I-Hydroxypropyl methylcellulose (HPMC)isetshenziswa njengenye yezinto ezisiza kakhulu kwezemithi ekhaya naphesheya. I-HPMC ingasetshenziswa njenge-ejenti yokwakha ifilimu, i-adhesive, i-ejenti yokukhululwa okuqhubekayo, i-ejenti yokumiswa, i-emulsifier, i-ejenti ehlakazayo, njll.
Ama-excipients emithi ayingxenye ebalulekile yamalungiselelo emithi, futhi indima yabo ukuqinisekisa ukuthi izidakamizwa zihanjiswa ngokukhetha ezicutshini ngendlela ethile kanye nenqubo, ukuze izidakamizwa zikhishwe emzimbeni ngesivinini nesikhathi esithile. Ngakho-ke, ukukhethwa kwezinto ezisizayo ezifanelekile kungenye yezinto ezibalulekile zomphumela wokwelapha wamalungiselelo emithi.
1 Izakhiwo ze-HPMC
I-HPMC inezici eziningi abanye abasizi abangenazo. Inoncibilika kahle kakhulu emanzini abandayo. Uma nje yengezwe emanzini abandayo futhi inyakaziswa kancane, ingancibilika ibe yisixazululo esisobala. Ngokuphambene nalokho, empeleni ayincibiliki emanzini ashisayo angaphezu kuka-60E futhi ingancibilika kuphela. Ingabe i-non-ionic cellulose ether, isixazululo sayo asinayo i-ionic charge, kanye nosawoti wensimbi noma ama-ionic organic compounds, ukuze kuqinisekiswe ukuthi i-HPMC ayiphenduli nezinye izinto zokusetshenziswa ekulungiseni inqubo yokukhiqiza. Ngokuphikisana nokuzwela okuqinile, kanye nokwanda kwesakhiwo se-molecular of the degree of substitution, anti-sensitivity ibuye ithuthukiswe, kusetshenziswa i-HPMC njengezidakamizwa ze-adjuvant, ngokuphathelene nokusetshenziswa kwezinye izidakamizwa zendabuko (isitashi, i-dextrin, i-powder powder) izidakamizwa, izinga lenkathi ephumelelayo lizinzile kakhulu. Ine-inertia ye-metabolic. Njengezinto ezisizayo zemithi, ayikwazi ukuguqulwa noma ukumuncwa, ngakho-ke ayihlinzeki ngamakholori emithini nasekudleni. Inokusebenza okuyingqayizivele kwenani eliphansi le-calorific, imithi engenawo usawoti kanye ne-non-allergenic nokudla okudingekayo kubantu abanesifo sikashukela. I-HPMC izinze kakhulu ku-asidi ne-alkali, kodwa uma idlula i-pH2~11 futhi ingaphansi kwezinga lokushisa eliphezulu noma isikhathi sokulondoloza sinde, i-viscosity izoncipha. Isixazululo esine-aqueous sinikeza umsebenzi ongaphezulu futhi siveza ukungezwani kwendawo okumaphakathi kanye namanani wokungezwani phakathi kobuso. Ine-emulsification esebenzayo ohlelweni lwezigaba ezimbili futhi ingasetshenziswa njengesiqinisi esisebenzayo kanye ne-colloid evikelayo. Isixazululo se-Aqueous sinezakhiwo ezinhle kakhulu zokwakha ifilimu futhi siyinto enhle yokuhlanganisa amaphilisi namaphilisi. Ifilimu eyakhiwe yiyo ayinambala futhi iqinile. Ipulasitiki yayo nayo ingandiswa ngokungeza i-glycerol.
2.Ukusetshenziswa kwe-HPMC ekukhiqizweni kwethebhulethi
2.1 Yenza ngcono ukuhlakazwa
Ukusebenzisa isixazululo se-ethanol se-HPMC noma isisombululo samanzi njenge-ejenti yokumanzisa i-granulation, ukuze kuthuthukiswe ukuqedwa kwamaphilisi, umphumela uyamangalisa, futhi ucindezelwe ubulukhuni befilimu bungcono, ukubukeka okubushelelezi. Ukunyibilika kwethebhulethi ye-Renimodipine: ukunyibilika kwe-adhesive kwaba ngu-17.34% no-28.84% lapho okunamathelayo kungu-40% ethanol, 5% polyvinylpyrrolidone (40%) isixazululo se-ethanol, 1% sodium dodecyl sulfate (40%) isixazululo se-ethanol%, 3ch MC HP HP isixazululo, 3ch MC HP HP isixazululo, 5% HPMC isixazululo, ngokulandelana. 30.84%, 75.46%, 84.5%, 88%. Izinga lokuncibilika lamaphilisi e-piperic acid: lapho okunamathelayo kungu-12% ethanol, 1% HPMC(40%) isixazululo se-ethanol, 2% HPMC(40%) isixazululo se-ethanol, 3% HPMC(40%) isixazululo se-ethanol, izinga lokuncibilika ngu-80.94%, 86.9 9.8% ngokuhlonipha. Izinga lokuqedwa kwamaphilisi e-Cimetidine: lapho okunamathelayo bekuyi-10% isitashi slurry kanye nesixazululo se-ethanol esingu-3% se-HPMC (40%), izinga lokuchithwa lalingu-76.2% no-97.54%, ngokulandelana.
Kusukela kudatha engenhla, kungabonakala ukuthi isixazululo se-ethanol kanye nesisombululo se-aqueous se-HPMC sinomthelela wokuthuthukisa ukuchithwa kwezidakamizwa, okuwumphumela wokumiswa kanye nomsebenzi ongaphezulu we-HPMC, ukunciphisa ukungezwani kwendawo phakathi kwesisombululo nezidakamizwa eziqinile, okwandisa umswakama, okuvumela ukuqedwa kwezidakamizwa.
2.2 Thuthukisa ikhwalithi yokunamathela
I-HPMC njengezinto zokwakha ifilimu, uma kuqhathaniswa nezinye izinto zokwakha ifilimu (i-acrylic resin, i-polyethylene pyrrolidone), inzuzo enkulu kakhulu ukuncibilika kwayo kwamanzi, ayidingi izinyibilikisi eziphilayo, ukusebenza okuphephile, okulula. FuthiI-HPMCinezinhlobonhlobo zokucaciswa kwe-viscosity, ukukhetha okufanele, ikhwalithi yefilimu yokugqoka, ukubukeka kungcono kunezinye izinto. Amaphilisi e-Ciprofloxacin hydrochloride angamaphilisi amhlophe angenalutho anezinhlamvu ezizinhlangothi ezimbili. Lawa maphilisi okugcoba ifilimu encane kunzima, ngokusebenzisa ukuhlolwa, ukukhetha i-viscosity ye-50 mpa # s ye-plasticizer encibilikayo emanzini, anganciphisa ukucindezeleka kwangaphakathi kwefilimu encane, ithebhulethi yokugqoka ngaphandle kwebhuloho / umjuluko 0, 0, 0, 0 / orange peel / permeability oil, 0 / crack, njengenkinga yekhwalithi, ukumboza ifilimu ye-liquid ngaphandle kokwakheka kwe-liquid, kanye ne-aka eqinile ye-edge ehlangene elikhanyayo, elihle. Uma kuqhathaniswa noketshezi olujwayelekile lokumboza, lesi sidakamizwa silula futhi sinengqondo, futhi izindleko ziyancipha kakhulu.
Isikhathi sokuthumela: Apr-25-2024