Te pūhui hauwaiporoporo, he mea tāpiri rongoā, kua wehea ki te hydroxypropyl cellulose iti-whakakapinga (L-HPC) me te hydroxypropyl cellulose teitei-whakakapinga (H-HPC) e ai ki te ihirangi o tōna hydroxypropoxy whakakapinga. Ka pupuhi te L-HPC hei otinga colloidal i roto i te wai, he āhuatanga piri, he hanganga kiriata, he emulsification, me ētahi atu, ā, e whakamahia ana hei kaihoko pakaru me te here; i te mea ka wairewa te H-HPC i roto i te wai me ngā whakarewa rauropi rerekē i te pāmahana rūma, ā, he pai te thermoplasticity. , he hononga me ngā āhuatanga hanga kiriata, he mārō, he kanapa, he tino ngāwari te kiriata kua hangaia, ā, e whakamahia ana hei rauemi hanga kiriata me te rauemi paninga. Kua whakaurua inaianei te tono motuhake o te hydroxypropyl cellulose i roto i ngā whakaritenga totoka.
1. Hei whakarewa mō ngā whakaritenga totoka pērā i ngā papa
He koretake te mata o ngā matūriki tioata hydroxypropyl cellulose iti-whakakapinga, ā, he hanganga toka kua pakaru te āhua. Nā tēnei hanganga mata taratara, ehara i te mea ka nui ake te horahanga o te mata, engari ina pēhia ki roto i te papa me ngā rongoā me ētahi atu mea tāpiri, ka hangaia he maha ngā pūwero me ngā uaua toto i roto i te pūtake o te papa, kia taea ai e te pūtake o te papa te whakanui ake i te tere mimiti makuku, ā, ka whakanui ake te mimiti wai i te pupuhi. Mā te whakamahi i teL-HPCHei tāpiri, ka taea e te papa te tere memeha hei paura ōrite, ā, ka tino whakapai ake i te memeha, te whakarewa me te waatea o te papa. Hei tauira, mā te whakamahi i te L-HPC ka tere ake te memeha o ngā papa paracetamol, ngā papa aspirin, me ngā papa chlorpheniramine, me te whakapai ake i te tere memeha. He pai ake te memeha me te memeha o ngā rongoā ngoikore te wairewa pērā i ngā papa ofloxacin me te L-HPC hei memeha i ērā he PVPP hono-whiti, he CMC-Na hono-whiti me te CMS-Na hei memeha. He pai te whakamahi i te L-HPC hei memeha ā-roto o ngā granules i roto i ngā capsules ki te memeha o ngā granules, ka whakanui ake i te horahanga mata pa i waenga i te rongoā me te reo memeha, ka whakatairanga i te memeha o te rongoā, ā, ka whakapai ake i te waatea o te koiora. Ko ngā whakaritenga totoka tuku-tonu e tohuhia ana e ngā whakaritenga totoka tere-meme me ngā whakaritenga totoka tere-meme he pānga tere-meme, tere-meme, tere-mahi, teitei te bioavailability, whakaiti i te riri o te rongoā ki te korokoro me te ara gastrointestinal, ā, he watea ki te tango me te pai o te piri. me ētahi atu painga, e noho ana i tētahi tūranga nui i roto i te mara o te rongoā. Kua riro te L-HPC hei tētahi o ngā excipients tino nui mō ngā whakaritenga totoka tuku-tonu nā te kaha o te wai, te hygroscopicity, te whānui, te wā hysteresis poto mō te mimiti wai, te tere mimiti wai tere, me te tere mimiti wai. He whakarewa pai mō ngā papa whakarewa-waha. I whakaritea ngā papa whakarewa-waha Paracetamol me te L-HPC hei whakarewa, ā, i tere te memeha o ngā papa i roto i te 20 hēkona. Ka whakamahia te L-HPC hei whakarewa mō ngā papa, ā, ko tōna horopeta whānui he 2% ki te 10%, ko te nuinga he 5%.
