N'ime ụlọ ọrụ ọgwụ, a na-akpọ hypromellose (HPMC, METHOCEL™) enwere ike iji ya dị ka ihe na-emeju ihe, ihe na-ejikọ ihe, ihe mkpuchi mbadamba na ihe na-enye isi ihe iji chịkwaa mwepụta ọgwụ. Ejirila Hypromellose na mbadamba ihe karịrị afọ 60 ma ọ bụ ihe na-enye isi ihe eji eme ihe nke ukwuu na mbadamba ihe na-enye isi ...-enye isi ihe na mbadamba ihe na-enye isi ihe na-enye isi ihe na-enye isi ihe na-enye isi ihe na-enye isi ihe na-enye isi ihe na-enye isi ihe na-enye
Ọtụtụ ụlọ ọrụ ọgwụ na-eji hypromellose maka mwepụta ọgwụ a na-achịkwa, ọkachasị na usoro mbadamba gel matrix hydrophilic. Maka ngwaahịa hypromellose, ị nwere ike ịnọ na-eche otu esi eme nhọrọ - ọkachasị ma ọ bụrụ na ị na-achọ ihe ga-adị mma ma dịkwagide iji nye ndị ahịa gị ahịa. N'ime ntuziaka a, anyị ga-ekwu maka ihe ndị dị mkpa ị kwesịrị ịma gbasara hypromellose.
Gịnị bụ hypromellose?
Hypromellose, nke a makwaara dị kahydroxypropyl methylcellulose (HPMC), bụ polima e ji eme ihe dị ka ihe na-enye ọgwụ iji chịkwaa mwepụta ọgwụ sitere na mbadamba gel hydrophilic gel matrix ọnụ.
Hypromellose bụ ihe e ji selukosị mee nke sitere na cellulose, polima kachasị baa ụba n'okike. Ụfọdụ ihe ndị a na-ahụkarị gụnyere:
mmiri oyi na-agbaze
mmiri ọkụ anaghị agbaze
. Nonionic
A na-agbaze nke ọma na ihe mgbaze organic
Njirimara mgbanwe, jel okpomọkụ
Mmiri na viscosity na-adabereghị na pH
Surfactant
anaghị egbu egbu
Ụtọ na isi dị nro
Nguzogide enzyme
nkwụsi ike nke oke pH (2-13)
Enwere ike iji ya dị ka ihe na-eme ka ihe sie ike, ihe na-eme ka ihe dị nro, ihe na-ejikọta ihe, ihe na-achịkwa ọnụego, ihe nkiri
Kedu ihe bụ mbadamba Hydrophilic Gel Matrix?
Mbadamba matriks gel hydrophilic bụ ụdị onunu ogwu nke nwere ike ijikwa mwepụta ọgwụ site na mbadamba ahụ ruo ogologo oge.
Nkwadebe mbadamba ihe eji emepụta matriks jel hydrophilic:
dị mfe karịa
Naanị ngwa mkpakọ mbadamba ọkọlọtọ chọrọ
Gbochie ịtụfu ọgwụ ọjọọ
Ike mbadamba ma ọ bụ ike mkpakọ anaghị emetụta ya
Enwere ike ịgbanwe ntọhapụ ọgwụ dịka ọnụọgụ ihe mgbakwunye na polymers si dị
Ojiji nke hypromellose na mbadamba gel-matrix hydrophilic enwetala nkwado iwu sara mbara, hypromellose dịkwa mma iji ma nwee ezigbo ndekọ nchekwa, nke ọtụtụ nnyocha egosila. Hypromellose aghọwo nhọrọ kacha mma maka ụlọ ọrụ ọgwụ iji mepụta ma mepụta mbadamba ndị na-adịgide adịgide.
Ihe Ndị Na-emetụta Mwepụta Ọgwụ Site na Mbadamba Matrix:
Mgbe a na-emepụta mbadamba ọgwụ a na-ewepụta ogologo oge, e nwere isi ihe abụọ a ga-atụle: nhazi na nhazi. E nwekwara obere ihe ndị a ga-atụle mgbe a na-ekpebi nhazi na njirimara mwepụta nke ngwaahịa ọgwụ ikpeazụ.
Usoro:
Isi ihe ndị a ga-atụle maka mmepe mbụ:
1. Polyma (ụdị nnọchi, viscosity, ọnụọgụ na nha irighiri ihe)
2. Ọgwụ (nha na ike ịgbaze)
3. Ihe ndị na-eme ka ihe sie ike (mgbaze na usoro onunu ogwu)
4. Ihe ndị ọzọ na-enyere aka (ihe ndị na-eme ka ihe sie ike na ihe nchekwa)
Ọrụ aka:
Ihe ndị a metụtara otu esi emepụta ọgwụ ahụ:
1. Ụzọ mmepụta
2. Nha na Ọdịdị Mbadamba
3. Ike mbadamba
4. gburugburu pH
5. Mkpuchi ihe nkiri
Otu ọkpụkpụ skeleton si arụ ọrụ:
Mbadamba matriks gel hydrophilic nwere ike ijikwa mwepụta ọgwụ site na oyi akwa gel, gụnyere usoro abụọ nke mgbasa (ihe ndị na-agbaze agbaze) na mbuze (ihe ndị na-agbaze agbaze), yabụ viscosity nke polima nwere mmetụta dị ukwuu na profaịlụ ntọhapụ. Site na iji hypromellose, ụlọ ọrụ ọgwụ nwere ike iji teknụzụ mbadamba gel hydrophilic matrix gbanwee profaịlụ ntọhapụ nke ọgwụ ahụ, na-enye usoro onunu ogwu ka mma na nnabata onye ọrịa ka mma, si otú a na-ebelata ibu arọ nke ọgwụ n'ahụ ndị ọrịa. Ụzọ e si aṅụ ọgwụ otu ugboro n'ụbọchị ka mma karịa ahụmịhe nke ịṅụ ọtụtụ mbadamba ugboro ugboro n'ụbọchị.
Oge ozi: Eprel-25-2024