1. Te āhua taketake o te HPMC
Ko te Hypromellose, te ingoa Ingarihi hydroxypropyl methylcellulose, ko HPMC anō hoki. Ko tōna tauira ngota ko C8H15O8-(C10Hl8O6)n-C8Hl5O8, ā, ko te taumaha ngota he tata ki te 86,000. He rauemi hanga-haurua tēnei hua, he wāhanga o te rōpū methyl me te wāhanga o te polyhydroxypropyl ether o te cellulose. E rua ngā tikanga e taea ai te hanga: ko te tuatahi ko te rongoā i te methyl cellulose o te taumata e tika ana ki te NaOH, kātahi ka tauhohe ki te propylene oxide i raro i te pāmahana teitei me te pēhanga teitei. Me mau tonu te wā tauhohe kia taea ai e ngā rōpū methyl me te hydroxypropyl te hono ki te ether. Ko te āhua o te hono atu ki te mowhiti anhydroglucose o te cellulose, ā, ka taea te eke ki te taumata e hiahiatia ana; ko tētahi atu ko te rongoā i te miro miro, i te muka penupenu rakau rānei ki te houra tunutunu, kātahi ka whiwhi mā te tauhohe ki te methane chlorinated me te propylene oxide, kātahi ka whakapaia anō, ka kuru, ka hanga hei paura, hei kirikiri rānei, kia rite, kia pai hoki. He momo tipu tūturu te HPMC, ā, he mea tino pai hoki hei tāpiri rongoā, he whānui te pūtake. I tēnei wā, e whakamahia whānuitia ana i te kāinga me tāwāhi, ā, ko tētahi o ngā mea tāpiri rongoā me te reiti whakamahinga teitei rawa atu i roto i ngā rongoā ā-waha.
He mā ki te mā miraka te tae o tēnei hua, kāore he paitini, kāore hoki he reka, ā, he paura kirikiri, he muka rānei, he ngāwari te rere. He pumau tonu i raro i te māramatanga me te haumākū. Ka pupuhi i roto i te wai matao hei hanga i tētahi otinga kōrori mā miraka me tētahi taumata matotoru. Ka puta pea te āhuatanga whakawhiti sol-gel nā te huringa pāmahana o tētahi kukū o te otinga. He tino ngāwari te rewa ki roto i te 70% waipiro, te dimethyl ketone rānei, ā, e kore e rewa ki roto i te waipiro waikore, te chloroform, te ethoxyethane rānei.
He pai te pumau o te hypromellose ina kei waenga i te 4.0 me te 8.0 te pH, ā, ka taea te noho pumau i waenga i te 3.0 me te 11.0. I muri i te rongoa mō ngā rā 10 i te pāmahana 20°C me te haumākū whanaunga o te 80%, ko te tauwehenga mimiti makuku o te HPMC he 6.2%.
Nā te rerekētanga o te ihirangi o ngā whakakapinga e rua i roto i te hanganga o te hypromellose, te methoxy me te hydroxypropyl, kua puta mai ngā momo hua rerekē. I roto i te kukū motuhake, he momo hua rerekē te matotoru me te pāmahana whakamahana o ngā hua, nō reira, he rerekē ngā āhuatanga, ā, ka taea te whakamahi mō ngā kaupapa rerekē. He rerekē ngā whakaritenga me ngā kīanga o ngā pharmacopoeia o ngā whenua rerekē mō te tauira: Ko te Pharmacopoeia Pākehā e hangai ana ki ngā momo taumata o ngā matotoru rerekē me ngā nekehanga rerekē o te whakakapinga o ngā hua kei te mākete. Ka whakaatuhia e te tohu me te tau. Ko te waeine ko mPa•s. Whai muri i te tāpiri i ngā mati e 4 hei tohu i te ihirangi me te momo o ia whakakapinga o te hypromellose, hei tauira, hypromellose 2208, ko ngā mati tuatahi e rua e tohu ana i te ōrau tata o te rōpū methoxy, ko ngā mati whakamutunga e rua e tohu ana i te hydroxypropyl. Te ōrau tata o ngā take.
2. Te tikanga whakarewa HPMC ki te wai
2.1 Tikanga wai wera
Nā te mea kāore te hypromellose e rewa ki te wai wera, ka taea te whakamarara ōrite ki te wai wera i te tīmatanga, ā, ina whakamataohia, e rua ngā tikanga e whakaahuatia ana penei:
(1) Tāpirihia te nui o te wai wera e hiahiatia ana ki roto i te ipu, ka whakamahana kia tata ki te 70℃. Tāpirihia mārire te hua me te whakaoho mārire. I te tīmatanga, ka mānu te hua i runga i te mata o te wai, kātahi ka hanga mārire hei paraoa pokepoke. Whakamataohia te paraoa pokepoke.
(2) Tāpirihia te 1/3, te 2/3 rānei o te nui o te wai e hiahiatia ana ki roto i te ipu, ka whakamahana ki te 70°C hei whakamarara i te hua hei whakarite i te ranunga wai wera, kātahi ka tāpirihia te toenga o te wai matao, te wai huka rānei ki te ranunga wai wera. I roto i te ranunga, whakamataohia te ranunga i muri i te whakaoho.
