I-Hydroxypropyl cellulose, isithako samayeza, sahlulwe saba yi-hydroxypropyl cellulose (L-HPC) engaphantsi komhlaba kunye ne-hydroxypropyl cellulose (H-HPC) engaphantsi komhlaba ngokuhambelana nomxholo we-hydroxypropoxy yayo engaphantsi komhlaba. I-L-HPC iyanda ibe yisisombululo se-colloidal emanzini, ineempawu zokunamathela, ukwakheka kwefilimu, i-emulsification, njl.njl., kwaye isetyenziswa kakhulu njenge-arhente yokuqhekeka kunye ne-binder; ngelixa i-H-HPC inyibilika emanzini nakwii-organic solvents ezahlukeneyo kubushushu begumbi, kwaye ine-thermoplasticity elungileyo. , ukuhambelana kunye neempawu zokwenza ifilimu, ifilimu eyenziweyo iqinile, iyakhazimla, kwaye ithambile ngokupheleleyo, kwaye isetyenziswa kakhulu njengezinto zokwenza ifilimu kunye nezinto zokugquma. Ukusetyenziswa okukhethekileyo kwe-hydroxypropyl cellulose kumalungiselelo aqinileyo ngoku kwaziswa.
1. Njengento engasebenziyo kwizithako eziqinileyo ezifana neepilisi
Umphezulu wee-hydroxypropyl cellulose crystalline particles ezifakwe endaweni ephantsi azilingani, zinesakhiwo esicacileyo esifana nelitye eligugileyo. Esi sakhiwo somphezulu orhabaxa asikwenzi nje kuphela ukuba ube nomphezulu omkhulu, kodwa naxa ucinezelwe kwithebhulethi kunye namayeza kunye nezinye izinto ezincedisayo, ii-pores ezininzi kunye nee-capillaries zenziwa kwi-tablet core, ukuze i-tablet core ikwazi ukwandisa izinga lokufunxwa komswakama kwaye ukufunxwa kwamanzi kwandisa ukudumba.I-L-HPCnjengesixhobo sokuncedisa ithebhulethi ingenza ithebhulethi iqhekeke ngokukhawuleza ibe ngumgubo ofanayo, kwaye iphucule kakhulu ukuqhekeka, ukunyibilika kunye nokufumaneka kwethebhulethi. Umzekelo, ukusetyenziswa kwe-L-HPC kunokukhawulezisa ukuqhekeka kweethebhulethi ze-paracetamol, iithebhulethi ze-aspirin, kunye neethebhulethi ze-chlorpheniramine, kwaye kuphucule izinga lokunyibilika. Ukuqhekeka kunye nokunyibilika kwamayeza anganyibilikiyo kakuhle afana neethebhulethi ze-ofloxacin ezine-L-HPC njengee-disintegrants bekungcono kunezo zine-PVPP edibeneyo, i-CMC-Na edibeneyo kunye ne-CMS-Na njengee-disintegrants. Ukusebenzisa i-L-HPC njenge-disintegrant yangaphakathi yeegranules kwiikhaphu kuluncedo ekuqhekekeni kweegranules, kwandisa indawo yokudibana phakathi kweziyobisi kunye nendawo yokunyibilika, kukhuthaza ukunyibilika kwamayeza, kwaye kuphucula ukufumaneka kwawo. Amalungiselelo aqinileyo akhutshwa ngokukhawuleza amelwe ngamalungiselelo aqinileyo aqhekekayo ngokukhawuleza kunye namalungiselelo aqinileyo aqhekekayo ngokukhawuleza anemiphumo ekhawulezayo, eqhekekayo ngokukhawuleza, esebenza ngokukhawuleza, i-bioavailability ephezulu, ukuncipha kokucaphuka kwamayeza kwi-esophagus nakwindlela yesisu, kwaye kulula ukuwathatha kwaye athobele imithetho emihle. kunye nezinye iingenelo, ezithatha indawo ebalulekileyo kwicandelo lekhemesti. I-L-HPC ibe yenye yezona zinto zibalulekileyo ezincedayo kumalungiselelo aqinileyo akhutshwa ngokukhawuleza ngenxa ye-hydrophilicity yayo enamandla, i-hygroscopicity, i-expansibility, ixesha elifutshane le-hysteresis lokufunxa amanzi, isantya sokufunxa amanzi ngokukhawuleza, kunye nokwanda kwamanzi ngokukhawuleza. Yinto efanelekileyo yokufunxa iipilisi eziqhekekayo ngomlomo. Iipilisi zeParacetamol eziqhekekayo ngomlomo zilungiselelwe nge-L-HPC njenge-disintegrant, kwaye iipilisi zaqhekeka ngokukhawuleza kwisithuba seminyaka engama-20. I-L-HPC isetyenziswa njenge-disintegrant yeepilisi, kwaye idosi yayo iyonke yi-2% ukuya kwi-10%, uninzi lwayo yi-5%.
