HPMC yog hu ua hydroxypropyl methylcellulose.
Cov khoom HPMC xaiv cov paj rwb cellulose ntshiab heev ua cov khoom siv raw thiab ua los ntawm kev sib xyaw tshwj xeeb hauv qab cov xwm txheej alkaline. Tag nrho cov txheej txheem ua tiav raws li GMP cov xwm txheej thiab kev saib xyuas tsis siv neeg, tsis muaj cov khoom xyaw nquag xws li cov tsiaj txhu thiab roj.
Cov yam ntxwv ntawm HPMC:
Cov khoom HPMC yog non-ionic cellulose ether, qhov tsos yog hmoov dawb, tsis muaj ntxhiab, yaj hauv dej thiab feem ntau cov kuab tshuaj organic polar (xws li dichloroethane) thiab qhov sib piv ntawm ethanol / dej, propyl cawv / dej, thiab lwm yam. Cov kua dej muaj kev ua haujlwm ntawm qhov chaw, pob tshab siab thiab kev ua haujlwm ruaj khov. HPMC muaj cov khoom ntawm thermal gel, cov khoom dej kua yog cua sov los ua gel nag, thiab tom qab ntawd yaj tom qab txias, cov lus qhia sib txawv ntawm cov khoom gel kub yog txawv. Solubility hloov pauv nrog viscosity, qhov qis dua viscosity, qhov ntau dua solubility, cov lus qhia sib txawv ntawm HPMC muaj qee qhov sib txawv hauv nws cov khoom, HPMC hauv dej tsis cuam tshuam los ntawm PH tus nqi. Qhov loj me ntawm cov khoom me me: 100 mesh dhau tus nqi yog ntau dua 100%. Qhov ceev ntawm cov khoom loj: 0.25-0.70g / (feem ntau yog li 0.5g /), qhov hnyav tshwj xeeb 1.26-1.31. Qhov kub discoloration: 190-200 ℃, qhov kub carbonization: 280-300 ℃. Qhov nro ntawm qhov chaw: 42-56dyn/cm2 hauv 2% cov kua dej. Nrog rau kev nce ntawm cov ntsiab lus methoxyl, qhov taw tes gel txo qis, qhov dej solubility nce ntxiv, thiab qhov kev ua haujlwm ntawm qhov chaw kuj nce ntxiv. HPMC muaj cov yam ntxwv ntawm thickening, salting, cov ntsiab lus tshauv qis, PH stability, water retention, dimensional stability, zoo heev zaj duab xis tsim thiab kev tiv thaiv dav dav rau enzyme, dispersity thiab cohesiveness.
Cov Ntawv Thov HPMC:
1. Txheej ntsiav tshuaj: HPMC siv ua cov khoom siv txheej zaj duab xis hauv kev npaj khoom khov kho, tuaj yeem tsim cov zaj duab xis tawv, du thiab zoo nkauj, qhov siv concentration ntawm 2% -8%. Tom qab txheej, qhov ruaj khov ntawm tus neeg sawv cev rau lub teeb, cua sov thiab av noo nce ntxiv; Tsis muaj saj thiab tsis muaj ntxhiab, yooj yim noj, thiab HPMC pigment, tshuaj pleev thaiv hnub, roj nplua nyeem thiab lwm yam kev sib raug zoo ntawm cov ntaub ntawv. Txheej ib txwm: dej lossis 30-80% ethanol kom yaj HPMC, nrog 3-6% kua, ntxiv cov khoom xyaw pabcuam (xws li: av kub -80, roj castor, PEG400, talc, thiab lwm yam).
2. Txheej cais txheej enteric-soluble: ntawm qhov chaw ntawm cov ntsiav tshuaj thiab granules, HPMC txheej yog thawj zaug siv ua txheej cais txheej hauv qab, thiab tom qab ntawd coated nrog ib txheej ntawm HPMCP enteric-soluble khoom. HPMC zaj duab xis tuaj yeem txhim kho kev ruaj khov ntawm cov neeg sawv cev txheej enteric-soluble hauv kev khaws cia.
3. Kev npaj tso tawm ntev: siv HPMC ua tus neeg sawv cev rau qhov hws thiab cia siab rau ethyl cellulose ua cov khoom siv pob txha, cov ntsiav tshuaj ua haujlwm ntev uas tso tawm ntev tuaj yeem ua tau.
4. Tus neeg sawv cev thickening thiab colloid tiv thaiv cov nplaum thiab cov tshuaj qhov muag: HPMC rau tus neeg sawv cev thickening feem ntau siv cov concentration ntawm 0.45-1%.
5. Cov nplaum: HPMC ua tus binder dav dav concentration ntawm 2% -5%, siv los txhim kho qhov ruaj khov ntawm hydrophobic nplaum, feem ntau siv concentration ntawm 0.5-1.5%.
6. Tus neeg sawv cev ncua, tus neeg sawv cev tso tawm tswj thiab tus neeg sawv cev ncua. Tus neeg sawv cev ncua: qhov ntau npaum li cas ntawm tus neeg sawv cev ncua yog 0.5-1.5%.
7. Khoom noj khoom haus: HPMC ua tus neeg sawv cev thickening ntxiv rau ntau yam dej haus, khoom noj mis nyuj, condiments, khoom noj khoom haus, ua tus neeg sawv cev thickening, binder, emulsifier, suspension agent, stabilizer, dej retention agent, excifer, thiab lwm yam.
8. Siv rau hauv cov tshuaj pleev ib ce ua cov nplaum, cov emulsifiers, cov neeg sawv cev tsim zaj duab xis, thiab lwm yam.
Lub sijhawm tshaj tawm: Lub Ib Hlis-14-2022