Muindasitiri yemishonga, hypromellose (HPMC, METHOCEL™) inogona kushandiswa se filler, binder, tablet coating polymer uye key excipient kudzora kuburitswa kwemushonga. Hypromellose yave ichishandiswa mumapiritsi kwemakore anopfuura makumi matanhatu uye chinhu chakakosha chinoshandiswa zvakanyanya mumapiritsi ehydrophilic gel matrix.
Makambani mazhinji emishonga anoshandisa hypromellose kuti abudise mishonga inodzorwa, kunyanya mu hydrophilic gel matrix tablet formulations. Kana zvasvika kuzvigadzirwa zve hypromellose, ungangove uchishamisika kuti ungasarudza sei - kunyanya kana uchitsvaga chimwe chinhu chinonyoreswa zvakanaka uye chinogara kwenguva refu kuti chitengeswe nevatengi vako. Mugwaro iri, tichataura nezvezvinhu zvakakosha zvaunofanira kuziva nezve hypromellose.
Chii chinonzi hypromellose?
Hypromellose, inozivikanwawo sehydroxypropyl methylcellulose (HPMC), ipolymer inoshandiswa semushonga unobatsira mukurapa kudzora kuburitswa kwemishonga kubva pamapiritsi egel matrix anonwiwa nemuromo.
Hypromellose chinhu chinogadzirwa zvishoma chinobva mu cellulose, iyo inonyanya kuwanikwa mupolymer. Zvimwe zvezvimiro zvayo zvinosanganisira:
inonyungudika mumvura inotonhora
isinganyungudike mumvura inopisa
Nonionic
Inonyungudika zvakanyanya muzvinhu zvinonyungudutsa zvipenyu
Kugona kushanduka, hunhu hwegel inodziya
Kuwanda kwemvura uye kusimba kwemuviri (viscosity) zvisingaenderane ne pH
. Surfactant
.isina chepfu
Kuravira nekunhuhwirira zviri nyore
Kuramba ma enzyme
kugadzikana kwenzvimbo ye pH (2-13)
Inogona kushandiswa sechinosimbisa, chinosanganisa simbi, chinosunga, chinodzora mwero, kana kuti chinogadzirisa firimu.
Chii chinonzi Hydrophilic Gel Matrix Tablet?
Piritsi rematrix rehydrophilic gel rinogadzirwa nenzira yemushonga rinogona kudzora kuburitswa kwemushonga kubva mupiritsi kwenguva yakareba.
Kugadzirira piritsi reHydrophilic gel matrix:
zviri nyore
Inoda michina yekumanikidza mapiritsi chete
Dzivisa kuraswa kwemushonga wemishonga
Hazvikanganiswi nekuoma kwepiritsi kana simba rekudzvanya
Kuburitswa kwemushonga kunogona kugadziriswa zvichienderana nehuwandu hwezvinhu zvinobatsira uye mapolymers
Kushandiswa kwehypromellose mumapiritsi egel-matrix anonyungudika kwakagamuchirwa zvakanyanya nemutemo, uye hypromellose iri nyore kushandisa uye ine rekodhi yakanaka yekuchengetedzeka, izvo zvakaratidzwa nezvidzidzo zvakawanda. Hypromellose yave sarudzo yakanakisa kumakambani emishonga kuti agadzire uye agadzire mapiritsi anoburitswa kwenguva refu.
Zvinhu Zvinokanganisa Kuburitswa Kwemishonga Kubva Mumapiritsi eMatrix:
Pakugadzira piritsi rinobuda kwenguva refu, pane zvinhu zviviri zvikuru zvekufunga nezvazvo: kugadzira uye kugadzirisa. Kunewo zvinhu zvidiki zvekufunga nezvazvo pakusarudza fomura uye chimiro chekubuda kwemushonga wekupedzisira.
Fomura:
Zvinhu zvikuru zvekufunga nezvazvo pakukura kwekutanga:
1. Polymer (rudzi rwechinotsiva, viscosity, huwandu uye saizi yezvidimbu)
2. Mishonga (hukuru hwezvikamu uye kunyungudika)
3. Zvinokonzera kuunganidzwa kwemafuta (kunyungudika uye chiyero)
4. Zvimwe zvinhu zvinobatsira (zvinosimbisa uye zvinogadzirisa)
Unyanzvi:
Zvinhu izvi zvine chekuita nekugadzirwa kwemushonga uyu:
1. Nzira dzekugadzira
2. Saizi yepiritsi uye chimiro
3. Simba repiritsi
4. nharaunda ye pH
5. Kuputira firimu
Mashandiro anoita machipisi emapfupa:
Mapiritsi ehydrophilic gel matrix anogona kudzora kuburitswa kwemishonga kuburikidza negel layer, kusanganisira nzira mbiri dzekupararira (zvinoshandiswa zvinonyunguduka) uye kukurwa (zvinoshandiswa zvisinganyunguduke), saka viscosity yepolymer ine simba guru pakuburitswa kwemishonga. Vachishandisa hypromellose, makambani emishonga anogona kushandisa tekinoroji yepiritsi rehydrophilic gel matrix kugadzirisa kuburitswa kwemishonga, zvichipa huwandu hunoshanda uye kutevedzera zviri nani kwemurwere, nokudaro zvichideredza mutoro wemishonga pavarwere. Nzira yekutora mushonga kamwe chete pazuva iri nani pane ruzivo rwekutora mapiritsi akawanda kakawanda pazuva.
Nguva yekutumira: Kubvumbi-25-2024