E kiia ana te HPMC ko te hydroxypropyl methylcellulose.
Ka whiriwhiria e te hua HPMC te miro tino parakore hei rauemi mata, ā, ka hangaia mā te whakapūkara motuhake i raro i ngā āhuatanga kawakore. Ka oti te tukanga katoa i raro i ngā tikanga GMP me te aroturuki aunoa, kāore he kai hohe pēnei i ngā whekau kararehe me te hinu.
Ngā āhuatanga o te HPMC:
Ko te hua HPMC he etera cellulose kore-ionic, he paura ma te āhua, kāore he kakara, kāore he reka, ka wairewa i roto i te wai me te nuinga o ngā whakarewa waro polar (pērā i te dichloroethane) me te ōwehenga tika o te etanoru/wai, te waipiro propyl/wai, me ētahi atu. He nui te mahi mata o te otinga wai, he mārama teitei, ā, he pumau te mahi. He rite ngā āhuatanga o te HPMC ki te tiēre wera, ka whakamahanahia te otinga wai hua hei hanga i te tiēre, kātahi ka rewa i muri i te whakamatao, he rerekē ngā whakaritenga o te pāmahana tiēre hua. Ka huri te wairewatanga me te matotoru, ka iti ake te matotoru, ka nui ake te wairewatanga, he rerekē ngā āhuatanga o ngā whakaritenga rerekē o te HPMC, kāore te uara PH e pāngia e te HPMC i roto i te wai. Rahi matūriki: Ko te tere paahi 100 mata he nui ake i te 100%. Kiato papatipu: 0.25-0.70g/ (tata ki te 0.5g/), taumaha motuhake 1.26-1.31. Te pāmahana whakarerekētanga tae: 190-200℃, te pāmahana waro: 280-300℃. Te mānukanuka o te mata: 42-56dyn/cm i roto i te wairewa 2%. I te pikinga ake o te ihirangi methoxyl, ka heke te ira tio, ka piki ake te wairewatanga wai, ā, ka piki ake hoki te mahi o te mata. Ko ngā āhuatanga o te HPMC ko te whakamātotoru, te tote, te iti o te pungarehu, te pumau o te PH, te pupuri wai, te pumau o te āhua, te hanga kiriata pai rawa atu me te ātete nui ki te whākōkī, te marara me te piripono.
Ngā tono HPMC:
1. Paninga papa: Ka whakamahia te HPMC hei rauemi paninga kiriata i roto i te whakarite totoka, ka taea te hanga kiriata pakari, maeneene me te ataahua, ko te kukū whakamahi o te 2%-8%. I muri i te paninga, ka piki ake te pumau o te kaihoko ki te mārama, te wera me te haumākū; Kore reka, kore kakara, ngāwari ki te tango, ā, he pai te hototahi o ngā rauemi ki te tae HPMC, te hinu ārai rā, ngā hinu whakahinuhinu me ētahi atu. Paninga noa: wai, 30-80% etanoru rānei hei whakarewa i te HPMC, me te otinga 3-6%, me te tāpiri i ngā kai āwhina (pēnei i: te pāmahana oneone -80, te hinu kātoro, PEG400, te talc, me ētahi atu).
2. Paparanga wehewehe paninga wairewa-puku: i runga i te mata o ngā papa me ngā granules, ka whakamahia tuatahitia te paninga HPMC hei paparanga wehewehe paninga o raro, kātahi ka pania ki te paparanga o te rauemi wairewa-puku HPMCP. Ka taea e te kiriata HPMC te whakapai ake i te pumau o te kaihoko paninga wairewa-puku i roto i te rokiroki.
3. Te whakarite tukunga-roa: mā te whakamahi i te HPMC hei kaihoko whakapūpū-pūngao, me te whakawhirinaki ki te ethyl cellulose hei rauemi angaanga, ka taea te hanga papa tukunga-roa roa.
4. Kaihoko whakamaroke me te piripiri tiaki colloid me ngā pata kanohi: Ko te HPMC mō te kaihoko whakamaroke he kukū e whakamahia whānuitia ana o te 0.45-1%.
5. Piripiri: Ko te HPMC hei herenga whānui he 2%-5% te kukū, e whakamahia ana hei whakapai ake i te pumau o te piri hydrophobic, ko te kukū e whakamahia whānuitia ana he 0.5-1.5%.
6. Kaihoko whakaroa, kaihoko tukunga whakahaere me te kaihoko whakatārewatanga. Kaihoko whakatārewatanga: ko te horopeta noa o te kaihoko whakatārewatanga he 0.5-1.5%.
7. Kai: HPMC hei kaiwhakamātotoru i tāpirihia ki ngā inu, ngā hua miraka, ngā mea kakara, ngā kai totika, hei kaiwhakamātotoru, hei here, hei emulsifier, hei whakatārewatanga, hei whakaū, hei pupuri wai, hei excifer, me ētahi atu.
8. Whakamahia i roto i ngā mea whakapaipai hei piripiri, hei whakapūhui, hei hanga kiriata, me ētahi atu.
Wā tuku: Hanuere-14-2022