Hydroxypropyl methylcellulose (HPMC)wani muhimmin sinadarin cellulose ne mai suna nonionic cellulose ether wanda ake amfani da shi sosai a fannin gini, magunguna, abinci, da sinadarai na yau da kullum. Danko muhimmin alama ne don kimanta inganci da amfani da HPMC. Ba wai kawai yana nuna halayen rheological na maganin sa ba, har ma yana da alaƙa kai tsaye da kauri, riƙe ruwa, da kuma halayen samar da fim. Domin tabbatar da daidaiton ingancin samfur, dole ne a yi auna danko ta amfani da hanyar gwaji ta kimiyya da daidaito.
1. Ka'idar Gwaji
HPMC yana narkewa a cikin ruwa don samar da mafita mai haske ko bayyananne. Dankonsa ya dogara ne akan matakin polymerization, matakin maye gurbinsa, da kuma yawan maganin. Gwajin danko yana bayyana halayen kwararar maganin HPMC ta hanyar auna gogayya ta ciki na maganin yayin kwarara a wani takamaiman zafin jiki. Yawanci ana yin ma'auni ta amfani da na'urar juyawa (nau'in Brookfield) ko na'urar auna capillary. Hanyar juyawa ana amfani da ita sosai, domin tana ba da fahimtar halayen rage girman maganin a saurin juyawa daban-daban.
2. Ka'idoji da Sharuɗɗan Gwaji na gama gari
A halin yanzu, gwajin danko na HPMC ya dogara ne akan waɗannan masu zuwa:
Ma'aunin Sinanci: GB/T 12000 "Hanyoyin Gwaji na Gabaɗaya don Cellulose Ethers"
Ma'aunin Amurka: ASTM D1347 "Hanyoyin Gwaji na Daidaitacce don Maganin Cellulose Ether"
Aikin Masana'antu: Ana auna danko ta amfani da ruwan da ke da kashi 2% a zafin digiri 20 na Celsius ta amfani da na'urar auna juyawa ta Brookfield.
Yawan maganin gwajin gabaɗaya kashi 2% ne (ƙasa da yawa), amma nau'ikan HPMC daban-daban na iya buƙatar daidaitawa a kashi 1%, 2%, ko mafi girma. Dole ne a sarrafa zafin gwajin sosai a 20±0.1°C, saboda canjin zafin jiki na iya yin tasiri sosai ga karatun danko.
3. Tsarin Gwaji
3.1. Shiri na Reagent da Kayan Aiki
Daidaiton nazarin daidaito (daidaitaccen 0.1 mg)
Mita mai juyawa ta Brookfield (jerin LV da ake samu akai-akai)
3.2. Ruwan wanka mai yawan zafin jiki ko yanayin da zafin jiki ke sarrafawa
Ruwan da aka tsarkake (ya cika buƙatun ruwa na GB/T 6682 Grade III)
Tsaftace beaker da stirrer
3.3. Shiri na Maganin
Nauyin samfurin HPMC daidai 2.00 g (± 0.01 g).
Sanya kusan kashi 80% na adadin ruwan da aka yi niyya (kimanin 80 mL) a cikin tukunya sannan a dafa shi zuwa kimanin 80°C. A hankali a yayyafa HPMC a cikin tukunyar a hankali yayin da ake juyawa don guje wa taruwa.
A ci gaba da juyawa har sai HPMC ta jika sosai sannan ta wargaje. Sannan a zuba sauran ruwan sanyi a bar shi ya huce zuwa zafin ɗaki, wanda hakan zai kawo jimillar adadin zuwa 100 mL.
A sanya ruwan a cikin firiji a zafin digiri 4 a digiri 10 a cikin dare domin ya kumbura gaba ɗaya sannan a kawar da kumfa daga iska.
3.4. Ma'aunin Danko
A mayar da maganin zuwa wurin wanka na ruwa mai yawan zafin jiki, a kiyaye zafin jiki na 20 ± 0.1°C. A zaɓi sandar da ta dace (yawanci Lamba ta 2 ko Lamba ta 3) da kuma saurin gudu (yawanci 30 rpm).
Fara na'urar auna sigina (viscometer) sannan ka yi rikodin karatun bayan allurar ta daidaita. Maimaita kowace ma'auni sau uku, sannan ka ɗauki matsakaicin a matsayin sakamakon ƙarshe.
Idan karatun ya wuce iyakar kayan aikin, maye gurbin sandar ko daidaita yawan da ake buƙata sannan a sake aunawa.
4. Gargaɗi
Kula da zafin jiki yana da matuƙar muhimmanci. Ga kowace ƙaruwar zafin jiki a digiri 1 na Celsius, ɗanko yana raguwa da kusan kashi 2% zuwa 3%.
Dole ne a narkar da maganin gaba ɗaya kuma babu kumfa, in ba haka ba karatun zai yi ƙasa ko kuma ya yi ta canzawa.
HPMC yana da kaddarorin rage yankewa, don haka ya kamata a kiyaye saurin da lokacin aunawa akai-akai.
Dole ne ruwan da aka yi amfani da shi ya kasance babu ƙazanta da ions don guje wa rushewa da karantawa.
Ya kamata a riƙa daidaita kayan aikin akai-akai, kuma a riƙa tsaftace madaurin da kuma akwatin samfurin.
5. Binciken Abubuwan da Ke Tasiri
Matakin Polymerization da Matsayin Sauyawa: Mafi girman matakin polymerization na HPMC, tsawon sarkar kwayoyin halitta da kuma girman danko na mafita. Matakin maye gurbin methoxy da hydroxypropoxy shi ma yana shafar ingancin hydrophilicity da tsarin mafita.
Tattarawa: Yawan ruwan da kuma danko yana da alaƙa mai yawa, har ma da ƙananan canje-canje a cikin yawan ruwan da ke cikinsa na iya yin tasiri sosai ga sakamakon gwaji. Zafin jiki da pH: Ƙara yawan zafin jiki yana rage danko, yayin da canje-canjen pH gabaɗaya ba su da tasiri sosai ga danko na HPMC saboda shine cellulose ether mara ionic.
Tsufa daga Maganin: Danko na iya raguwa a hankali bayan an adana shi na tsawon lokaci. Ana ba da shawarar a kammala gwajin cikin awanni 24 bayan shiri.
6. Gabatar da Sakamako da Aikace-aikacen
Ana bayyana sakamakon gwaji a cikin mPa·s (milliPascals·seconds), misali, "maganin 2%, 20°C, 20,000 mPa·s." A aikace-aikacen masana'antu,HPMCAna nuna ma'aunin danko a cikin dubu, kamar 400 cps da 20,000 cps. Masu amfani za su iya zaɓar ma'auni daban-daban dangane da buƙatun aikace-aikace da ƙirar tsari.
Lokacin Saƙo: Yuli-30-2025