Cellulose na Hydroxypropyl, wani sinadari na magunguna, an raba shi zuwa hydroxypropyl cellulose mai ƙarancin maye gurbinsa (L-HPC) da hydroxypropyl cellulose mai yawan maye gurbinsa (H-HPC) bisa ga abubuwan da ke cikin hydroxypropoxy mai maye gurbinsa. L-HPC yana kumbura zuwa maganin colloidal a cikin ruwa, yana da halayen mannewa, samuwar fim, emulsification, da sauransu, kuma galibi ana amfani da shi azaman wakili mai wargazawa da mannewa; yayin da H-HPC yana narkewa a cikin ruwa da sauran sinadarai na halitta daban-daban a zafin ɗaki, kuma yana da kyawawan halaye na thermoplasticity, haɗin kai da kuma halayen samar da fim, fim ɗin da aka samar yana da tauri, sheki, kuma cikakke mai laushi, kuma galibi ana amfani da shi azaman kayan samar da fim da kayan shafa. Yanzu an gabatar da takamaiman aikace-aikacen hydroxypropyl cellulose a cikin shirye-shirye masu ƙarfi.
1. A matsayin maganin wargaza magunguna masu ƙarfi kamar allunan magani
Fuskar ƙwayoyin crystalline masu ƙarancin maye gurbin hydroxypropyl cellulose ba ta daidaita ba, tare da tsari mai kama da dutse mai kama da yanayi. Wannan tsarin saman da ba shi da ƙarfi ba kawai yana sa ya sami babban yanki na saman ba, har ma lokacin da aka matse shi cikin kwamfutar hannu tare da magunguna da sauran abubuwan taimako, ana samun ramuka da capillaries da yawa a cikin ƙwayar kwamfutar hannu, ta yadda ƙwayar kwamfutar za ta iya ƙara yawan shan danshi kuma shan ruwa yana ƙara kumburi.L-HPCKamar yadda wani abu mai taimako zai iya sa kwamfutar ta wargaje cikin sauri zuwa foda iri ɗaya, kuma ta inganta wargajewa, wargajewa da kuma samuwar kwayar halitta sosai. Misali, amfani da L-HPC na iya hanzarta wargajewar allunan paracetamol, allunan aspirin, da allunan chlorpheniramine, da kuma inganta saurin wargajewa. Wargajewa da wargajewar magungunan da ba sa narkewa sosai kamar allunan ofloxacin tare da L-HPC a matsayin wargajewa sun fi waɗanda ke da PVPP mai haɗin gwiwa, CMC-Na da CMS-Na a matsayin wargajewa. Amfani da L-HPC a matsayin wargajewar a cikin allunan a cikin allunan yana da amfani ga wargajewar allunan, yana ƙara yankin hulɗa tsakanin maganin da hanyar wargajewa, yana haɓaka wargajewar maganin, kuma yana inganta samuwar bioavailability. Shirye-shiryen da aka saki nan take waɗanda aka wakilta ta hanyar shirye-shiryen da suka lalace cikin sauri da kuma shirye-shiryen da suka lalace cikin sauri suna da tasirin da ke wargazawa cikin sauri, suna narkewa cikin sauri, suna da tasirin da ke aiki cikin sauri, suna da yawan bioavailability, suna rage ƙaiƙayin magani ga esophagus da hanyoyin narkewa, kuma suna da sauƙin ɗauka kuma suna da kyakkyawan bin ƙa'idodi. da sauran fa'idodi, suna da matsayi mai mahimmanci a fannin kantin magani. L-HPC ya zama ɗaya daga cikin mahimman abubuwan da ke taimakawa wajen samar da shirye-shiryen da suka lalace cikin sauri saboda ƙarfin hydrophilicity, hygroscopicity, faɗaɗawa, ɗan gajeren lokacin hysteresis don sha ruwa, saurin sha ruwa cikin sauri, da kuma cikar ruwa cikin sauri. Yana da kyau a wargaza allunan da ke wargaza baki. An shirya allunan Paracetamol da ke wargaza baki tare da L-HPC a matsayin mai wargaza baki, kuma allunan sun wargaza cikin sauri cikin shekaru 20. Ana amfani da L-HPC a matsayin mai wargaza allunan, kuma yawan maganinsa gabaɗaya shine 2% zuwa 10%, galibi 5%.
