I-Hydroxypropyl methylcellulose (HPMC)isetyenziswa njengenye yezona zinto zibalulekileyo ezinceda amayeza ekhaya nakwamanye amazwe. I-HPMC ingasetyenziswa njengearhente yokwenza ifilimu, i-adhesive, i-ejenti yokukhulula eqhubekayo, i-ejenti yokumiswa, i-emulsifier, i-ejenti yokudiliza, njl.njl.
Izinto ezincedisayo kumayeza ziyinxalenye ebalulekileyo yokulungiselela amayeza, kwaye indima yazo kukuqinisekisa ukuba amayeza athunyelwa ngokukhetha kwizicwili ngendlela ethile nangenkqubo ethile, ukuze amayeza akhutshwe emzimbeni ngesantya esithile nangexesha elithile. Ke ngoko, ukukhethwa kwezinto ezifanelekileyo ezincedisayo yenye yezona zinto zibalulekileyo kwimpembelelo yonyango lwezinto ezincedayo kumayeza.
1 Iimpawu ze-HPMC
I-HPMC ineempawu ezininzi ezingenazo ezinye izinto ezincedisayo. Inobunyibiliko bamanzi obuhle kakhulu emanzini abandayo. Ukuba nje yongezwa emanzini abandayo kwaye ixutywe kancinci, inokunyibilika ibe sisisombululo esicacileyo. Ngokwahlukileyo koko, ayinyibiliki emanzini ashushu angaphezu kwe-60E kwaye inokunyibilika kuphela. Yi-non-ionic cellulose ether, isisombululo sayo asinayo i-ionic charge, kunye neetyuwa zesinyithi okanye ii-ionic organic compounds, ukuqinisekisa ukuba i-HPMC ayisabelani nezinye izinto eziluhlaza kwinkqubo yokulungiselela imveliso. Ngobukrelekrele obunamandla bokulwa novakalelo, kunye nokwanda kwesakhiwo se-molecular kwinqanaba lokutshintshwa, ubukrelekrele bokulwa novakalelo luyaphuculwa, kusetyenziswa i-HPMC njengeziyobisi ezincedisayo, xa kuthelekiswa nokusetyenziswa kwezinye iziyobisi zemveli ezincedisayo (isitatshi, i-dextrin, i-sugar powder), umgangatho wexesha elisebenzayo uzinzile ngakumbi. Ine-metabolic inertia. Njengezinto ezincedisayo zamayeza, ayinakuxutywa okanye ifunxwe, ngoko ayiboneleli ngeekhalori kumayeza nasekutyeni. Isebenza ngokukodwa kwixabiso eliphantsi leekhalori, amayeza angenatyuwa kwaye angenazo i-allergies kunye nokutya okufunekayo kubantu abanesifo seswekile. I-HPMC izinzile ngakumbi kwi-asidi kunye ne-alkali, kodwa ukuba idlula i-pH2 ~ 11 kwaye iphantsi kobushushu obuphezulu okanye ixesha lokugcina lide, i-viscosity iya kuncipha. Isisombululo samanzi sinika umsebenzi womphezulu kwaye sibonisa uxinzelelo oluphakathi lomphezulu kunye namaxabiso oxinzelelo lwe-interfacial. Ine-emulsification esebenzayo kwinkqubo yezigaba ezimbini kwaye ingasetyenziswa njengesiqinisi esisebenzayo kunye ne-colloid ekhuselayo. Isisombululo samanzi sineempawu ezintle zokwenza ifilimu kwaye sisixhobo esihle sokugquma iipilisi kunye neepilisi. Ifilimu eyenziwe yiyo ayinambala kwaye iqinile. I-plasticity yayo inokwandiswa ngokongeza i-glycerol.
