Hauv kev sim thiab kev tsim khoom ntau ntawm cov ntsiav tshuaj nifedipine uas tso tawm tas mus li, cov ntsiav tshuaj tiv thaiv kev xeeb tub, cov ntsiav tshuaj stomachicangning, cov ntsiav tshuaj ferrous fumarate, cov ntsiav tshuaj buflomedil hydrochloride, thiab lwm yam, peb sivHydroxypropyl methylcellulose (HPMC)kua, Hydroxypropyl methylcellulose thiab polyacrylic acid resin kua, Opadry (muab los ntawm Colorcon, UK), thiab lwm yam yog cov kua txheej zaj duab xis, uas tau ua tiav siv cov txheej txheem txheej zaj duab xis, tab sis tau ntsib teeb meem hauv kev sim thiab kev tsim khoom. Tom qab qee qhov teeb meem kev siv tshuab, tam sim no peb tab tom sib txuas lus nrog cov npoj yaig txog cov teeb meem thiab kev daws teeb meem hauv cov txheej txheem txheej zaj duab xis.
Nyob rau xyoo tas los no, cov txheej txheem txheej zaj duab xis tau siv dav hauv kev npaj khoom khov. Cov txheej txheej zaj duab xis tuaj yeem tiv thaiv cov tshuaj ntawm lub teeb, dej noo thiab huab cua kom ua rau cov tshuaj ruaj khov; npog cov saj tsis zoo ntawm cov tshuaj thiab pab tus neeg mob noj nws; tswj qhov chaw tso tawm thiab qhov ceev ntawm cov tshuaj; tiv thaiv kev hloov pauv ntawm cov tshuaj; txhim kho qhov tsos ntawm cov ntsiav tshuaj Tos. Nws kuj muaj qhov zoo ntawm cov txheej txheem tsawg dua, lub sijhawm luv dua, kev siv hluav taws xob tsawg dua, thiab qhov hnyav ntawm cov ntsiav tshuaj tsawg dua. Qhov zoo ntawm cov ntsiav tshuaj txheej zaj duab xis feem ntau nyob ntawm cov khoom xyaw thiab qhov zoo ntawm lub hauv paus ntsiav tshuaj, kev sau ntawv ntawm cov kua txheej, cov xwm txheej ua haujlwm ntawm cov txheej, cov xwm txheej ntim khoom thiab khaws cia, thiab lwm yam. Cov khoom xyaw thiab qhov zoo ntawm lub hauv paus ntsiav tshuaj feem ntau pom hauv cov khoom xyaw nquag ntawm lub hauv paus ntsiav tshuaj, ntau yam khoom siv thiab qhov tsos, qhov nyuaj, cov khoom tawg, thiab cov duab ntawm lub hauv paus ntsiav tshuaj. Cov qauv ntawm cov kua txheej feem ntau muaj cov polymers molecular siab, cov yas ua kom zoo nkauj, cov xim, cov kuab tshuaj, thiab lwm yam, thiab cov xwm txheej ua haujlwm ntawm cov txheej yog qhov sib npaug ntawm kev txau thiab ziab thiab cov khoom siv txheej.
1. Ib sab puas, zaj duab xis ntug tawg thiab tev tawv
Qhov tawv ntawm qhov saum npoo ntawm sab saum toj ntawm lub plawv ntsiav tshuaj yog qhov me tshaj plaws, thiab nws yooj yim raug kev sib txhuam thiab kev ntxhov siab thaum lub sijhawm txheej txheem, thiab ib sab hmoov lossis cov khoom me me poob tawm, ua rau muaj cov pob lossis qhov hws ntawm qhov saum npoo ntawm lub plawv ntsiav tshuaj, uas yog ib sab hnav, tshwj xeeb tshaj yog nrog cov yeeb yaj kiab cim kos. Qhov tsis muaj zog tshaj plaws ntawm cov yeeb yaj kiab hauv cov ntsiav tshuaj txheej yog cov ces kaum. Thaum qhov kev nplaum lossis lub zog ntawm cov yeeb yaj kiab tsis txaus, qhov tawg thiab tev ntawm cov npoo ntawm cov yeeb yaj kiab yuav tshwm sim. Qhov no yog vim tias qhov volatilization ntawm cov kuab tshuaj ua rau cov yeeb yaj kiab ntsws, thiab qhov nthuav dav ntau dhau ntawm cov yeeb yaj kiab txheej thiab lub plawv ua rau muaj kev ntxhov siab sab hauv ntawm cov yeeb yaj kiab, uas tshaj qhov muaj zog tensile ntawm cov yeeb yaj kiab txheej.
