HPMC K392) me te konutai alginate hei rauemi piri-koiora, me te whakamaroke-tio hei whakarite i te insulin ā-waha. He pepa paparanga takirua piri. Ko te papa piri-koiora ā-waha insulin kua whakaritea he hanganga rite ki te hautai porous, he pai mō te tukunga insulin, ā, he paparanga tiaki hydrophobic, ka taea te whakarite i te tukunga kotahi-ahunga o te rongoā me te karo i te ngaronga o te rongoā. I whakarite hoki a Hao Jifu me ētahi atu i ngā papa piri-koiora ā-waha he piripiri kikorangi-kōwhai mā te whakamahi i te kāpia Baiji, te HPMC me te carbomer hei rauemi piri-koiora.
I roto i ngā pūnaha tuku rongoā tara, kua whānuitia hoki te whakamahi i te hangarau bioadhesion. I whakamahia e Zhu Yuting me ētahi atu te carbomer (CP) me te HPMC hei rauemi piri me te matrix tuku-roa hei whakarite i ngā papa tara clotrimazole bioadhesive me ngā hanganga me ngā ōwehenga rerekē, ā, i inehia ō rātou piri, te wā piri me te ōrau pupuhi i roto i te taiao o te wai tara horihori. , i tirotirohia te whakahaunga tika hei CP-HPMC1: 1, he pai te mahi piri o te pepa piri kua whakaritea, ā, he māmā, he taea hoki te mahi.
3.8 hei kirimi pani
Hei whakaritenga piri, he maha ngā painga o te tiēre pēnei i te haumaru, te ataahua, te ngāwari ki te horoi, te iti o te utu, te ngāwari o te tukanga whakarite, me te pai o te hototahi ki ngā rongoā. Te ahunga whanaketanga. Hei tauira, ko te tiēre transdermal he momo horopeta hou kua rangahauhia i ngā tau tata nei. Ehara i te mea ka taea anake te karo i te whakangaromanga o ngā rongoā i roto i te ara kai me te whakaiti i te rerekētanga o te kukū o te rongoā toto mai i te tihi ki te ara, engari kua noho hei tetahi o ngā pūnaha tukunga rongoā whai hua hei wikitoria i ngā pānga taha o te rongoā.
I rangahau a Zhu Jingjie me ētahi atu i te pānga o ngā matrices rerekē ki te tukunga o te scutellarin alcohol plastid gel i roto i te vitro, ā, i tirotirohia ki te carbomer (980NF) me te hydroxypropyl methylcellulose (HPMCK15M) hei matrices gel, ā, i whiwhi i te scutellarin e tika ana mō te scutellarin. Matrix gel o ngā plastids waipiro. E whakaatu ana ngā hua whakamātautau he 1.0% carbomer, 1.5% carbomer, 1.0% carbomer + 1.0% HPMC, 1.5% carbomer + 1.0% HPMC hei matrix gel. He pai ēnei e rua mō ngā plastids waipiro scutellarin. I roto i te whakamātautau, i kitea ka taea e te HPMC te whakarerekē i te aratau tukunga rongoā o te matrix gel carbomer mā te whakauru i te whārite kinetic o te tukunga rongoā, ā, ka taea e te 1.0% HPMC te whakapai ake i te 1.0% carbomer matrix me te 1.5% carbomer matrix. Tērā pea ko te tere o te horapa o te HPMC, ā, ko te tere o te horapa i te tīmatanga o te whakamātautau ka nui ake te āputa ngota o te rauemi tiēre carbomer, ka tere ake te tere tukunga o te rongoā. I whakamahia e Zhao Wencui me ētahi atu te carbomer-934 me te hydroxypropyl methylcellulose hei kaikawe ki te whakarite i te tiēre kanohi norfloxacin. He māmā noa iho te tukanga whakarite, ā, he rite te kounga ki ngā whakaritenga kounga o te tiēre kanohi o "Chinese Pharmacopoeia" (putanga 2010).
3.9 Te aukati i te ua mō te pūnaha whakapūhui-whaiaro
Ko te pūnaha tuku rongoā whaiaro-iti-whakarewa (SMEDDS) he momo hou o te pūnaha tuku rongoā ā-waha, he ranunga ōrite, pumau, mārama hoki e titoa ana i te rongoā, te wāhanga hinu, te emulsifier me te co-emulsifier. He māmā te hanganga o te whakahaunga, ā, he pai te haumaru me te pumau. Mō ngā rongoā ngoikore te wairewa, he maha ngā wā ka tāpirihia ngā rauemi polymer muka wairewa-wai, pērā i te HPMC, te polyvinylpyrrolidone (PVP), me ētahi atu, kia tutuki ai te wairewatanga o ngā rongoā kore utu me ngā rongoā kua whakauruhia ki roto i te emulsion iti i roto i te ara kai, kia nui ake ai te wairewatanga o te rongoā me te whakapai ake i te waatea o te koiora.
I whakaritea e Peng Xuan me ētahi atu he pūnaha tuku rongoā whakapūmau-whaiaro silibinin supersaturated (S-SEDDS). Ko te hinu kātoro hauwai-oxyethylene (Cremophor RH40), 12% caprylic capric acid polyethylene glycol glyceride (Labrasol) hei co-emulsifier, me te 50 mg·g-1 HPMC. Mā te tāpiri i te HPMC ki te SSEDDS ka taea te whakapūmau i te silibinin kore utu kia rewa ki roto i te S-SEDDS me te ārai i te silibinin kia kore e rere. Ki te whakatauritea ki ngā whakatakotoranga whakapūmau-whaiaro tuku iho, he nui ake te nui o te surfactant e tāpirihia ana hei ārai i te kapi kore o te rongoā. Mā te tāpiri i te HPMC ka taea te pupuri i te wairewa o te silibinin i roto i te reo rewa kia rite tonu, ka whakaiti i te whakapūmau i roto i ngā whakatakotoranga whakapūmau-whaiaro.
4. Whakamutunga
Ka kitea kua whānuitia te whakamahinga o te HPMC i roto i ngā whakaritenga nā ōna āhuatanga ā-tinana, ā-matū me ā-koiora, engari he maha ngā ngoikoretanga o te HPMC i roto i ngā whakaritenga, pērā i te āhuatanga o te tukunga i mua me muri i te pahūtanga. (methyl methacrylate) hei whakapai ake. I taua wā anō, i rangahauhia e ētahi kairangahau te whakamahinga o te ariā osmotic i roto i te HPMC mā te whakarite i ngā papa tukunga-tonu carbamazepine me ngā papa tukunga-tonu verapamil hydrochloride hei ako atu i tana tikanga tukunga. I roto i te poto, he maha ake ngā kairangahau e mahi ana i te nui o te mahi hei whakapai ake i te whakamahinga o te HPMC i roto i ngā whakaritenga, ā, me te rangahau hohonu o ōna āhuatanga me te whakapai ake i te hangarau whakaritenga, ka whānuitia te whakamahinga o te HPMC i roto i ngā momo horopeta hou me ngā momo horopeta hou. I roto i te rangahau o te pūnaha rongoā, kātahi ka whakatairanga i te whanaketanga tonu o te rongoā.
Wā tuku: Oketopa-08-2022