Selulose ya Hydroxypropyl, umuti ufasha mu by'imiti, ugabanyijemo hydroxypropyl cellulose (L-HPC) na hydroxypropyl cellulose (H-HPC) bitewe n'uko hydroxypropoxy yayo ingana. L-HPC yiyongera mu buryo bwa colloidal mu mazi, ifite imiterere yo gufatana, gukora firime, emulsification, nibindi, kandi ikoreshwa cyane cyane nk'ikintu gitandukanya no gufunga; mu gihe H-HPC ishongesha mu mazi no mu bintu bitandukanye by'umwimerere ku bushyuhe bw'icyumba, kandi ifite ubushobozi bwo gushonga neza, ifatanye neza kandi ikora firime, firime yakozwe ni ikomeye, irabagirana, kandi irareshya neza, kandi ikoreshwa cyane cyane nk'ibikoresho byo gukora firime no gusiga. Imikoreshereze yihariye ya hydroxypropyl cellulose mu gutegura ibintu bikomeye ubu iratangira.
1. Nk'ikintu kidakoreshwa mu gutegura ibintu bikomeye nk'ibinini
Ubuso bw'uduce duto twa hydroxypropyl cellulose crystalline dusimbuwe na gato ntabwo buringaniye, bufite imiterere isa n'iy'amabuye igaragara. Iyi miterere y'ubuso igoye ntabwo ituma gusa igira ubuso bunini, ahubwo no iyo ishyizwemo ikinini hamwe n'imiti n'ibindi bikoresho, imyenge myinshi n'imitsi ikora mu gice cy'imbere cy'ikinini, kugira ngo igice cy'imbere cy'ikinini gishobore kongera umuvuduko wo kwinjiza amazi kandi amazi yongere kubyimba.L-HPCnk'umuti ufasha mu gushonga bishobora gutuma ikinini gishonga vuba kikaba ifu imwe, kandi bikongera cyane uburyo ikinini gishonga, kigashonga neza kandi kikaboneka neza. Urugero, gukoresha L-HPC bishobora kwihutisha uburyo ibinini bya paracetamol, ibinini bya aspirine, na chlorpheniramine bishonga neza, kandi bikongera umuvuduko wo gushonga. Gushonga no gushonga kw'imiti idashonga neza nka ofloxacin hamwe na L-HPC nk'imiti ishonga byari byiza kurusha ibifite PVPP ihuza, CMC-Na ihuza na CMS-Na nk'imiti ishonga. Gukoresha L-HPC nk'imiti igabanya ubukana bw'ibinini biri muri capsules ni ingirakamaro mu gushonga kw'ibinini, byongera ubuso hagati y'umuti n'aho ushonga uturuka, bitera imbaraga zo gushonga k'umuti, kandi bikongera ubushobozi bwo gushonga. Imiti ikomeye isohoka vuba igaragazwa n'imiti ikomeye isohoka vuba kandi isohoka vuba, ifite ingaruka zo gushonga vuba, iboneka vuba, igabanuka ry'ubushyuhe bw'imiti mu muhogo no mu gifu, kandi byoroshye kuyifata no kuyikurikiza neza. hamwe n'izindi nyungu, ifite umwanya ukomeye mu rwego rwa farumasi. L-HPC yabaye imwe mu miti ikomeye ikoreshwa mu miti ikomeye isohoka vuba bitewe n'uko ifite ubushobozi bwo gushonga cyane, ubwiyongere bw'amazi, kwaguka, igihe gito cyo gufunga amazi, umuvuduko wayo wo kwinjiza amazi vuba, no kwinjiza amazi vuba. Ni imiti myiza isohoka vuba mu mitobe. Ibinini bya Paracetamol bisohoka vuba mu mitobe byateguwe hamwe na L-HPC nk'ibisohoka, kandi ibinini byasandaye vuba mu myaka ya za 20. L-HPC ikoreshwa nk'ibisohoka vuba mu binini, kandi ingano yabyo rusange ni 2% kugeza 10%, ahanini 5%.
