Isincedisi samayeza
I-Hydroxypropyl methylcellulose (HPMC) imhlophe okanye imhlophe njengobisi, ayinavumba, ayinancasa, ingumphunga okanye i-granule ene-fibrous, ukwehla kobunzima xa yomiswa akudluli kwi-10%, iyanyibilika emanzini abandayo kodwa hayi emanzini ashushu, kancinci emanzini ashushu Ukudumba, ukugcwala, nokwenza isisombululo se-colloidal esiqinileyo, esiba sisisombululo xa sipholile, kwaye sibe yijeli xa sishushu. I-HPMC ayinyibiliki kwi-ethanol, i-chloroform kunye ne-ether. Iyanyibilika kwi-solvent exutyiweyo ye-methanol kunye ne-methyl chloride. Ikwanyibilika kwi-solvent exutyiweyo ye-acetone, i-methyl chloride kunye ne-isopropanol kunye nezinye izinyibilikisi ze-organic. Isisombululo sayo samanzi sinokunyamezela ityuwa (isisombululo sayo se-colloidal asitshatyalaliswa yityuwa), kwaye i-pH yesisombululo samanzi esingu-1% yi-6-8. Ifomula ye-molecular ye-HPMC yi-C8H15O8-(C10H18O6) -C815O, kwaye ubunzima be-molecular obuhambelanayo bumalunga ne-86,000.
I-HPMC inokunyibilika kakuhle kwamanzi emanzini abandayo. Inganyibilika ibe sisisombululo esicacileyo ngokuxutywa kancinci emanzini abandayo. Ngokwahlukileyo koko, ayinyibiliki emanzini ashushu angaphezu kwama-60℃ kwaye inokudumba kuphela. Yi-non-ionic cellulose ether. Isisombululo sayo asinayo i-ionic charge, asidibani neetyuwa zesinyithi okanye ii-ionic organic compounds, kwaye asisabelani nezinye izinto eziluhlaza ngexesha lenkqubo yokulungiselela; ineempawu ezinamandla zokulwa ne-allergy, kwaye ngokwanda komlinganiselo wokutshintshwa kwisakhiwo se-molecular, iyamelana ngakumbi ne-allergies kwaye izinzile ngakumbi; ikwangena kwi-metabolically inert. Njengomxumi wamayeza, ayixutywanga okanye ayifunxwa. Ke ngoko, ayiboneleli ngeekhalori kumayeza nasekutyeni. Ayinazo iikhalori eziphantsi, ayinatyuwa, kwaye ayinatyuwa kwizigulane zeswekile. Amayeza kunye nokutya okubangela i-allergy kunokusetyenziswa okukhethekileyo; izinzile kwi-asidi kunye ne-alkalis, kodwa ukuba ixabiso le-PH lidlula i-2 ~ 11 kwaye ichatshazelwa ngamaqondo obushushu aphezulu okanye inexesha elide lokugcina, i-viscosity yayo iya kuncipha; Isisombululo sayo samanzi sinokubonelela ngomsebenzi womphezulu, sibonisa uxinzelelo oluphakathi lomphezulu kunye noxinzelelo oluphakathi; ine-emulsification esebenzayo kwinkqubo yezigaba ezibini, ingasetyenziswa njengesiqinisi esisebenzayo kunye ne-colloid ekhuselayo; isisombululo sayo samanzi sineempawu ezintle zokwenza ifilimu, sisixhobo esihle sokugquma ipilisi. Ugqumo lwefilimu olwenziwe yiyo luneengenelo zokungabi nombala kunye nokuqina. Ukongeza i-glycerin kunokuphucula ukuqina kwayo.
Iimveliso ze-AnxinCel® HPMC zingaphucuka ngezi mpawu zilandelayo kwi-Pharmaceutical Excipient:
·Xa sele inyibilika emanzini kwaye inyibilike ngesinyibilikisi, i-HPMC yenza ifilimu ecacileyo enamandla aphezulu okutsalwa.
·Yonyusa amandla okubopha.
·I-hydrophilic matrix esetyenziswa kunye ne-HPMC hydrates ukwenza umaleko wejeli, olawula ipateni yokukhululwa kwamayeza.
| Inqanaba elicetyiswayo: | Cela i-TDS |
| I-HPMC 60AX5 | Cofa apha |
| I-HPMC 60AX15 | Cofa apha |