Wothandizira Mankhwala
Hydroxypropyl methylcellulose (HPMC) ndi yoyera kapena yoyera ngati mkaka, yopanda fungo, yopanda kukoma, ufa kapena granule wa ulusi, kuchepetsa thupi pakuuma sikupitirira 10%, kumasungunuka m'madzi ozizira koma osati m'madzi otentha, pang'onopang'ono m'madzi otentha. Kutupa, kufalikira, ndikupanga yankho la colloidal lolimba, lomwe limakhala yankho likazizira, ndipo limakhala gel likatenthedwa. HPMC sisungunuka mu ethanol, chloroform ndi ether. Imasungunuka mu solvent yosakanikirana ya methanol ndi methyl chloride. Imasungunukanso mu solvent yosakanikirana ya acetone, methyl chloride ndi isopropanol ndi zina zosungunulira zachilengedwe. Yankho lake lamadzi limatha kupirira mchere (yankho lake la colloidal siliwonongedwa ndi mchere), ndipo pH ya yankho lamadzi la 1% ndi 6-8. Fomula ya molekyulu ya HPMC ndi C8H15O8-(C10H18O6) -C815O, ndipo kulemera kwa molekyulu ndi pafupifupi 86,000.
HPMC ili ndi madzi osungunuka bwino kwambiri m'madzi ozizira. Imatha kusungunuka kukhala yankho lowonekera bwino ndikusakaniza pang'ono m'madzi ozizira. M'malo mwake, siisungunuka m'madzi otentha opitilira 60℃ ndipo imatha kutupa kokha. Ndi ether ya cellulose yosakhala ionic. Yankho lake lilibe mphamvu ya ionic, siligwirizana ndi mchere wachitsulo kapena mankhwala a ionic organic, ndipo silichita ndi zinthu zina zopangira panthawi yokonzekera; lili ndi mphamvu zolimbana ndi ziwengo, ndipo chifukwa cha kuchuluka kwa kusintha kwa kapangidwe ka mamolekyu, limalimbana kwambiri ndi ziwengo komanso limakhazikika; komanso siligwira ntchito bwino. Monga chowonjezera cha mankhwala, silimasinthidwa kapena kuyamwa. Chifukwa chake, silipereka ma calories m'mankhwala ndi zakudya. Ndi otsika ma calories, alibe mchere, komanso alibe mchere kwa odwala matenda ashuga. Mankhwala ndi zakudya zomwe zimapangitsa kuti munthu asamavutike ndi ziwengo zimakhala ndi ntchito yapadera; ndi yokhazikika ku ma acid ndi alkalis, koma ngati PH yapitirira 2 ~ 11 ndipo imakhudzidwa ndi kutentha kwakukulu kapena nthawi yayitali yosungira, kukhuthala kwake kudzachepa; Yankho lake lamadzi limatha kupereka ntchito pamwamba, kusonyeza kupsinjika pang'ono pamwamba ndi kupsinjika kwa interfacial; lili ndi emulsification yothandiza mu dongosolo la magawo awiri, lingagwiritsidwe ntchito ngati stabilizer yothandiza komanso colloid yoteteza; Yankho lake lamadzi lili ndi mphamvu zabwino kwambiri zopangira filimu, ndi piritsi ndi piritsi. Chophimba cha filimu chomwe chimapangidwa ndi iyo chili ndi ubwino wosakhala ndi utoto komanso kulimba. Kuwonjezera glycerin kungathandizenso kusungunuka kwake.
Zogulitsa za AnxinCel® HPMC zimatha kusinthidwa ndi zinthu zotsatirazi mu Pharmaceutical Excipient:
· Ikasungunuka m'madzi ndikusungunuka kudzera mu zosungunulira, HPMC imapanga filimu yowonekera bwino yokhala ndi mphamvu yayikulu yogwira.
· Zimawonjezera mphamvu yomangirira.
·Hydrophilic matrix yomwe imagwiritsidwa ntchito limodzi ndi HPMC hydrates kuti ipange gel layer, yomwe imawongolera kapangidwe ka mankhwala.
| Giredi Yolimbikitsa: | Pemphani TDS |
| HPMC 60AX5 | Dinani apa |
| HPMC 60AX15 | Dinani apa |