Ibitabo bifitanye isano mu gihugu no mu mahanga mu gutegura imiti ifasha mu gukora imiti hydroxypropyl methylcellulose (HPMC) mu myaka yashize byarasuzumwe, binasesengurwa, binashyirwa mu byiciro, ndetse n'ikoreshwa ryayo mu gutegura ibintu bikomeye, gutegura amazi, gutegura ibintu birekura kandi bigenzurwa, gutegura capsule, gelatin. Ikoreshwa vuba mu bijyanye n'imiti mishya nka kole na bioadhesives. Bitewe n'itandukaniro ry'uburemere bwa molekile n'ubukonje bwa HPMC, ifite imiterere n'ikoreshwa rya emulsification, gufatana, gukuba, kongera ubukonje, guhagarara, gusiga gel no gukora filime. Ikoreshwa cyane mu gutegura imiti kandi izagira uruhare runini mu bijyanye n'imiti. Hamwe n'inyigo yimbitse ku miterere yayo no kunoza ikoranabuhanga ryo gukora imiti, HPMC izakoreshwa cyane mu bushakashatsi ku miterere mishya y'ibipimo n'uburyo bushya bwo gutanga imiti, bityo igateza imbere iterambere rihoraho ry'imiti.
hydroxypropyl methylcellulose; imiti ikoreshwa mu gupima; ibikoresho by'imiti.
Ibintu bifasha imiti mu gukora imiti ntabwo ari byo shingiro ry’ingenzi ryo gukora imiti isanzwe gusa, ahubwo binafitanye isano n’uburemere bw’uburyo bwo kuyitegura, ubuziranenge bw’imiti, ubuziranenge, umutekano, igipimo cyo gusohora imiti, uburyo ikora, ubushobozi bwo kuyikoresha mu buvuzi, no guteza imbere ubwoko bushya bw’imiti n’uburyo bushya bwo kuyikoresha. Bifitanye isano rya bugufi. Kuvuka kw’ibintu bifasha imiti mu gukora imiti bikunze gutuma habaho kunoza ubwiza bw’imiti no guteza imbere ubwoko bushya bw’imiti. Hydroxypropyl methylcellulose (HPMC) ni imwe mu miti ikunzwe cyane mu gihugu no mu mahanga. Bitewe n’uburemere bwayo butandukanye bwa molekile n’ubukana bwayo, ifite inshingano zo gukurura, gufatanya, gukuba, gukurura, guhagarika no gufunga. Imiterere n’ikoreshwa nko gufunga no gukora filime bikoreshwa cyane mu ikoranabuhanga ry’imiti. Iyi nkuru isuzuma cyane ikoreshwa rya hydroxypropyl methylcellulose (HPMC) mu miti mu myaka ya vuba aha.
1.Imiterere y'ibanze ya HPMC
Hydroxypropyl methyl cellulose (HPMC), formula ya molekile ni C8H15O8-(C10 H18O6) n-C8H15O8, kandi uburemere bwa molekile ni hafi 86.000. Iki gicuruzwa ni ibikoresho bya semi-synthetic, bigize methyl n'igice cya polyhydroxypropyl ether ya cellulose. Gishobora gukorwa mu buryo bubiri: Ubwa mbere ni uko methyl cellulose yo mu rwego rukwiye ivurwa na NaOH hanyuma igahuzwa na propylene oxide munsi y'ubushyuhe bwinshi n'umuvuduko mwinshi. Igihe cyo gukora response kigomba kumara igihe gihagije kugira ngo methyl na hydroxypropyl bikore ether bonds. Ihujwe n'impeta ya anhydroglucose ya cellulose mu buryo bwa cellulose, kandi ishobora kugera ku rugero rwifuzwa; ikindi ni ugukora caustic soda, hanyuma ugakorana na chlorine methane na propylene oxide bikurikirana, hanyuma ugakomeza kuyitunganya, ugasya neza kandi uhuje ifu cyangwa granules.
Ibara ry'iki gicuruzwa ni ibara ry'umweru kugeza ku ibara ry'amata, nta mpumuro cyangwa uburyohe, kandi imiterere yacyo ni ifu y'ibinyabutabire cyangwa iy'imigozi yoroshye gutemba. Iki gicuruzwa gishobora gushonga mu mazi kugira ngo kibe umuti w'umweru usobanutse kugeza ku ibara ry'amata ufite ubushyuhe runaka. Ihinduka rya sol-gel rishobora kubaho bitewe n'impinduka z'ubushyuhe bw'iki gicuruzwa hamwe n'ingano runaka.
