Hypromellose (HPMC) siv li cas hauv cov ntsiav tshuaj matrix tso tawm ntev?

Hauv kev lag luam tshuaj, hypromellose (HPMC, METHOCEL™) siv tau ua cov khoom sau, cov khoom sib txuas, cov tshuaj pleev xim rau cov ntsiav tshuaj thiab cov khoom siv tseem ceeb los tswj kev tso tshuaj. Hypromellose tau siv rau hauv cov ntsiav tshuaj tau ntau tshaj 60 xyoo thiab yog cov khoom siv tseem ceeb uas siv dav hauv cov ntsiav tshuaj hydrophilic gel matrix.

Muaj ntau lub tuam txhab tshuaj siv hypromellose los tswj kev tso tshuaj, tshwj xeeb tshaj yog hauv cov tshuaj ntsiav hydrophilic gel matrix. Thaum nws los txog rau cov khoom hypromellose, koj yuav xav paub yuav ua li cas xaiv - tshwj xeeb tshaj yog tias koj tab tom nrhiav ib yam dab tsi uas yooj yim rau kev sau npe thiab ruaj khov los ua lag luam rau koj cov neeg siv khoom. Hauv phau ntawv qhia no, peb yuav tham txog cov ntsiab lus tseem ceeb uas koj yuav tsum paub txog hypromellose.

Hypromellose yog dab tsi?

Hypromellose, tseem hu uaHydroxypropyl methylcellulose (HPMC), yog ib qho polymer siv los ua ib qho tshuaj excipient los tswj kev tso tawm ntawm cov tshuaj los ntawm cov ntsiav tshuaj hydrophilic gel matrix hauv qhov ncauj.

Hypromellose yog ib yam khoom siv semi-synthetic uas tau los ntawm cellulose, uas yog cov polymer uas muaj ntau tshaj plaws hauv xwm. Qee yam ntawm nws cov khoom muaj xws li:

. yaj tau hauv dej txias

. insoluble hauv dej kub

Tsis yog ionic

Xaiv tau soluble hauv cov organic solvents

. Kev hloov pauv tau, cov khoom siv thermal gel

Kev ntub dej thiab viscosity ywj pheej ntawm pH

. Cov tshuaj surfactant

. tsis muaj tshuaj lom

. Saj thiab tsw qab tsis muaj zog

. Kev tiv thaiv enzyme

Kev ruaj khov ntawm pH (2-13)

Nws tuaj yeem siv ua cov khoom siv tuab, emulsifier, binder, tus nqi tswj, zaj duab xis qub

Hydrophilic Gel Matrix Tablet yog dab tsi?

Cov ntsiav tshuaj hydrophilic gel matrix yog ib daim ntawv dosage uas tuaj yeem tswj cov tshuaj tso tawm ntawm lub ntsiav tshuaj rau lub sijhawm ntev.

Kev npaj tshuaj ntsiav hydrophilic gel matrix:

. yooj yim heev

Tsuas yog xav tau cov khoom siv nias ntsiav tshuaj txheem xwb

Tiv thaiv kev pov tseg tshuaj

Tsis cuam tshuam los ntawm lub zog ntawm lub ntsiav tshuaj lossis lub zog nias

. Kev tso tawm tshuaj tuaj yeem hloov kho raws li qhov ntau ntawm cov khoom siv thiab cov polymers

Kev siv cov tshuaj hypromellose hauv cov ntsiav tshuaj hydrophilic gel-matrix tau txais kev pom zoo los ntawm cov koom haum tswj hwm, thiab hypromellose yooj yim siv thiab muaj cov ntaub ntawv kev nyab xeeb zoo, uas tau ua pov thawj los ntawm ntau txoj kev tshawb fawb. Hypromellose tau dhau los ua qhov kev xaiv zoo tshaj plaws rau cov tuam txhab tshuaj los tsim thiab tsim cov ntsiav tshuaj uas tso tawm ntev.

Cov Yam Cuam Tshuam Rau Kev Tso Tshuaj Los Ntawm Matrix Cov Tshuaj Ntsuas:

Thaum tsim cov tshuaj ntsiav uas tso tawm ntev, muaj ob yam tseem ceeb uas yuav tsum xav txog: kev tsim cov tshuaj thiab kev ua cov tshuaj. Kuj tseem muaj cov yam me me uas yuav tsum xav txog thaum txiav txim siab txog cov tshuaj thiab cov qauv tso tawm ntawm cov tshuaj kawg.

Cov mis:

Cov yam tseem ceeb uas yuav tsum xav txog rau kev loj hlob thaum ntxov:

1. Polymer (hom hloov, viscosity, qhov ntau thiab qhov loj ntawm cov khoom me me)

2. Cov tshuaj (qhov loj me ntawm cov khoom me me thiab kev yaj tau)

3. Cov neeg sawv cev ua kom cov khoom loj (solubility thiab dosage)

4. Lwm cov khoom siv (cov khoom ruaj khov thiab cov khoom siv tsis zoo)

Khoom siv tes ua:

Cov yam no muaj feem cuam tshuam nrog seb cov tshuaj no raug tsim li cas:

1. Cov txheej txheem tsim khoom

2. Qhov Loj thiab Duab ntawm Lub Tshuaj Ntsuas

3. Lub zog ntsiav tshuaj

4. pH ib puag ncig

5. Zaj duab xis txheej

Cov pob txha chips ua haujlwm li cas:

Cov ntsiav tshuaj hydrophilic gel matrix tuaj yeem tswj kev tso tawm cov tshuaj los ntawm cov txheej gel, suav nrog ob txoj hauv kev ntawm kev sib kis (cov khoom xyaw uas yaj tau) thiab kev yaig (cov khoom xyaw uas tsis yaj tau), yog li qhov viscosity ntawm cov polymer muaj kev cuam tshuam loj heev rau qhov profile tso tawm. Siv hypromellose, cov tuam txhab tshuaj tuaj yeem siv cov thev naus laus zis hydrophilic gel matrix ntsiav tshuaj los kho qhov profile tso tawm ntawm cov tshuaj, muab cov tshuaj zoo dua thiab ua raws li tus neeg mob zoo dua, yog li txo qhov hnyav ntawm cov tshuaj rau cov neeg mob. Txoj kev noj tshuaj ib zaug ib hnub yog qhov zoo dua li kev paub ntawm kev noj ntau lub ntsiav tshuaj ntau zaus hauv ib hnub.