Mu nganda zikora imiti, hypromellose (HPMC, METHOCEL™) irashobora gukoreshwa nk'umunyururu, umufunga, polymer yo gusiga ibinini n'umunyururu w'ingenzi mu kugenzura isohoka ry'imiti. Hypromellose imaze imyaka irenga 60 ikoreshwa mu binini kandi ni umunyururu w'ingenzi ukoreshwa cyane mu binini bya gel matrix ya hydrophilic.
Amasosiyete menshi y’imiti akoresha hypromellose kugira ngo akoreshwe mu buryo bugenzurwa, cyane cyane mu binini bya gel matrix bikozwe muri hydrophilic. Ku bijyanye n’ibicuruzwa bya hypromellose, ushobora kuba wibaza uburyo wahitamo - cyane cyane niba ushaka ikintu cyoroshye ku birango kandi kirambye kugira ngo gikoreshwe ku bakiriya bawe. Muri iyi nyandiko, tuzavuga ku bintu by’ingenzi ugomba kumenya kuri hypromellose.
Hypromellose ni iki?
Hypromellose, izwi kandi nkahydroxypropyl methylcellulose (HPMC), ni polymer ikoreshwa nk'umuti ufasha mu kugenzura irekurwa ry'imiti iva mu binini bya gel matrix bikoresha amazi mu kanwa.
Hypromellose ni ibikoresho bikozwe muri semi-synthetic bikomoka kuri cellulose, polymer iboneka cyane mu miterere yayo. Zimwe mu miterere yayo isanzwe zirimo:
ishongeshwa mu mazi akonje
.ntishobora gushonga mu mazi ashyushye
Noniyonike
Ishobora gushonga mu bintu bikomoka ku bimera
Uburyo bwo guhindura imiterere ya gel ikoresha ubushyuhe
. Gutonyanga amazi n'ubushyuhe bw'amazi (viscosity) bitarimo pH
Surfactant
.ntibihumanya
Uburyohe n'impumuro ni byoroshye
Ubudahangarwa bwa enzyme
. pH (2-13) ihamye y'urutonde
Ishobora gukoreshwa nk'imashini igabanya ubushyuhe, igabanya ubushyuhe, igabanya ubushyuhe, igabanya ubushyuhe, cyangwa ikoresha firime
Ikinini cya Hydrophilic Gel Matrix ni iki?
Ikinini cya gel matrix gikoresha hydrophilic ni ubwoko bw'ibipimo bishobora kugenzura isohoka ry'umuti mu gihe kirekire.
Gutegura ikinini cya gel matrix gikoresha amazi:
byoroshye cyane
. Ikenera ibikoresho bisanzwe byo gukanda ibinini bya tableti gusa
Irinde ko imiti itabwa mu gipimo
Ntabwo bigizweho ingaruka n'ubukana bw'ibinini cyangwa imbaraga zo gukanda
Isohoka ry'imiti rishobora guhindurwa hakurikijwe ingano y'ibintu bifasha mu gukora imiti n'ibinyabutabire
Ikoreshwa rya hypromellose mu binini bya gel-matrix bikoresha amazi ryemejwe cyane n'amategeko, kandi hypromellose yoroshye kuyikoresha kandi ifite amateka meza y'umutekano, nk'uko byagaragajwe n'ubushakashatsi bwinshi. Hypromellose yabaye amahitamo meza ku bigo bicuruza imiti mu gukora no gukora ibinini birekura vuba.
Ibintu bigira ingaruka ku irekurwa ry'imiti iva mu binini bya Matrix:
Mu gihe cyo gushushanya ikinini gisohora imiti igihe kirekire, hari ibintu bibiri by'ingenzi bigomba kwitabwaho: uburyo bwo kuyitunganya no kuyitunganya. Hari kandi ibintu bito bigomba kwitabwaho mu gihe cyo kugena uburyo umuti uzavamo n'uburyo uzavamo.
Ifishi:
Ibintu by'ingenzi byo kuzirikana kugira ngo umuntu atere imbere hakiri kare:
1. Polima (ubwoko bw'isimbura, ubukana, ingano n'ingano y'uduce)
2. Imiti (ingano y'uduce duto n'uburyo dushonga)
3. Ibintu bigabanya ubushyuhe (uburyo bishonga n'ingano yabyo)
4. Ibindi bintu bifasha mu kubungabunga no gufunga (ibitera imbaraga)
Ubukorikori:
Ibi bintu bifitanye isano n'uburyo uyu muti ukorwa:
1. Uburyo bwo gukora
2. Ingano y'ikinini n'imiterere yacyo
3. Imbaraga z'ibinini
4. ibidukikije bya pH
5. Gusiga firime
Uko uduce tw'amagufwa dukora:
Ibinini bya gel matrix bikoresha hydrophilic bishobora kugenzura irekurwa ry'imiti binyuze mu gice cya gel, harimo uburyo bubiri bwo gukwirakwiza (ibintu bishongesha) n'isuri (ibintu bishongesha), bityo ubukana bwa polymer bugira ingaruka zikomeye ku irekurwa ry'umuti. Hakoreshejwe hypromellose, amasosiyete akora imiti ashobora gukoresha ikoranabuhanga rya gel matrix kugira ngo ahindure irekurwa ry'umuti, atanga ingano nziza kandi abarwayi bakurikiza amabwiriza meza, bityo bikagabanya umutwaro w'imiti ku barwayi. Uburyo bwo gufata umuti rimwe ku munsi birumvikana ko ari bwiza kuruta uburambe bwo gufata ibinini byinshi inshuro nyinshi ku munsi.
Igihe cyo kohereza: 25 Mata 2024