Bitewe n'itandukaniro ry'ibi bintu bibiri bisimbura mu miterere ya methoxy na hydroxypropyl, hagaragaye ubwoko butandukanye bw'ibicuruzwa. Mu ngano runaka, ubwoko butandukanye bw'ibicuruzwa bufite imiterere yihariye. Kubera iyo mpamvu, ubushyuhe n'ubushyuhe bwo gushyuha bifite imiterere itandukanye kandi bishobora gukoreshwa mu ntego zitandukanye. Pharmacopoeia y'ibihugu bitandukanye ifite amabwiriza n'ibisobanuro bitandukanye kuri iyo modeli: Pharmacopoeia y'i Burayi ishingiye ku byiciro bitandukanye by'ubushyuhe butandukanye n'ibipimo bitandukanye byo gusimbuza ibicuruzwa bigurishwa ku isoko, bigaragazwa n'ibipimo hamwe n'imibare, kandi igice ni "mPa s". Muri Pharmacopoeia yo muri Amerika, imibare 4 yongeweho nyuma y'izina rusange kugira ngo yerekane ingano n'ubwoko bwa buri kintu gisimbura hydroxypropyl methylcellulose, nka hydroxypropyl methylcellulose 2208. Imibare ibiri ya mbere igaragaza agaciro gateganijwe k'itsinda rya methoxy. Ijanisha, imibare ibiri ya nyuma igaragaza ijanisha riteganijwe rya hydroxypropyl.
Hydroxypropyl methylcellulose ya Calocan ifite urukurikirane 3, arirwo E series, F series na K series, buri rukurikirane rufite ubwoko butandukanye bwo guhitamo. E series ikoreshwa cyane cyane nk'imyambaro ya firime, ikoreshwa mu gusiga ibinini, ibice by'ibinini bifunze; E, F series zikoreshwa nk'ibice bigabanya ubushyuhe n'ibikoresho bigabanya ubushyuhe mu gutegura amaso, ibikoresho bihagarika, ibinini bigabanya ubushyuhe mu gutegura amazi, ibinini n'ibifunga by'ibinure; K series ikoreshwa cyane nk'ibikoresho bigabanya ubushyuhe n'ibikoresho bya gel matrix bigabanya ubushyuhe mu gutegura gusohora buhoro kandi bigagenzurwa.
Inganda zikora ibikoresho byo mu ngo zirimo cyane cyane Fuzhou No. 2 Chemical Factory, Huzhou Food and Chemical Co., Ltd., Sichuan Luzhou Pharmaceutical Accessories Factory, Hubei Jinxian Chemical Factory No. 1, Feicheng Ruitai Fine Chemical Co., Ltd., Shandong Liaocheng Ahua Pharmaceutical Co., Ltd., Xi'an Huian chemical composters, n'ibindi.
2.Ibyiza bya HPMC
HPMC yabaye imwe mu miti ikoreshwa cyane mu gihugu no mu mahanga, kuko HPMC ifite ibyiza kurusha izindi miti idafite.
2.1 Gushonga kw'amazi akonje
Ishobora gushonga mu mazi akonje ari munsi ya 40 ℃ cyangwa 70% ya ethanol, ntabwo ishongesha mu mazi ashyushye ari hejuru ya 60 ℃, ariko ishobora gushonga.
2.2 Ikoreshwa ry'imiti idakora neza
HPMC ni ubwoko bwa eteri ya cellulose itari ionic, umuti wayo nta charge ya ionic ufite kandi ntukorana n'imyunyungugu y'icyuma cyangwa imyuka ya ionic, bityo ibindi bintu biwugize ntibigira ingaruka nayo mu gihe cyo gukora itegurwa.
2.3 Ituze
Irahindagurika cyane haba kuri aside na alkali, kandi ishobora kubikwa igihe kirekire hagati ya pH 3 na 11 nta mpinduka nini mu bushyuhe. Umuti w'amazi wa HPMC urwanya ubushyuhe kandi ugakomeza ubushyuhe bwiza mu gihe kibitswe igihe kirekire. Ibyuma bikoresha imiti bikoresha HPMC bifite ubuziranenge bwiza kurusha ibikoresha ibintu bisanzwe bikoreshwa (nk'ibikomoka kuri dextrin, sitashi, nibindi).
2.4 Guhindura ubukana bw'ubucucike
Ibikomoka kuri viscosity bitandukanye bya HPMC bishobora kuvangwa mu bipimo bitandukanye, kandi viscosity yayo ishobora guhinduka hakurikijwe itegeko runaka, kandi ikagira isano nziza, bityo igipimo gishobora gutoranywa hakurikijwe ibyo bikenewe.
2.5 Kutagira ubushobozi bwo gukora metabolike
HPMC ntabwo yinjizwa cyangwa ngo ikoreshwe mu mubiri, kandi ntabwo itanga ubushyuhe, bityo ikaba ari umuti wizewe wo guteka imiti. 2.6 Umutekano Muri rusange, bifatwa ko HPMC ari ikintu kidahumanya kandi kidatera umujinya, igipimo cy’imbeba cyica ni 5 g·kg – 1, naho igipimo cy’imbeba cyica ni 5. 2 g · kg – 1. Igipimo cya buri munsi nta ngaruka mbi ku mubiri w’umuntu.
