Hydroxypropyl cellulose, chowonjezera mankhwala, chimagawidwa m'magulu awiri: hydroxypropyl cellulose (L-HPC) ndi hydroxypropyl cellulose (H-HPC) yosinthidwa pang'ono malinga ndi kuchuluka kwa hydroxypropoxy yake yosinthidwa. L-HPC imakula kukhala yankho la colloidal m'madzi, ili ndi mphamvu zomatira, kupanga filimu, emulsification, ndi zina zotero, ndipo imagwiritsidwa ntchito makamaka ngati chosungunula ndi chomangira; pomwe H-HPC imasungunuka m'madzi ndi zinthu zosiyanasiyana zachilengedwe kutentha kwa chipinda, ndipo ili ndi thermoplasticity yabwino. , mgwirizano ndi mphamvu zopangira filimu, filimu yopangidwayo ndi yolimba, yonyezimira, komanso yotanuka mokwanira, ndipo imagwiritsidwa ntchito makamaka ngati chinthu chopangira filimu ndi zinthu zokutira. Kugwiritsa ntchito kwapadera kwa hydroxypropyl cellulose mu zokonzekera zolimba tsopano kwayambitsidwa.
1. Monga chosakaniza cha mankhwala olimba monga mapiritsi
Pamwamba pa tinthu ta crystalline ta hydroxypropyl cellulose tomwe timalowetsedwa m'malo ochepa ndi osafanana, ndipo mawonekedwe ake ndi ofanana ndi miyala. Kapangidwe kameneka sikuti kamangopangitsa kuti ikhale ndi malo akuluakulu, komanso ikakanikizidwa kukhala piritsi limodzi ndi mankhwala ndi zinthu zina zowonjezerera, ma pores ndi mitsempha yambiri imapangidwa mkati mwa piritsi, kotero kuti pakati pa piritsi pakhoza kuonjezera kuchuluka kwa kuyamwa kwa chinyezi ndipo kuyamwa kwa madzi kumawonjezera kutupa.L-HPCMonga chowonjezera, piritsi limatha kusungunuka mwachangu kukhala ufa wofanana, ndikuwonjezera kwambiri kusungunuka, kusungunuka, ndi kupezeka kwa piritsi. Mwachitsanzo, kugwiritsa ntchito L-HPC kungathandize kusungunuka kwa mapiritsi a paracetamol, mapiritsi a aspirin, ndi mapiritsi a chlorpheniramine, ndikuwonjezera kuchuluka kwa kusungunuka. Kusungunuka ndi kusungunuka kwa mankhwala osasungunuka bwino monga mapiritsi a ofloxacin okhala ndi L-HPC ngati osungunuka kunali bwino kuposa omwe ali ndi PVPP yolumikizidwa, CMC-Na yolumikizidwa ndi CMS-Na ndi CMS-Na ngati osungunuka. Kugwiritsa ntchito L-HPC ngati kusungunuka kwamkati kwa ma granules omwe ali mu makapisozi kumathandiza kusungunuka kwa ma granules, kumawonjezera malo olumikizirana pakati pa mankhwala ndi malo osungunuka, kumathandizira kusungunuka kwa mankhwalawa, komanso kumawonjezera kupezeka kwa granules. Mankhwala olimba otulutsidwa nthawi yomweyo omwe amaimiridwa ndi mankhwala olimba osungunuka mwachangu komanso mankhwala olimba osungunuka nthawi yomweyo ali ndi zotsatira zosungunuka mwachangu, zosungunuka nthawi yomweyo, zogwira ntchito mwachangu, kupezeka kwa bioavailability yambiri, kuchepetsa kuyabwa kwa mankhwala ku mmero ndi m'mimba, ndipo ndi osavuta kutenga ndikutsatira bwino. ndi zabwino zina, zomwe zili ndi udindo wofunikira m'munda wa mankhwala. L-HPC yakhala imodzi mwa zinthu zofunika kwambiri zothandizira mankhwala olimba otulutsidwa nthawi yomweyo chifukwa cha mphamvu yake yosinthasintha madzi, hygroscopicity, expansibility, short hysteresis time for maning water, fast maning water, and fattuce of maning water. Ndi mankhwala abwino kwambiri osungunuka pakamwa pakamwa pakamwa. Mapiritsi a Paracetamol osungunuka pakamwa adakonzedwa ndi L-HPC ngati osungunuka, ndipo mapiritsiwo adasungunuka mwachangu mkati mwa zaka za m'ma 20. L-HPC imagwiritsidwa ntchito ngati mankhwala osokoneza mapiritsi, ndipo mlingo wake wonse ndi 2% mpaka 10%, makamaka 5%.