1.1 Kev tshuaj xyuas cov laj thawj tseem ceeb
Raws li qhov xwm txheej ntawm lub hauv paus chip, qhov laj thawj tseem ceeb yog tias qhov zoo ntawm lub hauv paus chip tsis zoo, thiab qhov nyuaj thiab brittleness me me. Thaum lub sijhawm txheej txheem, lub hauv paus ntsiav tshuaj raug kev sib txhuam muaj zog thaum dov hauv lub lauj kaub txheej, thiab nws nyuaj rau tiv taus lub zog zoo li no yam tsis muaj qhov nyuaj txaus, uas yog cuam tshuam nrog kev tsim thiab kev npaj ntawm lub hauv paus ntsiav tshuaj. Thaum peb ntim nifedipine cov ntsiav tshuaj tso tawm, vim qhov nyuaj me me ntawm lub hauv paus ntsiav tshuaj, hmoov tshwm sim ntawm ib sab, ua rau muaj qhov hws, thiab cov zaj duab xis ntsiav tshuaj txheej tsis du thiab muaj qhov tsis zoo. Tsis tas li ntawd, qhov tsis zoo ntawm txheej no kuj cuam tshuam nrog hom ntsiav tshuaj. Yog tias zaj duab xis tsis xis nyob, tshwj xeeb tshaj yog tias zaj duab xis muaj lub logo ntawm lub kaus mom, nws yooj yim dua rau ib sab hnav.
Thaum lub sijhawm ua haujlwm txheej, kev txau qeeb dhau thiab cua nkag ntau lossis qhov kub ntawm huab cua nkag siab yuav ua rau kom qhuav sai, cov txheej txheem tsim cov tub ntxhais ntsiav tshuaj qeeb, lub sijhawm ua haujlwm ntev ntawm cov tub ntxhais ntsiav tshuaj hauv lub lauj kaub txheej, thiab lub sijhawm hnav ntev. Qhov thib ob, lub zog atomization loj, qhov viscosity ntawm cov kua txheej yog qis, cov tee dej hauv qhov chaw atomization tau sib sau ua ke, thiab cov kuab tshuaj volatilizes tom qab cov tee dej kis mus, ua rau muaj kev ntxhov siab sab hauv loj; tib lub sijhawm, kev sib txhuam ntawm ib sab ntawm cov nto kuj ua rau muaj kev ntxhov siab sab hauv ntawm zaj duab xis thiab ua kom cov zaj duab xis nrawm dua. Cov npoo tawg.
Tsis tas li ntawd xwb, yog tias qhov kev sib hloov ceev ntawm lub lauj kaub txheej ceev dhau lossis qhov chaw teeb tsa baffle tsis tsim nyog, lub zog sib txhuam ntawm lub ntsiav tshuaj yuav loj, yog li cov kua txheej yuav tsis kis tau zoo, thiab cov zaj duab xis tsim yuav qeeb, uas yuav ua rau ib sab hnav.
Los ntawm cov kua txheej, nws yog vim muaj kev xaiv ntawm polymer hauv cov qauv thiab qhov tsis tshua muaj viscosity (concentration) ntawm cov kua txheej, thiab qhov tsis zoo ntawm cov zaj duab xis txheej thiab lub hauv paus ntsiav tshuaj.
