ʻO ka Hydroxypropyl methylcellulose (HPMC)hoʻohana ʻia ʻo ia kekahi o nā mea hoʻohui lāʻau lapaʻau nui loa ma ka home a ma waho. Hiki ke hoʻohana ʻia ʻo HPMC ma ke ʻano he mea hoʻokumu kiʻiʻoniʻoni, mea hoʻopili, mea hoʻokuʻu hoʻomau, mea hoʻokuʻu, emulsifier, mea hoʻoheheʻe, a pēlā aku.
He ʻāpana koʻikoʻi nā mea hoʻohui lāʻau lapaʻau o nā hoʻomākaukau lāʻau lapaʻau, a ʻo kā lākou kuleana ka hōʻoia ʻana e lawe koho ʻia nā lāʻau lapaʻau i nā ʻiʻo ma ke ʻano a me ke kaʻina hana, i hoʻokuʻu ʻia nā lāʻau lapaʻau i loko o ke kino i kahi wikiwiki a me ka manawa. No laila, ʻo ke koho ʻana i nā mea hoʻohui kūpono kekahi o nā kumu nui no ka hopena therapeutic o nā hoʻomākaukau lāʻau lapaʻau.
1 Nā Waiwai o HPMC
He nui nā ʻano o ka HPMC i loaʻa ʻole i nā mea hoʻohui ʻē aʻe. Loaʻa iā ia ka solubility maikaʻi loa i ka wai anuanu. Inā hoʻohui ʻia i loko o ka wai anuanu a hoʻoulu iki ʻia, hiki iā ia ke hoʻoheheʻe i loko o kahi hopena moakaka. Ma ke ʻano ʻē, ʻaʻole ia e hoʻoheheʻe ʻia i ka wai wela ma luna o 60E a hiki ke hoʻoheheʻe wale ʻia. He non-ionic cellulose ether, ʻaʻohe ona ionic charge, a me nā paʻakai metala a i ʻole nā hui organik ionic, i mea e hōʻoia ai ʻaʻole e pane ka HPMC me nā mea maka ʻē aʻe i ke kaʻina hana hoʻomākaukau. Me ka ikaika anti-sensitivity, a me ka hoʻonui ʻana o ke ʻano molekala o ke kekelē o ka pani ʻana, hoʻonui ʻia ka anti-sensitivity, me ka hoʻohana ʻana iā HPMC ma ke ʻano he adjuvant drugs, e pili ana i ka hoʻohana ʻana i nā adjuvants kuʻuna ʻē aʻe (starch, dextrin, sugar powder) drugs, ʻoi aku ka paʻa o ka maikaʻi o ka wā kūpono. Loaʻa iā ia ka inertia metabolic. Ma ke ʻano he mea kōkua lāʻau lapaʻau, ʻaʻole hiki ke metabolized a omo ʻia, no laila ʻaʻole ia e hāʻawi i nā calorie i ka lāʻau lapaʻau a me ka meaʻai. Loaʻa iā ia kahi hoʻohana kūikawā no ka waiwai haʻahaʻa haʻahaʻa, ka lāʻau lapaʻau ʻaʻohe paʻakai a me ka lāʻau lapaʻau ʻaʻole allergenic a me ka meaʻai e pono ai ka poʻe maʻi diabetes. ʻOi aku ka paʻa o ka HPMC i ka waikawa a me ka alkali, akā inā ʻoi aku ia ma mua o ka pH2 ~ 11 a ua hoʻokau ʻia i kahi mahana kiʻekiʻe a i ʻole ka manawa mālama lōʻihi, e hoʻemi ʻia ka viscosity. Hāʻawi ka hopena wai i ka hana ʻili a hōʻike i ka tension ʻili a me nā waiwai tension interfacial. Loaʻa iā ia ka emulsification maikaʻi i ka ʻōnaehana ʻelua-phase a hiki ke hoʻohana ʻia ma ke ʻano he mea hoʻopaʻa maikaʻi a me ka colloid pale. Loaʻa i ka hopena wai nā waiwai hana kiʻiʻoniʻoni maikaʻi loa a he mea uhi maikaʻi no nā papa a me nā pila. ʻO ke kiʻiʻoniʻoni i hana ʻia e ia he kala ʻole a paʻakikī. Hiki ke hoʻonui ʻia kona plasticity ma ka hoʻohui ʻana i ka glycerol.
