Ana kiran HPMC da hydroxypropyl methylcellulose.
Samfurin HPMC yana zaɓar cellulose mai tsarki na auduga a matsayin kayan da aka samar kuma ana yin sa ta hanyar etherification na musamman a ƙarƙashin yanayin alkaline. Ana kammala dukkan aikin a ƙarƙashin yanayin GMP da sa ido ta atomatik, ba tare da wani sinadarai masu aiki kamar gabobin dabbobi da mai ba.
Kayayyakin HPMC:
Samfurin HPMC ba shi da ionic cellulose ether, kamanninsa fari ne, ba shi da ƙamshi, yana narkewa a cikin ruwa da yawancin abubuwan narkewa na halitta (kamar dichloroethane) da kuma daidaitaccen rabo na ethanol/ruwa, propyl alcohol/ruwa, da sauransu. Maganin ruwa yana da aikin saman, babban bayyananne da aiki mai karko. HPMC yana da halayen gel na zafi, ana dumama ruwan samfurin don samar da ruwan gel, sannan a narke bayan sanyaya, takamaiman bayanai na zafin gel ɗin samfurin ya bambanta. Narkewa yana canzawa tare da danko, ƙarancin danko, mafi girman narkewa, ƙayyadaddun bayanai daban-daban na HPMC yana da takamaiman bambanci a cikin kaddarorinsa, ƙimar PH ba ta shafar HPMC a cikin ruwa. Girman barbashi: Ragewar raga 100 ya fi 100%. Yawan yawa: 0.25-0.70g/ (yawanci kusan 0.5g/), takamaiman nauyi 1.26-1.31. Zafin canza launi: 190-200℃, zafin carbonization: 280-300℃. Tashin hankali a saman: 42-56dyn/cm a cikin kashi 2% na ruwan da ke cikinsa. Tare da ƙaruwar sinadarin methoxyl, ma'aunin gel ɗin ya ragu, narkewar ruwan ya ƙaru, kuma aikin saman ya ƙaru. HPMC yana da halaye na kauri, gishiri, ƙarancin toka, kwanciyar hankali na PH, riƙe ruwa, kwanciyar hankali na girma, kyakkyawan samar da fim da juriya ga enzyme, warwatsewa da haɗin kai.
Aikace-aikacen HPMC:
1. Rufin Kwamfuta: Ana amfani da HPMC azaman kayan shafa fim a cikin shiri mai ƙarfi, yana iya samar da fim mai tauri, santsi da kyau, yawan amfani da shi shine 2%-8%. Bayan an shafa, kwanciyar hankali na wakili zuwa haske, zafi da danshi yana ƙaruwa; Ba shi da ɗanɗano kuma ba shi da ƙamshi, mai sauƙin ɗauka, da kuma launi na HPMC, man shafawa na rana, man shafawa da sauran dacewa mai kyau na kayan. Rufin yau da kullun: ruwa ko ethanol 30-80% don narke HPMC, tare da maganin 3-6%, ƙara kayan taimako (kamar: zafin ƙasa -80, man castor, PEG400, talc, da sauransu).
2. Layin keɓewa na shafi mai narkewa a cikin jiki: a saman allunan da granules, ana fara amfani da murfin HPMC azaman layin keɓewa na ƙasan shafi, sannan a shafa shi da wani Layer na kayan HPMCP mai narkewa a cikin jiki. Fim ɗin HPMC na iya inganta kwanciyar hankali na wakilin murfin mai narkewa a cikin jiki a cikin ajiya.
3. Shirye-shiryen sakin jiki mai ɗorewa: ta amfani da HPMC a matsayin maganin da ke haifar da ramuka da kuma dogaro da ethyl cellulose a matsayin kayan kwarangwal, ana iya yin allunan da ke aiki na dogon lokaci.
4. Maganin kauri da manne mai kariya daga colloid da digo na ido: HPMC don maganin kauri da aka saba amfani da shi shine 0.45-1%.
5. Manne: HPMC a matsayin babban taro na 2%-5%, ana amfani da shi don inganta kwanciyar hankali na manne mai hana ruwa, yawan amfani da shi na 0.5-1.5%.
6. Maganin jinkirtawa, maganin sakin da aka sarrafa da kuma maganin dakatarwa. Maganin dakatarwa: yawan maganin dakatarwa da aka saba amfani da shi shine 0.5-1.5%.
7. Abinci: HPMC a matsayin maganin kauri da aka ƙara a cikin nau'ikan abubuwan sha, kayayyakin kiwo, kayan ƙanshi, abinci mai gina jiki, a matsayin maganin kauri, mai ɗaurewa, mai emulsifier, wakilin dakatarwa, mai daidaita, wakilin riƙe ruwa, mai cire ruwa, da sauransu.
8. Ana amfani da shi a kayan kwalliya a matsayin manne, masu canza launin fata, masu samar da fim, da sauransu.
Lokacin Saƙo: Janairu-14-2022