I-Hydroxypropyl methylcellulose (HPMC)isetshenziswa njengenye yezinto ezinkulu kakhulu ezisiza ekhemisi ekhaya nakwamanye amazwe. I-HPMC ingasetshenziswa njenge-ejenti yokwakha ifilimu, i-glue, i-ejenti yokukhulula eqhubekayo, i-suspension agent, i-emulsifier, i-ejenti yokuqhekeka, njll.
Izinto ezisetshenziswa emithi ziyingxenye ebalulekile yokulungiselela imithi, futhi indima yazo ukuqinisekisa ukuthi imithi ithuthwa ngokukhetha iye ezicutshini ngendlela ethile nangenqubo ethile, ukuze imithi ikhishwe emzimbeni ngesivinini nesikhathi esithile. Ngakho-ke, ukukhethwa kwezinto ezisetshenziswa emithi kungenye yezinto ezibalulekile zomphumela wokwelapha wezinto ezisetshenziswa emithi.
1 Izakhiwo ze-HPMC
I-HPMC inezici eziningi ezingenazo ezinye izinto ezisizayo. Inomswakama omuhle kakhulu emanzini abandayo. Uma nje ifakwa emanzini abandayo futhi ivuselelwa kancane, ingancibilika ibe yisisombululo esibonakalayo. Ngokuphambene nalokho, ayincibiliki emanzini ashisayo angaphezu kuka-60E futhi ingancibilika kuphela. Iyi-non-ionic cellulose ether, isisombululo sayo asinayo i-ionic charge, kanye nosawoti wensimbi noma ama-ionic organic compounds, ukuze kuqinisekiswe ukuthi i-HPMC ayisabelani nezinye izinto zokusetshenziswa enqubweni yokukhiqiza yokulungiselela. Ngokumelana okunamandla, kanye nokwanda kwesakhiwo sama-molecule sezinga lokufakwa esikhundleni, ukulwa nokuzwela nakho kuyathuthukiswa, kusetshenziswa i-HPMC njengemithi yokusiza, uma kuqhathaniswa nokusetshenziswa kwezinye izidakamizwa zendabuko (isitashi, i-dextrin, i-sugar powder), ikhwalithi yesikhathi esisebenzayo izinzile kakhulu. Ine-metabolic inertia. Njengezinto ezisizayo zemithi, ayikwazi ukugaywa noma ukumuncwa, ngakho ayinikezi amakhalori kwezokwelapha nasekudleni. Isebenza ngendlela ehlukile enani eliphansi lama-calorie, imithi engenasawoti futhi engenazo izinto ezibangela ukungezwani komzimba kanye nokudla okudingwa abantu abanesifo sikashukela. I-HPMC izinzile kakhulu kuma-asidi nama-alkali, kodwa uma idlula i-pH2 ~ 11 futhi ibekwe ezingeni lokushisa eliphakeme noma isikhathi sokugcina isikhathi eside, i-viscosity izoncishiswa. Isixazululo samanzi sinikeza umsebenzi wobuso futhi sinikeza ukucindezelwa kobuso okumaphakathi kanye namanani okucindezelwa kobuso. Ine-emulsification ephumelelayo ohlelweni lwezigaba ezimbili futhi ingasetshenziswa njengesiqinisi esisebenzayo kanye ne-colloid evikelayo. Isixazululo samanzi sinezakhiwo ezinhle kakhulu zokwakha ifilimu futhi siyinto enhle yokumboza amaphilisi namaphilisi. Ifilimu eyakhiwe yiyo ayinambala futhi iqinile. I-plasticity yayo ingandiswa futhi ngokungeza i-glycerol.
2. Ukusetshenziswa kwe-HPMC ekukhiqizweni kwethebhulethi
2.1 Thuthukisa ukuqedwa
Ukusebenzisa isixazululo se-ethanol se-HPMC noma isixazululo samanzi njengesithako sokumanzisa ukuze kuhlanganiswe ama-granulation, ukuze kuthuthukiswe ukuncibilika kwamaphilisi, umphumela uyamangalisa, futhi ubulukhuni obucindezelwe bungcono, ukubukeka kubushelelezi. Ukuncibilika kwethebhulethi ye-Renimodipine: ukuncibilika kwe-glue kwakungu-17.34% kanye no-28.84% lapho i-glue yayingu-40% ethanol, isixazululo se-ethanol esingu-5% se-polyvinylpyrrolidone (40%), isixazululo se-ethanol esingu-1% se-sodium dodecyl sulfate (40%), i-3% ye-HPMC encibilikisiwe ku-10% we-starch pulp, isixazululo se-HPMC esingu-3%, isixazululo se-HPMC esingu-5%, ngokulandelana. 30.84%, 75.46%, 84.5%, 88%. Izinga lokuncibilika kwamaphilisi e-piperic acid: lapho ingcina ingu-12% we-ethanol, isixazululo se-ethanol esingu-1% we-HPMC(40%), isixazululo se-ethanol esingu-2% we-HPMC(40%), isixazululo se-ethanol esingu-3% we-HPMC(40%), izinga lokuncibilika lingu-80.94%, 86.23%, 90.45%, 99.88%, ngokulandelana. Izinga lokuncibilika kwamaphilisi e-Cimetidine: lapho ingcina ingu-10% wesitashi kanye nesixazululo se-ethanol esingu-3% we-HPMC(40%), izinga lokuncibilika lalingu-76.2% kanye no-97.54%, ngokulandelana.
Kusukela kudatha engenhla, kungabonakala ukuthi isixazululo se-ethanol kanye nesixazululo samanzi se-HPMC zinomphumela wokuthuthukisa ukuncibilika kwemithi, okuwumphumela wokumiswa kanye nomsebenzi wobuso be-HPMC, ukunciphisa ukungezwani kobuso phakathi kwesisombululo nemithi eqinile, kwandisa umswakama, okusiza ekuncibilikeni kwemithi.
2.2 Thuthukisa ikhwalithi yokumboza
I-HPMC njengezinto zokwakha ifilimu, uma iqhathaniswa nezinye izinto zokwakha ifilimu (i-acrylic resin, i-polyethylene pyrrolidone), inzuzo enkulu ukuncibilika kwayo emanzini, ayidingi izinyibilikisi eziphilayo, ukusebenza okuphephile, kulula.I-HPMCinezinhlobo ezahlukene ze-viscosity specifications, ukukhetha okufanele, ikhwalithi yefilimu yokumboza, ukubukeka kungcono kunezinye izinto. Amaphilisi e-Ciprofloxacin hydrochloride angamaphilisi amhlophe alula anezinhlamvu ezimbili. Lawa maphilisi okumboza ifilimu encane kunzima, ngokusebenzisa ukuhlolwa, akhetha i-viscosity engama-50 mpa # s ye-plasticizer encibilika emanzini, anganciphisa ukucindezeleka kwangaphakathi kwefilimu encane, ithebhulethi yokumboza engenabhuloho/ukujuluka 0, 0, 0, 0 / uwoyela we-orange peel/permeability, 0 / crack, njengenkinga yekhwalithi, ukwakheka kwefilimu yoketshezi yokumboza, ukunamathela okuhle, futhi alethe unqenqema lwamagama ngaphandle kokuvuza, okufundekayo, okukhanyayo ohlangothini olulodwa, okuhle. Uma kuqhathaniswa noketshezi lokumboza lwendabuko, lo muthi ulula futhi unengqondo, futhi izindleko zincishisiwe kakhulu.
Isikhathi sokuthunyelwe: Ephreli-25-2024