Indlela yoVavanyo lweHydroxypropyl Methylcellulose Viscosity

I-Hydroxypropyl methylcellulose (HPMC)yi-nonionic cellulose ether ebalulekileyo esetyenziswa kakhulu ekwakheni, kumayeza, ekutyeni, nakwiikhemikhali zemihla ngemihla. Ukuqina komzimba luphawu oluphambili lokuvavanya umgangatho kunye nokusebenza kwe-HPMC. Ayibonisi nje kuphela iimpawu ze-rheological zesisombululo sayo kodwa ikwanxulumene ngokuthe ngqo nokuqina kwayo, ukugcinwa kwamanzi, kunye neempawu zokwenza ifilimu. Ukuqinisekisa umgangatho wemveliso ohambelanayo, ukulinganiswa kwe-viscosity kufuneka kwenziwe kusetyenziswa indlela yovavanyo lwe-viscosity yesayensi nesemgangathweni.

1. Umgaqo woVavanyo

I-HPMC iyanyibilika emanzini ukuze yenze isisombululo esicacileyo okanye esikhanyayo. Ukuqina kwayo kuxhomekeke kakhulu kwinqanaba le-polymerization, izinga lokutshintshwa, kunye noxinzelelo lwesisombululo. Uvavanyo lwe-viscosity lubonisa iimpawu zokuhamba kwesisombululo se-HPMC ngokulinganisa ukungqubana kwangaphakathi kwesisombululo ngexesha lokuhamba kubushushu obuthile. Ukulinganisa kudla ngokwenziwa kusetyenziswa i-viscometer ejikelezayo (uhlobo lwaseBrookfield) okanye i-viscometer ye-capillary. Indlela ejikelezayo isetyenziswa kakhulu, njengoko inika ukuqonda okucacileyo kweempawu zokunciphisa ukucheba kwesisombululo kwizantya ezahlukeneyo zokujikeleza.

2. Imigangatho Eqhelekileyo kunye neMeko yoVavanyo

Okwangoku, uvavanyo lwe-HPMC viscosity lusekelwe ikakhulu koku kulandelayo:

Umgangatho waseTshayina: GB/T 12000 “Iindlela zoVavanyo oluQhelekileyo lwee-Ether zeCellulose”

Umgangatho wase-US: ASTM D1347 “Iindlela zoVavanyo oluQhelekileyo lweZisombululo ze-Cellulose Ether”

Indlela yokusebenza kushishino: Ubungakanani bulinganiswa kusetyenziswa isisombululo samanzi se-2% kwi-20°C kusetyenziswa i-Brookfield rotational viscometer.

Uxinaniso lwesisombululo sovavanyo ngokubanzi yi-2% (inxalenye yobunzima), kodwa amanqanaba ahlukeneyo e-HPMC anokufuna ukulinganiswa kwi-1%, 2%, okanye amazinga aphezulu. Ubushushu bovavanyo kufuneka bulawulwe ngokungqongqo kwi-20±0.1°C, njengoko ukuguquguquka kobushushu kunokuchaphazela kakhulu ukufundwa kwe-viscosity.

3. Inkqubo yoVavanyo

3.1. Ukulungiswa kweReagent kunye neZixhobo

Ibhalansi yohlalutyo oluchanekileyo (ukuchaneka kwe-0.1 mg)

I-Brookfield rotational viscometer (uthotho lwe-LV olufumaneka rhoqo)

3.2. Ukuhlamba amanzi ngobushushu obuqhelekileyo okanye indawo elawulwa bubushushu

Amanzi acocekileyo (ahlangabezana neemfuno zamanzi ze-GB/T 6682 Grade III)

I-beaker ecocekileyo kunye ne-stirrer

3.3. Ukulungiselela Isisombululo

Linganisa ngokuchanekileyo i-2.00 g (± 0.01 g) yesampulu ye-HPMC.

Beka malunga ne-80% yomthamo wamanzi acocekileyo (malunga ne-80 mL) kwi-beaker uze uyifudumeze ukuya kuthi ga kwi-80°C. Kancinci nangokulinganayo fafaza i-HPMC kwi-beaker ngelixa uvuselela ukuze ungaqini.

