Hydroxypropyl methylcellulose (HPMC)ikoreshwa nk'imwe mu miti ikomeye ikoreshwa mu buvuzi mu gihugu no mu mahanga. HPMC ishobora gukoreshwa nk'umuti uhindura filime, kole, umuti urekura ibintu mu buryo buhoraho, umuti uhagarika imiti, umuti ugabanya ubushyuhe, umuti ugabanya ubushyuhe, n'ibindi.
Ibintu bifasha mu miti ni ingenzi mu gutegura imiti, kandi inshingano zabyo ni ukugenzura ko imiti ijyanwa mu ngingo mu buryo runaka no mu buryo runaka, kugira ngo imiti irekurwe mu mubiri ku muvuduko n'igihe runaka. Kubwibyo, guhitamo ibintu bifasha mu miti ni kimwe mu bintu by'ingenzi bituma imiti ikoreshwa mu kuvura.
1 Imiterere ya HPMC
HPMC ifite imiterere myinshi abandi bantu badafite. Ifite ubushobozi bwiza bwo gushonga mu mazi akonje. Igihe cyose yongewe mu mazi akonje ikavunga gato, ishobora gushonga mu buryo buboneye. Ahubwo, ntabwo ishongeshwa mu mazi ashyushye ari hejuru ya 60E kandi ishobora gushonga gusa. Ni eteri ya cellulose itari ionic, umuti wayo ntugira ingufu za ionic, n'umunyu w'icyuma cyangwa ibinyabutabire bya ionic, kugira ngo HPMC idakora n'ibindi bikoresho fatizo mu gutegura. Iyo irwanya cyane, kandi hamwe n'ubwiyongere bw'imiterere ya molekile ku rugero rwo gusimbuza, irwanya kandi irushaho kwiyongera, ikoresha HPMC nk'imiti y'inyongera, ugereranije n'ikoreshwa ry'indi miti gakondo y'inyongera (starch, dextrin, ifu y'isukari), ubwiza bw'igihe cy'imikorere burahamye kurushaho. Ifite ikibazo cya metabolisme. Nk'ibikoresho by'inyongera mu by'imiti, ntishobora guhindurwamo cyangwa ngo ikoreshwe, bityo ntitanga karori mu buvuzi no mu biribwa. Ifite ubushobozi bwihariye bwo gukoresha mu kuvura indwara ziterwa na karori nke, imiti idafite umunyu kandi idatera allergies, ndetse n'ibiribwa bikenewe n'abantu barwaye diyabete. HPMC irakomeye cyane ku bijyanye na aside na alkali, ariko iyo irenze pH 2 ~ 11 kandi ikagira ubushyuhe bwinshi cyangwa igihe kirekire cyo kubika, ubushyuhe buragabanuka. Amazi atanga imikorere ku buso kandi agaragaza ubushyuhe buri hagati y'ubuso n'ubushyuhe hagati y'ubuso. Ifite emulsification nziza mu buryo bw'ibice bibiri kandi ishobora gukoreshwa nk'umuti urinda indwara no kurinda colloid. Amazi afite ubushobozi bwiza bwo gukora firime kandi ni ibikoresho byiza byo gusiga ibinini n'ibinini. Filime ikorwa nayo nta ibara kandi ikomeye. Ubuziranenge bwayo bushobora kandi kongerwaho glycerol.
2. Gukoresha HPMC mu gukora ibinini
2.1 Kunoza iseswa
Gukoresha umuti wa ethanoli wa HPMC cyangwa umuti w'amazi nk'ikintu gitanga ububobere mu gushonga kw'ibinini, kugira ngo ibinini bishonge neza, ingaruka ni nziza, kandi ubukomere bushyirwa mu gice cy'urukiramende burushaho kuba bwiza, kandi bigaragara ko bumeze neza. Gushonga kw'ibinini bya Renimodipine: gushonga kw'ibinini byari 17.34% na 28.84% mu gihe ibinini byari 40% ethanoli, 5% polyvinylpyrrolidone (40%) ethanoli, 1% sodium dodecyl sulfate (40%) ethanoli, 3% HPMC yashongeshejwe mu 10% pulp ya starch, 3% HPMC, 5% HPMC, uko bikurikirana. 30.84%, 75.46%, 84.5%, 88%. Igipimo cyo gushonga kw'ibinini bya aside piperic: iyo kole ari 12% ya ethanol, 1% ya HPMC (40%) ya ethanol, 2% ya HPMC (40%) ya ethanol, 3% ya HPMC (40%) ya ethanol, igipimo cyo gushonga ni 80.94%, 86.23%, 90.45%, 99.88% uko bikurikirana. Igipimo cyo gushonga kw'ibinini bya Cimetidine: iyo kole yari 10% y'ibishyimbo bya starch na 3% ya HPMC (40%) ya ethanol, igipimo cyo gushonga cyari 76.2% na 97.54% uko bikurikirana.
Dukurikije amakuru yavuzwe haruguru, bigaragara ko umuti wa ethanol n'umuti w'amazi wa HPMC bigira ingaruka nziza zo kunoza uburyo imiti ishonga, ahanini bitewe n'imikorere y'umuti uhagarika n'ubuso bwa HPMC, bikagabanya ubukana bw'ubuso hagati y'umuti n'imiti ikomeye, byongera ubushuhe, ibyo bikaba bituma imiti ishonga.
2.2 Kunoza ubwiza bw'ipamba
HPMC nk'igikoresho gikora firime, ugereranije n'ibindi bikoresho bikora firime (acrylic resin, polyethylene pyrrolidone), inyungu nini ni uko ishonga mu mazi, ntikenera imiti ihumanya ikirere, ikora neza kandi yoroshye kuyikoresha.HPMCifite uburyo butandukanye bwo gupima ubukana, guhitamo neza, ubwiza bwa firime yo gusiga, imiterere iruta izindi. Ibinini bya Ciprofloxacin hydrochloride ni ibinini by'umweru bisanzwe bifite inyuguti ebyiri. Ibi binini byo gusiga firime yoroshye biragoye, binyuze mu igerageza, bitoranya ubukana bwa 50 mpa # s bwa pulasitiki ishongera amazi, bishobora kugabanya umuvuduko w'imbere wa firime yoroshye, ibinini byo gusiga firime yoroshye bidafite ikiraro/ibyuya 0, 0, 0, 0 / amavuta y'umuhondo/ubushyuhe, 0 / guturika, nk'ikibazo cy'ubwiza, gusiga firime y'amazi yo gusiga, gufata neza, no gutuma impande z'amagambo zidasohoka, zisomeka neza, zifite uruhande rumwe rurabagirana, nziza. Ugereranyije n'amazi asanzwe yo gusiga, iyi miti yoroshya kandi irasobanutse, kandi ikiguzi kiragabanuka cyane.
Igihe cyo kohereza ubutumwa: 25 Mata 2024