Selulose Hydroxypropyl, ihe na-enye ọgwụ, kewara n'ime hydroxypropyl cellulose dị ala (L-HPC) na hydroxypropyl cellulose dị elu (H-HPC) dịka ọdịnaya nke hydroxypropyl cellulose nnọchi ya si dị. L-HPC na-agbaba n'ime mmiri, nwere ihe onwunwe nke njikọta, nhazi ihe nkiri, emulsification, wdg., a na-ejikwa ya dịka ihe na-agbawa agbawa na ihe na-ejikọ; ebe H-HPC na-agbaze na mmiri na ihe dị iche iche na-agbaze na ihe na-eme ka ihe dị ndụ dị n'ime ụlọ, ma nwee ezigbo thermoplasticity. , njikọta na ihe na-eme ka ihe nkiri dị, ihe nkiri ahụ siri ike, na-egbuke egbuke, ma na-agbanwe agbanwe kpamkpam, a na-ejikwa ya dị ka ihe na-eme ka ihe nkiri na ihe mkpuchi. Ugbu a, etinyere ngwa kpọmkwem nke hydroxypropyl cellulose na nkwadebe siri ike.
1. Dịka ihe na-agbaze ihe maka nkwadebe siri ike dịka mbadamba
Elu nke ihe ndị dị na kristal hydroxypropyl cellulose nke na-adịghị agbanwe agbanwe adịghị nhata, yana nhazi doro anya dị ka nkume. Ọdịdị elu a siri ike abụghị naanị na ọ na-eme ka elu ya buru ibu, kamakwa mgbe a na-etinye ya na mbadamba yana ọgwụ na ihe ndị ọzọ na-enyere aka, a na-emepụta ọtụtụ oghere na capillaries na isi mbadamba ahụ, nke mere na isi mbadamba ahụ nwere ike ime ka ọnụego nnabata mmiri dịkwuo elu ma nnabata mmiri na-eme ka ọzịza dịkwuo elu.L-HPCDịka ihe mgbakwunye nwere ike ime ka mbadamba ahụ gbawaa ngwa ngwa ka ọ bụrụ ntụ ntụ otu, ma melite nke ukwuu nke na-emebi, na-agbaze na bioavailability nke mbadamba ahụ. Dịka ọmụmaatụ, iji L-HPC nwere ike ime ka mbadamba paracetamol, mbadamba aspirin, na mbadamba chlorpheniramine gbasaa ngwa ngwa, ma melite ọnụego mgbaze. Mbelata na mgbasa nke ọgwụ ndị na-anaghị agbaze nke ọma dịka mbadamba ofloxacin nwere L-HPC dị ka ndị na-agbaze dị mma karịa ndị nwere PVPP jikọtara ọnụ, CMC-Na na CMS-Na jikọtara ọnụ dị ka ndị na-agbaze. Iji L-HPC dị ka ihe na-agbaze n'ime granules dị na capsules bara uru na mgbaze nke granules, na-eme ka mpaghara kọntaktị dị n'etiti ọgwụ ahụ na ihe na-agbaze dịkwuo elu, na-akwalite mgbaze nke ọgwụ ahụ, ma na-eme ka bioavailability dịkwuo mma. Ngwakọta siri ike nke a na-ewepụta ozugbo, nke a na-anọchi anya ya site na nkwadebe siri ike na-agbaze ngwa ngwa na nkwadebe siri ike na-agbaze ngwa ngwa, nwere mmetụta na-agbaze ngwa ngwa, dị elu na-enweta, belata iwe ọgwụ na esophagus na eriri afọ, ha dịkwa mma iji ma nwee ezi nrubeisi. yana uru ndị ọzọ, na-eburu ọnọdụ dị mkpa n'ọhịa ọgwụ. L-HPC aghọwo otu n'ime ihe ndị kacha mkpa maka nkwadebe siri ike ewepụtara ozugbo n'ihi ike hydrophilicity ya siri ike, hygroscopicity, ịgbatị, obere oge hysteresis maka nnabata mmiri, ọsọ nnabata mmiri ngwa ngwa, na afọ ojuju mmiri ngwa ngwa. Ọ bụ ihe na-agbaze zuru oke maka mbadamba ndị na-agbaze ọnụ. E ji L-HPC kwadebe mbadamba Paracetamol ndị na-agbaze ọnụ dị ka ihe na-agbaze, mbadamba ndị ahụ gbazekwara ngwa ngwa n'ime afọ 20. A na-eji L-HPC eme ihe dị ka ihe na-agbaze maka mbadamba, ọnụọgụ ya n'ozuzu ya bụ 2% ruo 10%, ọkachasị 5%.