2. Nk'igikoresho cyo gufunga imiti nk'ibinini n'udukoko
Imiterere ya L-HPC igoye kandi ituma igira ingaruka nziza kuri mozayike hamwe n'imiti n'uduce, ibyo byongera urugero rwo guhuza, kandi ikagira ubushobozi bwiza bwo gukanda. Iyo imaze gushyirwa mu binini, igaragaza ubukana n'ububengerane, bityo bikazamura ubwiza bw'isura y'ikinini. Cyane cyane ku binini bitoroshye gukora, birekuye cyangwa byoroshye kubigaragaza, kongeramo L-HPC bishobora kunoza ingaruka. Ikinini cya ciprofloxacin hydrochloride ntigikomeye cyane, cyoroshye gucikamo ibice no gufatana, kandi biroroshye kugishyiraho nyuma yo kongeramo L-HPC, gifite ubukana bukwiye, gisa neza, kandi igipimo cyo gusenyuka cyujuje ibisabwa by'ubuziranenge. Nyuma yo kongeramo L-HPC mu kinini gikwirakwira, imiterere yacyo, ubukana bwacyo, ubukana bwacyo n'ibindi bintu birarushaho kunozwa. Nyuma y'uko sitashi iri mu nyandiko ya mbere yasimbuwe na L-HPC, ubukana bwa azithromycin ikwirakwira bwariyongereye, ubukana bwacyo bwararushijeho kuba bwiza, kandi ibibazo byo kubura impande n'impande zacyo za mbere byarakemutse. L-HPC ikoreshwa nk'icyuma gifunga ibinini, kandi igipimo rusange ni 5% kugeza 20%; mu gihe H-HPC ikoreshwa nk'icyuma gifunga ibinini, utunyangingo, nibindi, naho igipimo rusange ni 1% kugeza 5% by'umuti.
3. Gukoresha mu gusiga firime no gutegura irekurwa ryayo mu buryo burambye kandi bugenzurwa
Muri iki gihe, ibikoresho bishongesha amazi bikunze gukoreshwa mu gusiga filime birimo hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) n'ibindi. Hydroxypropyl cellulose ikunze gukoreshwa nk'ikintu gitanga filime mu gusiga filime mbere yo kuvanga kubera filime yayo ikomeye, irabagirana kandi irabagirana. Iyo hydroxypropyl cellulose ivanze n'ibindi bikoresho bitanga filime birwanya ubushyuhe, imikorere y'igisiga cyayo ishobora kunozwa kurushaho.
Hakoreshejwe ibikoresho n'ubuhanga bukwiye bwo gukora umuti mu binini bya matrix, ibinini biremereye mu gifu, ibinini by'urwego rwinshi, ibinini bitwikiriye, ibinini bya osmotic pump n'ibindi binini birekura buhoro buhoro kandi bigategekwa, akamaro kabyo ni: kongera urugero rw'imiti ifata no gutuza umuti mu maraso. Kwishyira hamwe, kugabanya ingaruka mbi, kugabanya umubare w'imiti, no kwihatira kongera ingaruka nziza zo kuvura hakoreshejwe dose nto, no kugabanya ingaruka mbi. Hydroxypropyl cellulose ni kimwe mu bintu by'ingenzi bifasha muri iyo miti. Gushonga no kurekura ibinini bya diclofenac sodium bigenzurwa hakoreshejwe hydroxypropyl cellulose na ethyl cellulose nk'ibikoresho by'ingingo n'amagufwa. Nyuma yo kunywa no gukora ku mutobe w'igifu, ubuso bw'ibinini bya diclofenac sodium birekura buri gihe buzaba bunyujijwe muri gel. Binyuze mu gushonga kwa gel no gukwirakwira kwa molecules z'imiti mu cyuho cya gel, intego yo kurekura buhoro kwa molecules z'imiti iragerwaho. Hydroxypropyl cellulose ikoreshwa nk'igice cy'ingenzi cy'ikinini, iyo ingano ya ethyl cellulose irinda ihoraho, ingano yayo mu kinini ni yo igena neza ingano y'isohoka ry'ikinini, kandi umuti uva mu kinini gifite ingano nyinshi ya hydroxypropyl cellulose iragabanuka buhoro. Uduce twasizwe twakozwe hakoreshejweL-HPCn'igice runaka cya HPMC nk'igisubizo cyo gusiga nk'urwego rwo kubyimba, kandi nk'urwego rugenzurwa rwo gusiga hakoreshejwe ethyl cellulose aqueous dispersion. Iyo amabwiriza n'ingano y'urwego rwo kubyimba bihamye, binyuze mu kugenzura ubunini bw'urwego rwo kubyimba rugenzurwa, uduce dupfundikiye dushobora kurekurwa mu bihe bitandukanye byitezwe. Ubwoko butandukanye bw'uduce dupfundikiye dufite uburemere butandukanye bw'urwego rwo kubyimba rugenzurwa buravangwa kugira ngo hakorwe utubumbe twa Shuxiong dusubimbye kurekurwa. Mu buryo bwo gushonga, uduce dutandukanye dupfundikiye dushobora kurekura imiti mu bihe bitandukanye, kugira ngo ibice bifite imiterere itandukanye y'umubiri n'iya chimique bisohoke icyarimwe mu gihe kimwe no kurekurwa burundu.
Igihe cyo kohereza: 25 Mata 2024