3.Ikoreshwa rya HPMC mu mikorere
3.1 Nk'ibikoresho byo gusiga firime n'ibikoresho byo gukora firime
Ikoresheje HPMC nk'igikoresho cy'ibinini gipfundikiye, iki gikoresho gipfundikiye nta nyungu zigaragara gifite mu guhisha uburyohe n'isura ugereranije n'ibinini bisanzwe bipfundikiye nka ibinini bipfundikiye isukari, ariko ubukana bwacyo, gucika intege, kwinjizwa k'ubushuhe, urugero rwo gupfundikira, kwiyongera k'uburemere n'ibindi bimenyetso by'ubwiza ni byiza kurushaho. Ingano y'ubushuhe buke bw'iki gikoresho ikoreshwa nk'igikoresho cyo gupfundikira firime gishonga amazi ku binini n'ibinini, naho ingano y'ubushuhe bwinshi ikoreshwa nk'igikoresho cyo gupfundikira firime ku buryo bw'ibinyabutabire, akenshi ku kigero cya 2% kugeza 20%.
Zhang Jixing n'abandi bakoresheje uburyo bwo kunoza ubuso bw'ingufu kugira ngo batunganye uburyo bwo gukora imvange ya HPMC nk'imvange ya firime. Bafashe ibikoresho bikora firime HPMC, ingano ya polyvinyl alcohol na plasticizer polyethylene glycol nk'ibintu by'iperereza, imbaraga zo gukurura no kwinjira kwa firime hamwe n'ubukana bw'igisubizo cyo gukurura firime ni igipimo cy'igenzura, kandi isano iri hagati y'igipimo cy'igenzura n'ibintu by'igenzura isobanurwa n'icyitegererezo cya mibare, kandi inzira nziza yo gukora iraboneka amaherezo. Ikoreshwa ryayo ni hydroxypropyl methylcellulose (HPMCE5) 11.88 g, polyvinyl alcohol 24.12 g, plasticizer polyethylene glycol 13.00 g, naho ubukana bwo gukurura firime ni 20 mPa·s, ubukana bw'ubukana n'imbaraga zo gukurura firime byageze ku ngaruka nziza. Zhang Yuan yanoje uburyo bwo gutegura, yakoresheje HPMC nk'icyuma gifunga kugira ngo asimbuze ibinure bya starch, kandi yahinduye ibinini bya Jiahua ibinini bya firime kugira ngo anonosore ireme ry'ibitegurwa byayo, anonosore hygroscopicity yayo, yoroshye gucika, ibinini birekuye, byacitsemo ibice n'ibindi bibazo, yongera ubudahangarwa bw'ibinini. Uburyo bwiza bwo gukora ibinini bwagenwe n'igerageza rya orthogonal, ni ukuvuga ko ingano y'ibinure yari 2% HPMC mu gisubizo cya ethanol 70% mu gihe cyo gusiga, naho igihe cyo gukangura mu gihe cyo gukaraba cyari iminota 15. Ibisubizo Ibinini bya Jiahua byakozwe n'uburyo bushya n'umuti byarushijeho kuba byiza mu miterere, igihe cyo gushwanyagurika no gukomera kw'imbere kurusha ibyakozwe n'uburyo bwa mbere bwo gusiga, kandi igipimo cyujuje ibisabwa cy'ibinini bya firime cyarushijeho kuba cyiza cyane. byageze ku kigero kirenga 95%. Liang Meiyi, Lu Xiaohui, n'abandi bakoresheje hydroxypropyl methylcellulose nk'ibikoresho byo gukora firime kugira ngo bategure ibinini byo gushyira patinae colon hamwe n'ibinini byo gushyira matrine colon, uko bikurikirana. Huang Yunran yateguye ibinini bya Dragon's Blood Colon Positioning, anashyira HPMC ku gikoresho cyo gutwikira urwego rwo kubyimba, kandi igice cyayo cyari 5%. Bigaragara ko HPMC ishobora gukoreshwa cyane mu buryo bwo gutanga imiti mu mara.
Hydroxypropyl methylcellulose si ibikoresho byiza byo gusiga firime gusa, ahubwo ishobora no gukoreshwa nk'ibikoresho byo gukora firime mu buryo bwa firime. Wang Tongshun n'ibindi byatunganyijwe neza hakurikijwe uburyo bwa elegitoroniki ya zinc licorice na aminolexanol, hamwe n'uburyo bworoshye, uburyo bungana, uburyo bworoshye, uburyo bworoshye bwo gukora firime nk'igipimo cy'ubushakashatsi, kubona uburyo bwiza bwo gutanga firime ni PVA 6.5 g, HPMC 0.1 g na 6.0 g bya propylene glycol byujuje ibisabwa kugira ngo birekure buhoro kandi bigire umutekano, kandi bishobora gukoreshwa nk'uburyo bwo gutegura firime ya elegitoroniki.
3.2 nk'ikintu gihuza n'ibindi
Ingano nto y'ubukonje bw'iki gicuruzwa ishobora gukoreshwa nk'ikintu gifunga n'ikivange ku binini, ibinini n'udukoko, kandi ingano nini y'ubukonje ishobora gukoreshwa nk'ikintu gifunga gusa. Ingano iratandukanye bitewe n'uburyo butandukanye n'ibisabwa. Muri rusange, ingano y'ikintu gifunga ku binini byumye ni 5%, naho ingano y'ikintu gifunga ku binini bitose ni 2%.
