Hydroxypropyl methylcellulose (HPMC)yog siv los ua ib qho ntawm cov tshuaj loj tshaj plaws hauv tsev thiab txawv teb chaws. HPMC tuaj yeem siv los ua tus neeg sawv cev tsim zaj duab xis, nplaum, tus neeg sawv cev tso tawm tas mus li, tus neeg sawv cev ncua, emulsifier, tus neeg sawv cev disintegrating, thiab lwm yam.
Cov tshuaj pab txhawb nqa yog ib feem tseem ceeb ntawm kev npaj tshuaj, thiab lawv lub luag haujlwm yog xyuas kom meej tias cov tshuaj raug xa mus rau cov ntaub so ntswg hauv ib txoj kev thiab txheej txheem, yog li cov tshuaj raug tso tawm hauv lub cev ntawm qhov ceev thiab lub sijhawm. Yog li ntawd, kev xaiv cov tshuaj pab txhawb nqa tsim nyog yog ib qho ntawm cov yam tseem ceeb rau kev kho mob ntawm cov tshuaj.
1 Cov Khoom ntawm HPMC
HPMC muaj ntau yam ntxwv uas lwm cov tshuaj tsis muaj. Nws muaj kev yaj dej zoo heev hauv dej txias. Tsuav yog ntxiv rau hauv dej txias thiab do me ntsis, nws tuaj yeem yaj mus rau hauv cov kua pob tshab. Ntawm qhov tsis sib xws, nws yeej tsis yaj hauv dej kub saum 60E thiab tsuas yog yaj tau. Nws yog ib qho cellulose ether uas tsis yog ionic, nws cov kua tsis muaj ionic them, thiab cov ntsev hlau lossis cov organic ionic, yog li ntawd HPMC tsis teb nrog lwm cov khoom siv raw hauv cov txheej txheem tsim khoom. Nrog rau kev tiv thaiv muaj zog, thiab nrog rau kev nce ntawm cov qauv molecular ntawm qib kev hloov pauv, kev tiv thaiv kev tiv thaiv kuj tau txhim kho, siv HPMC ua cov tshuaj adjuvant, piv rau kev siv lwm cov tshuaj adjuvants ib txwm muaj (starch, dextrin, suab thaj hmoov) tshuaj, qhov zoo ntawm lub sijhawm ua haujlwm ruaj khov dua. Nws muaj kev cuam tshuam metabolic. Raws li cov khoom siv pabcuam tshuaj, nws tsis tuaj yeem metabolized lossis nqus tau, yog li nws tsis muab calories hauv tshuaj thiab zaub mov. Nws muaj kev siv tshwj xeeb rau cov tshuaj uas tsis muaj calorific, tsis muaj ntsev thiab tsis ua rau ua xua thiab cov khoom noj uas cov neeg mob ntshav qab zib xav tau. HPMC ruaj khov dua rau cov kua qaub thiab alkali, tab sis yog tias nws tshaj pH2 ~ 11 thiab raug rau qhov kub siab dua lossis lub sijhawm khaws cia ntev dua, qhov viscosity yuav raug txo qis. Cov kua dej muab kev ua haujlwm ntawm qhov chaw thiab nthuav tawm qhov nruab nrab ntawm qhov chaw thiab qhov sib txuas ntawm qhov sib txuas. Nws muaj kev ua kom zoo hauv ob-theem system thiab tuaj yeem siv ua tus stabilizer zoo thiab tiv thaiv colloid. Cov kua dej muaj cov yam ntxwv zoo heev thiab yog cov khoom siv zoo rau cov ntsiav tshuaj thiab tshuaj ntsiav. Cov zaj duab xis tsim los ntawm nws tsis muaj xim thiab tawv. Nws cov yas kuj tseem tuaj yeem nce ntxiv los ntawm kev ntxiv glycerol.
