Hydroxypropyl methylcellulose (HPMC)a na-eji ya dịka otu n'ime ihe ndị kacha enye aka n'ọgwụ n'ụlọ na mba ofesi. Enwere ike iji HPMC mee ihe dịka ihe na-emepụta ihe nkiri, ihe na-arapara, ihe na-enye ntọhapụ na-adịgide adịgide, ihe na-enye nkwụsịtụ, ihe na-eme ka ihe dị nro, ihe na-eme ka ihe dị nro, ihe na-agbawa agbawa, wdg.
Ihe ndị e ji ọgwụ eme bụ akụkụ dị mkpa nke nkwadebe ọgwụ, ọrụ ha bụkwa ịhụ na a na-ebuga ọgwụ n'ime anụ ahụ n'ụzọ na usoro ụfọdụ, ka e wee wepụta ọgwụ n'ime ahụ n'oge na ọsọ ụfọdụ. Ya mere, nhọrọ nke ihe ndị kwesịrị ekwesị bụ otu n'ime ihe ndị dị mkpa maka mmetụta ọgwụgwọ nke nkwadebe ọgwụ.
1 Njirimara nke HPMC
HPMC nwere ọtụtụ ihe ndị ọzọ na-enweghị. Ọ nwere ezigbo mmiri na-agbaze na mmiri oyi. Ọ bụrụhaala na etinyere ya na mmiri oyi ma kpalie ya ntakịrị, ọ nwere ike ịgbaze ka ọ bụrụ ihe ngwọta doro anya. N'ụzọ megidere nke ahụ, ọ naghị agbaze na mmiri ọkụ karịa 60E ma ọ nwere ike ịgbaze naanị. Ọ bụ cellulose ether na-abụghị ionic, ihe ngwọta ya enweghị chajị ionic, yana nnu ígwè ma ọ bụ ngwakọta organic ionic, iji hụ na HPMC anaghị emeghachi omume na ihe ndị ọzọ dị na usoro mmepụta nkwadebe. Site na mgbochi mmetụta siri ike, yana mmụba nke nhazi molekul nke ọkwa nnọchi, a na-emekwa ka mgbochi mmetụta dịkwuo mma, na-eji HPMC dị ka ọgwụ mgbakwunye, ma e jiri ya tụnyere ojiji nke ọgwụ ndị ọzọ na-enye aka (starch, dextrin, ntụ shuga), ịdị mma nke oge dị irè na-adịgide adịgide. Ọ nwere ike ime ka metabolism ghara ịdị irè. Dịka ihe enyemaka ọgwụ, enweghị ike ịgbaze ma ọ bụ ịmịkọrọ ya, yabụ ọ naghị enye kalori na ọgwụ na nri. O nwere ike pụrụ iche maka obere kalori, ọgwụ enweghị nnu na nke na-anaghị akpata nfụkasị ahụ, yana nri ndị ọrịa mamịrị chọrọ. HPMC na-adịgide karịa acid na alkali, mana ọ bụrụ na ọ gafere pH2~11 ma nwee okpomọkụ dị elu ma ọ bụ oge nchekwa dị ogologo, viscosity ga-ebelata. Ngwọta mmiri na-enye ọrụ elu ma na-enye nrụgide elu dị ala na ụkpụrụ nrụgide interfacial. Ọ nwere emulsification dị irè na sistemụ usoro abụọ ma enwere ike iji ya dị ka ihe na-eme ka ọ kwụsie ike na colloid nchebe. Ngwọta mmiri nwere njirimara imepụta fim dị mma ma bụrụ ezigbo ihe mkpuchi maka mbadamba na mkpụrụ ọgwụ. Ihe nkiri ahụ nke o mepụtara enweghị agba ma sie ike. Enwere ike ịbawanye plasticity ya site na ịgbakwunye glycerol.