Li Houtao n'abandi bapimye agakoresho ko gufata ibinini bya tinidazole. 8% polyvinylpyrrolidone (PVP-K30), 40% sirupe, 10% starch slurry, 2.0% hydroxypropyl methylcellulose K4 (HPMCK4M), 50% ethanol byasuzumwe nk'uko ibinini bya tinidazole byafataga. Impinduka mu miterere y'ibinini bisanzwe n'igihe cyo gusiga byaragereranyijwe, kandi uburyo ibinini bitandukanye byo gusiga byapimwe uburyo bwo gucika, gukomera, igihe ntarengwa cyo gusenyuka n'igihe cyo gushonga. Ibisubizo Ibinini byakozwe na 2.0% hydroxypropyl methylcellulose byari bibengerana, kandi uburyo bwo gucika bwagaragaje ko nta kintu cyo gucika no gufunga impande, kandi nyuma yo gusiga, imiterere y'ibinini yari yuzuye kandi isura yari nziza. Kubwibyo, ibinini bya tinidazole byakozwe na 2.0% HPMC-K4 na 50% ethanol nk'ibikoresho byo gufata. Guan Shihai yize uburyo bwo gukora ibinini bya Fuganning, yasuzumye kole, anasuzuma ethanol 50%, sitashi 15%, PVP 10% na ethanol 50% hamwe n’uburyo bwo gukuba, koroha, no gukuba nk’ibipimo by’isuzuma. , 5% CMC-Na na 15% HPMC solution (5 mPa s). Ibisubizo Impapuro zakozwe na ethanol 50%, sitashi 15%, PVP 50% ethanol na 5% CMC-Na zari zifite ubuso bworoshye, ariko bworoshye gukuba kandi butoroshye, butashoboraga guhaza ibyo gusiba; 15% HPMC solution (5 mPa·s), ubuso bw’ikinini ni bworoshye, ubushobozi bwo gukuba burujuje ibisabwa, kandi ubushobozi bwo gukuba ni bwiza, bushobora guhaza ibyo gusiba. Kubwibyo, HPMC (5 mPa s) yatoranijwe nk’ubukorikori.
3.3 nk'umukozi uhagarika akazi
Ingano y'ubushyuhe bwinshi bw'iki gicuruzwa ikoreshwa nk'ikintu gihagarika kugira ngo gitegure itegurwa ry'amazi yo mu bwoko bwa suspension. Ifite ingaruka nziza zo guhagarika, yoroshye kongera gutatanya, ntifata ku rukuta, kandi ifite uduce duto tworoshye two gukurura. Igipimo gisanzwe ni 0.5% kugeza 1.5%. Song Tian n'abandi bakoresheje ibikoresho bya polymer bikunze gukoreshwa (hydroxypropyl methylcellulose, sodium carboxymethylcellulose, povidone, xanthan gum, methylcellulose, nibindi) nk'ibintu bihagarika kugira ngo bategure racecadotril. Binyuze mu gipimo cy'ingano y'imiti itandukanye, hagaragaye igipimo cyo gusubiramo, na rheology, viscosity yo guhagarika n'imiterere ya microscopic, kandi hasuzumwe uburyo uduce tw'imiti duhagaze mu igerageza ryihuse. Ibisubizo Isubizo ry'imiti ryakozwe na 2% HPMC nk'ikintu gihagarika ryari rifite inzira yoroshye kandi rihamye.
Ugereranyije na methyl cellulose, hydroxypropyl methyl cellulose ifite imiterere yo gukora umuti usobanutse neza, kandi hari ingano nto cyane y’ibintu bitarakwirakwira mu maraso, bityo HPMC nayo ikunze gukoreshwa nk'ikintu gihagarika mu mavuta y’amaso. Liu Jie n'abandi bakoresheje HPMC, hydroxypropyl cellulose (HPC), carbomer 940, polyethylene glycol (PEG), sodium hyaluronate (HA) hamwe n’uruvange rwa HA/HPMC nk’ibintu bihagarika kugira ngo bategure ibipimo bitandukanye. Ku bijyanye no guhagarika amaso ya Ciclovir, ingano y’ibice, ingano y’ibice n’ubushobozi bwo kongera gushonga ni byo byatoranijwe nk’ibipimo by’igenzura kugira ngo harebwe ikintu cyiza cyo guhagarika. Ibisubizo bigaragaza ko icyuma gihagarika amaso cya acyclovir cyateguwe na 0.05% HA na 0.05% HPMC nk’igikoresho gihagarika, ingano y’ibice ni 0.998, ingano y’ibice ni imwe, ubushobozi bwo kongera gushonga ni bwiza, kandi uburyo bwo gutegura buhamye.
