Hydroxypropyl methylcellulose (HPMC)inoshandiswa seimwe yemishonga mikuru inosanganisa mishonga kumba nekune dzimwe nyika. HPMC inogona kushandiswa semushonga wekugadzira mafirimu, kunamira, mushonga wekusunungura unoenderera mberi, mushonga wekumisa, mushonga we emulsifier, mushonga wekuparadzana, nezvimwewo.
Zvinhu zvinobatsira mumishonga chikamu chakakosha chemishonga, uye basa razvo nderekuona kuti mishonga inotakurwa nenzira yakasarudzwa kuenda munyama nenzira yakati uye maitiro, kuitira kuti mishonga ibudiswe mumuviri nekumhanya kwakati uye nenguva yakati. Nokudaro, kusarudzwa kwezvinhu zvinobatsira mumishonga chimwe chezvinhu zvakakosha pakurapa kwemishonga.
1 Hunhu hweHPMC
HPMC ine hunhu hwakawanda husina zvimwe zvinhu zvinobatsira. Ine mvura inonyunguduka zvakanaka mumvura inotonhora. Chero bedzi ikaiswa mumvura inotonhora yobva yakurungwa zvishoma, inogona kunyungudika kuita mhinduro yakajeka. Pane kudaro, hainyungudike mumvura inopisa iri pamusoro pe60E uye inogona kungonyungudika chete. Isiri ionic cellulose ether, mhinduro yayo haina ionic charge, uye metal salts kana ionic organic compounds, kuitira kuti HPMC isaite nezvimwe zvinhu zvisina kugadzika mukugadzirwa kwayo. Ne anti-sensitivity yakasimba, uye nekuwedzera kwechimiro chemamorekuru chedanho rekutsiva, anti-sensitivity inowedzerwawo, ichishandisa HPMC semishonga inobatsira, zvichienzaniswa nekushandiswa kwemishonga yetsika (starch, dextrin, shuga powder), mhando yenguva inoshanda inogadzikana. Ine metabolic inertia. Sezvinhu zvinobatsira zvemishonga, haigone kugayiwa kana kunyudzwa, saka haipe macalorie mumishonga nechikafu. Inoshanda zvakasiyana pakurapa zvine simba shoma, mishonga isina munyu uye isingarwisi allergies uye chikafu chinodiwa nevanhu vane chirwere cheshuga. HPMC inogara kwenguva refu kune acid nealkali, asi kana ikadarika pH2 ~ 11 uye ikanyanya kupisa kana kuti nguva yekuchengetedza yakareba, viscosity inodzikira. Mvura inopa kushanda kwepamusoro uye ine simba riri pakati nepakati uye inosimbisa kusimba kwemukati memuviri. Ine emulsification inoshanda muchimiro chezvikamu zviviri uye inogona kushandiswa se stabilizer inoshanda uye inodzivirira colloid. Mvura ine simba rakanaka rekugadzira firimu uye chinhu chakanaka chekufukidza mapiritsi nemapiritsi. Firimu rinogadzirwa naro harina ruvara uye rakaoma. Kusimba kwayo kunogonawo kuwedzerwa nekuwedzera glycerol.
2. Kushandiswa kweHPMC mukugadzirwa kwepiritsi
2.1 Kuvandudza kuputsika
Kushandisa mhinduro ye HPMC ethanol kana mhinduro yemvura semushonga wekunyorovesa granulation, pakuvandudza kunyungudika kwemapiritsi, mhedzisiro yacho inoshamisa, uye kuomarara kuri nani pakudzvanywa mufirimu, zvinoita sekunge kwakatsetseka. Kunyungudika kwepiritsi reRenimodipine: kunyungudika kweglue kwaive 17.34% uye 28.84% apo guede raive 40% ethanol, 5% polyvinylpyrrolidone (40%) ethanol solution, 1% sodium dodecyl sulfate (40%) ethanol solution, 3% HPMC yakanyungudutswa kuita 10% starch pulp, 3% HPMC solution, 5% HPMC solution, zvichiteerana. 30.84%, 75.46%, 84.5%, 88%. Mwero wekunyungudika kwemapiritsi epiperic acid: kana chinonamira chiri 12% ethanol, 1% HPMC(40%) ethanol solution, 2% HPMC(40%) ethanol solution, 3% HPMC(40%) ethanol solution, mwero wekunyungudika uri 80.94%, 86.23%, 90.45%, 99.88%, zvichiteerana. Mwero wekunyungudika kwemapiritsi eCimetidine: kana chinonamira chiri 10% starch slurry uye 3% HPMC(40%) ethanol solution, mwero wekunyungudika waiva 76.2% uye 97.54%, zvichiteerana.
Kubva padata riri pamusoro apa, zvinogona kuonekwa kuti mhinduro yeethanol nemhinduro yemvura yeHPMC zvine simba rekuvandudza kunyungudika kwemishonga, izvo zvinonyanya kukonzerwa nekumisikidzwa uye kushanda kwepamusoro kweHPMC, kuderedza kushushikana kwepamusoro pakati pemhinduro nemishonga yakasimba, kuwedzera hunyoro, izvo zvinoita kuti mishonga inyungudike.
2.2 Kuvandudza kunaka kwekuputira
HPMC sechigadzirwa chefirimu, kana ichienzaniswa nezvimwe zvinhu zvinogadzira firimu (acrylic resin, polyethylene pyrrolidone), mukana wayo mukuru ndewekunyungudika kwayo mumvura, haidi zvinonyungudutsa zveorganic, inoshanda zvakachengeteka, uye iri nyore kushandisa. UyeHPMCine mhando dzakasiyana dze viscosity specifications, sarudzo yakakodzera, kunaka kwefirimu rekuputira, chitarisiko chiri nani pane zvimwe zvinhu. Mapiritsi eCiprofloxacin hydrochloride mapiritsi machena asina mavara ane mavara maviri. Aya mapiritsi ekuputira firimu rakatetepa akaoma, kuburikidza nekuyedza, anosarudza viscosity ye50 mpa # s yepurasitiki inonyungudika mumvura, anogona kuderedza kushushikana kwemukati kwefirimu rakatetepa, piritsi rekuputira risina bridge/sweat 0, 0, 0, 0 / orange peel/permeability oil, 0 / crack, senge dambudziko remhando, kuputira firimu remvura rinoumbwa, kunamira kwakanaka, uye kuunza muromo wezwi pasina kubuda, inoverengwa, One - side yakajeka, yakanaka. Kana tichienzanisa ne coating liquid yechinyakare, mushonga uyu uri nyore uye une musoro, uye mutengo wacho wakaderera zvikuru.
Nguva yekutumira: Kubvumbi-25-2024