2. Monga chomangira cha mankhwala monga mapiritsi ndi granules
Kapangidwe kake kolimba ka L-HPC kamathandizanso kuti ikhale ndi zotsatira zabwino kwambiri za mosaic ndi mankhwala ndi tinthu tating'onoting'ono, zomwe zimawonjezera mgwirizano, komanso zimakhala ndi magwiridwe antchito abwino opondereza. Pambuyo pokanikizidwa m'mapiritsi, imawonetsa kuuma ndi kuwala kwambiri, zomwe zimapangitsa kuti mawonekedwe a piritsi awoneke bwino. Makamaka pamapiritsi omwe si osavuta kupanga, omasuka kapena osavuta kuvumbulutsa, kuwonjezera L-HPC kumatha kusintha zotsatira zake. Piritsi la ciprofloxacin hydrochloride silili lolimba, losavuta kugawa komanso lomata, ndipo ndi losavuta kupanga mutawonjezera L-HPC, lokhala ndi kuuma koyenera, mawonekedwe okongola, komanso kuchuluka kwa kusungunuka komwe kumakwaniritsa zofunikira zamtundu. Pambuyo powonjezera L-HPC mu piritsi losungunuka, mawonekedwe ake, kusinthasintha, kufanana kwa kufalikira ndi zina zimawongoleredwa kwambiri. Pambuyo poti wowuma womwe uli mu mankhwala oyamba wasinthidwa ndi L-HPC, kuuma kwa piritsi losungunuka la azithromycin kunawonjezeka, kusinthasintha kunawonjezeka, ndipo mavuto a ngodya zosoweka ndi m'mphepete mwa piritsi loyambirira adathetsedwa. L-HPC imagwiritsidwa ntchito ngati chomangira mapiritsi, ndipo mlingo wonse ndi 5% mpaka 20%; pomwe H-HPC imagwiritsidwa ntchito ngati chomangira mapiritsi, tinthu tating'onoting'ono, ndi zina zotero, ndipo mlingo wonse ndi 1% mpaka 5% ya mankhwalawo.
3. Kugwiritsa ntchito mu utoto wa filimu ndi kukonzekera kotulutsidwa kosalekeza komanso kolamulidwa
Pakadali pano, zinthu zosungunuka m'madzi zomwe zimagwiritsidwa ntchito kwambiri popaka utoto wa filimu ndi monga hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) ndi zina zotero. Hydroxypropyl cellulose nthawi zambiri imagwiritsidwa ntchito ngati chopangira filimu mu zinthu zopangira utoto wa filimu chifukwa cha filimu yake yolimba, yotanuka komanso yonyezimira. Ngati hydroxypropyl cellulose ikasakanizidwa ndi zinthu zina zopaka utoto zomwe sizitentha, magwiridwe antchito a utoto wake amatha kuwongoleredwa kwambiri.
Pogwiritsa ntchito zinthu zoyenera zowonjezerera mankhwala ndi njira zopangira mankhwalawa kukhala mapiritsi a matrix, mapiritsi oyandama m'mimba, mapiritsi okhala ndi zigawo zambiri, mapiritsi okhala ndi zokutira, mapiritsi a osmotic pump ndi mapiritsi ena otulutsa pang'onopang'ono komanso molamulidwa, kufunika kwake kuli mu: kuwonjezera kuchuluka kwa kuyamwa kwa mankhwala ndikukhazikitsa mankhwala m'magazi. Kukhazikika, kuchepetsa zotsatira zoyipa, kuchepetsa kuchuluka kwa mankhwala, ndikuyesetsa kukulitsa mphamvu yochiritsa ndi mlingo wocheperako, ndikuchepetsa zotsatira zoyipa. Hydroxypropyl cellulose ndi imodzi mwa zinthu zazikulu zowonjezerera mankhwalawa. Kusungunuka ndi kutulutsidwa kwa mapiritsi a diclofenac sodium kumayendetsedwa pogwiritsa ntchito hydroxypropyl cellulose ndi ethyl cellulose ngati chinthu cholumikizira mafupa ndi mafupa. Pambuyo pomwa ndi kukhudzana ndi madzi am'mimba, pamwamba pa mapiritsi a diclofenac sodium otulutsidwa nthawi zonse amathiridwa madzi kukhala gel. Kudzera mu kusungunuka kwa gel ndi kufalikira kwa mamolekyulu a mankhwala mu gel gap, cholinga chotulutsa pang'onopang'ono mamolekyu a mankhwala chimakwaniritsidwa. Hydroxypropyl cellulose imagwiritsidwa ntchito ngati matrix yowongolera kutulutsidwa kwa piritsi, pamene kuchuluka kwa ethyl cellulose yoletsa kumakhala kokhazikika, kuchuluka kwake mu piritsi kumatsimikizira mwachindunji kuchuluka kwa kutulutsidwa kwa mankhwala, ndipo mankhwala ochokera mu piritsi yokhala ndi kuchuluka kwa hydroxypropyl cellulose Kutulutsidwa kumakhala kochedwa. Ma pellets ophimbidwa adakonzedwa pogwiritsa ntchitoL-HPCndi gawo lina la HPMC ngati njira yothetsera chophimba ngati gawo lotupa, komanso ngati gawo lowongolera lotulutsa utoto ndi ethyl cellulose aqueous dispersion. Pamene mankhwala ndi mlingo wa gawo lotupa zakhazikika, powongolera makulidwe a gawo lowongolera lotulutsa utoto, ma pellets ophimbidwa amatha kutulutsidwa nthawi zosiyanasiyana zomwe zimayembekezeredwa. Mitundu ingapo ya ma pellets ophimbidwa okhala ndi kulemera kosiyana kwa gawo lowongolera lotulutsa utoto amasakanizidwa kuti apange makapisozi otulutsidwa okhazikika a Shuxiong. Mu dissolving medium, ma pellets osiyanasiyana ophimbidwa amatha kumasula mankhwala motsatizana nthawi zosiyanasiyana, kotero kuti zigawo zomwe zili ndi mphamvu zosiyanasiyana zakuthupi ndi zamankhwala Kutulutsa kofanana kumachitika nthawi imodzi ndi kutulutsidwa kokhazikika.
Nthawi yotumizira: Epulo-25-2024