Hydroxypropyl methylcellulose (HPMC)Ana amfani da shi a matsayin ɗaya daga cikin manyan abubuwan da ke ƙara wa magunguna ƙarfi a gida da waje. Ana iya amfani da HPMC a matsayin wakilin samar da fim, manne, wakilin sakin da ya daɗe, wakilin dakatarwa, mai hana ruwa gudu, wakilin wargazawa, da sauransu.
Sinadaran da ke taimakawa wajen samar da magunguna muhimmin bangare ne na shirye-shiryen magunguna, kuma aikinsu shi ne tabbatar da cewa ana jigilar magunguna zuwa kyallen takarda ta wata hanya da tsari, ta yadda za a saki magunguna a jiki a wani lokaci da kuma lokaci. Saboda haka, zabar sinadaran da suka dace yana daya daga cikin muhimman abubuwan da ke haifar da tasirin warkewa na shirye-shiryen magunguna.
1 Kadarorin HPMC
HPMC yana da halaye da yawa da sauran abubuwan da ke taimakawa wajen narkewar ruwa ba su da su. Yana da kyakkyawan narkewar ruwa a cikin ruwan sanyi. Muddin an ƙara shi a cikin ruwan sanyi kuma an gauraya shi kaɗan, zai iya narkewa ya zama mafita mai haske. Akasin haka, ba ya narkewa a cikin ruwan zafi sama da 60E kuma yana iya narkewa ne kawai. Yana da cellulose ether mara ionic, maganin sa ba shi da cajin ionic, da gishirin ƙarfe ko mahaɗan ionic na halitta, don tabbatar da cewa HPMC ba ta amsawa da wasu kayan masarufi a cikin tsarin samar da shiri ba. Tare da ƙarfin hana-sauƙin ji, da kuma ƙaruwar tsarin kwayoyin halitta na matakin maye gurbin, ana kuma inganta hana-sauƙin ji, ana amfani da HPMC azaman magungunan tallafi, idan aka kwatanta da amfani da wasu magungunan gargajiya (sitaci, dextrin, sukari foda), ingancin lokacin tasiri ya fi karko. Yana da rashin kuzarin metabolism. A matsayin kayan taimako na magunguna, ba za a iya narkewa ko sha ba, don haka ba ya samar da adadin kuzari a magani da abinci. Yana da amfani na musamman ga ƙarancin kalori, magani mara gishiri da rashin alerji, da kuma abincin da masu ciwon suga ke buƙata. HPMC ya fi daidaito ga acid da alkali, amma idan ya wuce pH2~11 kuma aka yi masa zafi mai yawa ko kuma lokacin ajiya ya fi tsayi, za a rage ɗanko. Maganin ruwa yana ba da aikin saman kuma yana gabatar da matsakaicin matsin lamba a saman da ƙimar tashin hankali a tsakanin fuska. Yana da ingantaccen emulsification a cikin tsarin matakai biyu kuma ana iya amfani da shi azaman mai daidaita aiki mai tasiri da kuma kariya daga colloid. Maganin ruwa yana da kyawawan kaddarorin samar da fim kuma kayan shafa ne mai kyau ga allunan da kwayoyi. Fim ɗin da aka samar ba shi da launi kuma yana da tauri. Hakanan ana iya ƙara ƙarfinsa ta hanyar ƙara glycerol.
2. Amfani da HPMC a cikin samar da kwamfutar hannu
2.1 Inganta rushewar
Amfani da maganin ethanol na HPMC ko maganin ruwa a matsayin maganin jika don granulation, don inganta narkewar allunan, tasirin yana da ban mamaki, kuma an matse shi cikin taurin fim ɗin ya fi kyau, bayyanar santsi. Narkewar allunan Renimodipine: narkewar manne shine 17.34% da 28.84% lokacin da manne shine ethanol 40%, 5% polyvinylpyrrolidone (40%) maganin ethanol, 1% sodium dodecyl sulfate (40%) maganin ethanol, 3% HPMC narke cikin ɓangaren sitaci 10%, 3% maganin HPMC, 5% maganin HPMC, bi da bi. 30.84%, 75.46%, 84.5%, 88%. Yawan narkewar ƙwayoyin piperic acid: idan manne ya kasance 12% ethanol, 1% HPMC (40%) maganin ethanol, 2% HPMC (40%) maganin ethanol, 3% HPMC (40%) maganin ethanol, 80.94%, 86.23%, 90.45%, 99.88%, bi da bi. Yawan narkewar ƙwayoyin Cimetidine: lokacin da manne ya kasance 10% sitaci slurry da 3% HPMC (40%) maganin ethanol, 76.2% da 97.54%, bi da bi.
Daga bayanan da ke sama, za a iya ganin cewa maganin ethanol da ruwan HPMC suna da tasirin inganta narkewar magunguna, wanda galibi sakamakon dakatarwa da aikin saman HPMC ne, rage tashin hankali tsakanin maganin da magungunan da ke da ƙarfi, yana ƙara danshi, wanda ke taimakawa wajen narkewar magunguna.
2.2 Inganta ingancin shafi
HPMC a matsayin kayan samar da fim, idan aka kwatanta da sauran kayan samar da fim (resin acrylic, polyethylene pyrrolidone), babban fa'idarsa ita ce narkewar ruwa, ba ya buƙatar sinadarai masu narkewa na halitta, aiki mai aminci, da dacewa.HPMCyana da nau'ikan takamaiman yanayin danko, zaɓin da ya dace, ingancin fim ɗin rufewa, kamanninsa ya fi sauran kayan aiki kyau. Allunan Ciprofloxacin hydrochloride fararen allunan ne masu launuka biyu. Waɗannan allunan don murfin fim mai siriri yana da wahala, ta hanyar gwaji, suna zaɓar ɗanko na 50 mpa # s na filastik mai narkewa cikin ruwa, yana iya rage damuwa ta ciki na fim ɗin siriri, yana shafa allunan ba tare da gada/gumi ba 0, 0, 0, 0 / bawon lemu/mai wucewa, 0 / fashewa, kamar matsalar inganci, samar da fim ɗin rufewa, kyakkyawan mannewa, da kuma kawo gefen kalma ba tare da zubewa ba, mai iya karantawa, Mai haske mai gefe ɗaya, kyakkyawa. Idan aka kwatanta da ruwan rufewa na gargajiya, wannan magani mai sauƙi ne kuma mai ma'ana, kuma farashin ya ragu sosai.
Lokacin Saƙo: Afrilu-25-2024