2. A matsayin abin ɗaurewa don shirye-shirye kamar allunan da granules
Tsarin L-HPC mai tsauri kuma yana sa ya sami ƙarin tasirin mosaic tare da magunguna da barbashi, wanda ke ƙara matakin haɗin kai, kuma yana da kyakkyawan aikin matsewa. Bayan an matse shi cikin allunan, yana nuna ƙarin tauri da sheƙi, don haka yana inganta ingancin bayyanar allunan. Musamman ga allunan da ba su da sauƙin samarwa, sako-sako ko sauƙin buɗewa, ƙara L-HPC na iya inganta tasirin. Allunan ciprofloxacin hydrochloride ba su da ƙarancin matsewa, mai sauƙin rabawa da mannewa, kuma yana da sauƙin samarwa bayan ƙara L-HPC, tare da tauri mai dacewa, kyakkyawan bayyanar, kuma ƙimar narkewa ta cika buƙatun inganci. Bayan ƙara L-HPC a cikin allunan da ke warwatse, an inganta bayyanarsa, friability, daidaiton warwatsewa da sauran fannoni sosai. Bayan an maye gurbin sitaci a cikin takardar asali da L-HPC, an ƙara taurin azithromycin mai warwatsewa, an inganta friability, kuma an magance matsalolin ɓacewar kusurwoyi da gefuna na allunan asali. Ana amfani da L-HPC a matsayin abin ɗaurewa ga allunan, kuma yawan maganin gabaɗaya shine 5% zuwa 20%; yayin da ake amfani da H-HPC a matsayin abin ɗaurewa ga allunan, granules, da sauransu, kuma yawan maganin gabaɗaya shine 1% zuwa 5% na maganin.
3. A yi amfani da shi a cikin murfin fim da kuma shirye-shiryen fitarwa masu dorewa da kuma sarrafawa
A halin yanzu, kayan da ake amfani da su wajen shafa fim sun haɗa da hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) da sauransu. Ana amfani da Hydroxypropyl cellulose a matsayin wakili mai samar da fim a cikin kayan haɗa fim saboda fim ɗinsa mai tauri, mai laushi da sheƙi. Idan aka haɗa hydroxypropyl cellulose tare da wasu sinadarai masu jure zafin jiki, za a iya ƙara inganta aikin murfinsa.
Ta amfani da kayan taimako da dabarun da suka dace don yin maganin a cikin allunan matrix, allunan ciki masu iyo, allunan da ke da layuka da yawa, allunan da aka shafa, allunan famfo na osmotic da sauran allunan saki masu jinkiri da sarrafawa, mahimmancin ya ta'allaka ne a cikin: ƙara yawan shan magani da daidaita maganin a cikin jini. Mayar da hankali, rage mummunan sakamako, rage adadin magunguna, da kuma ƙoƙari don haɓaka tasirin magani da ƙaramin allurai, da rage mummunan sakamako. Hydroxypropyl cellulose yana ɗaya daga cikin manyan abubuwan da ke taimakawa irin waɗannan shirye-shiryen. Ana sarrafa narkar da sakin allunan sodium na diclofenac ta hanyar amfani da hydroxypropyl cellulose da ethyl cellulose a matsayin kayan haɗin gwiwa da kwarangwal. Bayan shan baki da kuma hulɗa da ruwan ciki, saman allunan diclofenac sodium masu dorewa za a jika su cikin gel. Ta hanyar wargaza gel ɗin da yaɗuwar ƙwayoyin magani a cikin gibin gel, manufar sakin a hankali na ƙwayoyin magani an cimma. Ana amfani da Hydroxypropyl cellulose a matsayin matrix mai sarrafawa-saki na kwamfutar hannu, lokacin da abun cikin ethyl cellulose mai toshewa ya kasance akai-akai, abun da ke cikin kwamfutar hannu kai tsaye yana ƙayyade ƙimar sakin maganin, kuma maganin daga kwamfutar hannu mai yawan abun ciki na hydroxypropyl cellulose Sakin yana da jinkiri. An shirya ƙwayoyin da aka rufe ta amfani da su.L-HPCda kuma wani kaso na HPMC a matsayin maganin shafawa don shafawa a matsayin Layer na kumburi, da kuma a matsayin Layer na sakin da aka sarrafa don shafawa da ethyl cellulose mai watsa ruwa. Lokacin da aka daidaita umarnin Layer na kumburi da kuma yawan da aka bayar, ta hanyar sarrafa kauri na Layer na sakin da aka sarrafa, ana iya sakin ƙwallayen da aka rufe a lokutan da ake tsammani daban-daban. Ana haɗa nau'ikan ƙwallaye da aka rufe da yawa tare da ƙarin nauyi daban-daban na Layer na sakin da aka sarrafa don yin ƙwayoyin Shuxiong mai dorewa. A cikin yanayin narkewa, ƙwallaye daban-daban masu rufi na iya sakin magunguna a jere a lokuta daban-daban, don haka abubuwan da ke da halaye daban-daban na jiki da sinadarai ana samun sakin lokaci guda a lokaci guda tare da sakin da ya ci gaba.
Lokacin Saƙo: Afrilu-25-2024