Isimo sokuthuthukiswa kobuchwepheshe bokukhiqiza i-HPMC kanye nenqubo ye-hydroxypropyl methyl cellulose eShayina

Isimo sokuthuthukiswa kobuchwepheshe bokukhiqiza i-HPMC kanye nenqubo ye-hydroxypropyl methyl cellulose eShayina

I-Hydroxypropyl methyl celluloseI-HPMCUbuchwepheshe be-Wuxi Chemical Industry Research and Design Institute eChina buqala ngo-1970, kanti impumelelo yocwaningo isekelwe ekukhuthazeni, okwangempela yindlela yokusabela kwe-etherification yegesi, ngoba imishini ayivumelani nezwe lethu, yabe isisebenza ngendlela yokusabela kwe-etherification ye-liquid phase. Kuze kube manje, indlela yokusabela kwe-etherification ye-liquid phase isalokhu iyinqubo eyinhloko yokukhiqiza yabakhiqizi be-cellulose ether abaziwayo.

Ukukhiqizwa kwe-HPMC ye-hydroxypropyl methyl cellulose yasekhaya ngokuvamile kusebenzisa ukotini ocwengekile njengezinto zokusetshenziswa (abanye abakhiqizi nabo baqala ukuzama ukusebenzisa i-pulp yokhuni), kanye ne-grinder yasekhaya egaya noma basebenzise ngqo i-alkalization kakotini ocwengekile, i-etherification besebenzisa i-binary mixed organic solvent, ukusabela ku-reactor eqondile. Inqubo yokuhlanza isebenzisa inqubo eqhubekayo lapho i-organic solvent isuswa ku-reactor bese umkhiqizo ongahluziwe uhlanzwa ngokuwasha okuningana kanye nokuphelelwa amanzi emzimbeni ngokusebenzisa ama-scrubbers nama-centrifuges. Ukucubungula umkhiqizo okuqediwe nge-granulation eqhubekayo, ngaphansi kwesimo sokushisa (kukhona nomkhiqizi ngaphandle kwe-granulation), ukomisa nokuchoboza ngendlela evamile, iningi lokucubungula okukhethekile kumane nje kubambezela isikhathi sokuhlanza umkhiqizo (ukuncibilikisa ngokushesha) ukucubungula ngaphandle kokuvimbela isikhunta kanye nokucubungula ukusatshalaliswa, ukusetshenziswa kokupakisha ngendlela yesandla.

Indlela yesigaba soketshezi inezinzuzo ezilandelayo: inqubo yokusabela kwemishini ingcindezi yangaphakathi incane, izidingo zomthamo wokucindezela imishini ziphansi, ingozi encane; Ngemva kokuminza nge-lye,i-celluloseingandiswa ngokugcwele futhi i-alkalized ngokulinganayo. I-Lye inokungena okungcono kanye nokuvuvukala kwe-cellulose. I-reactor ye-etherification incane, ihambisana nokuvuvukala okufanayo kwe-alkali cellulose, ngakho-ke ikhwalithi yomkhiqizo kulula ukuyilawula, izinga lokushintshana kanye ne-viscosity kungatholakala imikhiqizo efanayo, izinhlobo nazo kulula ukuzishintsha.

Kodwa-ke, le nqubo inazo izinkinga ezilandelayo: i-reactor ngokuvamile ayinkulu kakhulu, ukulinganiselwa kwezibalo kuholela emkhiqizweni omncane, ukuze kuthuthukiswe umkhiqizo, kuyadingeka ukwandisa inani lama-reactor; Imikhiqizo eluhlaza ehlanziwe futhi ehlanziwe idinga imishini eyengeziwe, ukusebenza okuyinkimbinkimbi, ukuqina kwabasebenzi; Ngoba akukho ukwelashwa okulwa nokukhunta kanye nokuhlanganiswa, okuholela ekuzinzeni kwe-viscosity yomkhiqizo kanye nezindleko zokukhiqiza ziyathinteka; Ukupakishwa ngendlela yesandla, ukuqina kwabasebenzi, izindleko eziphezulu zabasebenzi; Izinga lokulawula ukusabela ngokuzenzakalelayo liphansi kunelenqubo yesigaba segesi, ngakho-ke ukunemba kokulawula kuphansi kakhulu. Uma kuqhathaniswa nenqubo yesigaba segesi, kudingeka izinhlelo zokubuyisa i-solvent eziyinkimbinkimbi.

Ngokuthuthukiswa kwe-hydroxypropyl methyl cellulose yasekhayaI-HPMCubuchwepheshe bokukhiqiza, amanye amabhizinisi ngokusebenzisa ukusungula izinto ezintsha okuqhubekayo, indlela yesigaba soketshezi esikhulu se-kettle ithuthukiswe ngokushesha okukhulu, futhi inezici zayo zobuchwepheshe. I-Anxin chemistry isebenzisa inqubo yokuqala yokukhiqiza ye-HPMC, hhayi nje kuphela inqubo yokukhiqiza enengqondo, amapharamitha okulawula ukusebenza anembile futhi athembekile, ukusetshenziswa okugcwele nokunengqondo kwezinto zokusetshenziswa nezinye izici, kanye nezinga lokushintsha umkhiqizo liyafana, ukusabela kuphelele ngokuphelele, ukucaca kwesixazululo kuhle, futhi ngesikhathi esifanayo ukuqinisekisa ukuzinza kwekhwalithi yomkhiqizo. Umugqa wokukhiqiza we-HPMC wamanye amabhizinisi ube ukuguqulwa okuzenzakalelayo, ukuze kufezwe izidingo zokulawula ngokuzenzakalela kwe-DCS yedivayisi, izinto ezifaka uketshezi, izinto zokusetshenziswa eziqinile zingasetshenziswa ukukala ngokunembile nokwengeza uhlelo lwe-DCS, izinga lokushisa kanye nokulawula ingcindezi enkambisweni yokusabela konke kuyabonakala ukulawula okuzenzakalelayo kwe-DCS kanye nokuqapha okude, Ngokuphathelene nokusebenziseka, ukuthembeka, ukuzinza kanye nokuphepha kokukhiqiza, kusobala ukuthi kuthuthukisiwe uma kuqhathaniswa nemodi yokukhiqiza yendabuko, engagcini nje ngokusindisa abasebenzi, inciphise ukuqina kwabasebenzi, kodwa futhi ithuthukisa indawo yokusebenza esizeni.