2. Daim ntawv thov ntawm HPMC hauv kev tsim cov ntsiav tshuaj
2.1 Txhim kho kev yaj
Siv cov tshuaj HPMC ethanol lossis cov tshuaj aqueous ua tus neeg sawv cev rau kev ua kom cov granulation, rau kev txhim kho kev yaj ntawm cov ntsiav tshuaj, cov nyhuv yog qhov zoo kawg nkaus, thiab nias rau hauv zaj duab xis hardness zoo dua, qhov zoo li du. Solubility ntawm Renimodipine ntsiav tshuaj: qhov solubility ntawm cov nplaum yog 17.34% thiab 28.84% thaum cov nplaum yog 40% ethanol, 5% polyvinylpyrrolidone (40%) ethanol kua, 1% sodium dodecyl sulfate (40%) ethanol kua, 3% HPMC yaj rau hauv 10% starch pulp, 3% HPMC kua, 5% HPMC kua, feem. 30.84%, 75.46%, 84.5%, 88%. Tus nqi yaj ntawm cov ntsiav tshuaj piperic acid: thaum cov nplaum yog 12% ethanol, 1% HPMC (40%) ethanol kua, 2% HPMC (40%) ethanol kua, 3% HPMC (40%) ethanol kua, tus nqi yaj yog 80.94%, 86.23%, 90.45%, 99.88%, raws li. Tus nqi yaj ntawm Cimetidine ntsiav tshuaj: thaum cov nplaum yog 10% hmoov txhuv nplej siab slurry thiab 3% HPMC (40%) ethanol kua, tus nqi yaj yog 76.2% thiab 97.54%, raws li.
Los ntawm cov ntaub ntawv saum toj no, nws tuaj yeem pom tias cov tshuaj ethanol thiab cov tshuaj aqueous ntawm HPMC muaj cov txiaj ntsig ntawm kev txhim kho kev yaj ntawm cov tshuaj, uas feem ntau yog qhov tshwm sim ntawm kev ncua thiab kev ua haujlwm ntawm HPMC, txo qhov kev ntxhov siab ntawm qhov chaw ntawm cov tshuaj thiab cov tshuaj khov, ua rau cov dej noo ntau ntxiv, uas yog qhov zoo rau kev yaj ntawm cov tshuaj.
2.2 Txhim kho qhov zoo ntawm txheej
HPMC ua cov khoom siv tsim zaj duab xis, piv nrog lwm cov ntaub ntawv tsim zaj duab xis (acrylic resin, polyethylene pyrrolidone), qhov zoo tshaj plaws yog nws cov dej solubility, tsis xav tau cov organic solvents, kev ua haujlwm zoo, yooj yim. ThiabHPMCMuaj ntau yam viscosity specifications, xaiv tau zoo, zoo li zaj duab xis txheej, thiab zoo li zoo dua lwm yam khoom siv. Ciprofloxacin hydrochloride ntsiav tshuaj yog cov ntsiav tshuaj dawb dawb nrog ob sab ntawv. Cov ntsiav tshuaj no nyuaj rau txheej zaj duab xis nyias, los ntawm kev sim, xaiv qhov viscosity ntawm 50 mpa # s ntawm cov dej-soluble plasticizer, tuaj yeem txo qhov kev ntxhov siab sab hauv ntawm zaj duab xis nyias, ntsiav tshuaj txheej tsis muaj choj/hws 0, 0, 0, 0 / txiv kab ntxwv tev/permeability roj, 0 / tawg, xws li qhov teeb meem zoo, txheej kua zaj duab xis tsim, nplaum zoo, thiab coj cov lus ntug tsis muaj qhov xau, nyeem tau, Ib sab ci, zoo nkauj. Piv nrog cov kua txheej ib txwm muaj, cov tshuaj no yooj yim thiab tsim nyog, thiab tus nqi raug txo qis heev.
Lub sijhawm tshaj tawm: Plaub Hlis-25-2024