1.2 Kev daws teeb meem
Ib qho yog kho cov txheej txheem sau tshuaj lossis cov txheej txheem tsim khoom ntawm cov ntsiav tshuaj kom txhim kho qhov nyuaj ntawm cov ntsiav tshuaj. HPMC yog cov khoom siv txheej txheem uas siv ntau. Qhov sib txuas ntawm cov tshuaj ntsiav tshuaj yog cuam tshuam nrog cov pab pawg hydroxyl ntawm cov tshuaj ntxiv, thiab cov pab pawg hydroxyl tsim cov hydrogen bonds nrog cov pab pawg sib xws ntawm HPMC kom tsim cov nplaum siab dua; Qhov sib txuas tsis muaj zog, thiab ib sab thiab zaj duab xis txheej feem ntau sib cais. Tus lej ntawm cov pab pawg hydroxyl ntawm cov saw molecular ntawm microcrystalline cellulose yog siab, thiab nws muaj lub zog nplaum siab, thiab cov ntsiav tshuaj npaj los ntawm lactose thiab lwm yam suab thaj muaj lub zog nplaum nruab nrab. Kev siv cov roj nplua nyeem, tshwj xeeb tshaj yog cov roj nplua nyeem hydrophobic xws li stearic acid, magnesium stearate, thiab glyceryl stearate, yuav txo qhov sib txuas hydrogen ntawm cov ntsiav tshuaj thiab cov polymer hauv cov tshuaj txheej txheem, ua rau qhov sib txuas Lub zog txo qis, thiab nrog kev nce ntawm lubricity, lub zog nplaum maj mam tsis muaj zog. Feem ntau, qhov ntau ntawm cov roj nplua nyeem, qhov ntau ntawm qhov sib txuas tsis muaj zog. Tsis tas li ntawd xwb, thaum xaiv hom ntsiav tshuaj, hom ntsiav tshuaj puag ncig biconvex yuav tsum tau siv kom deb li deb tau rau kev txheej, uas tuaj yeem txo qhov tshwm sim ntawm cov qhov tsis zoo ntawm txheej.
Qhov thib ob yog kho qhov kev sau ntawm cov kua txheej, nce cov khoom khov hauv cov kua txheej lossis qhov viscosity ntawm cov kua txheej, thiab txhim kho lub zog thiab kev nplaum ntawm cov zaj duab xis txheej, uas yog ib txoj hauv kev yooj yim los daws qhov teeb meem. Feem ntau, cov khoom khov hauv cov txheej txheem txheej dej yog 12%, thiab cov khoom khov hauv cov txheej txheem organic solvent yog 5% txog 8%.
Qhov sib txawv ntawm viscosity ntawm cov kua txheej cuam tshuam rau qhov ceev thiab qib ntawm kev nkag mus rau hauv lub plawv ntawm cov ntsiav tshuaj. Thaum muaj me ntsis lossis tsis muaj kev nkag mus, qhov kev nplaum yog qis heev. Qhov viscosity ntawm cov kua txheej thiab cov khoom ntawm cov zaj duab xis txheej muaj feem cuam tshuam nrog qhov nruab nrab molecular hnyav ntawm cov polymer hauv cov qauv. Qhov siab dua qhov nruab nrab molecular hnyav, qhov ntau dua qhov nyuaj ntawm cov zaj duab xis txheej, qhov tsawg dua elasticity thiab kev tiv thaiv hnav. Piv txwv li, HPMC muaj nyob hauv khw muaj cov qib viscosity sib txawv rau kev xaiv vim qhov sib txawv ntawm qhov nruab nrab molecular hnyav. Ntxiv nrog rau qhov cuam tshuam ntawm cov polymer, ntxiv cov yas lossis nce cov ntsiab lus ntawm talc tuaj yeem txo qhov tshwm sim ntawm cov zaj duab xis ntug tawg, tab sis kev ntxiv cov xim hlau oxide thiab titanium dioxide kuj tuaj yeem cuam tshuam rau lub zog ntawm cov zaj duab xis txheej, yog li nws yuav tsum tau siv rau hauv kev ntsuas.