3.4 Nk'ikintu kibuza, gitebuka kandi kigenzurwa n'uburekura bw'imyenge n'ikintu kirema imyenge
Ingano y'ubukana bwinshi bw'iki gicuruzwa ikoreshwa mu gutegura ibinini bya gel matrix bivangwa na hydrophilic, ibiziba n'ibinini bivangwa na matrix bivangwa na hygiene, kandi bigira ingaruka zo gutinza irekurwa ry'imiti. Ingano yabyo ni 10% kugeza 80%. Ingano y'ubukana buke ikoreshwa nk'ibinini bigabanya ubukana mu gutegura irekurwa ry'imiti cyangwa igenzurwa. Ingano y'ibanze ikenewe kugira ngo ibinini nk'ibi bivurwe ishobora kugerwaho vuba, hanyuma ingaruka yo kurekurwa cyangwa igenzurwa iraboneka, kandi ingano y'imiti mu maraso igakomeza mu mubiri. . Hydroxypropyl methylcellulose iranyurwa kugira ngo ikore urwego rwa gel iyo ihuye n'amazi. Uburyo bwo kurekurwa kw'imiti mu binini bya matrix bukubiyemo ahanini gukwirakwira kw'urwego rwa gel no kwangirika k'urwego rwa gel. Jung Bo Shim n'abandi bateguye ibinini bya carvedilol bivangwa na HPMC nk'ibikoresho bivangwa na HPMC.
Hydroxypropyl methylcellulose ikoreshwa cyane mu binini bya matrix birekura burundu by’ubuvuzi gakondo bw’Abashinwa, kandi ibyinshi mu bintu bikora, ibice bifatika n’ibiryo bimwe by’ubuvuzi gakondo bw’Abashinwa birakoreshwa. Liu Wen n’abandi bakoresheje 15% hydroxypropyl methylcellulose nk’ibikoresho bya matrix, 1% lactose na 5% microcrystalline cellulose nk’ibyuzuza, kandi bateguye Jingfang Taohe Chengqi Decoction mu binini bya matrix birekura burundu. Icyitegererezo ni Higuchi equation. Uburyo bwo gukora formula ni bworoshye, gutegura biroroshye, kandi amakuru asohoka arahamye, byujuje ibisabwa na Pharmacopoeia y’Abashinwa. Tang Guanguang n’abandi bakoresheje saponins zose za Astragalus nk’umuti w’icyitegererezo, bategura ibinini bya matrix bya HPMC, kandi basesengura ibintu bigira ingaruka ku irekurwa ry’umuti mu bice bifatika by’ubuvuzi gakondo bw’Abashinwa mu binini bya matrix bya HPMC. Ibisubizo Uko igipimo cya HPMC cyagendaga cyiyongera, irekurwa rya astragaloside ryaragabanutse, kandi igipimo cyo kurekurwa k’umuti cyari gifite isano hafi ya buri murongo n’igipimo cyo gusenyuka kwa matrix. Muri ikinini cya hypromellose HPMC matrix, hari isano iri hagati yo kurekura igice cy’ingirakamaro cy’ubuvuzi gakondo bw’Abashinwa n’ingano n’ubwoko bwa HPMC, kandi inzira yo kurekura monomer y’ikinyabutabire gishyuha isa nayo. Hydroxypropyl methylcellulose ntikwiriye gusa ku bintu bishyuha mu mazi, ahubwo inakwiriye no ku bintu bitari ibishyuha mu mazi. Liu Guihua yakoresheje 17% ya hydroxypropyl methylcellulose (HPMCK15M) nk’ibikoresho bya matrix bisubirwamo, maze ategura ibinini bya matrix bisubirwamo bya Tianshan Xuelian hakoreshejwe uburyo bwo gukurura no gupima. Ingaruka zo kurekura mu buryo burambye zari zigaragara, kandi inzira yo gutegura yari ihamye kandi ishoboka.
Hydroxypropyl methylcellulose ntikoreshwa gusa ku binini bya matrix birekura burundu by’ibintu bikora n’ibice by’ingirakamaro by’ubuvuzi gakondo bw’Abashinwa, ahubwo inakoreshwa cyane mu gutegura imiti gakondo y’Abashinwa. Wu Huichao n’abandi bakoresheje 20% hydroxypropyl methyl cellulose (HPMCK4M) nk’ibikoresho bya matrix, kandi bakoresheje uburyo bwo gukanda ifu mu gutegura ikinini cya Yizhi hydrophilic gel matrix gishobora kurekura umuti buri gihe kandi mu buryo buhoraho mu gihe cy’amasaha 12. Saponin Rg1, ginsenoside Rb1 na Panax notoginseng saponin R1 byakoreshejwe nk'ibipimo byo gusuzuma irekurwa ryawo muri vitro, kandi ikigereranyo cyo kurekura umuti cyashyizweho kugira ngo cyige uburyo bwo kurekura umuti. Ibisubizo Uburyo bwo kurekura umuti bwakurikije ikigereranyo cya zero-order kinetic na ikigereranyo cya Ritger-Peppas, aho geniposide yarekurwaga hakoreshejwe uburyo butari ubwa Fick, kandi ibice bitatu muri Panax notoginseng byarekuwe n’ikwirakwizwa ry’amagufwa.
3.5 Kole irinda umuntu nk'iy'ingufu kandi ikanakoresha koloyide
Iyo iki gicuruzwa gikoreshejwe nk'ikinyabutabire, igipimo gisanzwe ni 0.45% kugeza 1.0%. Kinashobora kongera ubushobozi bwa kole irinda amazi, kikarema koloyide irinda, kikabuza uduce duto guhuriza hamwe no kwibumbira hamwe, bityo kikabuza ikorwa ry'ibisigazwa. Igipimo gisanzwe ni 0.5% kugeza 1.5%.
