Mu makampani opanga mankhwala, hypromellose (HPMC, METHOCEL™) ingagwiritsidwe ntchito ngati filler, binder, tablet coating polymer ndi key excipient kuti ichepetse kutuluka kwa mankhwala. Hypromellose yakhala ikugwiritsidwa ntchito m'mapiritsi kwa zaka zoposa 60 ndipo ndi key excipient yomwe imagwiritsidwa ntchito kwambiri m'mapiritsi a hydrophilic gel matrix.
Makampani ambiri opanga mankhwala amagwiritsa ntchito hypromellose kuti atulutse mankhwala olamulidwa, makamaka mu mapiritsi a hydrophilic gel matrix. Ponena za mankhwala a hypromellose, mwina mukudzifunsa momwe mungasankhire - makamaka ngati mukufuna chinthu chosavuta kulemba komanso chokhazikika kuti chigulitsidwe kwa makasitomala anu. Mu bukhuli, tikambirana za zinthu zofunika kwambiri zomwe muyenera kudziwa zokhudza hypromellose.
Kodi hypromellose ndi chiyani?
Hypromellose, yomwe imadziwikanso kutihydroxypropyl methylcellulose (HPMC), ndi polima yomwe imagwiritsidwa ntchito ngati chowonjezera cha mankhwala kuti ilamulire kutulutsidwa kwa mankhwala kuchokera ku mapiritsi a gel matrix opangidwa ndi hydrophilic.
Hypromellose ndi chinthu chopangidwa pang'ono chochokera ku cellulose, polima wochuluka kwambiri m'chilengedwe. Zina mwa zinthu zake zodziwika bwino ndi izi:
. Sungunuka m'madzi ozizira
osasungunuka m'madzi otentha
Nonionic
Amasungunuka m'zinthu zachilengedwe zosungunulira
Kusinthasintha, makhalidwe a gel yotenthetsera
Kuchuluka kwa madzi ndi kukhuthala kosadalira pH
. Surfactant
.opanda poizoni
Kukoma ndi fungo ndi zofewa
Kukana kwa ma enzyme
Kukhazikika kwa pH (2-13)
Itha kugwiritsidwa ntchito ngati chokhuthala, emulsifier, binder, rate regulator, filimu yakale
Kodi mapiritsi a Hydrophilic Gel Matrix ndi chiyani?
Piritsi la hydrophilic gel matrix ndi mtundu wa mlingo womwe ungachepetse kutuluka kwa mankhwala kuchokera mu piritsi kwa nthawi yayitali.
Kukonzekera piritsi la hydrophilic gel matrix:
zosavuta
Imafuna zida zokhazikika zochepetsera mapiritsi
Pewani kutaya mlingo wa mankhwala
Sizikhudzidwa ndi kuuma kwa piritsi kapena mphamvu yokakamiza
Kutulutsa mankhwala kumatha kusinthidwa malinga ndi kuchuluka kwa zinthu zowonjezerera ndi ma polima
Kugwiritsa ntchito hypromellose m'mapiritsi a gel-matrix ophilic kwavomerezedwa kwambiri ndi malamulo, ndipo hypromellose ndi yosavuta kugwiritsa ntchito ndipo ili ndi mbiri yabwino yotetezeka, zomwe zawonetsedwa ndi maphunziro ambiri. Hypromellose yakhala chisankho chabwino kwambiri kwa makampani opanga mankhwala kuti apange ndikupanga mapiritsi otulutsa mankhwala nthawi zonse.
Zinthu Zomwe Zimakhudza Kutulutsidwa kwa Mankhwala Kuchokera ku Mapiritsi a Matrix:
Popanga piritsi lotulutsa mankhwala kwa nthawi yayitali, pali zinthu ziwiri zazikulu zomwe muyenera kuganizira: kupanga ndi kukonza. Palinso zinthu zazing'ono zomwe muyenera kuganizira posankha mtundu wa mankhwala ndi mtundu wa mankhwala otulutsidwa.
Fomula:
Zinthu zofunika kuziganizira pakukula msanga:
1. Polima (mtundu wosinthira, kukhuthala, kuchuluka ndi kukula kwa tinthu)
2. Mankhwala (kukula kwa tinthu tating'onoting'ono ndi kusungunuka kwa madzi)
3. Zosakaniza zolemera (kusungunuka ndi mlingo)
4. Zowonjezera zina (zokhazikika ndi zotetezera)
Ukadaulo:
Zinthu izi zikugwirizana ndi momwe mankhwalawa amapangira:
1. Njira zopangira
2. Kukula ndi Mawonekedwe a Piritsi
3. Mphamvu ya piritsi
4. pH chilengedwe
5. Kuphimba filimu
Momwe zidutswa za mafupa zimagwirira ntchito:
Mapiritsi a hydrophilic gel matrix amatha kuwongolera kutulutsa mankhwala kudzera mu gel layer, kuphatikiza njira ziwiri zofalitsira (zosakaniza zosungunuka) ndi kukokoloka (zosakaniza zosungunuka), kotero kukhuthala kwa polima kumakhudza kwambiri mawonekedwe otulutsidwa. Pogwiritsa ntchito hypromellose, makampani opanga mankhwala amatha kugwiritsa ntchito ukadaulo wa mapiritsi a hydrophilic gel matrix kuti asinthe mawonekedwe otulutsidwa a mankhwalawa, kupereka mlingo wogwira mtima komanso kutsatira bwino kwa odwala, potero kuchepetsa kulemera kwa mankhwala kwa odwala. Njira yomwa mankhwala kamodzi patsiku ndi yabwino kwambiri kuposa kumwa mapiritsi angapo kangapo patsiku.
Nthawi yotumizira: Epulo-25-2024