Qhov thib peb, thaum lub sijhawm ua haujlwm txheej, nws yog qhov tsim nyog los nce qhov ceev ntawm kev txau, tshwj xeeb tshaj yog thaum pib txheej thawj zaug, qhov ceev ntawm kev txau yuav tsum sai dua me ntsis, kom lub plawv ntawm lub ntsiav tshuaj tau npog nrog ib txheej zaj duab xis hauv lub sijhawm luv luv, uas ua lub luag haujlwm tiv thaiv lub plawv ntawm lub ntsiav tshuaj. Kev nce qhov nrawm ntawm kev txau kuj tseem tuaj yeem txo qhov kub ntawm lub txaj, qhov nrawm ntawm kev ua pa thiab qhov kub ntawm zaj duab xis, txo qhov kev ntxhov siab sab hauv, thiab tseem txo qhov tshwm sim ntawm zaj duab xis tawg. Tib lub sijhawm, kho qhov ceev ntawm lub lauj kaub txheej mus rau qhov zoo tshaj plaws, thiab teeb tsa lub baffle kom tsim nyog kom txo qhov kev sib txhuam thiab hnav.
2. Kev nplaum thiab kev ua kom tawg
Thaum lub sijhawm txheej, thaum qhov sib txuas ntawm ob daim ntau dua li lub zog sib cais molecular, ntau daim (ntau yam khoom me me) yuav sib txuas luv luv thiab tom qab ntawd sib cais. Thaum qhov sib npaug ntawm kev tsuag thiab ziab tsis zoo, zaj duab xis ntub dhau, zaj duab xis yuav lo rau ntawm phab ntsa ntawm lub lauj kaub lossis lo rau ib leeg, tab sis kuj ua rau zaj duab xis tawg ntawm qhov chaw lo; Hauv kev tsuag, thaum cov tee dej tsis qhuav tag, cov tee dej tsis tawg yuav nyob hauv zaj duab xis txheej hauv zos, muaj cov npuas me me, tsim cov txheej txheej npuas, yog li daim ntawv txheej tshwm sim npuas.
2.1 Kev tshuaj xyuas cov laj thawj tseem ceeb
Qhov dav thiab qhov tshwm sim ntawm qhov tsis zoo ntawm cov txheej no feem ntau yog vim cov xwm txheej ua haujlwm ntawm cov txheej, qhov tsis sib npaug ntawm kev tsuag thiab kev ziab. Qhov ceev ntawm kev tsuag sai dhau lossis qhov ntim ntawm cov pa roj atomized loj dhau. Qhov ceev ntawm kev ziab qeeb dhau vim qhov ntim cua nkag qis lossis qhov kub ntawm huab cua nkag qis thiab qhov kub ntawm lub txaj ntawv qis. Daim ntawv tsis qhuav txheej los ntawm txheej hauv lub sijhawm thiab cov nplaum lossis npuas tshwm sim. Tsis tas li ntawd, vim lub kaum sab xis lossis qhov deb tsis raug ntawm kev tsuag, lub khob uas tsim los ntawm kev tsuag yog me me, thiab cov kua txheej tau sib sau ua ke hauv ib cheeb tsam, ua rau muaj dej noo hauv zos, ua rau muaj kev nplaum. Muaj lub lauj kaub txheej qeeb qeeb, lub zog centrifugal me dhau, zaj duab xis dov tsis zoo kuj tseem yuav tsim cov nplaum.
Qhov viscosity ntawm cov kua pleev xim loj dhau kuj yog ib qho ntawm cov laj thawj. Qhov viscosity ntawm cov kua khaub ncaws loj heev, yooj yim rau kev tsim cov pos huab loj dua, nws lub peev xwm nkag mus rau hauv lub plawv tsis zoo, ntau dua ib sab sib sau ua ke thiab lo rau, tib lub sijhawm, qhov ceev ntawm zaj duab xis tsis zoo, ntau npuas. Tab sis qhov no tsis muaj ntau yam cuam tshuam rau kev lo rau ib ntus.
