Te Hydroxypropyl methylcellulose (HPMC)e whakamahia ana hei tētahi o ngā matū rongoā nui rawa atu i te kāinga me tāwāhi. Ka taea te whakamahi i te HPMC hei kaihoko hanga kiriata, hei piripiri, hei kaihoko tukunga pumau, hei kaihoko whakatārewatanga, hei emulsifier, hei kaihoko pakaru, me ētahi atu.
He wāhanga nui ngā tāpiringa rongoā o ngā whakaritenga rongoā, ā, ko tā rātou mahi he whakarite kia tere te kawe i ngā rongoā ki ngā kiko i roto i tētahi huarahi me tētahi tikanga, kia tukuna ai ngā rongoā ki roto i te tinana i tētahi tere me tētahi wā. Nō reira, ko te whiriwhiri i ngā tāpiringa e tika ana tētahi o ngā mea matua mō te pānga rongoā o ngā whakaritenga rongoā.
1 Ngā Āhuatanga o te HPMC
He maha ngā āhuatanga o te HPMC kāore i te rite ki ētahi atu mea tāpiri. He tino pai te wairewatanga o te wai i roto i te wai matao. Mena ka tāpirihia ki te wai matao, ka whakaohokia, ka taea te rewa hei otinga mārama. Engari, kāore e rewa i roto i te wai wera i runga ake i te 60E, ā, ka rewa noa iho. He etera cellulose kore-ionic, kāore he utu ionic i roto i tana otinga, kāore hoki he tote whakarewa, he matū waro ionic rānei, kia kore ai e tauhohe te HPMC ki ētahi atu rauemi mata i roto i te tukanga whakaputa. Nā te kaha o te ārai-aro, me te pikinga o te hanganga ngota o te nekehanga whakakapinga, ka whakanuia hoki te ārai-aro, mā te whakamahi i te HPMC hei rongoā tāpiri, ki te whakataurite ki te whakamahinga o ētahi atu rongoā tāpiri tuku iho (māngaro, dextrin, paura huka), he pumau ake te kounga o te wā whai hua. He ngoikore te pākia. Hei rauemi āwhina rongoā, kāore e taea te whakapūkara, te mimiti rānei, nō reira kāore e whakaratohia he kaora i roto i te rongoā me te kai. He āhua motuhake tōna whakamahinga mō te iti o te uara karori, te kore tote, te kore mate pāwera me ngā kai e hiahiatia ana e te hunga mate huka. He pakari ake te HPMC ki te waikawa me te kawakore, engari ki te neke atu i te pH2~11, ā, ka tukuna ki te pāmahana teitei ake, ki te roa ake rānei te wā rokiroki, ka heke te matotoru. Ka whakaratohia e te otinga wai te mahi mata, ā, he taurite te taumahatanga mata me te taumahatanga ā-mata. He whai hua te whakaemulsification i roto i te pūnaha rua-wāhanga, ā, ka taea te whakamahi hei whakaū me te colloid tiaki whai hua. He tino pai ngā āhuatanga hanga kiriata o te otinga wai, ā, he rauemi paninga pai mō ngā papa me ngā pire. He kore tae te kiriata i hangaia e ia, ā, he pakari. Ka taea hoki te whakanui ake i tōna kirihou mā te tāpiri i te glycerol.
2. Te whakamahinga o te HPMC i roto i te hanga papa
2.1 Whakapai ake i te whakarewatanga
Mā te whakamahi i te otinga etanoru HPMC, i te otinga wai rānei hei mākū mō te whakapūkara, hei whakapai ake i te whakarewatanga o ngā papa, he mea whakamiharo te pānga, ā, he pai ake te pakeke o te pēhi ki roto i te kiriata, he maeneene te āhua. Te wairewatanga o te papa Renimodipine: ko te wairewatanga o te piripiri he 17.34% me te 28.84% i te wā i whakamahia ai te piripiri ki te 40% etanoru, 5% otinga etanoru polyvinylpyrrolidone (40%), 1% otinga etanoru konutai dodecyl sulfate (40%), 3% HPMC i rewa ki roto i te 10% penupenu māngaro, 3% otinga HPMC, 5% otinga HPMC. 30.84%, 75.46%, 84.5%, 88%. Te tere whakarewa o ngā papa waikawa piperic: ina he 12% etanoru, 1% otinga etanoru HPMC(40%), 2% otinga etanoru HPMC(40%), 3% otinga etanoru HPMC(40%), ko te tere whakarewa he 80.94%, 86.23%, 90.45%, 99.88%, ia. Te tere whakarewa o ngā papa Cimetidine: ina he 10% paraoa māngaro me te 3% otinga etanoru HPMC(40%) te piri, ko te tere whakarewa he 76.2% me te 97.54%, ia.
Mai i ngā raraunga o runga ake nei, ka kitea ko te hua o te otinga etanoru me te otinga wai o te HPMC he whakapai ake i te whakarewatanga o ngā rongoā, ko te hua matua o te whakatārewatanga me te mahi mata o te HPMC, ka whakaiti i te taumahatanga mata i waenga i te otinga me ngā rongoā totoka, ka whakanui ake i te makuku, ka whai hua ki te whakarewatanga o ngā rongoā.
2.2 Whakapai ake i te kounga o te paninga
Ko te HPMC hei rauemi hanga kiriata, ki te whakaritea ki ētahi atu rauemi hanga kiriata (te kapia kiriaku, te polyethylene pyrrolidone), ko te painga nui ko tōna wairewatanga wai, kāore e hiahiatia he whakarewa waro, he haumaru te whakahaere, he watea hoki. Ā,HPMCHe maha ngā whakatakotoranga matotoru, he tika te kōwhiringa, he kounga kiriata paninga, he pai ake te āhua i ētahi atu rauemi. He papa ma te papa Ciprofloxacin hydrochloride me ngā reta taha-rua. He uaua ēnei pire mō te paninga kiriata angiangi, mā te whakamātautau, ka tīpakohia te matotoru o te 50 mpa # s o te plasticizer wairewa-wai, ka taea te whakaiti i te ahotea o roto o te kiriata angiangi, te papa paninga kāore he piriti/werawera 0, 0, 0, 0 / kiri karaka/hinu uruhanga, 0 / ngatata, pērā i te raruraru kounga, te hanga kiriata wai paninga, he pai te piri, me te kawe mai i te taha kupu me te kore turuturu, he mārama te pānui, he kanapa te taha kotahi, he ataahua. Ki te whakataurite ki te wai paninga tuku iho, he māmā, he whaitake hoki tēnei whakahaunga, ā, he tino iti te utu.
Wā tuku: Paenga-whāwhā-25-2024