Wang Zhen n'abandi bakoresheje uburyo bwa L9 orthogonal mu gushushanya imiterere y'igerageza kugira ngo bakore ubushakashatsi ku itegurwa rya enema ya karubone ikoreshwa mu buvuzi. Ibisabwa kugira ngo hamenyekane neza enema ya karubone ikoreshwa mu buvuzi ni ugukoresha 0.5% sodium carboxymethyl cellulose na 2.0% hydroxypropyl methylcellulose (HPMC irimo 23.0% methoxyl group, hydroxypropoxyl Base 11.6%) nk'umubyibuho, imiterere y'iyi gahunda ifasha kongera umubyibuho wa karubone ikoreshwa mu buvuzi. Zhang Zhiqiang n'abandi bakoze gel ya levofloxacin hydrochloride ophthalmic yiteguye gukoreshwa ifite pH kandi ikora neza, ikoresheje carbopol nk'umubyibuho wa gel na hydroxypropyl methylcellulose nk'umubyibuho ukomeza kwiyongera. Uburyo bwiza bwo gutanga imiti bukoreshejwe igerageza, amaherezo bubona uburyo bwiza bwo gutanga imiti ni levofloxacin hydrochloride 0.1 g, carbopol (9400) 3 g, hydroxypropyl methylcellulose (E50 LV) 20 g, disodium hydrogen phosphate 0.35 g, aside phosphoric 0.45 g ya sodium dihydrogen, 0.50 g ya sodium chloride, 0.03 g ya ethyl paraben, n'amazi byongewemo kugira ngo bikore mL 100. Mu igerageza, umwanditsi yasuzumye urukurikirane rwa hydroxypropyl methylcellulose METHOCEL rwa Colorcon Company rufite ibisobanuro bitandukanye (K4M, E4M, E15 LV, E50LV) kugira ngo ategure ibikoresho binini bifite ubunini butandukanye, maze ibisubizo bitoranya HPMC E50 LV nk'uburyo bunini. Ibyinshi kuri levofloxacin hydrochloride instant gels ifite pH.
3.6 nk'ibikoresho bya kapsule
Ubusanzwe, ibikoresho by'agapfukamunwa k'udupfukamunwa ahanini biba ari gelatin. Uburyo bwo gukora agapfukamunwa k'udupfukamunwa bworoshye, ariko hari ibibazo bimwe na bimwe nko kudakingira ubushuhe n'imiti iterwa na ogisijeni, kugabanuka kw'imiti, no gutinda kwangirika k'udupfukamunwa mu gihe cyo kubika. Kubwibyo, hydroxypropyl methylcellulose ikoreshwa nk'isimbura udupfukamunwa twa gelatin mu gutegura udupfukamunwa, ibyo bikaba binoza ubushobozi bwo gukora udupfukamunwa n'ingaruka zo gukoreshwa, kandi byamamajwe cyane mu gihugu no mu mahanga.
Bakoresheje theophylline nk'umuti ugenzura, Podczeck n'abandi basanze igipimo cyo gusenya imiti ya capsules hamwe n'ibishishwa bya hydroxypropyl methylcellulose cyari kinini kurusha icya capsules za gelatin. Impamvu y'isesengura ni uko gusenya kwa HPMC ari ugusenya capsule yose icyarimwe, mu gihe gusenya capsule ya gelatin ari ugusenya imiterere y'urusobe rw'imiyoboro mbere na mbere, hanyuma igasenya capsule yose, bityo capsule ya HPMC ikwiriye cyane ibishishwa bya Capsule kugira ngo bisohoke ako kanya. Chiwele n'abandi nabo babonye imyanzuro nk'iyo maze bagereranya gusenya kwa gelatin, gelatin/polyethylene glycol n'ibishishwa bya HPMC. Ibisubizo byagaragaje ko ibishishwa bya HPMC byashongeshejwe vuba mu bihe bitandukanye bya pH, mu gihe capsules za gelatin zigira ingaruka zikomeye ku miterere itandukanye ya pH. Tang Yue n'abandi basuzumye ubwoko bushya bw'ibishishwa bya capsules ku buryo bworoshye bwo gutwara ifu yumye y'umuti. Ugereranyije n'agasanduku k'inyunganiramirire ka hydroxypropyl methylcellulose n'agasanduku k'inyunganiramirire ka gelatin, hasuzumwe uburyo agasanduku k'inyunganiramirire kameze n'imiterere y'ifu iri mu gasanduku mu bihe bitandukanye, maze hakorwa isuzuma ry'uburyo gashobora gucika. Ibisubizo bigaragaza ko ugereranije n'udusanduku twa gelatin, udusanduku twa HPMC dufite ubushobozi bwo gucika no kurinda ifu, dufite ubushobozi bwo kwirinda ubushuhe bwinshi, kandi dufite ubushobozi bwo gucika ugereranyije n'udusanduku twa gelatin, bityo udusanduku twa HPMC tw'inyunganiramirire tubereye cyane udusanduku twa HPMC two guhumeka ifu yumye.