Tsis tas li ntawd xwb, hom zaj duab xis tsis zoo kuj yuav tshwm sim lo rau. Yog tias zaj duab xis tiaj tiaj hauv lub lauj kaub txheej dov tsis zoo, yuav sib tshooj ua ke, nws yooj yim ua rau muaj ob lossis ntau txheej zaj duab xis. Hauv peb qhov kev sim tsim cov ntsiav tshuaj buflomedil hydrochloride, ntau daim sib tshooj tau tshwm sim hauv lub lauj kaub txheej dej txiv ntseej vim yog lub txheej tiaj tiaj.
2.2 Cov Kev Daws Teeb Meem
Feem ntau yog kho qhov ceev ntawm kev tsuag thiab ziab kom ua tiav qhov sib npaug ntawm lub zog. Txo qhov ceev ntawm kev tsuag, nce qhov ntim ntawm huab cua nkag thiab qhov kub ntawm huab cua, nce qhov kub ntawm lub txaj thiab qhov ceev ntawm kev ziab. Ua kom thaj chaw npog ntawm kev tsuag, txo qhov nruab nrab ntawm cov khoom me me ntawm cov tee dej tsuag lossis kho qhov deb ntawm rab phom tsuag thiab lub txaj ntawv, kom qhov tshwm sim ntawm kev lo rau ib ntus txo qis nrog kev hloov kho qhov deb ntawm rab phom tsuag thiab lub txaj ntawv.
Kho cov tshuaj pleev xim, nce cov khoom khov hauv cov tshuaj pleev xim, txo cov kuab tshuaj lossis nce qhov concentration ntawm ethanol kom haum rau qhov ntau ntawm viscosity; Cov tshuaj tiv thaiv nplaum kuj tseem tuaj yeem ntxiv kom haum, xws li hmoov talcum, magnesium stearate, silica gel hmoov lossis oxide peptide. Tuaj yeem txhim kho qhov ceev ntawm lub lauj kaub pleev xim, ua rau lub zog centrifugal ntawm lub txaj nce ntxiv.
Xaiv cov ntawv txheej uas tsim nyog. Txawm li cas los xij, rau cov ntawv tiaj tiaj, xws li cov ntsiav tshuaj buflomedil hydrochloride, cov txheej tau ua tiav tom qab los ntawm kev siv lub lauj kaub txheej zoo lossis los ntawm kev teeb tsa lub baffle hauv lub lauj kaub txheej ib txwm kom txhawb kev dov ntawm daim ntawv.
3. Ib sab tawv nqaij ntxhib thiab ntsws
Thaum lub sijhawm txheej, vim tias cov kua txheej tsis nthuav dav zoo, cov polymer qhuav tsis tawg, cov khoom tsis sib xws lossis lo rau ntawm qhov chaw ntawm zaj duab xis, ua rau xim tsis zoo thiab tsis sib xws. Cov tawv nqaij ntsws yog ib hom nto ntxhib, yog qhov pom tsis meej heev.
3.1 Kev tshuaj xyuas cov laj thawj tseem ceeb
Thawj qhov yog hais txog lub hauv paus ntawm lub chip. Qhov loj dua qhov roughness ntawm qhov chaw pib ntawm lub hauv paus, qhov loj dua qhov roughness ntawm cov khoom coated yuav.
Qhov thib ob, nws muaj kev sib raug zoo heev nrog cov tshuaj pleev xim. Feem ntau ntseeg tias qhov hnyav molecular, concentration thiab cov khoom ntxiv ntawm cov polymer hauv cov tshuaj pleev xim muaj feem cuam tshuam rau qhov roughness ntawm cov zaj duab xis txheej. Lawv ua haujlwm los ntawm kev cuam tshuam rau qhov viscosity ntawm cov tshuaj pleev xim, thiab qhov roughness ntawm cov zaj duab xis txheej yog yuav luag linear nrog rau viscosity ntawm cov tshuaj pleev xim, nce nrog rau qhov nce ntawm viscosity. Cov khoom khov ntau dhau hauv cov tshuaj pleev xim tuaj yeem ua rau ib sab coarsening.