2. Hoʻohana ʻia ʻo HPMC i ka hana papa
2.1 Hoʻomaikaʻi i ka hoʻopau ʻana
Ke hoʻohana nei i ka hopena ethanol HPMC a i ʻole ka hopena wai e like me ka mea hoʻomaʻū no ka granulation, no ka hoʻomaikaʻi ʻana i ka hoʻoheheʻe ʻana o nā papa, he mea kupaianaha ka hopena, a ʻoi aku ka maikaʻi o ka paʻakikī o ke kiʻiʻoniʻoni, ʻoi aku ka maikaʻi o ke ʻano o ka laumania. ʻO ka solubility o ka papa Renimodipine: ʻo ka solubility o ka mea hoʻopili he 17.34% a me 28.84% i ka wā he 40% ethanol ka mea hoʻopili, 5% polyvinylpyrrolidone (40%) ethanol solution, 1% sodium dodecyl sulfate (40%) ethanol solution, 3% HPMC i hoʻoheheʻe ʻia i loko o 10% starch pulp, 3% HPMC solution, 5% HPMC solution, kēlā me kēia. 30.84%, 75.46%, 84.5%, 88%. Ka nui o ka hoʻoheheʻe ʻana o nā papa waikawa piperic: i ka wā he 12% ethanol ka mea hoʻopili, 1% HPMC (40%) hopena ethanol, 2% HPMC (40%) hopena ethanol, 3% HPMC (40%) hopena ethanol, ʻo ka nui o ka hoʻoheheʻe ʻana he 80.94%, 86.23%, 90.45%, 99.88%, kēlā me kēia. Ka nui o ka hoʻoheheʻe ʻana o nā papa Cimetidine: i ka wā he 10% slurry starch a me 3% HPMC (40%) hopena ethanol ka mea hoʻopili, ʻo ka nui o ka hoʻoheheʻe ʻana he 76.2% a me 97.54%, kēlā me kēia.
Mai ka ʻikepili ma luna, hiki ke ʻike ʻia he hopena ka hopena ethanol a me ka hopena wai o HPMC i ka hoʻomaikaʻi ʻana i ka hoʻoheheʻe ʻana o nā lāʻau lapaʻau, ʻo ia ka hopena nui o ka hoʻokuʻu ʻana a me ka hana ʻili o HPMC, e hōʻemi ana i ka ʻili ma waena o ka hopena a me nā lāʻau paʻa, e hoʻonui ana i ka makū, kahi mea e kōkua ai i ka hoʻoheheʻe ʻana o nā lāʻau lapaʻau.
2.2 Hoʻomaikaʻi i ka maikaʻi o ka uhi ʻana
ʻO HPMC ma ke ʻano he mea hana kiʻiʻoniʻoni, i hoʻohālikelike ʻia me nā mea hana kiʻiʻoniʻoni ʻē aʻe (acrylic resin, polyethylene pyrrolidone), ʻo ka pōmaikaʻi nui loa ʻo ia ka solubility wai, ʻaʻole pono nā mea hoʻoheheʻe organik, hana palekana, maʻalahi. A meHPMCLoaʻa i nā ʻano kikoʻī like ʻole o ka viscosity, ke koho kūpono, ke ʻano o ka ʻili uhi, ʻoi aku ka maikaʻi o ke ʻano ma mua o nā mea ʻē aʻe. ʻO nā papa Ciprofloxacin hydrochloride he mau papa keʻokeʻo maʻemaʻe me nā leka ʻelua ʻaoʻao. He paʻakikī kēia mau pila no ka uhi ʻili lahilahi, ma o ka hoʻokolohua, koho i ka viscosity o 50 mpa # s o ka plasticizer wai-soluble, hiki ke hōʻemi i ke kaumaha kūloko o ka ʻili lahilahi, ka papa uhi me ka ʻole o ke alahaka/hou 0, 0, 0, 0 / ʻili ʻalani/ʻaila permeability, 0 / māwae, e like me ka pilikia maikaʻi, ka hoʻokumu ʻana i ka ʻili wai uhi, hoʻopili maikaʻi, a lawe mai i ka lihi huaʻōlelo me ka ʻole o ka leakage, heluhelu ʻia, ʻālohilohi hoʻokahi ʻaoʻao, nani. Ke hoʻohālikelike ʻia me ka wai uhi kuʻuna, he maʻalahi a kūpono kēia kauoha, a ua hoʻemi nui ʻia ke kumukūʻai.
Ka manawa hoʻouna: ʻApelila-25-2024