2. Hei here mō ngā whakaritenga pēnei i ngā papa me ngā granules
Nā te hanganga taratara o te L-HPC ka nui ake te pānga mosaic ki ngā rongoā me ngā matūriki, ka piki ake te taumata o te piripono, ā, he pai te mahi whakakōpeketanga. I muri i te pēhitanga ki roto i ngā papa, ka nui ake te pakeke me te kanapa, ā, ka pai ake te kounga o te āhua o te papa. Ina koa mō ngā papa kāore i te ngāwari ki te hanga, i te wetewete, i te ngāwari rānei ki te hura, ka taea e te tāpiri i te L-HPC te whakapai ake i te pānga. He ngoikore te pēhitanga o te papa ciprofloxacin hydrochloride, he ngāwari ki te wehe me te piri, ā, he ngāwari ki te hanga i muri i te tāpiri i te L-HPC, me te pakeke e tika ana, te āhua ataahua, ā, ka tutuki te tere whakarewanga i ngā whakaritenga paerewa kounga. I muri i te tāpiri i te L-HPC ki roto i te papa marara, ka tino pai ake tōna āhua, tōna ngawari ki te pakarukaru, tōna ōritetanga marara me ētahi atu āhuatanga. I muri i te whakakapinga o te māngaro i roto i te whakahaunga taketake ki te L-HPC, ka piki ake te pakeke o te papa marara azithromycin, ka pai ake te pakarukaru, ā, ka whakatauhia ngā raruraru o ngā kokonga ngaro me ngā taha pirau o te papa taketake. Ka whakamahia te L-HPC hei here mō ngā papa, ā, ko te horopeta whānui he 5% ki te 20%; ko te H-HPC ia e whakamahia ana hei here mō ngā papa, ngā kirikiri, me ētahi atu, ā, ko te horopeta whānui he 1% ki te 5% o te whakaritenga.
3. Te whakamahinga i roto i te paninga kiriata me ngā whakaritenga tukunga pumau me te whakahaere
I tēnei wā, ko ngā rauemi wairewa-wai e whakamahia whānuitia ana mō te paninga kiriata ko te hydroxypropylmethylcellulose (HPMC), te hydroxypropylcellulose, te polyethylene glycol (PEG) me ētahi atu. He maha ngā wā ka whakamahia te hydroxypropyl cellulose hei kaihanga kiriata i roto i ngā rauemi i mua i te whakaranu i te paninga kiriata nā te mea he pakari, he pīataata, he kanapa hoki tōna kiriata. Mēnā ka konatunatua te hydroxypropyl cellulose ki ētahi atu kaihoko paninga ātete-mahana, ka taea te whakapai ake i te mahi o tōna paninga.
Mā te whakamahi i ngā mea tāpiri me ngā tikanga tika hei hanga i te rongoā hei papa matrix, papa puku mānu, papa maha-paparanga, papa pania, papa papu osmotic me ētahi atu papa tuku puhoi me te whakahaere, ko te hiranga kei roto i: te whakanui ake i te taumata o te mimiti rongoā me te whakau i te rongoā ki roto i te toto. Te kukū, te whakaiti i ngā tauhohenga kino, te whakaiti i te maha o ngā rongoā, me te whai kia nui ake te pānga whakaora me te horopeta iti rawa, me te whakaiti i ngā tauhohenga kino. Ko te hydroxypropyl cellulose tētahi o ngā mea tāpiri matua o aua whakaritenga. Ka whakahaeretia te whakarewatanga me te tukunga o ngā papa diclofenac sodium mā te whakamahi i te hydroxypropyl cellulose me te ethyl cellulose hei rauemi hononga me te angaanga. I muri i te horopeta ā-waha me te pā ki te wai puku, ka whakamakukuhia te mata o ngā papa diclofenac sodium sustainable-release ki roto i te gel. Mā te whakarewatanga o te gel me te horapa o ngā ngota rongoā i roto i te āputa gel, ka tutuki te kaupapa o te tuku puhoi o ngā ngota rongoā. Ka whakamahia te hydroxypropyl cellulose hei pūnaha tukunga-whakahaere o te papa. Ina pumau te ihirangi o te aukati ethyl cellulose, ko tōna ihirangi i roto i te papa ka whakatau tika i te tere tukunga o te rongoā, ā, ka puhoi ake te tukunga o te rongoā mai i te papa he nui ake te ihirangi o te hydroxypropyl cellulose. I whakaritea ngā pire kua pania mā te whakamahi iL-HPCme tētahi wāhanga motuhake o te HPMC hei otinga paninga mō te paninga hei paparanga pupuhi, me te paparanga tukunga whakahaere mō te paninga ki te marara wai ethyl cellulose. Ina whakaritea te whakahaunga me te horopeta o te paparanga pupuhi, mā te whakahaere i te matotoru o te paparanga tukunga whakahaere, ka taea te tuku i ngā pirepire pania i ngā wā rerekē e tumanakohia ana. He maha ngā momo pirepire pania me te pikinga taumaha rerekē o te paparanga tukunga whakahaere ka whakaranua hei hanga i ngā kāpūre tukunga pumau Shuxiong. I roto i te reo whakarewa, ka taea e ngā pirepire pania te tuku i ngā rongoā i ngā wā rerekē, kia tutuki ai te tukunga kotahi i te wā kotahi me te tukunga pumau.
Wā tuku: Paenga-whāwhā-25-2024