Thaum kawg, nws muaj feem cuam tshuam rau kev ua haujlwm ntawm txheej. Qhov ceev ntawm atomization qis dhau los yog siab dhau (qhov cuam tshuam ntawm atomization tsis zoo), uas tsis txaus los nthuav cov dej pos huab thiab tsim ib sab ntawm daim tawv nqaij uas muaj qhov ntxhib. Thiab qhov ntim ntau dhau ntawm huab cua qhuav (cov pa tawm loj dhau) lossis kub dhau, ua kom cov dej noo sai, tshwj xeeb tshaj yog cov cua ntws loj dhau, tsim cov dej ntws eddy, kuj ua rau cov dej ntws tsis zoo.
3.2 Cov Kev Daws Teeb Meem
Thawj qhov yog los txhim kho qhov zoo ntawm lub hauv paus. Raws li lub hauv paus ntawm kev ua kom zoo ntawm lub hauv paus, kho cov tshuaj pleev xim thiab txo qhov viscosity (concentration) lossis cov khoom khov ntawm cov tshuaj pleev xim. Koj tuaj yeem xaiv cov tshuaj pleev xim uas yaj tau hauv cawv lossis cawv-2-dej. Tom qab ntawd kho cov xwm txheej ua haujlwm, txhim kho qhov ceev ntawm lub lauj kaub pleev xim kom zoo, ua kom zaj duab xis dov sib npaug, ua kom muaj kev sib txhuam ntau ntxiv, txhawb kev sib kis ntawm cov kua pleev xim. Yog tias qhov kub ntawm lub txaj siab, txo qhov ntim cua nkag thiab qhov kub ntawm huab cua nkag. Yog tias muaj laj thawj txau, yuav tsum nce lub zog atomization kom nrawm dua, thiab yuav tsum txhim kho qib atomization thiab qhov ntim txau kom cov pos huab nthuav dav rau ntawm daim ntawv, kom tsim cov pos huab nrog lub cheeb me dua thiab tiv thaiv kev tshwm sim ntawm cov pos huab loj, tshwj xeeb tshaj yog rau cov kua pleev xim nrog viscosity loj. Qhov deb ntawm rab phom txau thiab lub txaj ntawv kuj tuaj yeem hloov kho. Xaiv rab phom txau nrog lub taub me me (015 mm ~ 1.2 mm) thiab tus nqi ntws siab ntawm cov pa atomizing. Cov duab tsuag tau kho kom haum rau ntau yam ntawm lub khob tiaj tiaj lub kaum sab xis pos huab ntws, yog li cov tee dej tau tawg mus rau hauv thaj chaw loj dua.
4. Txheeb xyuas tus choj
4.1 Kev tshuaj xyuas cov laj thawj tseem ceeb
Qhov no tshwm sim thaum lub ntsej muag ntawm zaj duab xis yog cim lossis cim. Vim tias daim ntaub ntawm cov khaub ncaws muaj cov yam ntxwv tsim nyog, xws li cov coefficient elasticity siab, lub zog zaj duab xis tsis zoo, kev nplaum tsis zoo, thiab lwm yam., thaum lub sijhawm ziab khaub ncaws, daim ntaub ntawm cov khaub ncaws yuav rub rov qab siab, los ntawm kev luam tawm ntawm daim ntaub ntawm cov khaub ncaws, daim ntaub rub rov qab thiab txuas ntxiv tshwm sim, ua rau ib sab ntawm daim ntaub ploj lossis lub logo tsis meej, yog vim li cas rau qhov xwm txheej no nyob rau hauv cov kua dej txheej.
4.2 Kev daws teeb meem
Kho qhov kev sau tshuaj ntawm cov tshuaj pleev xim. Siv cov polymers uas tsis muaj molecular hnyav lossis cov khoom siv ua zaj duab xis uas lo rau siab; Ua kom cov kuab tshuaj ntau ntxiv, txo qhov viscosity ntawm cov tshuaj pleev xim; Ua kom cov yas ntau ntxiv, txo qhov kev ntxhov siab sab hauv. Cov nyhuv yas sib txawv txawv, polyethylene glycol 200 zoo dua li propylene glycol, glycerin. Kuj tseem tuaj yeem txo qhov ceev ntawm kev txau. Ua kom qhov kub ntawm huab cua nkag, ua kom qhov kub ntawm lub txaj ntawv nce, kom cov txheej txheej tsim muaj zog, tab sis kom tiv thaiv kev tawg ntawm ntug. Tsis tas li ntawd, thaum tsim cov pwm cim, peb yuav tsum tau them sai sai rau qhov dav ntawm lub kaum sab xis txiav thiab lwm qhov me me, kom deb li deb tau kom tiv thaiv qhov tshwm sim ntawm tus choj.
