Hydroxypropyl methylcellulose (HPMC)imhando inokosha ye nonionic cellulose ether inoshandiswa zvakanyanya mukuvaka, mishonga, chikafu, uye makemikari ezuva nezuva. Viscosity chiratidzo chikuru chekuongorora mhando uye kushanda kweHPMC. Haingoratidzi chete hunhu hwe rheological hwemushonga wayo asiwo ine chekuita zvakananga nekukora kwayo, kuchengetedza mvura, uye hunhu hwekugadzira firimu. Kuti ive nechokwadi chekuti chigadzirwa chinoenderana, kuyerwa kwe viscosity kunofanirwa kuitwa uchishandisa nzira yesainzi uye yakajairika yekuyedza viscosity.
1. Nheyo yeKuedza
HPMC inonyunguduka mumvura kuti igadzire mhinduro yakajeka kana inopenya. Kupenya kwayo kunonyanya kuenderana nehuwandu hwekupomera, huwandu hwekutsiva, uye huwandu hwemhinduro. Kuyedzwa kweViscosity kunoratidza hunhu hwekuyerera kwemhinduro yeHPMC nekuyera kukweshana kwemukati kwemhinduro panguva yekuyerera patembiricha chaiyo. Kuyera kunowanzoitwa uchishandisa rotational viscometer (rudzi rweBrookfield) kana capillary viscometer. Nzira yekutenderera inonyanya kushandiswa, sezvo ichipa kunzwisisa kwakajeka kwehunhu hwekuchekerera kwemhinduro nekumhanya kwakasiyana kwekutenderera.
2. Mitemo Yakafanana uye Mamiriro Ebvunzo
Parizvino, kuyedzwa kweHPMC viscosity kunonyanya kuenderana nezvinotevera:
Chiyero cheChinese: GB/T 12000 "Nzira Dzekuyedza Dzese dzeCellulose Ethers"
Muyero weUS: ASTM D1347 "Nzira Dzakajairika Dzekuyedza dzeCellulose Ether Solutions"
Maitiro eindasitiri: Kusviba kunoyerwa uchishandisa mhinduro yemvura ye2% pa20°C uchishandisa Brookfield rotational viscometer.
Kuwanda kwemhinduro yekuedza kunowanzova 2% (chikamu chehuremu), asi magiredhi akasiyana eHPMC angadawo kuenzaniswa pa1%, 2%, kana kuti pamusoro. Tembiricha yekuedza inofanira kudzorwa zvakasimba pa20±0.1°C, sezvo kushanduka-shanduka kwetembiricha kunogona kukanganisa zvakanyanya kuverenga kweviscosity.
3. Maitiro Ekuyedza
3.1. Kugadzirira Reagent uye Zvishandiso
Kunyatsoongorora kwakaringana (0.1 mg kururama)
Brookfield rotational viscometer (inowanzo kuwanikwa muLV series)
3.2. Kugeza nemvura tembiricha yenguva dzose kana nzvimbo inodzorwa tembiricha
Mvura yakachena (inosangana nezvinodiwa zvemvura zveGB/T 6682 Grade III)
Chenesa beaker ne stirrer
3.3. Kugadzirira Mhinduro
Kurema nemazvo 2.00 g (± 0.01 g) yesampuro yeHPMC.
Isa inenge 80% yehuwandu hwemvura yakacheneswa (inenge 80 mL) mugaba woipisa kusvika inenge 80°C. Zvishoma nezvishoma uye zvakaenzana sasa HPMC mugaba uku uchikurunga kuti isaungane.
Ramba uchikurunga kusvika HPMC yanyoroveswa zvakanaka uye yapararira. Wobva wawedzera mvura inotonhora yasara woitonhodza kusvika patembiricha yemukamuri, zvichiita kuti huwandu hwese husvike 100 mL.
Isa mushonga mufiriji pa4°C husiku hwese kuti uzvimbe zvakakwana uye ubvise mabubble emhepo.
3.4. Kuyera Kusviba
Chinja mushonga wacho mubhavhu remvura rinodziya nguva dzose, uchichengetedza tembiricha ye20 ± 0.1°C. Sarudza spindle yakakodzera (kazhinji Nhamba 2 kana Nhamba 3) uye kumhanya (kazhinji 30 rpm).
Tanga viscometer wonyora kuverenga mushure mekunge tsono yagadzikana. Dzokorora chiyero chega chega katatu, wobva watora avhareji semhedzisiro yekupedzisira.
Kana kuverenga kwacho kwakapfuura mwero wekushandiswa kwechishandiso, chinja spindle kana gadzirisa huwandu hwacho wozoyerazve.
4. Kungwarira
Kudzora tembiricha kwakakosha. Pakuwedzera kwetembiricha kwega kwega kwe1°C, viscosity inoderera neinenge 2% kusvika 3%.
Mushonga unofanira kunyungudutswa zvachose uye usina mabubhu, zvikasadaro kuverenga kwacho kuchava kwakaderera kana kuchinja-chinja.
HPMC ine hunhu hwekuchekerera ganda, saka kumhanya nenguva yekuyera zvinofanirwa kuchengetedzwa nguva dzose.
Mvura inoshandiswa inofanira kunge isina tsvina uye maayoni kuti isakanganise kunyungudika uye kuverenga.
Chishandiso chinofanira kugadzikiswa nguva nenguva, uye simende nemudziyo wemuenzaniso zvinofanira kucheneswa.
5. Kuongororwa Kwezvinhu Zvinopesvedzera
Dhigirii rePolymerization uye Dhigirii reKutsiva: Kana HPMC ikawedzera, HPMC inowedzera kureba uye solution viscosity inowedzera. Dhigirii remethoxy nehydroxypropoxy substitution rinokanganisawo hydrophilicity yayo uye chimiro chesolution.
Kuwanda kwemvura: Kuwanda kwemvura uye kusimba kwemvura zvine hukama hwakakura, uye kunyangwe shanduko diki mukukura kwemvura zvinogona kukanganisa zvakanyanya mhedzisiro yebvunzo. Tembiricha nepH: Kuwedzera kwekupisa kunoderedza kusimba kwemvura, nepo kuchinja kwepH kazhinji kusinganyanyi kukanganisa kusimba kweHPMC nekuti i nonionic cellulose ether.
Mhinduro Yekukwegura: Kusviba kunogona kudzikira zvishoma nezvishoma mushure mekuchengetedza kwenguva refu. Zvinokurudzirwa kuti bvunzo ipedzwe mukati memaawa makumi maviri nemana ekugadzirira.
6. Mharidzo yeMhedzisiro uye Mashandisirwo
Mhedzisiro yebvunzo inoratidzwa mu mPa·s (milliPascals·seconds), semuenzaniso, "2% solution, 20°C, 20,000 mPa·s." Mukushandiswa kwemaindasitiri,HPMCMagiredhi ekupenya anowanzo ratidzwa muzvikamu zvechiuru, zvakaita se400 cps uye 20,000 cps. Vashandisi vanogona kusarudza magiredhi akasiyana zvichienderana nezvinodiwa pakushandisa uye dhizaini yekugadzira.
Nguva yekutumira: Chikunguru-30-2025