Hydroxypropyl methylcellulose (HPMC)Firimu rine mashandiro akanaka kwazvo, asi nekuti HPMC igel rinopisa, viscosity patembiricha yakaderera yakaderera, izvo zvisingakodzeri kuputira (kana kunyudza) nekuomesa patembiricha yakaderera kuti firimu rinodyiwa rigadzirirwe, zvichikonzera mashandiro asina kunaka ekugadzirisa; pamusoro pezvo, mutengo wayo wepamusoro unodzikamisa kushandiswa kwayo. Hydroxypropyl starch (HPS) igel rinotonhora rinodhura zvishoma, kuwedzerwa kwaro kunogona kuwedzera viscosity yeHPMC patembiricha yakaderera, kunatsiridza mashandiro ekugadzirisa eHPMC, uye kuderedza mutengo wekugadzira, uyezve, hydrophilicity imwechete, mayuniti eglucose uye mapoka ehydroxypropyl zvese zvinobatsira mukuvandudza kuenderana kwemapolymer maviri aya. Saka, sisitimu yekubatanidza gel inotonhora-inotonhora yakagadzirwa nekusanganisa HPS neHPMC, uye mhedzisiro yekupisa pachimiro chegel cheHPMC/HPS hot-cold gel blend system yakaongororwa zvakarongeka uchishandisa rheometer uye small angle X-ray scattering techniques. , pamwe chete nekupesvedzera kwemamiriro ekurapa kupisa pa microstructure uye hunhu hwe membrane system, uye zvakazovaka hukama pakati pechimiro chegel che blend system-membrane structure-membrane hunhu pasi pemamiriro ekurapa kupisa.
Zvakabuda zvinoratidza kuti pakupisa kwakanyanya, gel ineHPMCZviri mukati zvine modulus yakakwira uye maitiro akakosha akafanana neakasimba, chimiro che gel scatterers chakafanana zvakanyanya, uye saizi ye gel aggregates yakakura; patembiricha yakaderera, huwandu hwe HPS Samples dze gel dzakakwirira dzine modulus yakakwira, maitiro akajeka akafanana neakasimba, uye chimiro chakasimba chakafanana nea gel scatterers. Kune sampuli dzine chiyero chakafanana chekusanganisa, kukosha kwe modulus uye maitiro akafanana neakasimba uye huwandu hwakafanana hwema gels anotongwa ne HPMC patembiricha yepamusoro zvakakwirira kupfuura izvo zvinotongwa ne HPS patembiricha yakaderera. Tembiricha yekuomesa inogona kukanganisa chimiro che gel chesystem isati yaoma, uye yozokanganisa chimiro che crystalline uye chimiro chisina chimiro chefirimu, uye pakupedzisira ine simba rakakosha pahunhu hwemuchina wefirimu, zvichikonzera simba rekudhonza uye modulus yefirimu yaoma patembiricha yakakwira. Yakakwira kupfuura yakaoma patembiricha yakaderera. Mwero wekutonhora hauna simba riri pachena pachimiro che crystalline chesystem, asi ine simba pahuwandu hwe microdomain self-similar body yefirimu. Muhurongwa uhu, kuwanda kwechimiro chakafanana chefirimu kunogona kukanganisa hunhu hwemuchina wefirimu. Kushanda kwayo kune simba guru.
Zvichibva pakugadzirira membrane yakasanganiswa, chidzidzo ichi chakawana kuti kushandiswa kwe iodine solution kusarudza dhayi ye HPMC/HPS blended membrane kwakagadzira nzira itsva yekuona zvakajeka kugoverwa kwechikamu uye kuchinja kwechikamu kwesystem yakasanganiswa pasi pe microscope. nzira, ine kukosha kwekutungamira kwenzira yekudzidza kugoverwa kwechikamu kwemasisitimu ekubatanidza akavakirwa pastarch. Kushandisa nzira iyi itsva yekutsvagisa, yakasanganiswa ne infrared spectroscopy, scanning electron microscopy uye extensometer, kuchinja kwechikamu, kuenderana uye hunhu hwemakanika hwesisitimu zvakaongororwa uye kudzidzwa, uye hukama pakati pekushanda, kuchinja kwechikamu uye chitarisiko chefirimu hwakavakwa. Mhedzisiro yekutarisa microscope inoratidza kuti sisitimu inopfuudzwa nekuchinja kwechikamu kana HPS ratio iri 50%, uye chiitiko chekusanganisa pakati pechikamu chiripo mufirimu, zvichiratidza kuti sisitimu ine mwero wakati wekuenderana; infrared, thermogravimetric analysis uye SEM results zvinowedzera kusimbisa kusanganiswa. Sisitimu ine mwero wakati wekuenderana. Modulus yefirimu yakasanganiswa inoshanduka kana HPS iri 50%. KanaHPSzviri mukati zvinopfuura 50%, kona yekubatana yemuenzaniso wakasanganiswa inotsauka kubva pamutsetse wakatwasuka unobatanidza makona ekubatana esampuli dzakachena, uye kana iri pasi pe50%, inotsauka zvisina kunaka kubva pamutsetse uyu wakatwasuka. , izvo zvinonyanya kukonzerwa nekuchinja kwechikamu.
Nguva yekutumira: Kubvumbi-25-2024