3.7 nk'ikintu gifata umubiri
Ikoranabuhanga rya Bioadhesion rikoresha ibikoresho bifasha mu gufata imiti hamwe na polymeri zifata imiti. Binyuze mu gufata imiti mu mubiri, byongera uburyo ikorana n'imitsi ikomeza gukorana, bityo umuti urekurwa buhoro buhoro kandi ukinjizwa mu mitsi kugira ngo ugere ku ntego yo kuvura. Ukoreshwa cyane muri iki gihe. Kuvura indwara zo mu nzira y'igifu, mu gitsina, mu kanwa n'ibindi bice.
Ikoranabuhanga ryo gufata imiti mu mara ni uburyo bushya bwo gutanga imiti bwakozwe mu myaka ya vuba aha. Ntabwo byongera gusa igihe cyo kuba imiti mu nzira y'igifu, ahubwo binanoza imikorere y'umuti n'urukiramende rw'uturemangingo aho umuti ushyirwa, bigahindura uburyo urukiramende rw'uturemangingo rukora, kandi bigatuma kwinjira k'umuti mu turemangingo duto tw'amara birushaho kwiyongera, bityo bikongera ubushobozi bwo gufata imiti. Wei Keda n'abandi basuzumye imiti yo mu bwoko bwa HPMCK4M na Carbomer 940 nk'ibintu by'iperereza, kandi bakoresheje igikoresho cyo gufata imiti mu mara kugira ngo bapime imbaraga zo gukura hagati y'ikinini n'urukiramende rw'amazi rwifashishijwe mu ishashi ya pulasitiki. , kandi amaherezo bahisemo ingano ya HPMCK40 na carbomer 940 kuri 15 na 27.5 mg mu gice cyiza cya NCaEBT tablet cores, uko bikurikirana, kugira ngo bategure NCaEBT tablet cores, bigaragaza ko ibikoresho bifata umubiri (nka hydroxypropyl methylcellulose) bishobora kugabanya cyane uburyo umuti ufatana n’ingingo.
Uburyo bwo gufata imiti mu kanwa nabwo ni ubwoko bushya bw'uburyo bwo gutanga imiti bwizweho cyane mu myaka ya vuba aha. Uburyo bwo gufata imiti mu kanwa bushobora gufata umuti mu gice cy'umunwa cyangiritse, ibyo bigatuma igihe cy'umuti kiguma mu kanwa, ndetse bikanarinda mucosa yo mu kanwa. Ingaruka nziza zo kuvura no kunoza uburyo imiti iboneka. Xue Xiaoyan n'abandi banonosoye uburyo bwo gukora ibinini bya insuline bifata mu kanwa, bakoresheje apple pectin, chitosan, carbomer 934P, hydroxypropyl methylcellulose (HPMC K392) na sodium alginate nk'ibikoresho bifata mu kanwa, ndetse no kumisha insuline mu kanwa. Urupapuro rwo gufata mu kanwa rufite imiterere isa n'iy'ibisuguti, ifasha insuline kurekurwa, kandi ifite urwego rwo kurinda amazi, rushobora kwemeza ko umuti urekurwa mu cyerekezo kimwe kandi hirindwa ko umuti ubura. Hao Jifu n'abandi bateguye kandi uduce duto tw'ubururu n'umuhondo tw'amasaro yo mu kanwa hakoreshejwe kole ya Baiji, HPMC na carbomer nk'ibikoresho bifata mu kanwa.
Mu buryo bwo gutanga imiti mu gitsina, ikoranabuhanga ryo gufata imiti mu gitsina ryakoreshejwe cyane. Zhu Yuting n'abandi bakoresheje carbomer (CP) na HPMC nk'ibikoresho byo gufata imiti hamwe n'uburyo bwo gusohora imiti mu gihe kirekire kugira ngo bategure ibinini bya clotrimazole bifata imiti mu gitsina bifite imiterere n'ibipimo bitandukanye, kandi bapimye uburyo bifata imiti mu gitsina, igihe cyo gufata imiti n'ijanisha ryo kubyimba mu bidukikije by'amazi y'igitsina cy'ubukorano. , imiti ikwiye yasuzumwe nka CP-HPMC1: 1, urupapuro rwakozwe rwo gufata imiti rwari rufite ubushobozi bwo gufata imiti neza, kandi inzira yari yoroshye kandi ishoboka.
3.8 nk'umuti wo mu bwoko bwa gel
Nk'umuti ufata neza, gel ifite ibyiza byinshi nko kwirinda ingaruka mbi, ubwiza, koroshya gusukurwa, ihendutse, uburyo bworoshye bwo kuyitegura, no guhuza neza n'imiti. Icyerekezo cy'iterambere. Urugero, gel ya transdermal ni ubwoko bushya bw'ibipimo byizweho cyane mu myaka ya vuba aha. Ntabwo ishobora kwirinda gusa kwangirika kw'imiti mu nzira y'igifu no kugabanya ihindagurika ry'umubare w'imiti mu maraso, ahubwo yanabaye imwe mu nzira nziza yo gusohora imiti mu kurwanya ingaruka mbi z'imiti.
