I-Hydroxypropyl cellulose, isithako semithi, sihlukaniswe sibe yi-hydroxypropyl cellulose (L-HPC) engaphansi kwe-substituted kanye ne-hydroxypropyl cellulose (H-HPC) engaphansi kwe-substituted ngokuya ngokuqukethwe kwe-hydroxypropoxy yayo engaphansi kwe-substituent. I-L-HPC ikhukhumala ibe yisisombululo se-colloidal emanzini, inezimpawu zokunamathela, ukwakheka kwefilimu, i-emulsification, njll., futhi isetshenziswa kakhulu njenge-ejenti yokuqhekeka kanye ne-binder; kuyilapho i-H-HPC incibilika emanzini kanye nezinyibilikisi ezahlukahlukene eziphilayo ekushiseni kwegumbi, futhi ine-thermoplasticity enhle. , ukuhlangana kanye nezakhiwo zokwakha ifilimu, ifilimu eyakhiwe iqinile, iyacwebezela, futhi iyanwebeka ngokuphelele, futhi isetshenziswa kakhulu njengezinto zokwakha ifilimu kanye nezinto zokumboza. Ukusetshenziswa okukhethekile kwe-hydroxypropyl cellulose kumalungiselelo aqinile manje sekwethulwa.
1. Njengesithako esingasebenzi kahle samalungiselelo aqinile njengamaphilisi
Ubuso bezinhlayiya zekristalu ze-hydroxypropyl cellulose ezifakwe endaweni ephansi abulingani, ngesakhiwo esicacile esifana nedwala eligugile. Lesi sakhiwo sobuso obumahhadla asigcini nje ngokwenza kube nendawo enkulu, kodwa futhi uma sicindezelwa sibe yithebhulethi kanye nemithi nezinye izinto ezisizayo, kwakheka ama-pores amaningi nama-capillary enkabeni yethebhulethi, ukuze ingaphakathi lethebhulethi likwazi ukwandisa izinga lokumuncwa komswakama kanye nokumuncwa kwamanzi kwandisa ukuvuvukala.I-L-HPCNjenge-excipient kungenza ithebhulethi liqhekeke ngokushesha libe yimpuphu efanayo, futhi kuthuthukise kakhulu ukuqhekeka, ukuqhekeka kanye nokutholakala kwe-bioavailability kwethebhulethi. Isibonelo, ukusetshenziswa kwe-L-HPC kungasheshisa ukuqhekeka kwamaphilisi e-paracetamol, amaphilisi e-aspirin, kanye namaphilisi e-chlorpheniramine, futhi kuthuthukise izinga lokuqhekeka. Ukuqhekeka kanye nokuqhekeka kwemithi engancibiliki kahle njengethebhulethi ye-ofloxacin ene-L-HPC njenge-disintegrants bekungcono kunaleyo ene-PVPP exhumene ne-cross-linked, i-CMC-Na exhumene ne-cross-linked kanye ne-CMS-Na njenge-disintegrants. Ukusebenzisa i-L-HPC njenge-disintegrant yangaphakathi yama-granules kuma-capsules kuzuzisa ekuqhekekeni kwama-granules, kwandisa indawo yokuxhumana phakathi komuthi kanye nendawo yokuqhekeka, kukhuthaza ukuqhekeka komuthi, futhi kuthuthukise ukutholakala kwe-bioavailability. Amalungiselelo aqinile akhishwa ngokushesha amelwe amalungiselelo aqinile aqhekeka ngokushesha kanye namalungiselelo aqinile aqhekeka ngokushesha anemiphumela eqhekeka ngokushesha, eqhekeka ngokushesha, esebenza ngokushesha, ukutholakala okuphezulu kwe-bioavailability, ukucasuka kwemithi okuncishisiwe emgogodleni kanye nomgudu wokugaya ukudla, futhi kulula ukuwathatha futhi abe nokuhambisana okuhle. kanye nezinye izinzuzo, ethatha isikhundla esibalulekile emkhakheni wekhemisi. I-L-HPC isibe ngesinye sezithako ezibaluleke kakhulu zamalungiselelo aqinile akhishwa ngokushesha ngenxa yokuqina kwayo kwamanzi, i-hygroscopicity, ukunwebeka, isikhathi esifushane se-hysteresis sokumunca amanzi, isivinini sokumunca amanzi ngokushesha, kanye nokugcwala kwamanzi ngokushesha. Kuyisithako esifanele samaphilisi aqhekeka ngomlomo. Amaphilisi e-Paracetamol aqhekeka ngomlomo alungiswa nge-L-HPC njengesithako, kanti amaphilisi aqhekeka ngokushesha kungakapheli iminyaka engama-20. I-L-HPC isetshenziswa njengesithako samaphilisi, futhi umthamo wayo ojwayelekile u-2% kuya ku-10%, ikakhulukazi u-5%.
