I-HPMC ibizwa ngokuthi i-hydroxypropyl methylcellulose.
Umkhiqizo we-HPMC ukhetha i-cellulose kakotini emsulwa kakhulu njengezinto zokusetshenziswa futhi wenziwa nge-etherification ekhethekile ngaphansi kwezimo ze-alkaline. Yonke inqubo iqedwa ngaphansi kwezimo ze-GMP kanye nokuqapha okuzenzakalelayo, ngaphandle kwezithako ezisebenzayo njengezitho zezilwane kanye namafutha.
Izakhiwo ze-HPMC:
Umkhiqizo we-HPMC awuyona i-ionic cellulose ether, ukubukeka kwawo kuyimpuphu emhlophe, awunaphunga, uncibilika emanzini kanye nezinyibilikisi eziningi eziphilayo (njenge-dichloroethane) kanye nesilinganiso esifanele se-ethanol/amanzi, i-propyl alcohol/amanzi, njll. Isixazululo samanzi sinomsebenzi wobuso, ukucaca okuphezulu kanye nokusebenza okuzinzile. I-HPMC inezakhiwo zejeli yokushisa, isixazululo samanzi somkhiqizo siyashiswa ukuze sakhe i-gel precipitation, bese sincibilika ngemva kokupholisa, izici ezahlukene zokushisa kwejeli yomkhiqizo zihlukile. Ukuncibilika kuyashintsha nge-viscosity, lapho i-viscosity iphansi, kulapho ukuncibilika kukhulu, izici ezahlukene ze-HPMC zinomehluko othile ezimpahleni zayo, i-HPMC emanzini ayithinteki yinani le-PH. Usayizi wezinhlayiya: Izinga lokudlula le-mesh eli-100 likhulu kune-100%. Ubuningi: 0.25-0.70g/ (ngokuvamile cishe i-0.5g/), amandla adonsela phansi athile 1.26-1.31. Izinga lokushisa lokushintsha kombala: 190-200℃, izinga lokushisa le-carbonization: 280-300℃. Ukucindezeleka kobuso: 42-56dyn/cm kusisombululo samanzi esingu-2%. Ngokukhula kokuqukethwe kwe-methoxyl, iphuzu lejeli lehlile, ukuncibilika kwamanzi kwanda, kanye nomsebenzi wobuso nawo wanda. I-HPMC inezici zokuqina, ukufaka usawoti, okuqukethwe komlotha okuphansi, ukuzinza kwe-PH, ukugcinwa kwamanzi, ukuzinza kobukhulu, ukwakheka kwefilimu okuhle kakhulu kanye nokumelana okukhulu ne-enzyme, ukuhlakazeka kanye nokuhlangana.
Izinhlelo Zokusebenza ze-HPMC:
1. Ukufakwa kwethebhulethi: I-HPMC esetshenziswa njengezinto zokufakwa kwefilimu ekulungiseleleni okuqinile, ingakha ifilimu eqinile, ebushelelezi futhi enhle, ukuhlushwa kokusetshenziswa okungu-2%-8%. Ngemva kokufakwa, ukuzinza kwento ekukhanyeni, ekushiseni nasekuswakameni kuyakhuphuka; Ayinambitheki futhi ayinaphunga, kulula ukuyithatha, kanye nombala we-HPMC, i-sunscreen, amafutha okugcoba kanye nokunye ukuhambisana okuhle kwezinto. Ukufakwa okuvamile: amanzi noma i-ethanol engu-30-80% yokuncibilikisa i-HPMC, enesisombululo esingu-3-6%, enezela izithako ezisizayo (ezifana: izinga lokushisa lomhlabathi -80, uwoyela we-castor, i-PEG400, i-talc, njll.).
2. Isendlalelo sokwahlukanisa i-enteric-soluble coating: ebusweni bamaphilisi nama-granule, isendlalelo se-HPMC sisetshenziswa kuqala njengesendlalelo sokwahlukanisa i-enteric coating esingezansi, bese simbozwa ngesendlalelo sezinto ezincibilikayo ze-HPMCP enteric. Ifilimu ye-HPMC ingathuthukisa ukuzinza kwe-ejenti yokwahlukanisa i-enteric-soluble coating egcinweni.
3. Ukulungiswa kokukhululwa okuqhubekayo: kusetshenziswa i-HPMC njenge-ejenti ebangela imbobo kanye nokuthembela ku-ethyl cellulose njengezinto zamathambo, kungenziwa amaphilisi asebenza isikhathi eside akhululwa okuqhubekayo.
4. I-ejenti yokujiya kanye ne-colloid protective adhesive adhesive kanye namaconsi wamehlo: I-HPMC ye-ejenti yokujiya evame ukusetshenziswa ukuhlushwa okungu-0.45-1%.
5. I-Adhesive: I-HPMC njenge-binder general concentration engu-2%-5%, esetshenziselwa ukuthuthukisa ukuzinza kwe-hydrophobic adhesive, i-concentration evame ukusetshenziswa engu-0.5-1.5%.
6. I-agent yokubambezeleka, i-agent yokukhulula elawulwayo kanye ne-agent yokumiswa. I-agent yokumiswa: umthamo ojwayelekile we-agent yokumiswa ngu-0.5-1.5%.
7. Ukudla: I-HPMC njenge-ejenti yokujiya engezwe eziphuzweni ezahlukahlukene, imikhiqizo yobisi, izinongo, ukudla okunempilo, njenge-ejenti yokujiya, i-binder, i-emulsifier, i-suspension agent, i-stabilizer, i-ejenti yokugcina amanzi, i-excifer, njll.
8. Kusetshenziswa ezimonyweni njengezinamathelisi, ama-emulsifier, ama-ejenti okwakha amafilimu, njll.
Isikhathi sokuthunyelwe: Jan-14-2022