Isithako Semithi
I-Hydroxypropyl methylcellulose (HPMC) imhlophe noma imhlophe njengobisi, ayinaphunga, ayinambitheki, iyimpuphu noma i-granule ene-fibrous, ukwehla kwesisindo lapho komiswa akudluli u-10%, incibilika emanzini abandayo kodwa hhayi emanzini ashisayo, kancane emanzini ashisayo Ukuvuvukala, ukugaya, nokwakha isixazululo se-colloidal esiqinile, esiba yisisombululo lapho sipholile, futhi siba yijeli uma sishiswa. I-HPMC ayincibiliki ku-ethanol, i-chloroform kanye ne-ether. Iyancibilika ku-solvent exubile ye-methanol kanye ne-methyl chloride. Iphinde incibilike ku-solvent exubile ye-acetone, i-methyl chloride kanye ne-isopropanol kanye nezinye izinyibilikisi eziphilayo. Isixazululo sayo samanzi singabekezelela usawoti (isixazululo sayo se-colloidal asibhujiswa usawoti), kanti i-pH yesisombululo samanzi esingu-1% ingu-6-8. Ifomula yama-molecule ye-HPMC yi-C8H15O8-(C10H18O6) -C815O, kanti isisindo sama-molecule esihlobene singaba ngu-86,000.
I-HPMC inokuncibilika kwamanzi okuhle kakhulu emanzini abandayo. Ingancibilika ibe yisisombululo esibonakalayo ngokuxutshwa kancane emanzini abandayo. Ngokuphambene nalokho, ayincibiliki emanzini ashisayo angaphezu kuka-60℃ futhi ingavuvukala kuphela. Iyi-non-ionic cellulose ether. Isixazululo sayo asinayo i-ionic charge, asihlangani nosawoti wensimbi noma ama-ionic organic compounds, futhi asisabeli nezinye izinto zokusetshenziswa ngesikhathi senqubo yokulungiselela; inezakhiwo eziqinile zokulwa nokungezwani komzimba, futhi ngokwanda kwezinga lokushintsha isakhiwo sama-molecule, imelana kakhulu nokungezwani komzimba futhi izinzile kakhulu; futhi ayisebenzi kahle ngokwe-metabolic. Njengomuthi wokwelapha, ayigaywa noma ayimuncwa. Ngakho-ke, ayinikezi amakhalori emithini nasekudleni. Ayinamakhalori aphansi, ayinawo usawoti, futhi ayinawo usawoti ezigulini ezinesifo sikashukela. Imithi nokudla okubangela ukungezwani komzimba kunokusebenza okuhlukile; izinzile kuma-acid nama-alkali, kodwa uma inani le-PH lidlula u-2~11 futhi lithintwa amazinga okushisa aphezulu noma inesikhathi eside sokugcina, i-viscosity yayo izoncipha; Isixazululo sayo samanzi singanikeza umsebenzi womphezulu, sibonisa ukucindezeleka okuphakathi kobuso kanye nokucindezeleka kokuxhumana; ine-emulsification ephumelelayo ohlelweni lwezigaba ezimbili, ingasetshenziswa njengesiqinisi esisebenzayo kanye ne-colloid evikelayo; isixazululo sayo samanzi sinezakhiwo ezinhle kakhulu zokwakha ifilimu, iyithebhulethi kanye nephilisi. Isembozo sefilimu esakhiwe yiyo sinezinzuzo zokungabi nombala nokuqina. Ukwengeza i-glycerin kungathuthukisa nokuqina kwayo.
Imikhiqizo ye-AnxinCel® HPMC ingathuthuka ngezimpawu ezilandelayo ku-Pharmaceutical Excipient:
Uma isincibilikile emanzini futhi iguquguquka nge-solvent, i-HPMC yenza ifilimu ecacile enamandla amakhulu okudonseka.
·Kuthuthukisa amandla okubopha.
·I-matrix ye-hydrophilic esetshenziswa kanye ne-HPMC hydrates ukudala ungqimba lwejeli, olulawula iphethini yokukhishwa kwemithi.
| Ibanga Elinconywayo: | Cela i-TDS |
| I-HPMC 60AX5 | Chofoza lapha |
| I-HPMC 60AX15 | Chofoza lapha |