Zhu Jingjie n'abandi bigaga ingaruka z'ama-matrices atandukanye ku irekurwa rya gel ya plastid ya scutellarin alcohol muri vitro, maze basuzuma carbomer (980NF) na hydroxypropyl methylcellulose (HPMCK15M) nk'ama-matrices ya gel, maze babona scutellarin ikwiriye scutellarin. Matrix ya gel ya plastid ya alcohol. Ibisubizo by'igerageza bigaragaza ko 1.0% carbomer, 1.5% carbomer, 1.0% carbomer + 1.0% HPMC, 1.5% carbomer + 1.0% HPMC nk'ama-matrice ya gel. Zombi zikwiriye plastid ya alcohol ya scutellarin. Mu igerageza, byagaragaye ko HPMC ishobora guhindura uburyo bwo kurekura imiti ya gel ya carbomer ikoresheje uburyo bwo gushyira mu byiciro ikinetic equation yo kurekura imiti, naho 1.0% HPMC ishobora kunoza 1.0% carbomer matrix na 1.5% carbomer matrix. Impamvu ishobora kuba ari uko HPMC yaguka vuba, kandi kwaguka vuba mu ntangiriro z'igerageza bituma icyuho cya molekile cy'ibikoresho bya gel ya carbomer kirushaho kuba kinini, bityo bikihutisha umuvuduko wayo wo gusohora imiti. Zhao Wencui n'abandi bakoresheje carbomer-934 na hydroxypropyl methylcellulose nk'abatwara kugira ngo bategure gel ya ophthalmic ya norfloxacin. Uburyo bwo kuyitegura bworoshye kandi bushoboka, kandi ubwiza bujyanye na gel ya ophthalmic ya "Chinese Pharmacopoeia" (2010 edition) Ibisabwa ku bwiza.
3.9 Ibuza imvura kugwa mu buryo bwo kwiyinjizamo amazi mu buryo bwa microemulsifying system
Sisitemu yo gutanga imiti yigenga (SMEDDS) ni ubwoko bushya bw'uburyo bwo gutanga imiti mu kanwa, ikaba ari uruvange ruhuye, ruhamye kandi rubonerana rugizwe n'umuti, amavuta, emulsifier na co-emulsifier. Imiterere y'umuti ni yoroshye, kandi umutekano n'ubudahangarwa ni byiza. Ku miti idashonga neza, ibikoresho bya polymer bishongera mu mazi, nka HPMC, polyvinylpyrrolidone (PVP), nibindi, bikunze kongerwamo kugira ngo imiti ifunguye kandi imiti ifungishijwe muri microemulsion ishobore gushonga mu nzira y'igifu, kugira ngo wongere ubushobozi bwo gushonga no kunoza ubushobozi bwo kubaho kw'imiti.
Peng Xuan n'abandi bateguye sisitemu yo gutanga imiti yigenga ya silibinin (S-SEDDS). Oxyethylene hydrogenated castor oil (Cremophor RH40), 12% caprylic capric acid polyethylene glycol glyceride (Labrasol) nk'itsinda rihuza imiti, na 50 mg·g-1 HPMC. Kongera HPMC muri SSEDDS bishobora kongeramo silibinin yigenga kugira ngo ishonge muri S-SEDDS kandi bikarinda silibinin gusohoka. Ugereranyije n'imiti isanzwe yigenga, ingano nini ya surfactant ikunze kongerwamo kugira ngo hirindwe ko imiti idashobora gushonga neza. Kongeramo HPMC bishobora gutuma silibinin ishonga mu buryo bwo gushonga idahinduka, bigabanye ingano ya emulsification mu mikorere yigenga.
4. Umwanzuro
Bigaragara ko HPMC yakoreshejwe cyane mu gutegura bitewe n'imiterere yayo isanzwe, iy'ibinyabutabire n'iy'ibinyabuzima, ariko HPMC ifite kandi inenge nyinshi mu gutegura, nko kuba ikoreshwa mbere na nyuma yo gusohora. methyl methacrylate) kugira ngo inoze. Muri icyo gihe, bamwe mu bashakashatsi bakoze ubushakashatsi ku ikoreshwa rya theory ya osmotic muri HPMC bategura ibinini bya carbamazepine birekurwa by'agateganyo na verapamil hydrochloride birekurwa by'agateganyo kugira ngo barusheho kwiga uburyo bwo kuyisohora. Muri make, abashakashatsi benshi barimo gukora akazi kenshi kugira ngo HPMC ikoreshwe neza mu gutegura, kandi hamwe n'inyigo yimbitse ku miterere yayo no kunoza ikoranabuhanga ryo kuyitegura, HPMC izakoreshwa cyane mu buryo bushya bwo gupima no mu buryo bushya bwo gupima. Mu bushakashatsi ku buryo bw'imiti, hanyuma hagakurikiraho iterambere rihoraho rya farumasi.
Igihe cyo kohereza: Ukwakira-08-2022