Hydroxypropyl cellulose, chinhu chinobatsira mumishonga, chakakamurwa kuita hydroxypropyl cellulose (L-HPC) uye hydroxypropyl cellulose (H-HPC) zvichienderana nezviri mu hydroxypropoxy yayo inotsiva. L-HPC inokura kuita colloidal solution mumvura, ine hunhu hwekunamatira, kuumbwa kwefirimu, emulsification, nezvimwewo, uye inonyanya kushandiswa sechinhu chinoparadza uye chinosunga; nepo H-HPC ichinyungudika mumvura uye zvakasiyana-siyana zvinonyungudutsa patembiricha yemumba, uye ine thermoplasticity yakanaka. , kubatana uye hunhu hwekugadzira firimu, firimu rakaumbwa rakaoma, rinopenya, uye rinopfava zvakakwana, uye rinonyanya kushandiswa sechinhu chekugadzira firimu uye chinhu chekufukidza. Kushandiswa kwakananga kwehydroxypropyl cellulose mukugadzirira kwakasimba ikozvino kwatangwa.
1. Semushonga wekugadzirisa zvinhu zvakasimba zvakaita semapiritsi
Pamusoro pezvinhu zve hydroxypropyl cellulose crystalline particles zvisina kuenzana, zvine chimiro chakafanana nedombo chakatsvuka. Chimiro ichi chepamusoro chakakombama hachingoiti kuti chive nenzvimbo yakakura chete, asiwo kana chikamanikidzwa kuita piritsi pamwe chete nemishonga nezvimwe zvinhu zvinobatsira, maburi akawanda nema capillaries anoumbwa mukati mepiritsi, kuitira kuti mukati mepiritsi muwedzere mwero wekunwa kwemvura uye kunwa kwemvura kunowedzera kuzvimba.L-HPCSemushonga unobatsira mushonga unogona kuita kuti piritsi rikurumidze kupatsanuka kuita upfu hwakafanana, uye zvinovandudza zvakanyanya kuparara, kunyungudika uye kuwanikwa kwepiritsi. Semuenzaniso, kushandiswa kweL-HPC kunogona kukurumidzisa kuparara kwemapiritsi eparacetamol, mapiritsi easpirin, uye mapiritsi echlorpheniramine, uye kuwedzera mwero wekunyungudika. Kuparara nekunyungudika kwemishonga isinganyungudike zvakanyanya senge mapiritsi eofloxacin ane L-HPC semadimbu aive nani pane ane PVPP ine cross-linked, CMC-Na ine cross-linked uye CMS-Na semadimbu. Kushandisa L-HPC semushonga wemukati wemagranules ari mumacapsules kunobatsira pakupatsanuka kwemagranules, kunowedzera nzvimbo yekubata pakati pemushonga ne dissolving medium, kunokurudzira kunyungudika kwemushonga, uye kunovandudza kuwanikwa kwemishonga. Mishonga yakasimba inoburitswa nekukasika inomiririrwa nemishonga yakasimba inoputsika nekukasika uye mishonga yakasimba inoputsika nekukasika ine mhedzisiro inoputsika nekukasika, inoshanda nekukurumidza, inowanikwa zvakanyanya, inoderedza kutsamwiswa kwemushonga pagurokuro nemudumbu, uye iri nyore kutora uye ine kutevedzera kwakanaka. nezvimwe zvakanakira, zvichitora chinzvimbo chakakosha mumunda we pharmacy. L-HPC yave imwe yemishonga inonyanya kukosha yemishonga yakasimba inoputsika nekukasika nekuda kwesimba rayo re hydrophilicity, hygroscopicity, expansibility, short hysteresis time yekunyudza mvura, fast water absorption speed, uye fast watering water saturation. Ndiyo mishonga yakanaka yekuputsika nekukamwa. Mapiritsi eParacetamol anoputsika nekukamwa akagadzirwa neL-HPC seyakaputsika, uye mapiritsi akaputsika nekukasika mukati memakore ekuma20. L-HPC inoshandiswa seyakaputsika pamapiritsi, uye dosi yayo yese ndeye 2% kusvika 10%, kazhinji 5%.