Qhubeka uvuselela ide i-HPMC imanziswe kakuhle kwaye isasazeke. Emva koko, yongeza amanzi abandayo aseleyo uze uwapholise kubushushu begumbi, uze uzise umthamo opheleleyo kwi-100 mL.

Faka isisombululo efrijini kwi-4°C ubusuku bonke ukuze uvumele ukudumba okupheleleyo kwaye ususe amaqamza omoya.

3.4. Umlinganiselo wobungqindilili

Dlulisa isisombululo kwindawo yokuhlambela amanzi enobushushu obungaguqukiyo, ugcine ubushushu obuyi-20 ± 0.1°C. Khetha i-spindle efanelekileyo (ngesiqhelo iNombolo 2 okanye iNombolo 3) kunye nesantya (ngesiqhelo i-30 rpm).

Qalisa i-viscometer uze urekhode ukufundwa emva kokuba inaliti izinze. Phinda umlinganiselo ngamnye kathathu, uze uthathe umyinge njengesiphumo sokugqibela.

Ukuba ukufundwa kudlula umgama wesixhobo, tshintsha i-spindle okanye ulungise uxinaniso kwaye ulinganise kwakhona.

4. Amanyathelo okuzikhusela

Ulawulo lobushushu lubalulekile. Xa kukho ukunyuka kobushushu nge-1°C, i-viscosity iyancipha malunga ne-2% ukuya kwi-3%.

Isisombululo kufuneka sinyibilike ngokupheleleyo kwaye singabi namaqamza, kungenjalo ukufundwa kuya kuba sezantsi okanye kutshintshe.

I-HPMC ineempawu zokucheba, ngoko ke isantya kunye nexesha lokulinganisa kufuneka zigcinwe rhoqo.

Amanzi asetyenziswayo kufuneka angabi nabumdaka kunye nee-ion ukuze angachaphazeleki kukunyibilika kunye nokufundwa.

Isixhobo kufuneka silinganiswe rhoqo, kwaye i-spindle kunye nesitya sesampuli kufuneka zigcinwe zicocekile.

5. Uhlalutyo lwezinto ezinefuthe

Inqanaba lePolymerization kunye nenqanaba lokutshintsha: Okukhona inqanaba le-polymerization ye-HPMC liphezulu, kokukhona i-molecular chain ikhula kwaye i-solution viscosity inkulu. Inqanaba le-methoxy kunye ne-hydroxypropoxy substitution likwachaphazela i-hydrophilicity yayo kunye nesakhiwo sesisombululo.

Uxinaniso: Uxinaniso lwesisombululo kunye noxinaniso zihambelana kakhulu, kwaye notshintsho oluncinci kuxinaniso lunokuchaphazela kakhulu iziphumo zovavanyo. Ubushushu kunye ne-pH: Ukunyuka kobushushu kunciphisa uxinaniso, ngelixa utshintsho lwe-pH ngokubanzi alunampembelelo ingako kuxinaniso lwe-HPMC kuba yi-nonion cellulose ether.

Isisombululo sokwaluphala: Ukuqina kwesikhumba kunokuncipha kancinci emva kokugcinwa ixesha elide. Kucetyiswa ukuba uvavanyo lugqitywe kwiiyure ezingama-24 zokulungiselela.

6. Ukunikezelwa kweziphumo kunye nokusetyenziswa kwazo

Iziphumo zovavanyo zibonakaliswa kwi-mPa·s (milliPascals·seconds), umzekelo, “isisombululo se-2%, 20°C, 20,000 mPa·s.” Kwizicelo zoshishino,I-HPMCAmanqanaba e-viscosity adla ngokubonakaliswa ngokwee-kilometre, njenge-400 cps kunye ne-20,000 cps. Abasebenzisi banokukhetha amanqanaba ahlukeneyo ngokusekelwe kwiimfuno zesicelo kunye noyilo lwefomula.