2. Njengesihlanganisi semithi efana namaphilisi kanye nama-granule
Isakhiwo esiqinile se-L-HPC senza futhi sibe nomphumela omuhle kakhulu we-mosaic ngemithi nezinhlayiya, okwandisa izinga lokubumbana, futhi sinokusebenza okuhle kokubumba kokucindezela. Ngemva kokucindezelwa kumaphilisi, sibonisa ubulukhuni nokukhanya okwengeziwe, ngaleyo ndlela kuthuthukiswe ikhwalithi yokubukeka kwethebhulethi. Ikakhulukazi kumaphilisi akulula ukuwakha, akhululekile noma okulula ukuwavula, ukwengeza i-L-HPC kungathuthukisa umphumela. Ithebhulethi ye-ciprofloxacin hydrochloride inokucindezela okuncane, kulula ukuyihlukanisa futhi inamathela, futhi kulula ukuyikha ngemva kokufaka i-L-HPC, enobulukhuni obufanele, ukubukeka okuhle, kanye nezinga lokuncibilika lihlangabezana nezidingo ezijwayelekile zekhwalithi. Ngemva kokufaka i-L-HPC kuthebhulethi ehlakazekayo, ukubukeka kwayo, ukugobeka, ukufana kokuhlakazeka nezinye izici kuthuthukisiwe kakhulu futhi kuthuthukisiwe. Ngemuva kokuthi isitashi ku-prescription yokuqala sithathelwe indawo yi-L-HPC, ubulukhuni bethebhulethi ehlakazekayo ye-azithromycin banda, ukugobeka kwathuthuka, futhi izinkinga zamakhona angekho kanye nemiphetho ebolile yethebhulethi yokuqala zaxazululwa. I-L-HPC isetshenziswa njengesihlanganisi samaphilisi, kanti umthamo ojwayelekile uphakathi kuka-5% kuya ku-20%; kanti i-H-HPC isetshenziswa njengesihlanganisi samaphilisi, ama-granule, njll., kanti umthamo ojwayelekile uphakathi kuka-1% kuya ku-5% womuthi.
3. Ukusetshenziswa ekumbozweni kwefilimu kanye nokulungiswa kokukhululwa okuqhubekayo nokulawulwayo
Njengamanje, izinto ezincibilika emanzini ezivame ukusetshenziswa ekumbozweni kwefilimu zifaka phakathi i-hydroxypropylmethylcellulose (HPMC), i-hydroxypropylcellulose, i-polyethylene glycol (PEG) njalo njalo. I-Hydroxypropyl cellulose ivame ukusetshenziswa njenge-ejenti yokwakha ifilimu ezintweni zokuxuba ifilimu ngenxa yefilimu yayo eqinile, enwebekayo nekhazimulayo. Uma i-hydroxypropyl cellulose ixutshwa nezinye izinto zokugqoka ezingamelani nokushisa, ukusebenza kwengubo yayo kungathuthukiswa kakhulu.
Ukusebenzisa izinto ezisizayo namasu afanele ukwenza umuthi ube amaphilisi e-matrix, amaphilisi antantayo esiswini, amaphilisi anezingqimba eziningi, amaphilisi amboziwe, amaphilisi e-osmotic pump kanye namanye amaphilisi okukhululwa okuhamba kancane nokulawulwayo, ukubaluleka kuseku: ukwandisa izinga lokumuncwa kwemithi kanye nokuzinzisa umuthi egazini. Ukugxila, ukunciphisa ukusabela okubi, ukunciphisa inani lemithi, kanye nokulwela ukwandisa umphumela wokwelapha ngesilinganiso esincane kakhulu, kanye nokunciphisa ukusabela okubi. I-Hydroxypropyl cellulose ingenye yezinto ezisizayo eziyinhloko zalezi zidakamizwa. Ukuncibilika nokukhululwa kwamaphilisi e-diclofenac sodium kulawulwa ngokusebenzisa i-hydroxypropyl cellulose kanye ne-ethyl cellulose njengento ehlangene nethambo. Ngemva kokuphathwa ngomlomo kanye nokuxhumana nojusi wesisu, ubuso bamaphilisi e-diclofenac sodium akhululwayo buzofakwa emanzini abe yijeli. Ngokuncibilika kwejeli kanye nokusabalala kwama-molecule emithi esikhaleni sejeli, inhloso yokukhululwa kancane kwama-molecule emithi iyafezwa. I-Hydroxypropyl cellulose isetshenziswa njenge-matrix yokukhululwa okulawulwayo kwethebhulethi, lapho okuqukethwe kwe-blocker ethyl cellulose kungaguquguquki, okuqukethwe kwayo kuthebhulethi kunquma ngqo izinga lokukhululwa komuthi, kanti umuthi ovela kuthebhulethi onokuqukethwe okuphezulu kwe-hydroxypropyl cellulose Ukukhululwa kuhamba kancane. Ama-pellets ambozwe alungiswa ngokusebenzisaI-L-HPCkanye nengxenye ethile ye-HPMC njengesixazululo sokumboza sokumboza njengesendlalelo sokuvuvukala, kanye nesendlalelo sokukhululwa esilawulwayo sokumboza nge-ethyl cellulose aqueous dispersion. Lapho umuthi kanye nomthamo wesendlalelo sokuvuvukala kulungisiwe, ngokulawula ukujiya kwesendlalelo sokukhululwa esilawulwayo, ama-pellet ambozwe angakhishwa ngezikhathi ezahlukene ezilindelekile. Izinhlobo eziningana zama-pellet ambozwe anesisindo esihlukile sesendlalelo sokukhululwa esilawulwayo zixutshwa ukwenza ama-capsule e-Shuxiong ambozwe esiqhubekayo. Endaweni yokuncibilikisa, ama-pellet ahlukahlukene ambozwe angakhipha izidakamizwa ngokulandelana ngezikhathi ezahlukene, ukuze izingxenye ezinezakhiwo ezahlukene zomzimba nezamakhemikhali Ukukhululwa ngasikhathi sinye kufezwe ngesikhathi esifanayo nokukhululwa okuqhubekayo.
Isikhathi sokuthunyelwe: Ephreli-25-2024