2. Sechinhu chinosunga zvinhu zvakaita semapiritsi nemagranule
Maumbirwo asina kunaka eL-HPC anoitawo kuti ive nemhedzisiro yakakura yemosaic nemishonga nezvimedu, izvo zvinowedzera kubatana, uye ine mashandiro akanaka ekuumba. Mushure mekudzvanywa mumapiritsi, inoratidza kuomarara uye kupenya kwakanyanya, nokudaro ichivandudza kunaka kwechitarisiko chepiritsi. Kunyanya pamapiritsi asiri nyore kuumba, akasununguka kana ari nyore kuwana, kuwedzera L-HPC kunogona kuvandudza mhedzisiro. Piritsi re ciprofloxacin hydrochloride harina kusimba zvakanaka, riri nyore kupatsanura uye rinonamira, uye riri nyore kuumba mushure mekuwedzera L-HPC, nekuomarara kwakakodzera, chitarisiko chakanaka, uye mwero wekunyungudika unosangana nezvinodiwa zvemhando yepamusoro. Mushure mekuwedzera L-HPC mupiritsi rinonyungudika, chitarisiko chayo, kupfava, kufanana kwekupararira nezvimwe zvinhu zvinovandudzwa zvikuru uye zviri nani. Mushure mekunge starch mumishonga yekutanga yatsiviwa neL-HPC, kuomarara kwepiritsi rinonyungudika reazithromycin kwakawedzerwa, kupfava kwakagadziridzwa, uye matambudziko emakona asina kushaikwa uye mipendero yakaora yepiritsi rekutanga yakagadziriswa. L-HPC inoshandiswa sechinobatanidza mapiritsi, uye chiyero chemushonga chinobva pa5% kusvika 20%; nepo H-HPC ichishandiswa sechinobatanidza mapiritsi, granules, nezvimwewo, uye chiyero chemushonga chinobva pa1% kusvika 5% yemushonga wacho.
3. Kushandiswa mukupenda firimu uye kugadzirira kusunungurwa kwakasimba uye kwakadzorwa
Parizvino, zvinhu zvinonyungudika mumvura zvinonyanya kushandiswa mukupenda mafirimu zvinosanganisira hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) nezvimwewo. Hydroxypropyl cellulose inowanzo shandiswa semushonga wekugadzira mafirimu mukupenda mafirimu usati wasanganisa zvinhu nekuda kweganda rayo rakaoma, rinopfava uye rinopenya. Kana hydroxypropyl cellulose ikasanganiswa nezvimwe zvinhu zvinopenda kupisa, mashandiro ekupenda kwayo anogona kuvandudzwa zvakanyanya.
Kushandisa zvinhu zvinobatsira uye matekiniki akakodzera kugadzira mushonga uyu kuita mapiritsi e matrix, mapiritsi emudumbu anoyangarara, mapiritsi ane layer yakawanda, mapiritsi akaputirwa, mapiritsi e osmotic pump uye mamwe mapiritsi anononoka uye anodzorwa, kukosha kuri mu: kuwedzera mwero wekunyudzwa kwemushonga uye kudzikamisa mushonga muropa. Kuisa pfungwa pachinhu chimwe chete, kuderedza maitiro asina kunaka, kuderedza huwandu hwemishonga, uye kuedza kuwedzera mhedzisiro yekurapa ne dose diki, uye kuderedza maitiro asina kunaka. Hydroxypropyl cellulose ndeimwe yemishonga mikuru yemishonga yakadaro. Kunyungudika nekuburitswa kwe diclofenac sodium tablets kunodzorwa nekushandisa hydroxypropyl cellulose uye ethyl cellulose sechinhu chekubatana uye skeleton. Mushure mekunwa uye kusangana nemuto wemudumbu, pamusoro pemapiritsi e diclofenac sodium anosunungurwa kwenguva refu achanyungudutswa kuita gel. Kuburikidza nekunyungudika kwegel uye kupararira kwemamorekuru emushonga mugeji regel, chinangwa chekuburitswa zvishoma nezvishoma kwemamorekuru emushonga chinozadzikiswa. Hydroxypropyl cellulose inoshandiswa se "controlled-release matrix" yepiritsi, kana huwandu hwe ethyl cellulose mu blocker huchigara huripo, huwandu hwayo mupiritsi hunotarisa zvakananga huwandu hwekuburitswa kwemushonga, uye mushonga unobva mupiritsi rine huwandu hwakawanda hwe hydroxypropyl cellulose unoburitswa zvishoma nezvishoma. Mapellets akaputirwa akagadzirwa nekushandisaL-HPCuye chikamu chakati cheHPMC semhinduro yekuputira yekuvhara sechikamu chekuzvimba, uye sechikamu chekudzorwa-kusunungurwa chekuputira ne ethyl cellulose aqueous dispersion. Kana chirevo chechikamu chekuzvimba uye chiyero zvagadziriswa, nekudzora ukobvu hwechikamu chekusunungurwa chakadzorwa, mapellets akaputirwa anogona kuburitswa panguva dzakasiyana dzinotarisirwa. Mhando dzakasiyana dzemapellets akaputirwa ane huremu hwakasiyana hwechikamu chekusunungurwa chakadzorwa anosanganiswa kugadzira macapsules eShuxiong akagadziriswa. Munzvimbo yekunyungudika, mapellets akasiyana-siyana akaputirwa anogona kuburitsa mishonga yakatevedzana panguva dzakasiyana, kuitira kuti zvikamu zvine hunhu hwakasiyana hwemuviri nemakemikari Kuburitswa panguva imwe chete kunowanikwa panguva imwe chete nekusunungurwa kwenguva refu.
Nguva yekutumira: Kubvumbi-25-2024