I-Hydroxypropyl methylcellulose (igama le-INN: Hypromellose), ekwalula njenge-hypromellose (i-hydroxypropyl methylcellulose, efinyeziweyo njengeI-HPMC), luhlobo lwee-ethers ezixutyiweyo ze-cellulose ezingezizo i-ionic. Yi-polymer eyi-semi-synthetic, engasebenziyo, ene-viscoelastic esetyenziswa kakhulu njenge-lubricant kwi-ophthalmology, okanye njenge-excipient okanye i-excipient kwi-pharmaceuticals ezithethwa ngomlomo, kwaye ifumaneka rhoqo kwiimveliso ezahlukeneyo zorhwebo.
Njengesongezelelo sokutya, i-hypromellose inokudlala le ndima ilandelayo: i-emulsifier, i-thickener, i-suspending agent kunye ne-substitute ye-gelatin yezilwanyana. Ikhowudi yayo (i-E-code) kwi-Codex Alimentarius yi-E464.
Iimpawu zekhemikhali:
Imveliso egqityiweyo yei-hydroxypropyl methylcelluloseyipowder emhlophe okanye i-white loose fibrous solid, kwaye ubungakanani besuntswana budlula kwisihluzo se-80-mesh. Umlinganiselo womxholo we-methoxyl kumxholo we-hydroxypropyl wemveliso egqityiweyo wahlukile, kwaye i-viscosity yahlukile, ngoko ke iba ziintlobo ngeentlobo ezinemisebenzi eyahlukeneyo. Ineempawu zokunyibilika emanzini abandayo kwaye inganyibiliki emanzini ashushu afana ne-methyl cellulose, kwaye ukunyibilika kwayo kwi-organic solvents kudlula okwamanzi. Inganyibilika kwi-anhydrous methanol kunye ne-ethanol, kwaye inganyibilika nakwii-hydrocarbons ezine-chlorine ezifana ne-dichloro methane, i-trichloroethane, kunye ne-organic solvents ezifana ne-acetone, i-isopropanol, kunye ne-diacetone alcohol. Xa inyibilika emanzini, iya kudibana neemolekyuli zamanzi ukwenza i-colloid. Izinzile kwi-asidi kunye ne-alkali, kwaye ayichaphazeleki kuluhlu lwe-pH=2~12. I-Hypromellose, nangona ingenabungozi, iyatsha kwaye isabela ngamandla kwii-oxidizing agents.
Ubuninzi be-viscosity yeemveliso ze-HPMC buyanda ngokunyuka koxinzelelo kunye nobunzima be-molecular, kwaye xa ubushushu bunyuka, ubuninzi bayo buqala ukwehla. Xa ifikelela kubushushu obuthile, ubuninzi bayo bunyuka ngequbuliso kwaye ubude bayo buyanda. Isisombululo sayo samanzi sizinzile kubushushu begumbi, ngaphandle kokuba sinokuwohloka zii-enzymes, kwaye ubuninzi bayo abunanto yakwenza nokuwohloka. Ineempawu ezikhethekileyo zobushushu, iimpawu ezilungileyo zokwenza ifilimu kunye nomsebenzi womphezulu.
Ukwenza:
Emva kokuba i-cellulose iphathwe nge-alkali, i-alkoxy anion eveliswa kukususwa kweprotonation yeqela le-hydroxyl inokongeza i-propylene oxide ukuvelisa i-hydroxypropyl cellulose ether; ingakwazi nokuxinana ne-methyl chloride ukuvelisa i-methyl cellulose ether. I-Hydroxypropyl methylcellulose iveliswa xa zombini ii-reaction zenziwa ngaxeshanye.
Ukusebenzisa:
Ukusetyenziswa kwe-hydroxypropyl methylcellulose kufana nokwezinye ii-ether ze-cellulose. Isetyenziswa kakhulu njenge-dispersant, i-suspending agent, i-thickener, i-emulsifier, i-stabilizer kunye ne-adhesive kwiinkalo ezahlukeneyo. Ingcono kunezinye ii-ether ze-cellulose ngokubhekiselele ekunyibilikeni, ekusasazeka, ekukhanyeni nasekuchaseni ii-enzyme.
Kwishishini lokutya nelamayeza, isetyenziswa njengesongezelelo. Isetyenziswa njenge-glue, i-thickener, i-dispersant, i-Emollient, i-stabilizer kunye ne-emulsifier. Ayinatyhefu, ayinaxabiso lesondlo, kwaye ayinatshintsho kwi-metabolic.
Ukwengeza,I-HPMCIsetyenziswa kwi-synthetic resin polymerization, ii-petrochemicals, ii-ceramics, ukwenza iphepha, isikhumba, izinto zokuthambisa, ii-coating, izixhobo zokwakha kunye neepleyiti zokuprinta ezibuthathaka.
Ixesha leposi: Epreli-25-2024