Hydroxypropyl methylcellulose (HPMC)imagwiritsidwa ntchito ngati chimodzi mwa zinthu zazikulu kwambiri zogwiritsira ntchito mankhwala kunyumba ndi kunja. HPMC ingagwiritsidwe ntchito ngati chopangira filimu, chomatira, chotulutsira mpweya wokhazikika, choyimitsa, chosakaniza, chosungunula, ndi zina zotero.
Zinthu zothandizira mankhwala ndi gawo lofunika kwambiri pakukonzekera mankhwala, ndipo ntchito yawo ndikuwonetsetsa kuti mankhwala akusamutsidwa mosankha kupita ku minofu mwanjira inayake ndi njira, kuti mankhwala azitulutsidwa m'thupi pa liwiro ndi nthawi inayake. Chifukwa chake, kusankha zinthu zoyenera ndi chimodzi mwazinthu zofunika kwambiri pakuthandizira mankhwala.
1 Katundu wa HPMC
HPMC ili ndi makhalidwe ambiri omwe zinthu zina zowonjezerera madzi sizili nawo. Ili ndi madzi osungunuka bwino m'madzi ozizira. Bola ikawonjezedwa m'madzi ozizira ndikusunthidwa pang'ono, imatha kusungunuka kukhala yankho lowonekera. M'malo mwake, siisungunuka m'madzi otentha opitilira 60E ndipo imatha kusungunuka kokha. Ndi ether yopanda ionic cellulose, yankho lake lilibe mphamvu ya ionic, ndi mchere wachitsulo kapena mankhwala a ionic organic, kuti zitsimikizire kuti HPMC sichitapo kanthu ndi zinthu zina zopangira popanga. Ndi anti-sensitivity yamphamvu, komanso ndi kuwonjezeka kwa kapangidwe ka molekyulu ka digiri ya kusintha, anti-sensitivity imakulitsidwanso, pogwiritsa ntchito HPMC ngati mankhwala othandizira, poyerekeza ndi kugwiritsa ntchito mankhwala ena achikhalidwe (wowuma, dextrin, ufa wa shuga), mtundu wa nthawi yogwira ntchito umakhala wokhazikika. Ili ndi metabolic inertia. Monga chinthu chothandizira chamankhwala, sichingasinthidwe kapena kuyamwa, kotero sichipereka ma calories mu mankhwala ndi chakudya. Ili ndi ntchito yapadera pamtengo wotsika wa calorific, mankhwala opanda mchere komanso osayambitsa ziwengo komanso chakudya chomwe anthu odwala matenda ashuga amafunikira. HPMC ndi yokhazikika kwambiri ku asidi ndi alkali, koma ngati ikupitirira pH2 ~ 11 ndipo ikatenthedwa kwambiri kapena nthawi yosungira ikadali yayitali, kukhuthala kwake kudzachepa. Yamadzimadzi imapereka ntchito pamwamba ndipo imapereka mphamvu yocheperako komanso mphamvu yolumikizirana pakati pa nkhope. Ili ndi emulsification yogwira ntchito mu dongosolo la magawo awiri ndipo ingagwiritsidwe ntchito ngati stabilizer yothandiza komanso colloid yoteteza. Yamadzimadzi ali ndi mphamvu zabwino kwambiri zopangira filimu ndipo ndi chinthu chabwino chophikira mapiritsi ndi mapiritsi. Filimu yopangidwa nayo ndi yopanda utoto komanso yolimba. Kusungunuka kwake kumathanso kuwonjezeka powonjezera glycerol.
2. Kugwiritsa ntchito HPMC popanga piritsi
2.1 Kukonza kusungunuka
Pogwiritsa ntchito yankho la ethanol la HPMC kapena yankho lamadzi ngati chonyowetsa cha granulation, pokonza kusungunuka kwa mapiritsi, zotsatira zake zimakhala zodabwitsa, ndipo kuuma kwake kumakhala bwino, ndipo kumawoneka kosalala. Kusungunuka kwa piritsi la Renimodipine: kusungunuka kwa guluu kunali 17.34% ndi 28.84% pamene guluu linali 40% ethanol, 5% polyvinylpyrrolidone (40%) ethanol solution, 1% sodium dodecyl sulfate (40%) ethanol solution, 3% HPMC yosungunuka mu 10% starch pulp, 3% HPMC solution, 5% HPMC solution, motsatana. 30.84%, 75.46%, 84.5%, 88%. Kuchuluka kwa kusungunuka kwa mapiritsi a piperic acid: pamene guluu ndi 12% ethanol, 1% HPMC (40%) ethanol solution, 2% HPMC (40%) ethanol solution, 3% HPMC (40%) ethanol solution, kuchuluka kwa kusungunuka ndi 80.94%, 86.23%, 90.45%, 99.88%, motsatana. Kuchuluka kwa kusungunuka kwa mapiritsi a Cimetidine: pamene guluu linali 10% starch slurry ndi 3% HPMC (40%) ethanol solution, kuchuluka kwa kusungunuka kunali 76.2% ndi 97.54%, motsatana.
Kuchokera pa zomwe zili pamwambapa, zitha kuwoneka kuti yankho la ethanol ndi yankho lamadzi la HPMC zimathandiza kukonza kusungunuka kwa mankhwala, zomwe zimachitika makamaka chifukwa cha kuyimitsidwa ndi ntchito ya pamwamba pa HPMC, kuchepetsa kupsinjika kwa pamwamba pakati pa yankho ndi mankhwala olimba, kuwonjezera chinyezi, zomwe zimapangitsa kuti mankhwala asungunuke.
2.2 Kukweza ubwino wa zokutira
HPMC ngati chinthu chopangira filimu, poyerekeza ndi zipangizo zina zopangira filimu (acrylic resin, polyethylene pyrrolidone), ubwino wake waukulu ndi kusungunuka kwa madzi, sikufuna zosungunulira zachilengedwe, ntchito yake ndi yotetezeka, komanso yosavuta.HPMCIli ndi mitundu yosiyanasiyana ya ma viscosity specifications, kusankha koyenera, mtundu wa filimu yophimba, mawonekedwe ake ndi abwino kuposa zinthu zina. Mapiritsi a Ciprofloxacin hydrochloride ndi mapiritsi oyera osalala okhala ndi zilembo ziwiri. Mapiritsi awa a filimu yopyapyala ndi ovuta, kudzera mu kuyesera, amasankha ma viscosity a 50 mpa # s a pulasitiki wosungunuka m'madzi, amatha kuchepetsa kupsinjika kwamkati kwa filimu yopyapyala, piritsi lophimba lopanda mlatho/thukuta 0, 0, 0, 0 / mafuta a lalanje / mafuta olowa, 0 / ming'alu, monga vuto la khalidwe, kupanga filimu yamadzimadzi, kumamatira bwino, ndikubweretsa m'mphepete mwa mawu popanda kutayikira, kuwerengedwa, kowala mbali imodzi, kokongola. Poyerekeza ndi madzi achikhalidwe ophimba, mankhwalawa ndi osavuta komanso oyenera, ndipo mtengo wake ndi wotsika kwambiri.
Nthawi yotumizira: Epulo-25-2024