2. Dịka ihe na-ejikọ ihe dị ka mbadamba na granules
Nhazi siri ike nke L-HPC na-emekwa ka o nwee mmetụta mosaic ka ukwuu site na ọgwụ na ihe ndị dị n'ime ya, nke na-eme ka ogo njikọ dịkwuo elu, ma nwee arụmọrụ mmachi mkpakọ. Mgbe etinyere ya na mbadamba, ọ na-egosi ike na nchacha karịa, si otú a na-eme ka ọdịdị mbadamba ahụ ka mma. Karịsịa maka mbadamba ndị na-adịghị mfe ịkpụ, ndị na-adịghị mfe ịkpụ ma ọ bụ ndị dị mfe ikpughe, itinye L-HPC nwere ike ime ka mmetụta ahụ ka mma. Mbadamba ciprofloxacin hydrochloride enweghị nkpakọ dị mma, ọ dị mfe ịgbawa ma rapara, ọ dịkwa mfe ịkpụ mgbe etinyere L-HPC, yana ike kwesịrị ekwesị, ọdịdị mara mma, na ọnụego mgbaze na-emezu ihe achọrọ maka ọkọlọtọ mma. Mgbe etinyere L-HPC na mbadamba a na-agbasa, ọdịdị ya, ịdị nro ya, nha anya mgbasa na akụkụ ndị ọzọ na-akawanye mma ma ka mma. Mgbe ejiri L-HPC dochie starch dị na ọgwụ mbụ ahụ, ike nke mbadamba azithromycin a na-agbasa mụbara, friability ka mma, a dokwara nsogbu nke nkuku na-efu na nsọtụ rere ure nke mbadamba mbụ ahụ. A na-eji L-HPC eme ihe dị ka ihe na-ejikọ mbadamba, usoro ọgwụgwọ izugbe bụ 5% ruo 20%; ebe a na-eji H-HPC eme ihe dị ka ihe na-ejikọ mbadamba, granules, wdg, na usoro ọgwụgwọ izugbe bụ 1% ruo 5% nke nkwadebe ahụ.
3. Itinye ya n'ime mkpuchi ihe nkiri na nkwadebe mwepụta na-aga n'ihu ma na-achịkwa
Ugbu a, ihe ndị a na-ejikarị eme ihe na mkpuchi ihe nkiri gụnyere hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) na ndị ọzọ. A na-ejikarị hydroxypropyl cellulose eme ihe dị ka ihe na-emepụta ihe nkiri na ihe mkpuchi ihe nkiri n'ihi na ihe nkiri ya siri ike, na-agbanwe agbanwe ma na-egbuke egbuke. Ọ bụrụ na agwakọta hydroxypropyl cellulose na ihe mkpuchi ndị ọzọ na-eguzogide okpomọkụ, arụmọrụ nke mkpuchi ya nwere ike ime ka ọ ka mma.
Site n'iji ihe mgbakwunye na usoro kwesịrị ekwesị mee ka ọgwụ ahụ bụrụ mbadamba matrix, mbadamba afọ na-ese n'elu mmiri, mbadamba ọtụtụ oyi akwa, mbadamba mkpuchi, mbadamba osmotic pump na mbadamba mwepụ ndị ọzọ na-adịghị nwayọ ma na-achịkwa, ihe dị mkpa dị na: ịbawanye ogo nke nnabata ọgwụ na ime ka ọgwụ ahụ guzosie ike n'ọbara. Ntinye uche, belata mmeghachi omume ọjọọ, belata ọnụọgụ ọgwụ, ma gbalịa ịbawanye mmetụta ọgwụgwọ site na obere dose, ma belata mmeghachi omume ọjọọ. Hydroxypropyl cellulose bụ otu n'ime ihe ndị bụ isi na-enye ọgwụ ndị dị otú ahụ. A na-achịkwa mgbasa na mwepụ nke mbadamba sodium diclofenac site na iji hydroxypropyl cellulose na ethyl cellulose dị ka ihe nkwonkwo na ọkpụkpụ. Mgbe a na-aṅụ ya n'ọnụ ma metụ ihe ọṅụṅụ afọ, elu nke mbadamba diclofenac sodium na-adịgide adịgide ga-agba mmiri n'ime gel. Site na mgbasa nke gel na mgbasa nke mkpụrụ ndụ ọgwụ na oghere gel, a na-emezu ebumnuche nke mwepụta nke mkpụrụ ndụ ọgwụ nwayọ. A na-eji Hydroxypropyl cellulose eme ihe dị ka ihe a na-achịkwa nke mbadamba ahụ, mgbe ihe dị na ethyl cellulose na-egbochi ya na-agbanwe agbanwe, ihe dị na mbadamba ahụ na-ekpebi kpọmkwem ọnụego mwepụta nke ọgwụ ahụ, ọgwụ sitere na mbadamba ahụ nwere ọdịnaya dị elu nke hydroxypropyl cellulose na-ebelatakwa nwayọ. A na-eji pellets ndị a kpuchiri ekpuchi.L-HPCna oke HPMC dị ka ihe ngwọta mkpuchi maka mkpuchi dị ka oyi akwa ọzịza, yana dị ka oyi akwa a na-achịkwa maka mkpuchi na mgbasa mmiri ethyl cellulose. Mgbe a na-edozi ndenye na usoro onunu ogwu ahụ, site na ijikwa ọkpụrụkpụ nke oyi akwa ntọhapụ a na-achịkwa, enwere ike ịhapụ pellets a kpuchiri ekpuchi n'oge dị iche iche a tụrụ anya ya. A na-agwakọta ọtụtụ pellets a kpuchiri ekpuchi nwere oke ibu dị iche iche nke oyi akwa ntọhapụ a na-achịkwa iji mee ka mkpụrụ Shuxiong na-adịgide adịgide. N'ime usoro mgbasa, pellets a kpuchiri ekpuchi dị iche iche nwere ike ịhapụ ọgwụ n'usoro n'oge dị iche iche, ka ihe ndị nwere ihe dị iche iche nwere anụ ahụ na kemịkalụ wee nweta ntọhapụ n'otu oge ahụ dị ka ntọhapụ na-adịgide adịgide.
Oge ozi: Eprel-25-2024