2. Njengesixhobo sokubopha izinto ezifana neepilisi kunye neegranules
Isakhiwo esirhabaxa se-L-HPC sikwenza kube nefuthe elikhulu le-mosaic ngamayeza kunye namasuntswana, nto leyo enyusa izinga lokudibana, kwaye inokusebenza kakuhle kokubumbana koxinzelelo. Emva kokucinezelwa kwiipilisi, ibonisa ubunzima kunye nokukhazimla okungakumbi, ngaloo ndlela iphucula umgangatho wembonakalo yethebhulethi. Ingakumbi kwiipilisi ezingelulanga ukuzenza, ezikhululekileyo okanye ezilula ukuzityhila, ukongeza i-L-HPC kunokuphucula umphumo. Ithebhulethi ye-ciprofloxacin hydrochloride ayinakucinezeleka kakuhle, kulula ukuyiqhekeza kwaye inamathela, kwaye kulula ukuyenza emva kokongeza i-L-HPC, enobunzima obufanelekileyo, imbonakalo entle, kwaye izinga lokunyibilika lihlangabezana neemfuno ezisemgangathweni. Emva kokongeza i-L-HPC kwithebhulethi esasazekayo, imbonakalo yayo, ukuqhekeka kwayo, ukufana kokusasazeka kunye nezinye izinto ziphuculwe kakhulu kwaye ziphuculwe. Emva kokuba isitatshi kwiresiphi yokuqala sithatyathelwe indawo yi-L-HPC, ubunzima bethebhulethi esasazekayo ye-azithromycin banda, ukuqhekeka kwaphucuka, kwaye iingxaki zeekona ezilahlekileyo kunye nemiphetho ebolileyo yethebhulethi yokuqala zasonjululwa. I-L-HPC isetyenziswa njengesihlanganisi seetablethi, kwaye idosi ngokubanzi yi-5% ukuya kwi-20%; ngelixa i-H-HPC isetyenziswa njengesihlanganisi seetablethi, iigranules, njl.njl., kwaye idosi ngokubanzi yi-1% ukuya kwi-5% yokulungiselela.
3. Ukusetyenziswa kwi-coating yefilimu kunye namalungiselelo okukhululwa aqhubekayo nalawulwayo
Okwangoku, izinto ezinyibilikayo emanzini ezisetyenziswa kakhulu ekugqumeni ifilimu ziquka i-hydroxypropylmethylcellulose (HPMC), i-hydroxypropylcellulose, i-polyethylene glycol (PEG) njalo njalo. I-Hydroxypropyl cellulose idla ngokusetyenziswa njenge-arhente yokwenza ifilimu kwizixhobo zokuxuba ifilimu ngenxa yefilimu yayo eqinileyo, ethambileyo nekhazimlayo. Ukuba i-hydroxypropyl cellulose ixutywe nezinye izinto zokugcoba ezimelana nobushushu, ukusebenza kwengubo yayo kunokuphuculwa ngakumbi.
Ukusebenzisa izixhobo ezincedisayo kunye neendlela ezifanelekileyo zokwenza eli chiza libe ziipilisi ze-matrix, iipilisi ezintantayo zesisu, iipilisi ezinamaleko amaninzi, iipilisi ezigqunyiweyo, iipilisi ze-osmotic pump kunye nezinye iipilisi zokukhululwa kancinci nangokulawulwayo, ukubaluleka kukwi: ukwandisa izinga lokufunxwa kweziyobisi kunye nokuzinzisa ichiza egazini. Ukugxila, ukunciphisa iimpendulo ezimbi, ukunciphisa inani lamayeza, kunye nokuzama ukwandisa isiphumo sokunyanga ngedosi encinci, kunye nokunciphisa iimpendulo ezimbi. I-Hydroxypropyl cellulose yenye yezona zinto zincedayo kwezi ziyobisi. Ukunyibilika nokukhululwa kweethebhulethi ze-diclofenac sodium kulawulwa ngokusebenzisa i-hydroxypropyl cellulose kunye ne-ethyl cellulose njengento edibeneyo kunye ne-skeleton. Emva kokusetyenziswa ngomlomo kunye nokudibana nejusi yesisu, umphezulu weethebhulethi ze-diclofenac sodium ezikhutshwayo uya kumanziswa kwijeli. Ngokunyibilika kwejeli kunye nokusasazwa kweemolekyuli zamayeza kwisithuba sejeli, injongo yokukhululwa kancinci kweemolekyuli zamayeza iyafezekiswa. I-Hydroxypropyl cellulose isetyenziswa njenge-matrix elawulwayo yokukhululwa kwethebhulethi, xa umxholo we-blocker ethyl cellulose ungaguquki, umxholo wayo kwithebhulethi umisela ngokuthe ngqo izinga lokukhululwa kweyeza, kwaye iyeza elivela kwithebhulethi elinomxholo ophezulu we-hydroxypropyl cellulose Ukukhululwa kuhamba kancinci. Iipellets ezigqunyiweyo zilungiselelwe ngokusebenzisaI-L-HPCkunye nenxalenye ethile ye-HPMC njengesisombululo sokugquma sokugquma njengomaleko wokudumba, kunye nomaleko wokukhulula olawulwayo wokugquma nge-ethyl cellulose aqueous dispersion. Xa ireyithingi yomaleko wokudumba kunye nomthamo zilungisiwe, ngokulawula ubukhulu bomaleko wokukhulula olawulwayo, iipellets ezigqunyiweyo zinokukhutshwa ngamaxesha ahlukeneyo alindelekileyo. Iintlobo ezahlukeneyo zeepellets ezigqunyiweyo ezinobunzima obahlukeneyo bomaleko wokukhulula olawulwayo ziyaxutywa ukwenza iicapsules zeShuxiong eziqhutyelwe phambili. Kwindawo yokunyibilikisa, iipellets ezahlukeneyo ezigqunyiweyo zinokukhupha amayeza ngokulandelelana ngamaxesha ahlukeneyo, ukuze izinto ezineempawu ezahlukeneyo zomzimba nezekhemikhali Ukukhululwa ngaxeshanye kufezekiswe ngexesha elinye nokukhululwa okuqhubekayo.
Ixesha leposi: Epreli-25-2024