I-Hydroxypropyl methylcellulose (HPMC)Ifilimu isebenza kahle kakhulu, kodwa ngenxa yokuthi i-HPMC iyijeli yokushisa, i-viscosity ekushiseni okuphansi iphansi kakhulu, okungavumeli ukumbozwa (noma ukucwiliswa) nokomiswa ekushiseni okuphansi ukulungiselela ifilimu edliwayo, okuholela ekusebenzeni kabi kokucubungula; ngaphezu kwalokho, izindleko zayo eziphakeme zinciphisa ukusetshenziswa kwayo. Isitashi se-Hydroxypropyl (HPS) siyijeli ebandayo engabizi kakhulu, ukwengeza kwayo kungandisa i-viscosity ye-HPMC ekushiseni okuphansi, kuthuthukise ukusebenza kokucubungula kwe-HPMC, futhi kunciphise izindleko zokukhiqiza, ngaphezu kwalokho, i-hydrophilicity efanayo, amayunithi e-glucose kanye namaqembu e-hydroxypropyl konke kunegalelo ekuthuthukiseni ukuhambisana kwala ma-polymer amabili. Ngakho-ke, uhlelo lokuxuba ijeli ebanda kakhulu lwalungiswa ngokuxuba i-HPS ne-HPMC, futhi umphumela wokushisa esakhiweni sejeli sohlelo lokuxuba ijeli ebanda kakhulu ye-HPMC/HPS wafundwa ngokuhlelekile ngokusebenzisa amasu e-rheometer kanye ne-X-ray scattering encane. , kuhlanganiswe nomthelela wezimo zokwelapha ukushisa esakhiweni esincane kanye nezakhiwo zesistimu ye-membrane, bese kwakhiwe ubudlelwano phakathi kwesakhiwo sejeli sezakhiwo ze-blend system-membrane structure-membrane ngaphansi kwezimo zokwelapha ukushisa.
Imiphumela ikhombisa ukuthi ekushiseni okuphezulu, ijeli ene-I-HPMCOkuqukethwe kune-modulus ephezulu kanye nokuziphatha okufana nokuqinile okuphawulekayo, isakhiwo esifana nesisodwa sama-gel scatterer sinzima kakhulu, kanti ubukhulu bama-gel aggregates bukhulu; ekushiseni okuphansi, okuqukethwe yi-HPS Amasampula aphezulu e-gel ane-modulus ephezulu, ukuziphatha okufana nokuqinile okuvelele kakhulu, kanye nesakhiwo esifana nesisodwa sama-gel scatterer. Kumasampula anesilinganiso esifanayo sokuxuba, ukubaluleka kwe-modulus kanye nokuziphatha okufana nokuqinile kanye nobuningi besakhiwo obufana nesisodwa sama-gel alawulwa yi-HPMC ekushiseni okuphezulu kuphakeme kunalawo alawulwa yi-HPS ekushiseni okuphansi. Izinga lokushisa lokomisa lingathinta isakhiwo se-gel sohlelo ngaphambi kokomisa, bese lithinta isakhiwo se-crystalline kanye nesakhiwo esingaguquki sefilimu, futhi ekugcineni libe nomthelela obalulekile ezimpahleni zemishini zefilimu, okuholela emandleni okudonsa kanye ne-modulus yefilimu eyomile ekushiseni okuphezulu. Kuphakeme kunokomile ekushiseni okuphansi. Izinga lokupholisa alinawo umphumela ocacile esakhiweni se-crystalline sohlelo, kodwa linomthelela ekumisweni komzimba we-microdomain ofana nesisodwa wefilimu. Kulesi simiso, ubuningi besakhiwo esifana nefilimu bungathikameza izakhiwo zefilimu. Ukusebenza kunomthelela omkhulu.
Ngokusekelwe ekulungiseleleni i-membrane exubile, ucwaningo luthole ukuthi ukusetshenziswa kwesisombululo se-iodine ukuze kudaye ngokukhethekile i-membrane exubile ye-HPMC/HPS kwasungula indlela entsha yokubuka ngokucacile ukusatshalaliswa kwesigaba kanye nokuguquka kwesigaba sohlelo oluxubile ngaphansi kwendlela ye-microscope, enokubaluleka kokuqondisa kwendlela yokufunda ukusatshalaliswa kwesigaba kwezinhlelo zokuxuba ezisekelwe kusitashi. Kusetshenziswa le ndlela entsha yocwaningo, kuhlanganiswe ne-infrared spectroscopy, i-scanning electron microscopy kanye ne-extensometer, ukuguqulwa kwesigaba, ukuhambisana kanye nezakhiwo zemishini zesistimu kwahlaziywa futhi kwafundwa, futhi ukuhambisana, ukuguqulwa kwesigaba kanye nokubukeka kwefilimu kwakhiwa. Imiphumela yokubuka kwe-microscope ikhombisa ukuthi uhlelo ludlula ekushintsheni kwesigaba lapho isilinganiso se-HPS singama-50%, futhi into yokuxubana phakathi kwesigaba ikhona efilimini, okubonisa ukuthi uhlelo lunezinga elithile lokuhambisana; ukuhlaziywa kwe-infrared, i-thermogravimetric kanye nemiphumela ye-SEM kuqinisekisa ngokwengeziwe ukuhlanganiswa. Uhlelo lunezinga elithile lokuhambisana. I-modulus yefilimu exubile iyashintsha lapho okuqukethwe kwe-HPS kungu-50%. LaphoI-HPSokuqukethwe kungaphezu kuka-50%, i-engeli yokuxhumana yesampula ehlanganisiwe iyaphambuka emgqeni oqondile oxhumanisa ama-engeli okuxhumana amasampula ahlanzekile, futhi uma ingaphansi kuka-50%, iphambuka kabi kulo mugqa oqondile. , okubangelwa kakhulu ukuguquka kwesigaba.
Isikhathi sokuthunyelwe: Ephreli-25-2024