I-HPMC ibizwa ngokuba yi-hydroxypropyl methylcellulose.
Imveliso ye-HPMC ikhetha i-cotton cellulose ecocekileyo kakhulu njengezinto eziluhlaza kwaye yenziwa nge-etherification ekhethekileyo phantsi kweemeko ze-alkaline. Yonke le nkqubo igqitywa phantsi kweemeko ze-GMP kunye nokubeka esweni ngokuzenzekelayo, ngaphandle kwezithako ezisebenzayo ezifana nezitho zezilwanyana kunye negrisi.
Iipropati ze-HPMC:
Imveliso ye-HPMC yi-non-ionic cellulose ether, imbonakalo yayo yipowder emhlophe, ayinavumba, ayinyibiliki emanzini nakwizinyibilikisi ezininzi ze-polar organic (ezifana ne-dichloroethane) kwaye ilingana ne-ethanol/amanzi, i-propyl alcohol/amanzi, njl. Isisombululo samanzi sinomsebenzi womphezulu, sibonakala kakuhle kwaye sisebenza ngokuzinzileyo. I-HPMC ineempawu zejeli yobushushu, isisombululo samanzi semveliso siyafudunyezwa ukuze senze i-gel precipitation, size sinyibilike emva kokuba sipholile, iinkcukacha ezahlukeneyo zobushushu bejeli yemveliso zahlukile. Utshintsho lokunyibilika nge-viscosity, okukhona i-viscosity iphantsi, kokukhona ukunyibilika kukhulu, iinkcukacha ezahlukeneyo ze-HPMC zinomahluko othile kwiimpawu zayo, i-HPMC emanzini ayichaphazeleki lixabiso le-PH. Ubungakanani bezinto ezincinci: Izinga lokudlula le-mesh eli-100 likhulu kune-100%. Ubuninzi: 0.25-0.70g/ (ngesiqhelo malunga ne-0.5g/), ubunzima obuthile 1.26-1.31. Ubushushu bokutshintsha kombala: 190-200℃, ubushushu be-carbonization: 280-300℃. Uxinzelelo lomphezulu: 42-56dyn/cm kwisisombululo samanzi esiyi-2%. Ngokunyuka komxholo we-methoxyl, inqaku lejeli liyehla, ukunyibilika kwamanzi kuye kwanda, kwaye nomsebenzi womphezulu uye wanda. I-HPMC ineempawu zokutyeba, ukufaka ityuwa, umxholo womlotha ophantsi, ukuzinza kwe-PH, ukugcinwa kwamanzi, uzinzo olulinganayo, ukwakheka kwefilimu okugqwesileyo kunye nokumelana okukhulu ne-enzyme, ukusasazeka kunye nokuhambelana.
Izicelo ze-HPMC:
1. Ugqunywe ngethebhulethi: I-HPMC isetyenziswa njengezinto zogqunywe ngefilimu xa ilungiswa kakuhle, inokwenza ifilimu eqinileyo, egudileyo nentle, uxinaniso lokusetyenziswa luyi-2%-8%. Emva kogqunywe, uzinzo lwesixhobo ekukhanyeni, kubushushu nakumswakama luyanda; Ayinancasa kwaye ayinavumba, kulula ukuyithatha, kunye nombala we-HPMC, i-sunscreen, izinto zokuthambisa kunye nezinye izinto ezihambelana kakuhle. Ugqunywe oluqhelekileyo: amanzi okanye i-ethanol engama-30-80% yokunyibilikisa i-HPMC, kunye nesisombululo se-3-6%, songeza izithako ezincedisayo (ezifana: ubushushu bomhlaba -80, ioyile ye-castor, i-PEG400, i-talc, njl.njl.).
2. Umaleko wokuzihlukanisa we-enteric-soluble coating: phezu kweepilisi kunye neegranules, i-HPMC coating isetyenziswa kuqala njengomaleko wokuzihlukanisa we-enteric-soluble coating esezantsi, ize igqunywe ngomaleko we-HPMCP enteric-soluble material. Ifilimu ye-HPMC inokuphucula uzinzo lwe-enteric-soluble coating agent kwindawo yokugcina.
3. Ukulungiswa kokukhululwa okuqhubekekayo: kusetyenziswa i-HPMC njengearhente ebangela iimbobo kwaye kuxhomekeke kwi-ethyl cellulose njengezinto ezisetyenziswa kumathambo, kunokwenziwa iipilisi ezikhupha ixesha elide eziqhubekekayo.
4. I-arhente yokutyeba kunye ne-colloid protective adhesive kunye namaconsi eliso: I-HPMC yearhente yokutyeba esetyenziswa rhoqo yi-0.45-1%.
5. I-Adhesive: I-HPMC njenge-binder general concentration ye-2%-5%, isetyenziselwa ukuphucula uzinzo lwe-hydrophobic adhesive, i-concentration esetyenziswa rhoqo ye-0.5-1.5%.
6. I-arhente yokulibazisa, i-arhente yokukhulula elawulwayo kunye ne-arhente yokumiswa. I-arhente yokumiswa: idosi eqhelekileyo ye-arhente yokumiswa yi-0.5-1.5%.
7. Ukutya: I-HPMC njengearhente yokutyebisa yongezwa kwiintlobo ngeentlobo zeziselo, iimveliso zobisi, iziqholo, ukutya okunesondlo, njengearhente yokutyebisa, i-binder, i-emulsifier, iarhente yokumisa, i-stabilizer, iarhente yokugcina amanzi, i-excifer, njl.njl.
8. Isetyenziswa kwizithambiso njengezinto zokuncamathelisa, izinto ezixubayo, izinto zokwenza iifilimu, njl.njl.
Ixesha lokuposa: Jan-14-2022