2. Ukusetyenziswa kwe-HPMC kwimveliso yeethebhulethi
2.1 Ukuphucula ukuqhekeka
Ukusebenzisa isisombululo se-ethanol se-HPMC okanye isisombululo samanzi njengesixhobo sokumanzisa i-granulation, ukuphucula ukunyibilika kweepilisi, isiphumo siyamangalisa, kwaye ubulukhuni obucinezelweyo kwifilimu bungcono, ukubonakala buthambile. Ukunyibilika kwethebhulethi yeRenimodipine: ukunyibilika kweglue yayiyi-17.34% kunye ne-28.84% xa iglue yayiyi-40% ye-ethanol, isisombululo se-5% se-polyvinylpyrrolidone (40%) ye-ethanol, isisombululo se-1% se-sodium dodecyl sulfate (40%) ye-ethanol, i-3% ye-HPMC enyibilikisiweyo kwi-10% ye-starch pulp, isisombululo se-3% se-HPMC, isisombululo se-5% se-HPMC, ngokulandelanayo. 30.84%, 75.46%, 84.5%, 88%. Izinga lokunyibilika kweepilisi ze-asidi ye-piperic: xa i-adhesive iyi-12% ye-ethanol, isisombululo se-ethanol esingu-1% se-HPMC(40%), isisombululo se-ethanol esingu-2% se-HPMC(40%), isisombululo se-ethanol esingu-3% se-HPMC(40%), izinga lokunyibilika yi-80.94%, 86.23%, 90.45%, 99.88%, ngokwahlukeneyo. Izinga lokunyibilika kweepilisi ze-Cimetidine: xa i-adhesive yayiyi-10% ye-starch slurry kunye nesisombululo se-ethanol esingu-3% se-HPMC(40%), izinga lokunyibilika yayiyi-76.2% kunye ne-97.54%, ngokwahlukeneyo.
Ukusuka kule datha ingentla, kunokubonwa ukuba isisombululo se-ethanol kunye nesisombululo samanzi se-HPMC zinefuthe lokuphucula ukunyibilika kwamayeza, okubangelwa ikakhulu kukumiswa kunye nomsebenzi womphezulu we-HPMC, ukunciphisa uxinzelelo lomphezulu phakathi kwesisombululo kunye namayeza aqinileyo, kwandisa ukufuma, okukhuthaza ukunyibilika kwamayeza.
2.2 Ukuphucula umgangatho wokugquma
I-HPMC njengesixhobo sokwenza ifilimu, xa ithelekiswa nezinye izinto zokwenza ifilimu (i-acrylic resin, i-polyethylene pyrrolidone), eyona nzuzo inkulu kukunyibilika kwayo emanzini, ayidingi zinyibilikisi zendalo, isebenza ngokukhuselekileyo, ilula ukuyisebenzisa.I-HPMCineenkcazo ezahlukeneyo ze-viscosity, ukhetho olufanelekileyo, umgangatho wefilimu yokugquma, imbonakalo ingcono kunezinye izinto. Iipilisi ze-Ciprofloxacin hydrochloride ziipilisi ezimhlophe ezicacileyo ezinoonobumba abamacala amabini. Ezi pilisi zokugquma ifilimu encinci kunzima, ngokusebenzisa uvavanyo, zikhetha i-viscosity ye-50 mpa # s ye-plasticizer enyibilikayo emanzini, zinokunciphisa uxinzelelo lwangaphakathi lwefilimu encinci, ithebhulethi yokugquma engenabhuloho/ukubila 0, 0, 0, 0 / i-oyile ye-orenji eqweqwe/yokungena, 0 / ukuqhekeka, okufana nengxaki yomgangatho, ukugquma ifilimu yolwelo, ukunamathela okuhle, kunye nokuletha umda wamagama ngaphandle kokuvuza, okufundekayo, okukhanyayo kwicala elinye, okuhle. Xa kuthelekiswa nolwelo lokugquma lwendabuko, olu nyango lulula kwaye lufanelekile, kwaye ixabiso linciphile kakhulu.
Ixesha leposi: Epreli-25-2024