2.2 Tikanga whakaranu paura
Ka marara katoatia ngā matūriki paura me ētahi atu kai paura o te rahinga ōrite, nui atu rānei mā te whakaranu maroke, kātahi ka tāpirihia he wai hei whakarewa. I tēnei wā, ka taea te whakarewa i te hypromellose me te kore e whakaemi.
3. Ngā Painga o te HPMC
3.1 Te wairewatanga i roto i te wai matao
Ka wairewa i roto i te wai matao i raro i te 40°C, i te 70% rānei o te etanoru. Kāore e wairewa i roto i te wai wera i runga ake i te 60°C, engari ka taea te whakakorikori.
3.2 Te koretake o te matū
Ko te Hypromellose (HPMC) he momo cellulose ether kore-ionic. Kāore he utu ionic o tōna otinga, ā, kāore e taunekeneke ki ngā tote whakarewa, ki ngā matū waro ionic rānei. Nō reira, kāore ētahi atu mea tāpiri e taunekeneke ki a ia i te wā e whakaritea ana.
3.3 Te Pūmautanga
He tino pumau ki te waikawa me te kawakore, ā, ka taea te penapena mō te wā roa i waenga i te pH 3 ki te 1 rita, ā, kāore he rerekētanga kitea o tōna matotoru. He pānga ārai-pokepoke te wai o te hypromellose (HPMC), ā, ka taea te pupuri i te pumau matotoru pai i te wā e penapena ana mō te wā roa. He pai ake te pumau o ngā matū rongoā e whakamahi ana i te HPMC i ērā e whakamahi ana i ngā matū tuku iho (pērā i te dextrin, te māngaro, me ētahi atu).
3.4 Te whakarerekētanga o te matotoru
Ka taea te whakaranu i ngā momo matotoru rerekē o te HPMC i ngā ōwehenga rerekē, ā, ka taea te whakarerekē i tōna matotoru i runga i tētahi ture, ā, he pai te whanaungatanga raina, kia taea ai te whiriwhiri i runga i ngā whakaritenga.
3.5 Te ngoikore o te pūnaha io
Kāore te HPMC e mimitia, e whakapūkaratia rānei e te tinana, ā, kāore hoki e whakarato i ngā kaora, nō reira he mea haumaru hei tāpiri mō ngā whakaritenga rongoā.
3.6 Haumarutanga
E whakaponohia whānuitia ana he rauemi kore-paitini, kore-whakariri hoki te HPMC. Ko te horopeta whakamate toharite mō ngā kiore ko te 5g/kg, ā, ko te horopeta whakamate toharite mō ngā kiore ko te 5.2g/kg. Kāore he kino o te horopeta o ia rā ki te tinana tangata.
4. Te whakamahinga o te HPMC i roto i ngā whakaritenga
4.1 Whakamahia hei rauemi paninga kiriata me te rauemi hanga kiriata
Ko te Hypromellose (HPMC) e whakamahia ana hei rauemi papa paninga kiriata. Ki te whakatauritea ki ngā papa paninga tuku iho pērā i ngā papa paninga huka, kāore he painga kitea o ngā papa paninga ki te huna i te reka me te āhua, engari he pai ake te pakeke me te ngawari ki te pakarukaru, te mimiti makuku, te pakarukaru, te pikinga taumaha o te paninga me ētahi atu tohu kounga. Ko te taumata matotoru iti o tēnei hua e whakamahia ana hei rauemi paninga kiriata wairewa-wai mō ngā papa me ngā pire, ā, ko te taumata matotoru teitei e whakamahia ana hei rauemi paninga kiriata mō ngā pūnaha whakarewa waro. Ko te kukū whakamahinga he 2.0%-20%.
4.2 hei here me te whakarewa
Ka taea te whakamahi i te taumata matotoru iti o tēnei hua hei here me te whakarewa mō ngā papa, pire, me ngā kirikiri, ā, ko te taumata matotoru teitei ka taea anake te whakamahi hei here. Ka rerekē te horopeta i runga i ngā tauira me ngā whakaritenga rerekē. Ko te tikanga, ko te nui o te here e whakamahia ana mō ngā papa kirikiri maroke he 5%, ā, ko te nui o te here e whakamahia ana mō ngā papa kirikiri mākū he 2%.
4.3 Hei kaiwhakatārewatanga
He matū kirikiri matotoru te kaiārai whakatārewatanga, he wai-aroha. Mā te whakamahinga o te kaiārai whakatārewatanga i roto i te kaiārai whakatārewatanga ka taea te whakaroa i te tere o te whakatō o ngā matūriki, ā, ka taea hoki te tāpiri ki te mata o ngā matūriki hei ārai i te whakakotahitanga me te whakapūmautanga o ngā matūriki hei puranga. He mahi nui tā ngā kaiārai whakatārewatanga i roto i te hanga whakatārewatanga. He momo kaiārai whakatārewatanga pai rawa atu te HPMC. Ka taea e te otinga colloidal i rewa ki roto te whakaiti i te kukū o te atanga wai-totoka me te pūngao kore utu i runga i ngā matūriki totoka iti, ā, ka whakarei ake i te pumau o te pūnaha marara rerekē. He wai whakatārewatanga matotoru-teitei tēnei hua kua whakaritea hei kaiārai whakatārewatanga. He pai te pānga whakatārewatanga, he ngāwari ki te marara anō, kāore e piri, ā, he pai ngā matūriki kua pupuhi. Ko te nui noa ko te 0.5% ki te 1.5%.
