Imeko yophuhliso lwetekhnoloji yemveliso ye-HPMC kunye nenkqubo ye-hydroxypropyl methyl cellulose eTshayina

Imeko yophuhliso lwetekhnoloji yemveliso ye-HPMC kunye nenkqubo ye-hydroxypropyl methyl cellulose eTshayina

I-Hydroxypropyl methyl celluloseI-HPMCUbuchwepheshe be-Wuxi Chemical Industry Research and Design Institute eTshayina bubekwe phambili ngeminyaka yoo-1970, uphando luye lwaphunyezwa ngesiseko se-promotion, eyona ndlela yokuqala yindlela ye-etherification yegesi, kuba izixhobo azihambelani nelizwe lethu, emva koko zasebenza indlela ye-etherification ye-liquid phase, okwangoku indlela ye-etherification ye-liquid phase isasebenza njengenkqubo yemveliso eyintloko yabavelisi be-cellulose ether abaziwayo.

Imveliso ye-HPMC yasekhaya ye-hydroxypropyl methyl cellulose ngokubanzi isebenzisa umqhaphu ocoliweyo njengezinto eziluhlaza (abanye abavelisi nabo baqala ukuzama ukusebenzisa i-pulp yomthi), kunye ne-grinder yasekhaya yokusila okanye ukusebenzisa ngqo i-alkalization yekotoni ecoliweyo, i-etherification isebenzisa i-binary mixed organic solvent, i-reaction kwi-reactor ethe nkqo. Inkqubo yokucoca isebenzisa inkqubo engapheliyo apho i-organic solvent isuswa kwi-reactor kwaye imveliso engcolileyo ihlanjululwa ngokuhlamba okuliqela kunye nokukhupha amanzi emzimbeni ngokusebenzisa ii-scrubbers kunye ne-centrifuges. Ukulungiswa kwemveliso okugqityiweyo nge-granulation engapheliyo, phantsi kwemeko yokufudumeza (kukwakho nomenzi ongena-granulation), ukomisa nokutyumza ngendlela yesiqhelo, uninzi lwenkqubo ekhethekileyo kukulibaziseka nje ixesha lokufuma kwemveliso (ukunyibilika ngokukhawuleza) ukucubungula ngaphandle kokuthintela ukubola kunye nokusasazwa kokucubungula, ukusetyenziswa kwendlela yokupakisha ngesandla.

Indlela yesigaba solwelo inezi nzuzo zilandelayo: uxinzelelo lwangaphakathi lwenkqubo yokusabela kwezixhobo luncinci, iimfuno zomthamo woxinzelelo lwezixhobo ziphantsi, umngcipheko omncinci; Emva kokufunxa kwi-lye,i-celluloseinokwandiswa ngokupheleleyo kwaye i-alkalized ngokulinganayo. I-Lye inokungena okungcono kunye nokudumba kwe-cellulose. I-reactor ye-etherification incinci, idibene nokudumba okufanayo kwe-alkali cellulose, ngoko ke umgangatho wemveliso kulula ukuwulawula, inqanaba lokutshintshwa kunye ne-viscosity zinokufunyanwa iimveliso ezifanayo ngakumbi, iintlobo nazo kulula ukuzitshintsha.

Nangona kunjalo, le nkqubo ikwanazo nezi ngxaki zilandelayo: i-reactor idla ngokuba nkulu kakhulu, ukulinganiselwa kwezibalo kukhokelela kumthamo omncinci wemveliso, ukuze kuphuculwe imveliso, kuyimfuneko ukwandisa inani lee-reactor; Iimveliso ezicociweyo nezicociweyo zifuna izixhobo ezingaphezulu, ukusebenza okuntsonkothileyo, amandla abasebenzi; Ngenxa yokuba akukho nyango lokulwa nokungunda kunye ne-compound, okubangela uzinzo lwe-viscosity yemveliso kunye neendleko zemveliso ziyachaphazeleka; Ukupakishwa ngendlela yesandla, amandla abasebenzi, iindleko eziphezulu zomsebenzi; Izinga lolawulo lokuphendula oluzenzekelayo liphantsi kunelo lenkqubo yesigaba segesi, ngoko ke ukuchaneka kokulawula kuphantsi kakhulu. Xa kuthelekiswa nenkqubo yesigaba segesi, kufuneka iinkqubo zokubuyisela i-solvent ezintsonkothileyo.

Ngokuphuculwa kwe-hydroxypropyl methyl cellulose yasekhayaI-HPMCItekhnoloji yemveliso, amanye amashishini ngokusebenzisa ubuchule obuzimeleyo obuqhubekayo, indlela yesigaba solwelo olukhulu lwekettle iphuhlisiwe ngokukhawuleza, kwaye ineempawu zayo zobugcisa. Ikhemistri ye-Anxin isebenzisa inkqubo yokuqala yemveliso ye-HPMC, ayisiyo kuphela inkqubo yemveliso efanelekileyo, iiparameter zolawulo lokusebenza zichanekile kwaye zithembekile, ukusetyenziswa ngokupheleleyo nangokufanelekileyo kwezinto ezikrwada kunye nezinye iimpawu, kwaye isidanga sokutshintshwa kwemveliso siyafana, impendulo iphelele, ukucaca kwesisombululo kulungile, kwaye kwangaxeshanye ukuqinisekisa uzinzo lomgangatho wemveliso. Umgca wemveliso ye-HPMC kwamanye amashishini uye waguqulwa ngokuzenzekelayo, ukufezekisa iimfuno zolawulo lwe-DCS oluzenzekelayo lwesixhobo, izixhobo ezibandakanya ulwelo, izinto ezikrwada eziqinileyo zingasetyenziselwa ukulinganisa ngokuchanekileyo kunye nokongeza inkqubo ye-DCS, ubushushu kunye nolawulo loxinzelelo kwinkqubo yokusabela zonke ziyafezekiswa ulawulo oluzenzekelayo lwe-DCS kunye nokujonga kude, Ngokuphathelele ukwenzeka, ukuthembeka, uzinzo kunye nokhuseleko lwemveliso, ngokucacileyo iphuculwe xa ithelekiswa nendlela yemveliso yendabuko, engagcini nje ngokusindisa abasebenzi, inciphisa amandla abasebenzi, kodwa ikwaphucula imeko yokusebenza kwindawo.