5. Cov khaub ncaws membrane chromatism
5.1 Kev tshuaj xyuas cov laj thawj tseem ceeb
Hauv ntau cov tshuaj pleev xim muaj cov xim lossis cov xim zas uas tau dai rau hauv cov tshuaj pleev xim thiab vim yog kev ua haujlwm tsis zoo ntawm cov xim, cov xim faib tsis sib xws thiab qhov sib txawv ntawm cov xim tau tsim ntawm cov hlais lossis hauv ntau qhov sib txawv ntawm cov hlais. Qhov laj thawj tseem ceeb yog tias qhov ceev ntawm lub lauj kaub pleev xim qeeb dhau lossis qhov sib xyaw ua haujlwm tsis zoo, thiab cov nyhuv pleev xim tsis tuaj yeem ua tiav ntawm cov khoom hauv lub sijhawm pleev xim ib txwm; Qhov concentration ntawm cov xim lossis cov xim zas hauv cov kua pleev xim siab dhau lossis cov khoom khov siab dhau, lossis qhov ceev ntawm cov kua pleev xim ceev dhau, qhov kub ntawm lub txaj siab dhau, yog li cov kua pleev xim tsis dov tawm raws sijhawm; Kev nplaum ntawm zaj duab xis kuj tuaj yeem ua rau; Cov duab ntawm daim tsis haum, xws li daim ntev, daim zoo li lub tshuaj ntsiav, vim yog dov ua daim puag ncig, kuj tseem yuav ua rau muaj qhov sib txawv ntawm cov xim.
5.2 Kev daws teeb meem
Ua kom lub lauj kaub txheej ceev dua lossis tus lej ntawm lub baffle, kho kom haum rau lub xeev tsim nyog, kom daim ntawv hauv lub lauj kaub dov sib npaug. Txo qhov ceev ntawm cov kua txau txheej, txo qhov kub ntawm lub txaj. Hauv kev tsim cov tshuaj pleev xim, yuav tsum txo cov koob tshuaj lossis cov khoom khov ntawm cov xim lossis cov xim zas, thiab yuav tsum xaiv cov xim uas muaj zog npog. Cov xim lossis cov xim zas yuav tsum mos thiab cov khoom me me. Cov xim zas uas tsis yaj hauv dej zoo dua li cov xim zas uas yaj hauv dej, cov xim zas uas tsis yaj hauv dej tsis yooj yim ya mus nrog dej li cov xim zas uas yaj hauv dej, thiab ntxoov ntxoo, ruaj khov thiab txo cov pa dej, oxidation ntawm qhov permeability ntawm zaj duab xis kuj zoo dua li cov xim zas uas yaj hauv dej. Tsis tas li ntawd, xaiv hom daim tsim nyog. Hauv cov txheej txheem ntawm cov txheej zaj duab xis, feem ntau muaj ntau yam teeb meem, tab sis tsis hais hom teeb meem dab tsi, muaj ntau yam, tuaj yeem daws tau los ntawm kev txhim kho qhov zoo ntawm lub hauv paus, kho cov tshuaj pleev thiab kev ua haujlwm, kom ua tiav kev siv tau yooj yim thiab kev ua haujlwm sib txawv. Nrog kev paub txog cov txheej txheem txheej, kev txhim kho thiab kev siv cov tshuab txheej tshiab thiab cov ntaub ntawv txheej zaj duab xis, cov txheej txheem txheej yuav zoo dua qub, thiab cov txheej zaj duab xis kuj tseem yuav tau txais kev txhim kho sai hauv kev tsim cov khoom npaj khov.
Lub sijhawm tshaj tawm: Plaub Hlis-25-2024