4.4 Whakamahia hei aukati, hei kaihoko tuku puhoi, whakahaeretia hoki, me te kaihoko hanga pore
Ko te taumata matotoru teitei o tēnei hua e whakamahia ana hei whakarite i ngā papa tuku-tonu o te matrix gel hydrophilic, ngā mea whakaroa me ngā kaihoko tuku-mana mō ngā papa tuku-tonu o te matrix rauemi-whakauru. Ko tōna pānga he whakaroa i te tukunga rongoā. Ko tōna kukū whakamahinga he 10%~80% (W /W). Ko te taumata matotoru iti e whakamahia ana hei kaihoko hanga-pūwero mō ngā whakatakotoranga tuku-tonu, tuku-mana rānei. Ka taea te tere te whakatutuki i te horopeta tuatahi e hiahiatia ana mō te pānga rongoā o tēnei momo papa, kātahi ka puta te pānga tuku-tonu, tuku-mana rānei, ā, ka mau tonu te kukū rongoā toto whai hua i roto i te tinana. Ka whakamakuku te hypromellose hei hanga i tētahi paparanga gel ina tūtaki ki te wai. Ko te tikanga tukunga rongoā mai i te papa matrix ko te horapa o te paparanga gel me te mimiti o te paparanga gel.
4.5 Te kāpia tiaki e whakamahia ana hei whakamātotoru me te kōroiti
Ina whakamahia tēnei hua hei whakamātotoru, ko te kukū noa ko te 0.45%~1.0%. Ka taea hoki e tēnei hua te whakanui ake i te pumau o te kāpia hydrophobic, te hanga i tētahi colloid tiaki, te ārai i te whakakotahitanga me te kohikohinga o ngā matūriki, ā, ka ārai i te hanganga o ngā paru. Ko tōna kukū noa ko te 0.5%~1.5%.
4.6 Whakamahia hei rauemi kāpūru
Ko te tikanga, ko te anga o te kāpū he gelatin te nuinga. He māmā noa te tukanga hanga o te anga kāpū Ming, engari he raruraru me ngā āhuatanga anō hoki pērā i te kore e tiakina pai ngā rongoā e aro ana ki te makuku me te hāora, te iti o te whakarewanga o te rongoā, me te whakaroa i te pakaru o te anga kāpū i te wā e rongoatia ana. Nō reira, ka whakamahia te hypromellose hei whakakapi mō te rauemi kāpū i roto i te whakarite kāpū, e whakapai ake ana i te ngāwari o te pokepoke me te pānga whakamahi o te kāpū, ā, kua whānuitia te whakatairanga i roto i te kāinga me tāwāhi.
4.7 Hei piripiri koiora
Ko te hangarau piri-koiora, ko te whakamahinga o ngā mea tāpiri me ngā pūmua piri-koiora, mā te piri ki te kiriuhi pūtau koiora, ka whakarei ake i te haere tonu me te piri o te hononga i waenga i te whakaritenga me te kiriuhi pūtau, kia āta tukuna ai te rongoā, kia mimitia hoki e te kiriuhi pūtau kia tutuki ai te kaupapa o te maimoatanga. He whānui te whakamahinga i nāianei. Ka whakamahia hei rongoā i ngā mate o te kōhao ihu me te kiriuhi pūtau waha. Ko te hangarau piri-koiora puku he momo pūnaha tuku rongoā hou kua whakawhanakehia i ngā tau tata nei. Ehara i te mea ka roa ake te wā noho o ngā whakaritenga rongoā ki te ara puku, engari ka whakapai ake hoki i te mahi hononga o te rongoā ki te kiriuhi pūtau o te wāhi mimiti me te whakarerekē i te rere o te kiriuhi pūtau. Ka whakanuia te kaha uru o te rongoā ki ngā pūtau epithelial o te whekau iti, ā, ka whakapai ake i te waatea o te rongoā.
4.8 Hei kirimi pani
Hei takai piri mō te kiri, he maha ngā painga o te tiēre pēnei i te haumaru, te ataahua, te ngāwari ki te horoi, te iti o te utu, te ngāwari o te tukanga whakarite, me te pai o te hototahitanga ki ngā rongoā. I ngā tau tata nei, kua aro nuihia, ā, kua waiho hei whanaketanga o ngā takai o waho o te kiri.
4.9 Hei aukati i te rerenga wai i roto i te pūnaha whakaemulsification
Wā tuku: Hakihea-16-2021