HPMC imatchedwa hydroxypropyl methylcellulose.
Chogulitsa cha HPMC chimasankha cellulose yoyera kwambiri ya thonje ngati zinthu zopangira ndipo chimapangidwa ndi etherification yapadera pansi pa mikhalidwe ya alkaline. Ntchito yonseyi imamalizidwa pansi pa mikhalidwe ya GMP ndi kuyang'aniridwa kokha, popanda zosakaniza zilizonse zogwira ntchito monga ziwalo za nyama ndi mafuta.
Katundu wa HPMC:
Chogulitsa cha HPMC ndi ether yosakhala ya ionic cellulose, mawonekedwe ake ndi ufa woyera, wopanda fungo, wosungunuka m'madzi ndi zinthu zambiri zachilengedwe (monga dichloroethane) komanso kuchuluka koyenera kwa ethanol/madzi, propyl alcohol/madzi, ndi zina zotero. Yankho lamadzi limakhala ndi ntchito pamwamba, mawonekedwe owonekera bwino komanso magwiridwe antchito okhazikika. HPMC ili ndi mawonekedwe a gel yotenthetsera, yankho la madzi a chinthucho limatenthedwa kuti lipange gel, kenako limasungunuka litazizira, mawonekedwe osiyanasiyana a kutentha kwa gel ya chinthucho ndi osiyana. Kusintha kwa kusungunuka ndi kukhuthala, kukhuthala kutsika, kusungunuka kwakukulu, mawonekedwe osiyanasiyana a HPMC ali ndi kusiyana kwina kwa mawonekedwe ake, HPMC m'madzi sikhudzidwa ndi mtengo wa PH. Kukula kwa tinthu: 100 mesh pass rate ndi yayikulu kuposa 100%. Kuchuluka kwa ma mesh: 0.25-0.70g/ (nthawi zambiri pafupifupi 0.5g/), mphamvu yokoka 1.26-1.31. Kutentha kwa mtundu: 190-200℃, kutentha kwa carbonization: 280-300℃. Kukanika kwa pamwamba: 42-56dyn/cm mu yankho lamadzi la 2%. Pamene kuchuluka kwa methoxyl kumawonjezeka, mfundo ya gel imachepa, kusungunuka kwa madzi kumawonjezeka, ndipo ntchito ya pamwamba imawonjezekanso. HPMC ili ndi makhalidwe monga kukhuthala, kuthira mchere, phulusa lochepa, kukhazikika kwa PH, kusunga madzi, kukhazikika kwa mawonekedwe, kupanga filimu yabwino kwambiri komanso kukana kwambiri ma enzyme, kufalikira ndi kugwirizana.
Mapulogalamu a HPMC:
1. Chophimba cha piritsi: HPMC imagwiritsidwa ntchito ngati chophimba cha filimu pokonzekera bwino, imatha kupanga filimu yolimba, yosalala komanso yokongola, ndipo kuchuluka kwa 2%-8% pambuyo pophimba, kukhazikika kwa chopangiracho ku kuwala, kutentha ndi chinyezi kumawonjezeka; Chopanda kukoma komanso chopanda fungo, chosavuta kutenga, ndi utoto wa HPMC, mafuta oteteza ku dzuwa, mafuta ndi zina zogwirizana bwino ndi zinthu. Chophimba wamba: madzi kapena 30-80% ethanol kuti asungunuke HPMC, yokhala ndi yankho la 3-6%, kuwonjezera zosakaniza zina (monga: kutentha kwa nthaka -80, mafuta a castor, PEG400, talc, ndi zina zotero).
2. Chophimba chosungunuka m'matumbo: pamwamba pa mapiritsi ndi tinthu tating'onoting'ono, chophimba cha HPMC chimagwiritsidwa ntchito koyamba ngati chophimba chosungunuka pansi, kenako chimakutidwa ndi chophimba cha HPMCP chosungunuka m'matumbo. Filimu ya HPMC imatha kukonza kukhazikika kwa chophimba chosungunuka m'matumbo chomwe chimasungidwa.
3. Kukonzekera kokhazikika: pogwiritsa ntchito HPMC ngati chothandizira kubweretsa machubu komanso kudalira ethyl cellulose ngati zinthu za mafupa, mapiritsi okhazikika okhazikika amatha kupangidwa.
4. Chothandizira kukhuthala ndi guluu woteteza wa colloid ndi madontho a maso: HPMC ya chothandizira kukhuthala imagwiritsidwa ntchito kwambiri pa 0.45-1%.
5. Zomatira: HPMC monga binder general composition ya 2%-5%, yomwe imagwiritsidwa ntchito kukonza kukhazikika kwa hydrophobic glue, yomwe imagwiritsidwa ntchito kwambiri ndi 0.5-1.5%.
6. Choletsa, choletsa kutulutsa cholamulidwa ndi choletsa kuimitsa. Choletsa kuimitsa: Mlingo wamba wa choletsa kuimitsa ndi 0.5-1.5%.
7. Chakudya: HPMC ngati chowonjezera kukhuthala chomwe chimawonjezeredwa ku zakumwa zosiyanasiyana, mkaka, zokometsera, zakudya zopatsa thanzi, monga chowonjezera kukhuthala, chomangira, chosakaniza, chosungunula, chokhazikika, chosungira madzi, chowonjezera, ndi zina zotero.
8. Amagwiritsidwa ntchito mu zodzoladzola monga zomatira, zosakaniza, zopangira filimu, ndi zina zotero.
Nthawi yotumizira: Januwale-14-2022