Hydroxypropyl cellulose, ib yam khoom siv tshuaj, muab faib ua cov hydroxypropyl cellulose uas tsis muaj roj ntau (L-HPC) thiab cov hydroxypropyl cellulose uas muaj roj ntau (H-HPC) raws li cov ntsiab lus ntawm nws cov hydroxypropoxy hloov pauv. L-HPC swells mus rau hauv cov kua colloidal hauv dej, muaj cov khoom ntawm kev nplaum, kev tsim zaj duab xis, emulsification, thiab lwm yam, thiab feem ntau yog siv ua tus neeg sawv cev thiab binder; thaum H-HPC yaj tau hauv dej thiab ntau yam organic solvents ntawm chav tsev kub, thiab muaj thermoplasticity zoo. , kev sib koom ua ke thiab cov khoom tsim zaj duab xis, zaj duab xis tsim yog tawv, ci, thiab elastic tag nrho, thiab feem ntau yog siv ua cov khoom tsim zaj duab xis thiab cov khoom siv txheej. Daim ntawv thov tshwj xeeb ntawm hydroxypropyl cellulose hauv kev npaj khoom khov tam sim no tau qhia.
1. Ua ib qho tshuaj disintegrant rau cov khoom npaj khov kho xws li cov ntsiav tshuaj
Qhov saum npoo ntawm cov khoom siv crystalline hydroxypropyl cellulose uas tsis muaj ntau yam hloov pauv tsis sib xws, nrog rau cov qauv zoo li pob zeb uas pom tseeb. Cov qauv saum npoo no tsis yog tsuas yog ua rau nws muaj thaj chaw loj dua xwb, tab sis kuj thaum nws raug nias rau hauv lub ntsiav tshuaj ua ke nrog cov tshuaj thiab lwm yam khoom siv, ntau lub qhov hws thiab cov hlab ntsha tau tsim nyob rau hauv lub plawv ntsiav tshuaj, yog li lub plawv ntsiav tshuaj tuaj yeem ua rau kom muaj kev nqus dej ntau ntxiv thiab kev nqus dej ua rau o. SivL-HPCUa ib qho tshuaj ntxiv tuaj yeem ua rau cov ntsiav tshuaj tawg sai sai rau hauv cov hmoov sib xws, thiab txhim kho qhov kev tawg, kev yaj thiab bioavailability ntawm cov ntsiav tshuaj. Piv txwv li, kev siv L-HPC tuaj yeem ua kom cov ntsiav tshuaj paracetamol, cov ntsiav tshuaj aspirin, thiab cov ntsiav tshuaj chlorpheniramine tawg sai dua, thiab txhim kho qhov nrawm ntawm kev yaj. Kev tawg thiab kev yaj ntawm cov tshuaj tsis yaj xws li cov ntsiav tshuaj ofloxacin nrog L-HPC ua cov tshuaj yaj zoo dua li cov uas muaj PVPP sib txuas, CMC-Na sib txuas thiab CMS-Na ua cov tshuaj yaj. Kev siv L-HPC ua cov tshuaj yaj sab hauv ntawm cov granules hauv cov tshuaj ntsiav muaj txiaj ntsig zoo rau kev tawg ntawm cov granules, ua rau thaj chaw sib cuag ntawm cov tshuaj thiab cov tshuaj yaj, txhawb kev yaj ntawm cov tshuaj, thiab txhim kho qhov bioavailability. Cov tshuaj khov kho uas tso tawm tam sim ntawd uas sawv cev los ntawm cov tshuaj khov kho uas yaj sai thiab cov tshuaj khov kho uas yaj sai muaj cov tshuaj khov kho uas yaj sai, yaj sai, ua haujlwm sai, muaj bioavailability siab, txo cov tshuaj khaus rau txoj hlab pas thiab txoj hnyuv, thiab yooj yim rau kev noj thiab muaj kev ua raws li txoj cai zoo. thiab lwm yam zoo, nyob hauv txoj haujlwm tseem ceeb hauv kev lag luam tshuaj. L-HPC tau dhau los ua ib qho ntawm cov khoom siv tseem ceeb tshaj plaws rau cov tshuaj khov kho uas tso tawm tam sim ntawd vim nws muaj zog hydrophilicity, hygroscopicity, expansibility, lub sijhawm luv luv rau kev nqus dej, kev nqus dej sai, thiab kev nqus dej sai. Nws yog ib qho tshuaj zoo tagnrho rau kev rhuav tshem cov ntsiav tshuaj hauv qhov ncauj. Cov ntsiav tshuaj Paracetamol uas yaj hauv qhov ncauj tau npaj nrog L-HPC ua cov tshuaj rhuav tshem, thiab cov ntsiav tshuaj tawg sai sai hauv 20s. L-HPC yog siv los ua cov tshuaj rhuav tshem rau cov ntsiav tshuaj, thiab nws cov koob tshuaj feem ntau yog 2% txog 10%, feem ntau yog 5%.
