I-Hydroxypropyl methylcellulose (Igama le-INN: Hypromellose), nayo eyenziwe lula njenge-hypromellose (i-hydroxypropyl methylcellulose, efingqiwe njengeI-HPMC), iyinhlobonhlobo yama-ether axubile e-cellulose angewona ama-ionic. Iyi-polymer ehlanganisiwe, engasebenzi, ene-viscoelastic evame ukusetshenziswa njenge-lubricant ku-ophthalmology, noma njenge-excipient noma i-excipient emithini yomlomo, futhi ivame ukutholakala emikhiqizweni eyahlukahlukene yezentengiselwano.
Njengesengezo sokudla, i-hypromellose ingadlala izindima ezilandelayo: i-emulsifier, i-thickener, i-suspending agent kanye ne-substitute ye-gelatin yezilwane. Ikhodi yayo (i-E-code) ku-Codex Alimentarius yi-E464.
Izakhiwo zamakhemikhali:
Umkhiqizo oqediwe wei-hydroxypropyl methylcelluloseiyimpuphu emhlophe noma i-white loose fibrous solid, futhi usayizi wezinhlayiya udlula ngesihlungo sama-mesh angu-80. Isilinganiso sokuqukethwe kwe-methoxyl nokuqukethwe kwe-hydroxypropyl komkhiqizo oqediwe sihlukile, futhi i-viscosity ihlukile, ngakho-ke iba izinhlobo ezahlukahlukene ezisebenza ngendlela ehlukile. Inezici zokuthi incibilike emanzini abandayo futhi ayincibiliki emanzini ashisayo afana ne-methyl cellulose, futhi ukuncibilika kwayo ezincibilikisini eziphilayo kudlula okwamanzi. Ingancibilika ku-methanol engamanzi kanye ne-ethanol, futhi ingancibilika kuma-hydrocarbon ane-chlorine njenge-dichloro methane, i-trichloroethane, kanye nezincibilikisini eziphilayo njenge-acetone, i-isopropanol, kanye ne-diacetone alcohol. Uma incibilika emanzini, izohlangana nama-molecule amanzi ukuze yakhe i-colloid. Izinzile ku-acid kanye ne-alkali, futhi ayithinteki ebangeni le-pH=2~12. I-Hypromellose, yize ingeyona ubuthi, iyavutha futhi isabela ngamandla nama-oxidizing agents.
Ukuqina kwemikhiqizo ye-HPMC kuyanda ngokwanda kokuhlushwa kanye nesisindo sama-molecule, futhi lapho izinga lokushisa likhuphuka, ukuqina kwalo kuqala ukwehla. Uma lifika ezingeni lokushisa elithile, ukuqina kwalo kuyakhuphuka ngokuzumayo futhi ukuphakama kwalo kuyanda. Isixazululo salo samanzi sizinzile ekushiseni kwegumbi, ngaphandle kokuthi singawohloka ngama-enzyme, futhi ukuqina kwalo okuvamile akunawo umonakalo. Linezici ezikhethekile zokuqina kokushisa, izici ezinhle zokwakha ifilimu kanye nomsebenzi wobuso.
Ukwenza:
Ngemva kokuba i-cellulose iphathwe nge-alkali, i-alkoxy anion ekhiqizwa yi-deprotonation yeqembu le-hydroxyl ingangeza i-propylene oxide ukukhiqiza i-hydroxypropyl cellulose ether; ingaphinde ihlangane ne-methyl chloride ukukhiqiza i-methyl cellulose ether. I-hydroxypropyl methylcellulose ikhiqizwa lapho kokubili ukusabela kwenziwa ngesikhathi esisodwa.
Ukusebenzisa:
Ukusetshenziswa kwe-hydroxypropyl methylcellulose kufana nokwezinye i-cellulose ethers. Isetshenziswa kakhulu njenge-dispersant, i-suspending agent, i-thickener, i-emulsifier, i-stabilizer kanye ne-adhesive emikhakheni eyahlukahlukene. Ingcono kunezinye i-cellulose ethers ngokuya ngokuncibilika, ukuhlakazeka, ukubonakala kanye nokumelana ne-enzyme.
Embonini yokudla neyokwelapha, isetshenziswa njengesithasiselo. Isetshenziswa njengesinamathelisi, isithambisi, isihlakazi, isiqeda ukubola, isiqinisi kanye nesithambisi. Ayinabo ubuthi, ayinawo umsoco, futhi ayinazo izinguquko ze-metabolic.
Ngaphezu kwalokho,I-HPMCinezinhlelo zokusebenza ku-polymerization ye-resin yokwenziwa, amakhemikhali kaphethroli, izinto zobumba, ukwenza iphepha, isikhumba, izimonyo, ukumboza, izinto zokwakha kanye namapuleti okunyathelisa azwela ukukhanya.
Isikhathi sokuthunyelwe: Ephreli-25-2024