2. Ngwa nke HPMC na mmepụta mbadamba
2.1 Meziwanye mgbasa ahụ
Iji mmiri ọgwụ HPMC ma ọ bụ mmiri ọgwụ mee ihe dị ka ihe na-eme ka mmiri dị mmiri maka granulation, iji mee ka mmiri dị mma maka ịgbaze mbadamba, mmetụta ya dị egwu, a na-etinye ya n'ime ihe nkiri ahụ ka mma, ọ na-adị ka ọ dị nro. Mgbaze nke mbadamba Renimodipine: mgbaze nke ihe nrapado bụ 17.34% na 28.84% mgbe ihe nrapado ahụ bụ ethanol 40%, ngwọta ethanol 5% polyvinylpyrrolidone (40%), ngwọta ethanol 1% sodium dodecyl sulfate (40%), 3% HPMC agbazere n'ime 10% starch pulp, ngwọta HPMC 3%, ngwọta HPMC 5%, n'otu n'otu. 30.84%, 75.46%, 84.5%, 88%. Ọnụọgụ mgbaze nke mbadamba piperic acid: mgbe ihe mgbaze bụ ethanol 12%, 1% HPMC (40%) ihe mgbaze ethanol, 2% HPMC (40%) ihe mgbaze ethanol, 3% HPMC (40%) ihe mgbaze ethanol, ọnụego mgbaze bụ 80.94%, 86.23%, 90.45%, 99.88%, n'otu n'otu. Ọnụọgụ mgbaze nke mbadamba Cimetidine: mgbe ihe mgbaze bụ 10% starch slurry na 3% HPMC (40%) ihe mgbaze ethanol, ọnụego mgbaze bụ 76.2% na 97.54%, n'otu n'otu.
Site na data dị n'elu, a pụrụ ịhụ na mmiri ọgwụ ethanol na mmiri ọgwụ HPMC nwere mmetụta nke imeziwanye mgbasa ọgwụ, nke bụ isi ihe si na nkwụsịtụ na ọrụ elu nke HPMC pụta, na-ebelata nrụgide elu dị n'etiti mmiri ọgwụ na ọgwụ siri ike, na-eme ka mmiri dịkwuo elu, nke na-eme ka ọgwụ gbasaa.
2.2 Meziwanye mma nke mkpuchi ahụ
HPMC dị ka ihe e ji akpụ ihe nkiri, ma e jiri ya tụnyere ihe ndị ọzọ e ji akpụ ihe nkiri (acrylic resin, polyethylene pyrrolidone), uru kachasị bụ na mmiri anaghị agbaze, ọ dịghị mkpa ihe mgbaze organic, ọrụ dị mma, ọ dịkwa mma.HPMCnwere ọtụtụ nkọwapụta viscosity dị iche iche, nhọrọ kwesịrị ekwesị, ịdị mma nke ihe mkpuchi, ọdịdị ya ka mma karịa ihe ndị ọzọ. Mbadamba Ciprofloxacin hydrochloride bụ mbadamba ọcha nkịtị nwere mkpụrụedemede abụọ. Mkpụrụ ọgwụ ndị a maka mkpuchi ihe nkiri dị gịrịgịrị siri ike, site na nnwale ahụ, na-ahọrọ viscosity nke 50 mpa # s nke plastik mmiri na-agbaze, nwere ike ibelata nrụgide dị n'ime nke ihe nkiri dị gịrịgịrị, na-ekpuchi mbadamba na-enweghị bridge/sweat 0, 0, 0, 0 / mmanụ oroma peel/permeability, 0 / mgbawa, dị ka nsogbu ịdị mma, mkpuchi ihe nkiri mmiri mmiri, njikọta dị mma, na iweta ọnụ okwu na-enweghị ntapu, a na-agụ ya, Otu - akụkụ na-egbuke egbuke, mara mma. Ma e jiri ya tụnyere mmiri mkpuchi ọdịnala, ọgwụ a dị mfe ma dị mma, a na-ebelatakwa ọnụ ahịa ya nke ukwuu.
Oge ozi: Eprel-25-2024