2. Ua ib qho binder rau kev npaj xws li cov ntsiav tshuaj thiab cov granules
Cov qauv ntxhib ntawm L-HPC kuj ua rau nws muaj cov nyhuv mosaic ntau dua nrog cov tshuaj thiab cov khoom me me, uas ua rau qib kev sib koom ua ke nce ntxiv, thiab muaj kev ua haujlwm zoo ntawm kev sib sau ua ke. Tom qab raug nias rau hauv cov ntsiav tshuaj, nws qhia tau tias muaj qhov nyuaj thiab ci ntsa iab dua, yog li txhim kho qhov zoo ntawm cov ntsiav tshuaj. Tshwj xeeb tshaj yog rau cov ntsiav tshuaj uas tsis yooj yim rau tsim, xoob lossis yooj yim rau kev nthuav tawm, ntxiv L-HPC tuaj yeem txhim kho cov nyhuv. Cov ntsiav tshuaj ciprofloxacin hydrochloride muaj qhov tsis zoo compressibility, yooj yim rau kev faib thiab nplaum, thiab nws yooj yim rau kev tsim tom qab ntxiv L-HPC, nrog rau qhov nyuaj tsim nyog, zoo nkauj tsos, thiab tus nqi yaj ua tau raws li cov qauv zoo. Tom qab ntxiv L-HPC rau hauv cov ntsiav tshuaj dispersible, nws cov tsos, friability, dispersion uniformity thiab lwm yam tau txhim kho thiab txhim kho zoo heev. Tom qab cov hmoov txhuv nplej siab hauv daim ntawv qhia thawj zaug tau hloov los ntawm L-HPC, qhov nyuaj ntawm cov ntsiav tshuaj azithromycin dispersible tau nce ntxiv, qhov friability tau txhim kho, thiab cov teeb meem ntawm cov ces kaum ploj thiab cov npoo lwj ntawm cov ntsiav tshuaj thawj zaug tau daws. L-HPC siv ua cov khoom siv khi rau cov ntsiav tshuaj, thiab qhov ntau npaum li cas yog 5% txog 20%; thaum H-HPC siv ua cov khoom siv khi rau cov ntsiav tshuaj, cov hmoov, thiab lwm yam, thiab qhov ntau npaum li cas yog 1% txog 5% ntawm cov tshuaj.
3. Daim ntawv thov rau hauv zaj duab xis txheej thiab kev npaj tso tawm tas mus li thiab tswj tau
Tam sim no, cov ntaub ntawv yaj hauv dej uas feem ntau siv rau hauv txheej zaj duab xis suav nrog hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) thiab lwm yam. Hydroxypropyl cellulose feem ntau siv los ua tus neeg sawv cev tsim zaj duab xis hauv cov ntaub ntawv ua ntej txheej zaj duab xis vim nws cov zaj duab xis tawv, ywj thiab ci. Yog tias hydroxypropyl cellulose sib xyaw nrog lwm cov neeg sawv cev tiv taus kub, kev ua haujlwm ntawm nws cov txheej tuaj yeem txhim kho ntxiv.
Siv cov khoom siv thiab cov txheej txheem tsim nyog los ua cov tshuaj rau hauv cov ntsiav tshuaj matrix, cov ntsiav tshuaj gastric floating, cov ntsiav tshuaj ntau txheej, cov ntsiav tshuaj coated, cov ntsiav tshuaj osmotic twj tso kua mis thiab lwm cov ntsiav tshuaj qeeb thiab tswj tau, qhov tseem ceeb yog: nce qib ntawm kev nqus tshuaj thiab ruaj khov cov tshuaj hauv cov ntshav. Kev sib sau ua ke, txo cov kev tsis zoo, txo cov tshuaj, thiab siv zog ua kom muaj txiaj ntsig zoo tshaj plaws nrog cov koob tshuaj tsawg tshaj plaws, thiab txo cov kev tsis zoo. Hydroxypropyl cellulose yog ib qho ntawm cov khoom siv tseem ceeb ntawm cov kev npaj no. Kev yaj thiab tso tawm ntawm diclofenac sodium ntsiav tshuaj raug tswj los ntawm kev siv hydroxypropyl cellulose thiab ethyl cellulose ua cov khoom sib koom ua ke thiab pob txha. Tom qab kev noj tshuaj thiab kev sib cuag nrog kua txiv gastric, qhov chaw ntawm diclofenac sodium cov ntsiav tshuaj tso tawm yuav raug hydrated rau hauv gel. Los ntawm kev yaj ntawm gel thiab kev sib kis ntawm cov tshuaj molecules hauv qhov sib txawv gel, lub hom phiaj ntawm kev tso tawm qeeb ntawm cov tshuaj molecules tau ua tiav. Hydroxypropyl cellulose yog siv ua lub matrix tswj-tso tawm ntawm lub ntsiav tshuaj, thaum cov ntsiab lus ntawm cov blocker ethyl cellulose yog qhov tsis tu ncua, nws cov ntsiab lus hauv lub ntsiav tshuaj ncaj qha txiav txim siab qhov kev tso tawm ntawm cov tshuaj, thiab cov tshuaj los ntawm lub ntsiav tshuaj nrog cov ntsiab lus siab dua ntawm hydroxypropyl cellulose Kev Tso Tawm qeeb dua. Cov pellets coated tau npaj los ntawm kev sivL-HPCthiab ib qho feem ntawm HPMC ua cov tshuaj pleev rau txheej ua txheej o, thiab ua txheej tswj-tso rau txheej nrog ethyl cellulose aqueous dispersion. Thaum cov txheej o thiab cov tshuaj tau kho, los ntawm kev tswj qhov tuab ntawm cov txheej tswj tso tawm, cov pellets coated tuaj yeem tso tawm ntawm ntau lub sijhawm xav tau. Ntau hom pellets coated nrog qhov hnyav sib txawv ntawm cov txheej tswj tso tawm tau sib xyaw ua ke los ua Shuxiong sustained-release capsules. Hauv cov khoom siv yaj, ntau yam pellets coated tuaj yeem tso cov tshuaj sib law liag ntawm ntau lub sijhawm, yog li cov khoom sib xyaw nrog cov khoom sib txawv ntawm lub cev thiab tshuaj lom neeg tib lub sijhawm tso tawm tau ua tiav tib lub sijhawm nrog kev tso tawm tas mus li.
Lub sijhawm tshaj tawm: Plaub Hlis-25-2024